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The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

GtoImmuPdb ligands only: Low molecular weight, non-polymeric compounds produced via either total synthesis or semi-synthetic processes.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  Y  Z 

Ligand name ID Synonyms
A Back to top
852A 9025
A286982 6592 A 286982, A-286982
A438079 4118 A 438079, A-438079
abediterol 9326 LAS-100977
abrocitinib 9991 compound 25 [PMID: 29298069], PF-04965842, PF04965842
ABT-737 8320 ABT 737, ABT737, compound 2 [PMID 17256834]
AC430 9177 AC-430
acalabrutinib 8912 ACP-196, Calquence®, Example 6 [US20140155385 A1]
ACT-389949 9511
acumapimod 9203 BCT 197, BCT-197, BCT197, compound A [WO2013139809]
adavivint 9620 SM0-4690, SM04690
ADU-S100 10192 dithio-(Rp,Rp)-[cyclic[A(2',5')pA(3',5')p]], MIW815, ML RR-S2 CDA, S100
AF-219 9540 AF219, MK7264, MK‐7264
agatolimod 9843 CpG 7909, CpG7909, PF 3512676, PF-3512676, ProMune, VaxImmune
AH10-7 9899
AH6809 1896 AH 6809, AH-6809
alcaftadine 7587 Lastacaft®, R-89674
alimemazine 7237 Nedeltran®, trimeprazine
3 alpha-aminocholestane 9564 3AC, 3 α-aminocholestane
alvelestat 6476 AZD 9668, AZD-9668, AZD9668, KB-105160
AM-461 10170 AM461, Compound 1 [WO2011085033]
amcinonide 7060 CL-34699, Cyclocort®
amelubant 8463 BIIL 284, BIIL-284
AMG319 8917 AMG 319, AMG-319
aminopyridine 2 10051
amiselimod 9319 Example 1 [US20090137530], MT-1303, MT1303
amiselimod phosphate 9491 amiselimod-P
amlexanox 7113 AA-673, Amlexanox®, Aphthasol®, CHX-3673
ancriviroc 804 SCH 351125, SCH-351125, SCH-C
andrographolide 9675
apafant 1860 WEB 2086 BS, WEB-2086
apilimod 9859 STA 5326, STA-5326, STA5326
apratastat 6482 compound 5h [PMID: 16426848], TMI-05, TMI005
apremilast 7372 CC-10004, Otezla®
arformoterol 7479 Brovana®, YM-08316
ARN19702 10120 ARN-19702, compound 8 [PMID: 27404798]
ARN726 9178 ARN-726, compound 6 [PMID: 25874594]
(R)-ARN2508 9000 compound (-)-10r [PMID: 26774927], example 19 [WO2014023643]
(S)-ARN2508 8999 compound (+)-10r [PMID: 26774927], example 20 [WO2014023643]
arpromidine 1221 ARP
ARRY-382 9108 ARRY 382, ARRY382
ARRY-502 10179 ARRY502, example 237, enantiomer 1 [WO2009158426A1]
AS101 437 ammonium tri-chloro(dioxoethylene-O,O'-)tellurate, AS 101, AS-101
asimadoline 9279 EMD 61 753, EMD 61753, EMD-61753
asivatrep 9621 Example 230 [US7858621], PAC-14028
ASN002 10000 example 189 [WO2013028818A1], gusacitinib (proposed INN)
ASP4058 9569 ASP-4058
aspirin 4139 Acetophen®, acetylsalicylic acid, Aspirin®
AT38 9020 [3-(aminocarbonyl)furoxan-4-yl]methyl salicylate
ATB-346 9534 ATB 346, ATB-346, (S)-, ATB346, otenaproxesul (proposed INN)
atracurium 9537 atracurium besilate, atracurium dibesylate, BW 33A, Tracrium®
auranofin 6306 Ridaura®, SK&F-39162, SK-39162
avacopan 9450 CCX-168, CCX168
avapritinib 10368 BLU-285, BLU285
AVE 0991 5579 AVE-0991, AVE0991
AZ13102909 9577 AZ909
AZ2 10233
AZ3451 9560
AZ7188 9586
AZ8838 9585
azacitidine 6796 5-AZAC, 5-azacytidine, ladakamycin, U-18496, Vidaza®
azatadine 7119 Optimine®, SCH-10649
azathioprine 7120 Azasan®, BW-57-322, Imuran®
AZD1236 7844 AZD 1236, AZD-1236
AZD1678 9679 AZD-1678, compound 49 [PMID: 28947948]
AZD1981 7680 AZD 1981, AZD-1981
AZD2098 9678 AZD-2098, compound 47 [PMID: 28947948]
AZD2423 7825 AZD 2423, AZD-2423
AZD5069 8948
AZD5672 7686 AZD 5672, AZD-5672
AZD5718 10352 compound 12 [PMID: 30869888]
AZD6605 7823 AZ 11920155, AZ-11920155, AZ11920155, AZD 6605, AZD-6605
AZD6703 7687 AZ 12012199, AZ-12012199, AZ12012199, AZD 6703, AZD-6703
AZD7594 9325 AZ13189620, compound 15m [PMID: 28937774], velsecorat (proposed INN)
AZD7986 9412 brensocatib (proposed INN), compound 30
AZD8848 9256 DSP-3025
AZD9056 7826 AZD 9056, AZD-9056
AZD9567 9812 AZD 9567, AZD-9567, compound 15 [PMID: 29424542], example 1 [WO2016046260A1]
AZD9898 10479 AZD-9898, example 62 [WO2016177845A1]
azelaic acid 7484 Azelex®, Finacea®, ZK-62498
AZ11657312 (salt free) 7722
 
B Back to top
bafetinib 7906 INNO-406, Lyn-IN-1, NS-187
balamapimod 9925 MKI-833, MKI833
bardoxolone 2717 CDDO, RTA-401
baricitinib 7792 INCB-028050, INCB028050, LY-3009104, LY3009104, Olumiant®
BAYu9773 3381 BAY u9773, BAY-u 9773
beclometasone 7059 beclomethasone, SCH-18020W
beclometasone dipropionate 5894 beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase®
belnacasan 9035 VX-765
bentamapimod 9926 AS-602801, AS602801, PGL-5001, PGL5001
benzodrocortisone 9731 compound 1 [WO2013071010], hydrocortisone 17-benzoate
3beta-Hydroxy-20(29)-lupene 9028 Fagarasterol, Lupeol
BI-1935 9717 BI 1935, example 3 [WO2007067836]
BI-1950 9719
BI-2545 9791 BI2545, compound 19 [PMID: 29259743]
BI605906 9357 3-Amino-4-(1,1-difluoro- propyl)-6-(4-methanesulfonyl- piperidin-1-yl)-thieno[2,3- b]pyridine-2-carboxylic acid amide, compound 115 [US20070293533]
BI 653048 9715 (R)-39, BI 653048 BS H3PO4, BI-653048, BI653048
BI 665915 9716 BI-665915, compound 69 [PMID: 25671290]
BI-6901 9714 BI 6901, BI 6901, BI6901, eut-22
bimosiamose 9049 compound 15e [PMID: 9544210], TBC 1269, TBC-1269, TBC1269
BIRT 377 9720 BIRT-377
BLZ945 8250 BLZ 945, BLZ-945
BML-281 9664 compound 3 [PMID: 18642892]
BMS-1001 10191 BMS1001, Example 1001 [WO2015160641A2]
BMS-1166 9608 compound 2c [PMID: 28613862], Example 1166 [WO2015160641A2]
BMS-202 9607 compound 1c [PMID: 28613862], PD1-PDL1 inhibitor 2
BMS-345541 5669 BMS 345541, BMS345541
BMS-509744 9994 BMS 509744, BMS509744, compound 3 [PMID:16682193]
BMS-561392 6509 BMS 561392, BMS561392, DPC-333
BMS-582949 7838 BMS 582949, BMS582949, PS 540446, PS-540446, PS540446
BMS-681 9430 compound 13d [PMID: 25893046]
BMS-817399 9497 compound 29 [PMID: 25101488]
BMS-986142 9857 BMS986142, compound 14f [PMID: 27583770]
BMS-986165 10432 compound 11 [PMID: 31318208}, Tyk2-IN-4
BMS-986195 9869 BMS986195, branebrutinib (proposed INN), Example 223 [US20160115126A1]
BMS-986205 9707 BMS986205
bortezomib 6391 peptide boronate, PS-341, Velcade®
bosutinib 5710 Bosulif®, SK 606, SK-606, SKI 606
brimonidine 520 Alphagan®, Lumify®, Mirvaso®, UK14,304, UK14304
BRL-15572 10 BRL 15572, BRL-15,572, BRL15572
bromfenac 7131 AHR-10282B, Bromday®, Prolensa®, Xibrom®
BT-11 10363 analogue 7 [PMID: 27933891], BT11, Example 1 [US9556146B2]
BTK inhibitor 4b 10094 compound 4b [PMID: 30216722]
BTP2 2438 YM-58483
BX 471 767 BX-471, BX-741
BX-795 8006 BX 795, BX795
 
C Back to top
C108297 9180 Compound 52 [PMID:18226897]
C391 9570 compound 5 [PMID: 27994760]
C646 7004
CA-4948 10152 AU-4948, AU4948, CA4948, example 1 [WO2015104688A1]
canertinib 5675 CI 1033, CI-1033, PD 183805 dihydrochloride
carprofen 7141 Ro-205720000
CBS-3595 9610
CC-885 9224
CCR2-RA-[R] 9431 analog 49 (Dasse et al., 2007)
CCX354 10164 CCX 354, CCX-354, CCX-354-C
CDP840 9330 CDP 840, CDP-840
celecoxib 2892 Celecox®, Onsenal®, SC-58635, SC58635
cenerimod 9824 ACT-334441
cenicriviroc 801 TAK 652, TAK-652, TAK652, TBR-652
cerdulatinib 8957 PRT 062070, PRT-062070, PRT-2070, PRT062070
cetirizine 1222 Reactine®, Zyrtec®
CG200745 10055 CG-2, CG-200745, HDCG-0745
2'3'-cGAMP 9207 cyclic [G(2',5')pA(3',5')p], cyclic GMP-AMP, Cyclic guanosine monophosphate-adenosine monophosphate
CGI1746 8066 CGI 1746, CGI-1746
CGI560 9264 CGI-560
CH-4051 9844 Formula (10) [WO2012078708A1]
chloroquine 5535 Aralen®, chloraquine, Malaquin®
CHMFL-BTK-11 9516
cicaprost 1917 ZK 96480, ZK-96480
ciclesonide 7469 Alvesco®, Omnaris®, RPR-251526
ciforadenant 10190 CPI-444, CPI444, V-81444, V81444
cilomilast 7407 SB-207499
cintirorgon 10045 compound 32J [WO2016201225A1], LYC-55716, LYC55716
cipemastat 6466 Ro 28-2653
clemastine 6063 HS-592, meclastin, Tavegil®, Tavist®
clemizole 10285
clobenpropit 1223 VUF 9153, VUF-9153
clobetasone 9088 Eumovate®
clodronic acid 9605 Bonefos®, Clasteon ®, clodronate, Loron®
clofazimine 9184 Lamprene®
clopidogrel (active metabolite) 1772
CM4620 10087 CM-4620, compound I [WO2016138472A1]
CNX-774 9266
compound 48/80 5531
compound 3a [Pipionne et al, 2018] 9965
compound 10a [PMID: 31283223] 10435
compound 12a [PMID: 29031075] 9684
compound 19a [PMID: 26506089] 9842
compound 8a [PMID: 23713581] 8856
compound 21b [PMID: 31136173] 10403
compound 5b [PMID: 29457898] 9835
compound 5b [PMID: 31287314] 10434
compound 18c [PMID: 25901531] 9227
compound 7c [PMID: 22041175] 9931
compound 8c [PMID: 28760529] 9671
Compound 9 [doi:10.26434/chemrxiv.7072592.v1] 10083
compound 17d [PMID: 23099093] 8196
compound 5d [PMID: 31335136] 10441 Example 59 [WO2018121550]
compound 7d [PMID: 29672049] 9937
compound 5e [PMID: 28580438] 9712
compound 20f [PMID: 28520415] 9961
compound 7f [PMID: 29191554] 9794 example 32 [WO2011078413]
compound 7f [PMID: 29283260] 9780
compound 2g [PMID: 27390066] 9682
compound 4g [PMID: 2680437] 9198
compound 8ic [PMID: 19081254] 9478 CCR4 Antagonist
compound III [PMID: 24045148] 9709
compound II [PMID: 21329883] 9579
compound 9 [Kumar et al., 2019] 10448
compound 17l [PMID: 26288691] 10035
compound 29 [Moslin et al., 2017] 9992
compound 12p [Larson et al., 2017] 9690
compound 10 [PMID: 31411465] 10488 example 8 (cis racemate) [WO2017060855A1]
compound 11 [PMID: 29442501] 9819
compound 12 [PMID: 27448772] 9453
compound 15 [PMID: 25411721] 9078 example 252 [WO2007110237]
compound 15 [PMID: 29852070] 9997
compound 16 [PMID: 26794040] 9223
compound 17 [PMID: 29741897] 10005
compound 1 [PMID: 24930776] 9092 DB36
compound 1 [PMID: 28611375] 9673
compound 1 [PMID: 31477924] 10481
compound 21 [PMID: 22802221] 6918 C21
compound 21 [PMID: 24900635] 8187
compound 24 [PMID: 26987013 ] 9252
compound 25 [PMID: 28038940] 9700
compound 25 [PMID: 31260299] 10428
compound 27 [PMID: 24900635] 10133
compound 28 [PMID: 28671460] 9670
compound 31 [PMID: 31259550] 10417
compound 36 [PMID: 21958547] 9391
compound 37 [PMID: 29193967] 9797
compound 3 [PMID: 28603634] 9628
compound 3 [PMID: 29633584] 9960
compound 41 [PMID: 25000588] 9349
compound 43 [PMID: 26751273] 9492
compound 47 [PMID: 28737909] 9646
compound 52 [PMID: 28541707] 10001
compound 76 [PMID: 28657314] 9609
compound 7 [PMID: 31381331] 10450
compound 9 [PMID: 26006010] 9761
compound 2q [PMID: 30986068] 10365 example 2-8 [US20150353552]
compound T.14 10385
compound 3v [PMID: 27390066] 9683
compound 1 [WO2012007375] 8084
compound 7 [WO2012007375] 8085
CORM-2 9535
CP-195543 6155 CP 195543, CP-195,543, CP195543
CPUY192018 9710 compound 18e [PMID: 26258437], compound 2 [PMID: 24512214]
CR6086 9845
CRAC channel inhibitor 5b [PMID: 26256403] 10042
CRAC channel inhibitor 1 [PMID: 26256403] 10041
crenolanib 7882 ARO-002, CP 868596, CP-868,596, CP-868596
crisaborole 9151 AN 2728, AN2728, compound 5b [PMID: 19303290], Eucrisa®
cromoglicic acid 7608 cromoglycate, cromolyn, cromolyn sodium, FPL-670, Intal®, Opticrom®, sodium cromoglicate
CRX-555 10091 CRX555, N-[(3R)-3-(Octanoyloxy)myristoyl]-O-[2-[[(3R)-3-(octanoyloxy)myristoyl]amino]-3-O-[(3R)-3-(octanoyloxy)myristoyl]-4-O-phosphono-2-deoxy-beta-D-glucopyranosyl]-L-serine
CU-CPT8m 9795 7-(m-Tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, compound 5 [PMID: 29155428]
CX549 9701 compound 63 [WO2016048861], CX-549
CXCR4 antagonist 22 10146
CY-09 10057
CZ415 9837 compound 3 [PMID: 27563401], CZ-415
 
D Back to top
D4476 5940 casein kinase I inhibitor, CK1 inhibitor, D 4476
dagrocorat 9650 PF-00251802
danirixin 8500 GSK-1325756B, GSK1325756, GSK1325756B
dapansutrile 10056 OLT-1177, OLT1177
darapladib 6696 SB 480848, SB-480848
dasatinib 5678 BMS 345825, BMS 354825, BMS 35482513, Sprycel®
DDR1/2 inhibitor 5n 10105
decernotinib 8309 adelatinib, VRT-831509, VX-509
deflazacort 9477 Emflaza®, MDL 458
delgocitinib 9619 JTE-052, JTE052
desloratadine 7157 Clarinex®, SCH-34117
dexamethasone 2768 Decadron®, desametasone, fluormethylprednisolone
dezapelisib 9728 compound 67 [PMID: 22924688], example 15 [WO2011008487], INCB 40093, INCB40093
diamorphine 9082 acetomorphine, diacetylmorphine, heroin
diclofenac 2714 Cataflam®, CGP-45840B, GP-45840, Voltaren®, Voltarol®
difamilast 9776 example 352 [WO2007058338], MM36, OPA-15406
diflapolin 10080
diflunisal 7162 Dolobid®
dilmapimod 7815 SB-681323
dimethyl fumarate 7045 BG-12, BG00012, fumaric acid, Tecfidera®
dimethyl itaconate 9939 dimethylitaconate, itaconic acid dimethyl ester
dimetindene 10101 (+/-)-dimethindene, dimethindene, dimethpyrindene, Fenistil®, Vibrocil®
(S)-dimetindene 10104 (+)-dimethindene, (+)-dimetindene, (S)-dimethindene
diminazene 10307 Azidin®, Berenil®, Pirocide®
dinaciclib 7379 SCH727965
diphenylpyraline 7165 Hispril®
diprovocim-1 10341 compound 3 [PMID: 30272974]
diroleuton 9775 8,11,14-Eicosatrienoic acid, DGLA, dihomo-gamma-linolenic acid, DS107, Homo-gamma-linolenic acid
DMAT 9323 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole, CK2 Inhibitor II
DO264 10250 compound 46, DO-264
doramapimod 5668 BIRB 796BS, BIRB-796, BIRB796
doxycycline 6464 BMY-28689, Monodox®, Vibramycin®
dual sEH/FAAH inhibitor 11 10124 compound B-11 [WO2017160861], example 28 [WO2017160861]
duvelisib 7795 compound 4904 [Patent US8193182], Copiktra®, INK-1197, IPI-145
 
E Back to top
6E11 9749
E-52862 10431 compound 28 [PMID: 22784008], E52862, MR309, sigma 1 receptor antagonist (S1RA)
E6201 7836 E 6201, E-6201
edicotinib 8942 JNJ-40346527, JNJ40346527, US8497376, 15
EG01377 9904 (3-((5-(4-(aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene- 2-carbonyl)-L-arginine, compound 1 [PMID: 29648813]
elubirixin 8499 SB 656933, SB-656933, SB656933
enexasogaol 9773 6-Shogaol, [6]-shogaol, trans-6-shogaol
EP4A 1952 EP4A, L-161982, L161982
epacadostat 8221 IDO inhibitor 1, INCB 24360, INCB-24360, INCB024360
epinastine 7176 Elestat®, epinastine hydrochloride
ER-27319 9611
esflurbiprofen 9420 (S)-flurbiprofen, BTS-24332, SFPP, TT-063
etodolac 7185 AY-24236, Lodine®
etoricoxib 2896 Arcoxia®, MK 0663, MK-0663, MK0663
etrasimod 9331 APD-334, APD334, APD334-003, compound 4 [PMID: 25516790]
everolimus 5889 Afinitor®, Certican®, RAD-001, RAD001, rapamycin, 42-O-(2-hydroxyethyl)-, Zortress®
evobrutinib </