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cerebral dopamine neurotrophic factor   Click here for help

GtoPdb Ligand ID: 13048

Synonyms: arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Compound class: Endogenous peptide in human, mouse or rat
Comment: CDNF is a dopamine neuron neurotropic factor [5]. It provides cytoprotective effects in neurodegenerative disease models by reducing the activating effect of endoplasmic reticulum stress on the unfolded protein response (UPR) pathway [4,7]. Specifically, CDNF has been shown to protect dopamine neurons and improve motor function in animal Parkinson's disease models [1-2,5-6,8]. However therapeutic use of proteins like CDNF is invasive (intracranial administration) and requires clinical expertise.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CDNF cerebral dopamine neurotrophic factor Human cerebral dopamine neurotrophic factor precursor -
Database Links Click here for help
Ensembl Gene ENSG00000185267 (Hs)
Entrez Gene 441549 (Hs)
GtoPdb PubChem SID 491299830
Human Protein Atlas ENSG00000185267 (Hs)
OMIM 611233 (Hs)
RefSeq Protein NP_001025125 (Hs)
UniProtKB Q49AH0 (Hs)