The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list
GtoImmuPdb ligands only: Peptides encoded in the human, rat and mouse genomes.
| Ligand name | ID | Synonyms | |||||||
| A | Back to top | ||||||||
| ACTH {Sp: Human} |
|
|
3633 | Acthar®, adrenocorticotropic hormone (1-39), corticotropin | |||||
| adrenomedullin {Sp: Human} |
|
683 | AM | ||||||
| amphiregulin {Sp: Human} |
|
4864 | colorectal cell-derived growth factor (CRDGF) | ||||||
| APRIL {Sp: Human} |
|
5068 | A proliferation-inducing ligand, TALL2, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TRDL-1, ZTNF2 | ||||||
| B | Back to top | ||||||||
| BAFF {Sp: Human} |
|
5069 | B cell-activating factor, CD257 antigen, dendritic cell-derived TNF-like molecule | ||||||
| C | Back to top | ||||||||
| C5a {Sp: Human} |
|
573 | C5a anaphylatoxin, complement component C5a, human complement protein | ||||||
| CCL1 {Sp: Human} |
|
812 | I309, TCA-3 | ||||||
| CCL11 {Sp: Human} |
|
769 | eotaxin | ||||||
| CCL13 {Sp: Human} |
|
770 | monocyte chemotactic protein-4 | ||||||
| CCL14 {Sp: Human} |
|
753 | CCL14a, CKβ1, haemofiltrate CC chemokine 1 (HCC-1), HCC-1(1-74) | ||||||
| CCL15 {Sp: Human} |
|
754 | Lkn-1 [Leukotactin-1], macrophage inflammatory protein-1δ, MIP-1δ | ||||||
| CCL16 {Sp: Human} |
|
1272 | |||||||
| CCL17 {Sp: Human} |
|
797 | TARC, thymus- and activation-regulated chemokine | ||||||
| CCL18 {Sp: Human} |
|
4382 | macrophage inflammatory protein 4, small-inducible cytokine A18 | ||||||
| CCL19 {Sp: Human} |
|
810 | β-chemokine exodus-3, ck β-11, ckβ11, MIP-3β | ||||||
| CCL2 {Sp: Human} |
|
771 | |||||||
| CCL20 {Sp: Human} |
|
808 | LARC, liver and activation-regulated chemokine, macrophage inflammatory protein-3α, MIP-3α | ||||||
| CCL21 {Sp: Human} |
|
811 | ckβ9, TCA-4 | ||||||
| CCL22 {Sp: Human} |
|
798 | dc/β-ck, macrophage-derived chemokine, STCP1 | ||||||
| CCL23 {Sp: Human} |
|
755 | ckβ8-1, myeloid progenitor inhibitor factor-1 | ||||||
| CCL24 {Sp: Human} |
|
775 | eotaxin-2 | ||||||
| CCL25 {Sp: Human} |
|
817 | |||||||
| CCL26 {Sp: Human} |
|
776 | MIP-4α, PTEC | ||||||
| CCL27 {Sp: Human} |
|
3646 | |||||||
| CCL28 {Sp: Human} |
|
3649 | |||||||
| CCL3 {Sp: Human} |
|
756 | macrophage inflammatory protein-1α, MIP-1α | ||||||
| CCL4 {Sp: Human} |
|
757 | HC21, macrophage inflammatory protein-1β, MIP-1β | ||||||
| CCL5 {Sp: Human} |
|
758 | eosinophil chemotactic cytokine [EoCP], regulated upon activation normal T cell expressed and secreted (RANTES) | ||||||
| CCL7 {Sp: Human} |
|
759 | |||||||
| CCL8 {Sp: Human} |
|
772 | monocyte chemotactic protein-2 | ||||||
| CCL1 {Sp: Mouse} |
|
4404 | |||||||
| CCL11 {Sp: Mouse} |
|
787 | murine eotaxin | ||||||
| CCL12 {Sp: Mouse} |
|
4435 | |||||||
| CCL19 {Sp: Mouse} |
|
4417 | |||||||
| CCL2 {Sp: Mouse} |
|
4406 | |||||||
| CCL20 {Sp: Mouse} |
|
4418 | |||||||
| CCL22 {Sp: Mouse} |
|
4420 | |||||||
| CCL24 {Sp: Mouse} |
|
4421 | |||||||
| CCL25 {Sp: Mouse} |
|
4422 | |||||||
| CCL27 {Sp: Mouse} |
|
4462 | |||||||
| CCL28 {Sp: Mouse} |
|
4463 | |||||||
| CCL3 {Sp: Mouse} |
|
4408 | |||||||
| CCL4 {Sp: Mouse} |
|
4410 | |||||||
| CCL7 {Sp: Mouse} |
|
4413 | |||||||
| CCL8 {Sp: Mouse} |
|
4415 | |||||||
| CCL9 {Sp: Mouse} |
|
4434 | |||||||
| CCL5 {Sp: Mouse, Rat} |
|
4412 | |||||||
| CCL11 {Sp: Rat} |
|
4416 | |||||||
| CCL2 {Sp: Rat} |
|
4407 | |||||||
| CCL20 {Sp: Rat} |
|
4419 | |||||||
| CCL3 {Sp: Rat} |
|
4409 | |||||||
| CCL4 {Sp: Rat} |
|
4411 | |||||||
| CCL7 {Sp: Rat} |
|
4414 | |||||||
| Ccl21a {Sp: Mouse} |
|
8651 | 6Ckine-Ser, Exodus-2 | ||||||
| Ccl21b {Sp: Mouse} |
|
8652 | 6Ckine-Leu, Exodus-2 | ||||||
| CD40 ligand {Sp: Human} |
|
5077 | CD40 ligand, membrane form | ||||||
| complement C3 {Sp: Human} |
|
9414 | |||||||
| complement C5 {Sp: Human} |
|
8712 | |||||||
| CRAMP {Sp: Mouse} |
|
6266 | |||||||
| CXCL1 {Sp: Human} |
|
819 | GROα, melanocyte growth-stimulatory activity, MIP-2 | ||||||
| CXCL10 {Sp: Human} |
|
835 | |||||||
| CXCL11 {Sp: Human} |
|
836 | IP9, ITAC | ||||||
| CXCL12α {Sp: Human} |
|
4358 | CXCL12 α, SDF-1α, stromal cell-derived factor-1α | ||||||
| CXCL12β {Sp: Human} |
|
845 | SDF-1β, stromal cell-derived factor-1 (SDF-1), stromal cell-derived factor-1β | ||||||
| CXCL12δ {Sp: Human} |
|
8531 | |||||||
| CXCL12ε {Sp: Human} |
|
8532 | |||||||
| CXCL12γ {Sp: Human} |
|
8530 | |||||||
| CXCL12φ {Sp: Human} |
|
8533 | |||||||
| CXCL13 {Sp: Human} |
|
3645 | BCA-1 | ||||||
| CXCL14 {Sp: Human} |
|
3680 | BMAC | ||||||
| CXCL16 {Sp: Human} |
|
855 | |||||||
| CXCL17 {Sp: Human} |
|
6479 | C-X-C motif chemokine 17, dendritic cell and monocyte chemokine-like protein | ||||||
| CXCL2 {Sp: Human} |
|
827 | GROβ, MIP-2α | ||||||
| CXCL3 {Sp: Human} |
|
828 | GROγ, MIP-2β | ||||||
| CXCL4 {Sp: Human} |
|
3685 | platelet factor 4 (PF4) | ||||||
| CXCL5 {Sp: Human} |
|
829 | ENA-78 | ||||||
| CXCL6 {Sp: Human} |
|
820 | |||||||
| CXCL7 {Sp: Human} |
|
830 | PPBP | ||||||
| CXCL8 {Sp: Human} |
|
821 | interleukin-8 | ||||||
| CXCL9 {Sp: Human} |
|
837 | MIG, monokine induced by gamma-interferon | ||||||
| CX3CL1 {Sp: Human} |
|
856 | fractalkine, neurotactin | ||||||
| CXCL1 {Sp: Mouse} |
|
4423 | |||||||
| CXCL10 {Sp: Mouse} |
|
4430 | |||||||
| CXCL11 {Sp: Mouse} |
|
4432 | |||||||
| CXCL12 {Sp: Mouse} |
|
4465 | |||||||
| CXCL13 {Sp: Mouse} |
|
4466 | |||||||
| CXCL15 {Sp: Mouse} |
|
3862 | lungkine (mouse) | ||||||
| CXCL16 {Sp: Mouse} |
|
4433 | |||||||
| CXCL2 {Sp: Mouse} |
|
4424 | macrophage inflammatory protein 2 (MIP-2) | ||||||
| CXCL3 {Sp: Mouse} |
|
4426 | |||||||
| CXCL5 {Sp: Mouse} |
|
4428 | |||||||
| CXCL9 {Sp: Mouse} |
|
4429 | |||||||
| CX3CL1 {Sp: Mouse} |
|
4468 | |||||||
| CXCL1 {Sp: Rat} |
|
826 | CINC, GROα, macrophage inflammatory protein-2 | ||||||
| CXCL10 {Sp: Rat} |
|
4431 | |||||||
| CXCL16 {Sp: Rat} |
|
4467 | |||||||
| CXCL2 {Sp: Rat} |
|
4425 | |||||||
| CXCL3 {Sp: Rat} |
|
4427 | |||||||
| CXCL5 {Sp: Rat} |
|
4464 | |||||||
| CX3CL1 {Sp: Rat} |
|
4469 | |||||||
| E | Back to top | ||||||||
| elafin {Sp: Human} |
|
12035 | cementoin, trappin-2 | ||||||
| F | Back to top | ||||||||
| Fas ligand {Sp: Human} |
|
5078 | apoptosis antigen ligand, CD95L | ||||||
| G | Back to top | ||||||||
| galectin-1 {Sp: Human} |
|
6603 | GBP | ||||||
| galectin-3 {Sp: Human} |
|
6619 | galectin 3, GALIG, LGALS2, MAC-2 | ||||||
| galectin 9 {Sp: Human} |
|
9594 | Ecalectin, Gal-9, Tumor antigen HOM-HD-21 | ||||||
| galectin-3 binding protein {Sp: Human} |
|
6615 | L3 antigen, Mac-2-binding protein, MAC-2-BP | ||||||
| G-CSF {Sp: Human} |
|
|
4934 | Granocyte® | |||||
| GM-CSF {Sp: Human} |
|
4942 | colony-stimulating factor, CSF | ||||||
| GPR15L {Sp: Human} |
|
10567 | antimicrobial peptide-57, colon-derived SUSD2 binding factor | ||||||
| H | Back to top | ||||||||
| hsp60 {Sp: Human} |
|
4953 | heat shock 60kD protein 1 (chaperonin), HSP-60, mitochondrial matrix protein P1 | ||||||
| I | Back to top | ||||||||
| ICOS ligand {Sp: Human} |
|
9593 | CD275, B7 homolog 2, B7-H2, B7-related protein 1, B7RP-1, ICOS-L | ||||||
| IFN-α10 {Sp: Human} |
|
4956 | IFN alpha-10, interferon alpha-10, interferon alpha-6L, interferon alpha-C | ||||||
| IFN-α1/13 {Sp: Human} |
|
4955 | IFN-α1, IFN-α13, IFN-alpha 1/13, interferon alpha-1/13, interferon alpha-D | ||||||
| IFN-α14 {Sp: Human} |
|
4957 | IFN alpha-14, interferon alpha-14, interferon alpha-H, interferon lambda-2-H | ||||||
| IFN-α16 {Sp: Human} |
|
4958 | IFN alpha-16, interferon alpha-16, interferon alpha-WA | ||||||
| IFN-α17 {Sp: Human} |
|
4959 | IFN alpha-17, interferon alpha-17, interferon alpha-88, interferon alpha-T | ||||||
| IFN-α2 {Sp: Human} |
|
|
4960 | IFN-alpha-2, interferon alpha-2, Roferon A® | |||||
| IFN-α21 {Sp: Human} |
|
4961 | IFN-alpha 21, interferon alpha-21, interferon alpha-F | ||||||
| IFN-α4 {Sp: Human} |
|
4962 | IFN-alpha-4, interferon alpha-4 , interferon alpha-4B, interferon alpha-76, interferon alpha-M1 | ||||||
| IFN-α5 {Sp: Human} |
|
4963 | IFN-alpha-5, interferon alpha-5, interferon alpha-61, interferon alpha-G | ||||||
| IFN-α6 {Sp: Human} |
|
4964 | IFN-alpha-6, interferon alpha-54, interferon alpha-6, interferon alpha-K | ||||||
| IFN-α7 {Sp: Human} |
|
4965 | IFN-alpha-7, interferon alpha-7, interferon alpha-J, interferon alpha-J1 | ||||||
| IFN-α8 {Sp: Human} |
|
4966 | IFN-alpha-8, interferon alpha-8, interferon alpha-B, interferon alpha-B2 | ||||||
| IFN-β {Sp: Human} |
|
4967 | Avonex® (recombinant IFN-beta-1a), fibroblast interferon, interferon beta | ||||||
| IFN-γ {Sp: Human} |
|
|
4968 | Actimmune®, immune interferon, interferon gamma | |||||
| IFN-κ {Sp: Human} |
|
4969 | interferon kappa | ||||||
| IFN-λ1 {Sp: Human} |
|
4993 | IFN-lambda-1, interferon lambda-1, interferon-λ1, interleukin-29 | ||||||
| IFN-λ2 {Sp: Human} |
|
4991 | cytokine Zcyto20, IFN-lambda-2, interferon lambda-2, interferon-λ2, interleukin-28A | ||||||
| IFN-λ3 {Sp: Human} |
|
4992 | cytokine Zcyto22, IFN-lambda-3, IFN-lambda-4, interleukin-28B (IL-28B), interleukin-28C (IL-28C) | ||||||
| IFN-ω {Sp: Human} |
|
4970 | interferon alpha-II-1, interferon omega-1 | ||||||
| IL-10 {Sp: Human} |
|
4975 | interleukin-10 | ||||||
| IL-11 {Sp: Human} |
|
4976 | interleukin-11 | ||||||
| IL-12 {Sp: Human} |
|
4977 | IL-12 p70 | ||||||
| IL-13 {Sp: Human} |
|
4980 | hematopoietic growth factor, interleukin-13, mast cell growth factor, multipotential colony-stimulating factor, P-cell-stimulating factor | ||||||
| IL-15 {Sp: Human} |
|
4981 | interleukin-15 | ||||||
| IL-18 {Sp: Human} |
|
4983 | ibocatdekin, interferon-γ-inducing factor, interleukin-1 gamma (IL-1 gamma), interleukin-18 | ||||||
| IL-19 {Sp: Human} |
|
4984 | interleukin-19, melanoma differentiation-associated protein-like protein | ||||||
| IL-1α {Sp: Human} |
|
4973 | hematopoietin-1, interleukin-1 alpha | ||||||
| IL-1β {Sp: Human} |
|
4974 | catabolin, interleukin-1 beta | ||||||
| IL-2 {Sp: Human} |
|
|
4985 | aldesleukin, interleukin-2, Proleukin® | |||||
| IL-20 {Sp: Human} |
|
4986 | cytokine Zcyto10, interleukin-20 | ||||||
| IL-21 {Sp: Human} |
|
4987 | interleukin-21, ZA11 | ||||||
| IL-22 {Sp: Human} |
|
4988 | cytokine Zcyto18, interleukin-22 | ||||||
| IL-23 {Sp: Human} |
|
4978 | |||||||
| IL-24 {Sp: Human} |
|
4990 | interleukin-24, MDA-7, melanoma differentiation-associated gene 7 protein | ||||||
| IL-25 {Sp: Human} |
|
5876 | IL-17E, interleukin-17E, interleukin-25 | ||||||
| IL-27 {Sp: Human} |
|
6151 | |||||||
| IL-3 {Sp: Human} |
|
4994 | interleukin-3 (IL-3), multilineage-colony-stimulating factor (mCSF) | ||||||
| IL-31 {Sp: Human} |
|
4995 | interleukin-31 | ||||||
| IL-33 {Sp: Human} |
|
5880 | IL-1F11 | ||||||
| IL-34 {Sp: Human} |
|
8975 | |||||||
| IL-36α {Sp: Human} |
|
5881 | FIL1 epsilon, interleukin-1 epsilon (IL-1 epsilon) | ||||||
| IL-36β {Sp: Human} |
|
5882 | FIL1 eta, IL-1 eta, interleukin-1 eta | ||||||
| IL-36γ {Sp: Human} |
|
5883 | IL-1-related protein 2 (IL-1RP2), interleukin-1 epsilon (IL-1E), interleukin-1 family member 9, interleukin-36 gamma | ||||||
| IL-37 {Sp: Human} |
|
6149 | IL-1ζ, IL-23, interleukin-1ζ, interleukin-1-related protein (IL1RP), interleukin-23 | ||||||
| IL-4 {Sp: Human} |
|
4996 | B-cell stimulatory factor 1, binetrakin, interleukin-4, pitrakinra | ||||||
| IL-5 {Sp: Human} |
|
4997 | |||||||
| IL-6 {Sp: Human} |
|
4998 | B-cell stimulatory factor 2, CTL differentiation factor, hybridoma growth factor, interferon β2, interleukin-6 | ||||||
| IL-7 {Sp: Human} |
|
4999 | interleukin-7 | ||||||
| IL-9 {Sp: Human} |
|
5000 | interleukin-9 | ||||||
| IL-12A {Sp: Human} |
|
5001 | IL-12 p35, interleukin-12A, NKSF1 | ||||||
| IL-17A {Sp: Human} |
|
4982 | CTLA-8, interleukin-17 alpha | ||||||
| IL-23A {Sp: Human} |
|
4989 | IL-23p19, IL23A, interleukin-23 subunit alpha, interleukin-23A | ||||||
| IL-17A/IL-17F {Sp: Human} |
|
5874 | |||||||
| IL-12B {Sp: Human} |
|
5002 | IL-12 p40, IL-12B monomer, interleukin-12β, interleukin-12B, natural killer cell stimulatory factor 2 | ||||||
| IL-17B {Sp: Human} |
|
5877 | |||||||
| IL-17C {Sp: Human} |
|
5875 | cytokine CX2, interleukin-17C | ||||||
| IL-17F {Sp: Human} |
|
5873 | cytokine ML-1, Interleukin-17F | ||||||
| IL-1 receptor antagonist {Sp: Human} |
|
5878 | IL-1ra, interleukin-1 receptor antagonist protein, IRAP | ||||||
| IL-36 receptor antagonist {Sp: Human} |
|
5879 | IL-1 related protein 3 (IL1RP3), IL-1F5, IL-36ra, IL1F5, interleukin 1 family member 5 (delta) | ||||||
| IL-27 subunit α {Sp: Human} |
|
6152 | IL-27 subunit alpha, interleukin-27 subunit alpha, p28 | ||||||
| IL-27 subunit β {Sp: Human} |
|
6153 | EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, interleukin-27 subunit beta | ||||||
| L | Back to top | ||||||||
| LIF {Sp: Human} |
|
5016 | cholinergic differentiation factor (CDF), differentiation-inducing factor (DIF), human interleukin in DA cells (HILDA) | ||||||
| LIGHT {Sp: Human} |
|
5070 | Herpesvirus entry mediator-ligand, TR2 | ||||||
| liver enriched antimicrobial peptide 2 {Sp: Human} |
|
9734 | LEAP2 | ||||||
| LL-37 {Sp: Human} |
|
5527 | antibacterial protein LL-37, cathelicidin LL 37 (human) | ||||||
| 5-LOX activating protein {Sp: Human} |
|
5183 | FLAP, 5-lipoxygenase-activating protein, arachidonate 5-lipoxygenase-activating protein | ||||||
| lymphotoxin-α {Sp: Human} |
|
5064 | TNFSF1, LTα, TNFβ | ||||||
| M | Back to top | ||||||||
| macrophage migration inhibitory factor {Sp: Human} |
|
9981 | L-dopachrome isomerase, MMIF | ||||||
| M-CSF {Sp: Human} |
|
4905 | CSF-1, lanimostim, macrophage-CSF | ||||||
| [Met]enkephalin {Sp: Human, Mouse, Rat} |
|
1614 | 1-5 Adrenorphin, [Met]-enkephalin, IRT-101, methionine enkephalin, np2 enkephalin, opioid growth factor (OGF) | ||||||
| mucosal addressin cell adhesion molecule 1 {Sp: Human} |
|
9339 | MAdCAM-1, addressin, MAdCAM1 | ||||||
| N | Back to top | ||||||||
| Natural cytotoxicity triggering receptor 3 ligand 1 {Sp: Human} |
|
11142 | B7H6, B7-H6 | ||||||
| O | Back to top | ||||||||
| OX-40 ligand {Sp: Human} |
|
5076 | glycoprotein Gp34, TXGP-1 | ||||||
| P | Back to top | ||||||||
| programmed cell death 1 ligand 1 {Sp: Human} |
|
9606 | PD-L1, B7 homolog 1, B7-H1, PDL1, programmed death ligand 1 | ||||||
| R | Back to top | ||||||||
| RANK ligand {Sp: Human} |
|
5066 | receptor activator of nuclear factor κB ligand, osteoclast differentiation factor (ODF), osteoprotegerin ligand, TNFSF11 | ||||||
| S | Back to top | ||||||||
| selectin P ligand {Sp: Human} |
|
10014 | |||||||
| semaphorin 3A {Sp: Human} |
|
9902 | |||||||
| stem cell factor {Sp: Human} |
|
5055 | SCF, c-Kit ligand | ||||||
| T | Back to top | ||||||||
| TGFβ1 {Sp: Human} |
|
5060 | TGF-beta-1, transforming growth factor beta-1 | ||||||
| thymic stromal lymphopoietin {Sp: Human} |
|
5083 | TSLP | ||||||
| TL6 {Sp: Human} |
|
5072 | activation-inducible TNF-related ligand, glucocorticoid- induced TNF-related ligand | ||||||
| TL1A {Sp: Human} |
|
5071 | Tumor necrosis factor ligand superfamily member 15, membrane form | ||||||
| tumour necrosis factor membrane form {Sp: Human} |
|
5073 | TNF membrane form, cachectin, necrosin, TNFα | ||||||
| tumour necrosis factor shed form {Sp: Human} |
|
5074 | TNF shed form, cachectin, necrosin, TNF alpha soluble form, tumor necrosis factor soluble form | ||||||
| U | Back to top | ||||||||
| ulinastatin {Sp: Human} |
|
|
10359 | Miraclid®, Ulinase®, Urinastatin® | |||||
| V | Back to top | ||||||||
| VIP {Sp: Human, Mouse, Rat} |
|
1152 | |||||||
| X | Back to top | ||||||||
| XCL1 {Sp: Human} |
|
3647 | c motif cytokine 1, cytokine SCM-1α, lymphotactin α | ||||||
| XCL2 {Sp: Human} |
|
4370 | C motif cytokine 2, lymphotactin β | ||||||
| XCL1 {Sp: Mouse} |
|
4447 | lymphotactin-α | ||||||
| XCL1 {Sp: Rat} |
|
4446 | lymphotactin-α | ||||||
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