IFN-α2

Ligand id: 4960

Name: IFN-α2

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interferons
Approved drug? Yes (FDA (1989))
Synonyms
IFN-alpha-2 | interferon alpha-2 | Roferon A®
Comments
IFN-α2 is a type I IFN. The sequence of the recombinant peptide used clinically and known as interferon alfa-2a, is identical to that of human IFN-α2. Interferon alfa-2a has anti-viral, immunomodulatory and antineoplastic actions.
Pegylated IFN alfa 2a is on the World Health Organization's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
IFNA2 interferon alpha 2 Human prepro-interferon alpha-2 alpha-2a interferon, IFNA, IFN-alphaA, interferon, alpha 2, interferon alpha 2b, interferon alpha A
Database Links
Specialist databases
IMGT/mAb-DB 624
Other databases
Ensembl Gene ENSG00000188379 (Hs)
GtoPdb PubChem SID 178101658
Human Protein Atlas ENSG00000188379 (Hs)
UniProtKB P01563 (Hs)
Wikipedia IFNA2