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IL-2   Click here for help

GtoPdb Ligand ID: 4985

Synonyms: aldesleukin | interleukin-2 | Proleukin®
Approved drug Immunopharmacology Ligand
IL-2 is an approved drug (FDA (1992))
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-2 and IL-15 are cytokines that share common biological effects, but also exhibit distinct, and sometimes competing, functions [6]. Recombinant IL-2 is used clinically with the generic name aldesleukin.
Abbas et al. (2018) have written a review of IL-2 biology and the progress that has been made in developing IL-2 therapeutics [1].
Species: Human
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: interleukin-2

Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Approved drug? Yes. US FDA (1992)
Synonyms Click here for help
aldesleukin | interleukin-2 | Proleukin®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IL2 interleukin 2 Human prepro-interleukin-2 IL-2, T cell growth factor, TCGF
Database Links Click here for help
Ensembl Gene ENSG00000109471 (Hs)
GtoPdb PubChem SID 178101682
Human Protein Atlas ENSG00000109471 (Hs)
UniProtKB P60568 (Hs)
Wikipedia Interleukin_2