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The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

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GtoImmuPdb ligands only: Ligands which are currently, or have been in the past, approved for human clinical use by a regulatory agency.
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Ligand name ID Synonyms
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abatacept Approved drug Immunopharmacology Ligand 6891 BMS-188667, CTLA4-IgG4m, Orencia®, RG-1046, RG-2077
abrocitinib Approved drug PDB Ligand Immunopharmacology Ligand 9991 Cibinqo®, compound 25 [PMID: 29298069], PF-04965842, PF04965842
acalabrutinib Approved drug PDB Ligand Immunopharmacology Ligand 8912 ACP-196, Calquence®, Example 6 [US20140155385 A1]
ACTH Approved drug Immunopharmacology Ligand 3633 Acthar®, adrenocorticotropic hormone (1-39), corticotropin
adalimumab Approved drug Immunopharmacology Ligand 4860 D2E7, Humira®
(-)-adrenaline Approved drug PDB Ligand Immunopharmacology Ligand 479 adrenalin, Auvi-Q®, Epipen®, l-adrenaline, L-epinephrine, levoepinephrine
alcaftadine Approved drug Immunopharmacology Ligand 7587 Lastacaft®, R-89674
alefacept Approved drug Immunopharmacology Ligand 6787 Amevive®, BG 9273, BG 9712, BG-9273, BG-9712, Lfa3Tip
alemtuzumab Approved drug Immunopharmacology Ligand 6770 campath 1H, Campath®, campath-1H, Lemtrada®
alimemazine Approved drug Immunopharmacology Ligand 7237 Nedeltran®, trimeprazine
amcinonide Approved drug Immunopharmacology Ligand 7060 CL-34699, Cyclocort®
amlexanox Approved drug PDB Ligand Immunopharmacology Ligand 7113 AA-673, Amlexanox®, Aphthasol®, CHX-3673
anakinra Approved drug Immunopharmacology Ligand 6972 antril, Kineret®
anifrolumab Approved drug Immunopharmacology Ligand 8258 anifrolumab-fnia, MDX-1333, MEDI-546, Saphnelo®
apremilast Approved drug PDB Ligand Immunopharmacology Ligand 7372 CC-10004, Otezla®
arformoterol Approved drug PDB Ligand Immunopharmacology Ligand 7479 (-)-Formoterol, (R,R)-Formoterol, Brovana®, YM-08316
aspirin Approved drug PDB Ligand Immunopharmacology Ligand 4139 Acetophen®, acetylsalicylic acid, Aspirin®
atezolizumab Approved drug Immunopharmacology Ligand 7990 MPDL3280A, Tecentriq®
atracurium Approved drug Immunopharmacology Ligand 9537 atracurium besilate, atracurium dibesylate, BW 33A, Tracrium®
auranofin Approved drug Immunopharmacology Ligand 6306 MMV688978, Ridaura®, SK&F-39162, SK-39162
avacincaptad pegol Approved drug Immunopharmacology Ligand 12857 ARC-1905, ARC1905, Izervay®, Zimura
avacopan Approved drug PDB Ligand Immunopharmacology Ligand 9450 CCX-168, CCX168, Tavneos®
avapritinib Approved drug PDB Ligand Immunopharmacology Ligand 10368 Ayvakit®, Ayvakyt®, BLU-285, BLU285
avelumab Approved drug Immunopharmacology Ligand 8735 Bavencio®, MSB-0010718C, MSB0010718C
azacitidine Approved drug PDB Ligand Immunopharmacology Ligand 6796 5-AZAC, 5-azacytidine, ladakamycin, Onureg®, Onureg® (CC-486; oral azacitidine), U-18496, Vidaza®
azatadine Approved drug Immunopharmacology Ligand 7119 Optimine®, SCH-10649
azathioprine Approved drug Immunopharmacology Ligand 7120 Azasan®, BW-57-322, Imuran®, Jayempi®
azelaic acid Approved drug PDB Ligand Immunopharmacology Ligand 7484 Azelex®, Finacea®, ZK-62498
azithromycin Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6510
 
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baricitinib Approved drug PDB Ligand Immunopharmacology Ligand 7792 INCB-028050, INCB028050, LY-3009104, LY3009104, Olumiant®
basiliximab Approved drug Immunopharmacology Ligand 6879 CHI-621, L04AC02, SDZ-CHI-621, Simulect®
beclometasone Approved drug PDB Ligand Immunopharmacology Ligand 7059 beclomethasone, SCH-18020W
beclometasone dipropionate Approved drug Immunopharmacology Ligand 5894 beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase®
belantamab mafodotin Approved drug Immunopharmacology Ligand 11117 belamaf, belantamab mafodotin-blmf, Blenrep®, GSK-2857916, GSK2857916
belatacept Approved drug Immunopharmacology Ligand 6892 BMS-224818, LEA29Y, Nulojix®
belimumab Approved drug Immunopharmacology Ligand 6887 Benlysta®, hBlySmAb-1.1, LimphoStat-B, lymphostat-B
belumosudil Approved drug PDB Ligand Immunopharmacology Ligand 9558 KD-025, KD025, Rezurock®, SLx 2119, SLx2119
benralizumab Approved drug Immunopharmacology Ligand 7674 BIW-8405, Fasenra®, KHK4563, MEDI-563
betamethasone Approved drug Immunopharmacology Ligand 7061 SCH-4831
bimekizumab Approved drug Immunopharmacology Ligand 9411 bimekizumab-bkzx, Bimzelx®, CA028_0496, CDP4940, gL7gH9, UCB-4940, UCB4940, Zu-G1
blinatumomab Approved drug Immunopharmacology Ligand 7384 Blincyto®, bscCD19xCD3, MEDI-538, MT-103, MT103
bortezomib Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6391 peptide boronate, PS-341, Velcade®
bosutinib Approved drug PDB Ligand Immunopharmacology Ligand 5710 Bosulif®, SK 606, SK-606, SKI 606
brentuximab vedotin Approved drug Immunopharmacology Ligand 6772 Adcetris®, anti-CD30 ADC SGN-35, SGN 35
brimonidine (UK14304) Approved drug PDB Ligand Immunopharmacology Ligand 520 Alphagan®, Lumify®, Mirvaso®, UK14,304, UK14304
brodalumab Approved drug Immunopharmacology Ligand 7540 AMG-827, AMG827, Kyntheum®, Lumicef®, Siliq®
bromfenac Approved drug PDB Ligand Immunopharmacology Ligand 7131 AHR-10282B, Bromday®, Prolensa®, Xibrom®
budesonide Approved drug Immunopharmacology Ligand 7434 Entocort®, Eohilia® (budesonide oral suspension), Jorveza®, Pulmicort®, S-1320, Uceris®
 
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cadonilimab Approved drug Immunopharmacology Ligand 12966 AK-104, AK104
camrelizumab Approved drug Immunopharmacology Ligand 9758 INCSHR1210, SHR-1210
canakinumab Approved drug Immunopharmacology Ligand 6773 ACZ 885, ACZ885, Ilaris®
carotegrast methyl Approved drug Immunopharmacology Ligand 10510 AJM-300, AJM300, Carogra®
carprofen Approved drug Immunopharmacology Ligand 7141 Ro-205720000
celecoxib Approved drug PDB Ligand Immunopharmacology Ligand 2892 Celecox®, Elyxyb® (DFN-15; oral solution), Onsenal®, SC-58635, SC58635
cemiplimab Approved drug Immunopharmacology Ligand 10090 cemiplimab-rwlc, Libtayo®, REGN-2810, REGN2810, SAR-439684, SAR439684
certolizumab pegol Approved drug Immunopharmacology Ligand 6774 CDP870, Cimzia®, PHA 738144
cetirizine Approved drug Immunopharmacology Ligand 1222 Reactine®, Zyrtec®
cetrorelix Approved drug Immunopharmacology Ligand 1190 Cetrotide®, SB-075
chloroquine Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 5535 Aralen®, chloraquine, Malaquin®
ciclesonide Approved drug Immunopharmacology Ligand 7469 Alvesco®, Omnaris®, RPR-251526
clemastine Approved drug Immunopharmacology Ligand 6063 HS-592, meclastin, Tavegil®, Tavist®
clobetasol propionate Approved drug PDB Ligand Immunopharmacology Ligand 7062 CCI-4725, Clobex®, Dermovate®, GR 2/925, Temovate®
clobetasone Approved drug Immunopharmacology Ligand 9088 Eumovate®
clodronic acid Approved drug Immunopharmacology Ligand 9605 Bonefos®, Clasteon ®, clodronate, Loron®
clofazimine Approved drug Immunopharmacology Ligand 9184 Lamprene®
colchicine Approved drug PDB Ligand Immunopharmacology Ligand 2367 Colcrys®, methoxylated analogue of XD1, XD25
corticotropin zinc hydroxide Approved drug Immunopharmacology Ligand 6967
cortisol Approved drug PDB Ligand Immunopharmacology Ligand 2868 Acticort®, Efmody®, Plenadren®
crisaborole Approved drug Immunopharmacology Ligand 9151 AN 2728, AN2728, compound 5b [PMID: 19303290], Eucrisa®, Staquis®
crizotinib Approved drug PDB Ligand Immunopharmacology Ligand 4903 (R)-crizotinib, PF 2341066, PF-02341066, PF-2341066, PF2341066, Xalkori®
cromoglicic acid Approved drug Immunopharmacology Ligand 7608 cromoglycate, cromolyn, cromolyn sodium, FPL-670, Intal®, Opticrom®, sodium cromoglicate
crovalimab Approved drug Immunopharmacology Ligand 12790 crovalimab-akkz, Piasky®, RG-6107, RG6107, Senkai® (China), SKY59
cyclosporin A Approved drug Immunopharmacology Ligand 1024 ciclosporin, cyclosporine, cyclosporine A, Ikervis® (opthalmic solution), Neoral®, Sandimmun®, Verkazia® (opthalmic solution)
 
D Back to top
daclizumab Approved drug Immunopharmacology Ligand 6880 L04AC01, RO-24-7375, Ro-247375, Zenapax®
daratumumab Approved drug Immunopharmacology Ligand 7395 3003-005, Darzalex®, HuMax-CD38, JNJ-54767414
dasatinib Approved drug PDB Ligand Immunopharmacology Ligand 5678 BMS 345825, BMS 354825, BMS 35482513, Sprycel®
deflazacort Approved drug Immunopharmacology Ligand 9477 Emflaza®, MDL 458
delgocitinib Approved drug PDB Ligand Immunopharmacology Ligand 9619 Anzupgo®, Corectim®, ent-60, JTE-052, JTE052
denileukin diftitox Approved drug Immunopharmacology Ligand 7044 DAB389 IL2, denileukin diftitox-cxdl, LY 335348, Lymphir®, Ontak®
desloratadine Approved drug PDB Ligand Immunopharmacology Ligand 7157 Clarinex®, SCH-34117
desonide Approved drug Immunopharmacology Ligand 7066 D-2083, Desowen®
desoximetasone Approved drug Immunopharmacology Ligand 7067 A-41-304, HOE-304, R-2113, Topicort®
deucravacitinib Approved drug Immunopharmacology Ligand 10432 BMS-986165, BMS986165, compound 11 [PMID: 31318208}, Sotyktu®, Tyk2-IN-4
deuruxolitinib Approved drug Immunopharmacology Ligand 11410 CTP-543, CTP543, D8-ruxolitinib, Leqselvi®
dexamethasone Approved drug PDB Ligand Immunopharmacology Ligand 2768 Decadron®, desametasone, fluormethylprednisolone
diclofenac Approved drug PDB Ligand Immunopharmacology Ligand 2714 Cataflam®, CGP-45840B, GP-45840, Voltaren®, Voltarol®
difamilast Approved drug Immunopharmacology Ligand 9776 example 352 [WO2007058338], MM36, Moizerto®, OPA-15406
difelikefalin Approved drug Immunopharmacology Ligand 9044 CR845, D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid], FE-202845, Kapruvia®, Korsuva®, SEQ ID NO: 2
diflorasone diacetate Approved drug Immunopharmacology Ligand 7068 Psorcon®, U-34865
diflunisal Approved drug PDB Ligand Immunopharmacology Ligand 7162 Dolobid®
difluprednate Approved drug Immunopharmacology Ligand 7474 DFBA, Durezol®, W-6309
dimethyl fumarate Approved drug PDB Ligand Immunopharmacology Ligand 7045 BG-12, BG00012, fumaric acid, Tecfidera®
dimetindene Approved drug Immunopharmacology Ligand 10101 (+/-)-dimethindene, dimethindene, dimethpyrindene, Fenistil®, Vibrocil®
diphenylpyraline Approved drug Immunopharmacology Ligand 7165 Hispril®
diroximel fumarate Approved drug Immunopharmacology Ligand 10525 ALKS-8700, ALKS8700, BIIB098, Vumerity®
divozilimab Approved drug Immunopharmacology Ligand 13087 BCD 132, BCD-132, Ivlizi®
dopamine Approved drug PDB Ligand Immunopharmacology Ligand 940 3-hydroxytyramine
dostarlimab Approved drug Immunopharmacology Ligand 11518 ANB-011, dostarlimab-gxly, Jemperli®, TSR-042, WBP-285
doxycycline Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6464 BMY-28689, Monodox®, Vibramycin®
dupilumab Approved drug Immunopharmacology Ligand 7574 Dupixent®, REGN668, SAR231893
durvalumab Approved drug Immunopharmacology Ligand 7985 anti-B7H1 monoclonal antibody, Imfinzi®, MEDI-4736, MEDI4736
duvelisib Approved drug Immunopharmacology Ligand 7795 compound 4904 [Patent US8193182], Copiktra®, INK-1197, IPI-145
dyphylline Approved drug Immunopharmacology Ligand 7070 Dilor®
 
E Back to top
ecallantide Approved drug Immunopharmacology Ligand 6955 DX-88, FOV2302, Kalbitor®
eculizumab Approved drug Immunopharmacology Ligand 6884 h5G1.1, h5G1.1VHC, Soliris®
efalizumab Approved drug Immunopharmacology Ligand 6593 anti alphaL integrin, antiCD11 alpha, hu1124, Raptiva®
efgartigimod alfa Approved drug Immunopharmacology Ligand 9777 ARGX-113, efgartigimod alfa-fcab, Vyvgart®
elotuzumab Approved drug Immunopharmacology Ligand 8361 BMS-901608, Empliciti®, HuLuc63
elranatamab Approved drug Immunopharmacology Ligand 12889 elranatamab-bcmm, Elrexfio®, PF-06863135, PF06863135
emapalumab Approved drug Immunopharmacology Ligand 9295 emapalumab-lzsg, Gamifant®, NI-0501, NI0501
ensifentrine Approved drug Immunopharmacology Ligand 11865 Ohtuvayre®, RPL554, VMX 554, VMX-554, VMX554
envafolimab Approved drug Immunopharmacology Ligand 10492 Envida®, KN-035, KN035
epcoritamab Approved drug Immunopharmacology Ligand 11442 epcoritamab-bysp, Epkinly®, GEN-3013, GEN3013, Tepkinly®
epinastine Approved drug Immunopharmacology Ligand 7176 Elestat®, epinastine hydrochloride
esflurbiprofen Approved drug PDB Ligand Immunopharmacology Ligand 9420 (S)-flurbiprofen, BTS-24332, SFPP, TT-063
etanercept Approved drug Immunopharmacology Ligand 6789 Enbrel®, Rhu Tnfr:Fc, TNFR-Fc, TNR 001
etodolac Approved drug Immunopharmacology Ligand 7185 AY-24236, Lodine®
etoricoxib Approved drug PDB Ligand Immunopharmacology Ligand 2896 Arcoxia®, MK 0663, MK-0663, MK0663
etrasimod Approved drug Immunopharmacology Ligand 9331 APD-334, APD334, APD334-003, compound 4 [PMID: 25516790], Velsipity®
everolimus Approved drug Immunopharmacology Ligand 5889 Afinitor®, Certican®, RAD-001, RAD001, rapamycin, 42-O-(2-hydroxyethyl)-, Zortress®
 
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fenoprofen Approved drug Immunopharmacology Ligand 4820 fenoprofen calcium, Nalfon®
fexofenadine Approved drug Immunopharmacology Ligand 4819 Allegra®, fexofenadine HCl
filgotinib Approved drug PDB Ligand Immunopharmacology Ligand 7913 GLPG-0634, GLPG0634, Jyseleca®
filgrastim Approved drug Immunopharmacology Ligand 6968 Filcad®, Imumax ®, R-METHUG-CSF
fingolimod Approved drug Immunopharmacology Ligand 2407 FTY-720, FTY720, Gilenya®
fludroxycortide Approved drug Immunopharmacology Ligand 7606 Cordran®, flurandrenolide, flurandrenolone, Haelan®
flufenamic acid Approved drug PDB Ligand Immunopharmacology Ligand 2447
flumethasone pivalate Approved drug Immunopharmacology Ligand 7075 Locorten®
flunisolide Approved drug Immunopharmacology Ligand 7076 AeroBid®, RS-3999
fluocinolone acetonide Approved drug Immunopharmacology Ligand 7077 Capex®, Iluvien®, Synalar®
fluocinonide Approved drug Immunopharmacology Ligand 7078 Fluonex®, Lidex®
fluorometholone Approved drug Immunopharmacology Ligand 7079 Flarex®, FML®
flurbiprofen Approved drug Immunopharmacology Ligand 4194 Ansaid®, Froben®
fluticasone Approved drug Immunopharmacology Ligand 6699 Advair®, Avamys®, Flovent HFA®, Veramyst®
fluticasone furoate Approved drug PDB Ligand Immunopharmacology Ligand 10892 Arnuity Ellipta, Avamys, FF, Flonase Sensimist, Veramyst
fluticasone propionate Approved drug Immunopharmacology Ligand 7080 Advair Diskus®, ArmonAir RespiClickTM, CCI-18781, Flovent®
fluvoxamine Approved drug PDB Ligand Immunopharmacology Ligand 7189 Luvox®, U-23000
formoterol Approved drug Immunopharmacology Ligand 3465 BD-40A, CGP-25827A, Foradil®, Oxeze/Oxis®, YM-08316
fostamatinib Approved drug PDB Ligand Immunopharmacology Ligand 7796 R 788, R-788, R7935788, Tavalisse®, Tavlesse®
 
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gabapentin Approved drug PDB Ligand Immunopharmacology Ligand 5483 CI 945, Go 3450, GOE 2450, GOE 3450, Neurontin®
galcanezumab Approved drug Immunopharmacology Ligand 8967 clone III, Emgality®, galcanezumab-gnlm, LY-2951742, LY2951742
G-CSF Approved drug Immunopharmacology Ligand 4934 Granocyte®
gefapixant Approved drug PDB Ligand Immunopharmacology Ligand 9540 AF-219, AF219, Lyfnua®, MK7264, MK‐7264
gemtuzumab ozogamicin Approved drug Immunopharmacology Ligand 6775 CDP 771, CMA 676, hP67.6-calicheamicin, Mylotarg®, WAY-CMA 676
glibenclamide Approved drug PDB Ligand Immunopharmacology Ligand 2414 Amglidia®, Diabeta®, glyburide, Glynase®
glycopyrrolate Approved drug Immunopharmacology Ligand 7459 AHR-504, Qbrexza® (glycopyrronium cloth), Robinul®, Seebri Neohaler®, Tovanor Breezhaler®
golimumab Approved drug Immunopharmacology Ligand 6776 CNTO-148, CNTO148, Simponi®
guselkumab Approved drug Immunopharmacology Ligand 7998 CNTO-1959, Tremfya®
 
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hydroxychloroquine Approved drug Immunopharmacology Ligand Antimalarial Ligand 7198 Dolquine®, Plaquenil®
hydroxyzine Approved drug Immunopharmacology Ligand 7199 Atarax®, hydroxyzine hydrochloride, hydroxyzine pamoate, Vistaril®
 
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ibalizumab Approved drug Immunopharmacology Ligand 10208 Hu5A8, ibalizumab-uiyk, TMB-355, TMB355, TNX-355, Trogarzo®
ibritumomab tiuxetan Approved drug Immunopharmacology Ligand 6777 IDEC-2B8, IDEC-Y2B8-yttrium ibritumomab tiuxetan, NSC-715848, Zevalin®
ibrutinib Approved drug PDB Ligand Immunopharmacology Ligand 6912 Imbruvica®, PCI-32765
ibudilast Approved drug PDB Ligand Immunopharmacology Ligand 7399 AV-411, KC-404, Ketas®, MN-166
ibuprofen Approved drug Immunopharmacology Ligand 2713 Advil®, Brufen®, ibuprofen lysine, ibuprofen sodium, Motrin®, Nurofen®, U-18573
icatibant Approved drug Immunopharmacology Ligand 667 D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]BK, Firazyr®, HOE 140, HOE140
idelalisib Approved drug PDB Ligand Immunopharmacology Ligand 6741 CAL-101/CAL101, GS-1101, Zydelig®
IFN-α2 Approved drug Immunopharmacology Ligand 4960 IFN-alpha-2, interferon alpha-2, Roferon A®
IFN-γ Approved drug Immunopharmacology Ligand 4968 Actimmune®, immune interferon, interferon gamma
IFN-β1b (recombinant human) Approved drug Immunopharmacology Ligand 8340 Betaferon®, Betaseron®, Extavia®, IFNb1b
iguratimod Approved drug PDB Ligand Immunopharmacology Ligand 9736 Careram®, Iremod, Kolbet®, T-614
IL-2 Approved drug Immunopharmacology Ligand 4985 aldesleukin, interleukin-2, Proleukin®
iloprost Approved drug Immunopharmacology Ligand 1895 Aurlumyn®, Ventavis®
imatinib Approved drug PDB Ligand Immunopharmacology Ligand 5687 CGP 57148, Gleevec®, Glivec®, STI571
imiquimod Approved drug PDB Ligand Immunopharmacology Ligand 5003 Aldara®, R837, S-26308, Zyclara®
indacaterol Approved drug Immunopharmacology Ligand 7455 Arcapta Neohaler®, Onbrez®, QAB-149, QAB149
indomethacin Approved drug PDB Ligand Immunopharmacology Ligand 1909 Indocid®, Indocin®
infliximab Approved drug Immunopharmacology Ligand 5004 cA2, Inflectra®, Remicade®, Remsima®, SB2, TA-650, Zymfentra® (subcutaneous formulation)
inotuzumab ozogamicin Approved drug Immunopharmacology Ligand 8266 Besponsa®, CMC-544
ipilimumab Approved drug Immunopharmacology Ligand 6888 MDX-010, MDX-101, MDX-CTLA-4, Yervoy®
ipratropium Approved drug Immunopharmacology Ligand 325 Atrovent®, Ipraxa®
iptacopan Approved drug PDB Ligand Immunopharmacology Ligand 10710 compound 41 [PMID: 32073845], Fabhalta®, LNP-023, LNP023
isoetarine Approved drug Immunopharmacology Ligand 7205 Bronkometer®, Bronkosol®, WIN-3406
itolizumab Approved drug Immunopharmacology Ligand 9421 Alzumab®, T1h
ivonescimab Approved drug Immunopharmacology Ligand 13396 AK-112, AK112, Idafang® (China), SMT-112, SMT112
ixekizumab Approved drug Immunopharmacology Ligand 7541 LY-2439821, LY2439821, Taltz®
 
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ketoprofen Approved drug Immunopharmacology Ligand 4795 Actron®, Orudis®
ketorolac Approved drug Immunopharmacology Ligand 6661 Acular®, Toradol®
 
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lebrikizumab Approved drug Immunopharmacology Ligand 7684 Ebglyss®, lebrikizumab-lbkz, MILR1444A, RG3637, TNX-650
leflunomide Approved drug Immunopharmacology Ligand 6825 Arabloc®, Arava®, HWA 486, HWA-486, lefunamide, SU-101
lenalidomide Approved drug Immunopharmacology Ligand 7331 CC-5013, CDC-501, Revlimid®
leniolisib Approved drug PDB Ligand Immunopharmacology Ligand 9424 CDZ-173, CDZ173, Example 67 [WO2012004299], Joenja®
levosalbutamol Approved drug PDB Ligand Immunopharmacology Ligand 9816 (-)-albuterol, (-)-salbutamol, (R)-salbutamol, levalbuterol, Xopenex®
lifitegrast Approved drug Immunopharmacology Ligand 7533 compound 1g [PMID: 24900456], SAR 1118, SAR-1118, SAR-1118-023, Xiidra®
lodoxamide Approved drug PDB Ligand Immunopharmacology Ligand 9743 Alomide®
loratadine Approved drug Immunopharmacology Ligand 7216 Claritin®, SCH-29851
loteprednol etabonate Approved drug Immunopharmacology Ligand 7085 HGP-1, Inveltys®, Lotemax®, P-5604
lovastatin Approved drug PDB Ligand Immunopharmacology Ligand 2739 (+)-mevinolin, 6α-methylcompactin, Mevacor®
lumiracoxib Approved drug PDB Ligand Immunopharmacology Ligand 2897 Prexige®
 
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maraviroc Approved drug Immunopharmacology Ligand 806 Celsentri®, Selzentry®, UK 427857, UK-427,857
mavorixafor Approved drug PDB Ligand Immunopharmacology Ligand 8580 AMD 070, AMD-070, AMD-11070, AMD11070, compound 2 [PMID: 20297846], X4P-001, X4P-001-IO, X4P-001-LD, Xolremdi®
meclofenamic acid Approved drug PDB Ligand Immunopharmacology Ligand 7219 CL-583, INF-4668, Meclomen®
medrysone Approved drug Immunopharmacology Ligand 7086 U-8471
mefenamic acid Approved drug PDB Ligand Immunopharmacology Ligand 2593 CI-473, CN-35355, INF-3355, Ponstan®, Ponstel®
melatonin Approved drug PDB Ligand Immunopharmacology Ligand 224 MLT, Circadin®
meloxicam Approved drug PDB Ligand Immunopharmacology Ligand 7220 Mobic®, UHAC-62XX
mepolizumab Approved drug Immunopharmacology Ligand 7685 Nucala®, SB-240563
mepyramine Approved drug PDB Ligand Immunopharmacology Ligand 1227 Anthisan®, mepiramine, mepyramine maleate, pyrilamine, pyrilamine tannate, Pyrlex®
mesalazine Approved drug Immunopharmacology Ligand 2700 5-aminosalicylic acid, 5-ASA, mesalamine (USAN), Pentasa®
metformin Approved drug PDB Ligand Immunopharmacology Ligand 4779 Glucophage®, LA-6023
methacholine Approved drug Immunopharmacology Ligand 7438 methacholine bromide, Provocholine®
methimazole Approved drug PDB Ligand Immunopharmacology Ligand 6649 Tapazole®, Thiamazole®
methotrexate Approved drug PDB Ligand Immunopharmacology Ligand 4815 Abitrexate®, amethopterin, Nordimet®, Rasuvo®
methylprednisolone Approved drug Immunopharmacology Ligand 7088 Medrol®, U-67590A
midostaurin Approved drug PDB Ligand Immunopharmacology Ligand 5702 CGP 41231, CGP 41251, N-benzoylstaurosporine, PKC412, Rydapt®
mifepristone Approved drug PDB Ligand Immunopharmacology Ligand 2805 Mifeprex®, RU-486, RU486
miltefosine Approved drug Immunopharmacology Ligand 11355 D-18506, D18506, Impavido®, Miltex®, n-hexadecylphosphorylcholine
mirikizumab Approved drug Immunopharmacology Ligand 9846 Antibody I [US9023358], LY-3074828, LY3074828, mirikizumab-mrkz, Omvoh®
mizolastine Approved drug Immunopharmacology Ligand 10102 Mizollen®, MKC-431, MKC431, SL 85.0324, SL-850324, SL850324
mogamulizumab Approved drug Immunopharmacology Ligand 6477 KW-0761, mogamulizumab-kpkc, Poteligeo®
mometasone Approved drug Immunopharmacology Ligand 9029 Elocon® (topical), Nasonex®
montelukast Approved drug PDB Ligand Immunopharmacology Ligand 3340 Singulair®
motixafortide Approved drug Immunopharmacology Ligand 10679 4F-Benzoyl-TN14003, Aphexda®, BKT140, BL-8040, TF14016
moxetumomab pasudotox Approved drug Immunopharmacology Ligand 7675 CAT-8015, GCR-8015, HA22, Lumoxiti®, moxetumomab pasudotox-tdfk
muromonab-CD3 Approved drug Immunopharmacology Ligand 6889 L04AA02, OKT-3, Orthoclone Okt3®
mycophenolate mofetil Approved drug Immunopharmacology Ligand 6831 Cellcept®, RS-61443, RS-61443-190
 
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nabumetone Approved drug PDB Ligand Immunopharmacology Ligand 7245 BRL-14777, Relafen®
naproxen Approved drug PDB Ligand Immunopharmacology Ligand 5230 (S)-naproxen, Aleve®, Naprosy®
natalizumab Approved drug Immunopharmacology Ligand 6591 AN100226, anti-alpha4 integrin, anti-VLA4, Tysabri®
nedocromil Approved drug Immunopharmacology Ligand 7607 FPL-59002, nedocromil sodium, Rapitil®, Tilade®
nemolizumab Approved drug Immunopharmacology Ligand 8720 CD14152, CIM 331, CIM331, Mitchga®, Nemluvio®
niflumic acid Approved drug PDB Ligand Immunopharmacology Ligand 2439
nimesulide Approved drug PDB Ligand Immunopharmacology Ligand 7401 R-805
nivolumab Approved drug Immunopharmacology Ligand 7335 BMS-936558, MDX-1106, ONO-4538, Opdivo®
 
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obinutuzumab Approved drug Immunopharmacology Ligand 6941 GA-101, GA101, Gazyva®
ocrelizumab Approved drug Immunopharmacology Ligand 7580 2H7, Ocrevus®, PRO70769, RG1594
ofatumumab Approved drug Immunopharmacology Ligand 6778 Arzerra®, GSK 1841157, GSK1841157, humax-CD20, Kesimpta® (subcutaneous), OMB-157, OMB157
olodaterol Approved drug PDB Ligand Immunopharmacology Ligand 7543 BI-1744, BI-1744-CL, Striverdi®
olopatadine Approved drug Immunopharmacology Ligand 7249 ALO-4943A, KW-4679, Opatanol®, Patanol®, Pazeo®
olverembatinib Approved drug PDB Ligand Immunopharmacology Ligand 10630 compound 10a [PMID: 23301703], GZD-824, GZD824, HQP-1351, HQP1351
omalizumab Approved drug Immunopharmacology Ligand 6890 IGE25, olizumab, R03DX05, RG-3648, rhumab-E25, Xolair®
omaveloxolone Approved drug Immunopharmacology Ligand 7573 RTA 408, RTA-408, Skyclarys®
oprelvekin Approved drug Immunopharmacology Ligand 6971 Neumega®
orelabrutinib Approved drug Immunopharmacology Ligand 10629 example 3 [WO2015048662A2], ICP-022, ICP022
oxaprozin Approved drug PDB Ligand Immunopharmacology Ligand 7252 Daypro®, WY-21743
ozagrel Approved drug Immunopharmacology Ligand 9866 Cataclot®, KCT-0809, OKY-046, Pulmoza®
ozanimod Approved drug PDB Ligand Immunopharmacology Ligand 8709 RPC-1063, RPC1063, Zeposia®
 
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parecoxib Approved drug PDB Ligand Immunopharmacology Ligand 2895 Dynastat®, SC-69124
pecazine Approved drug Immunopharmacology Ligand 9782 mepazine, nothiazine, Pacatal®
peficitinib Approved drug Immunopharmacology Ligand 8315 ASP015K, JNJ-54781532
pegcetacoplan Approved drug Immunopharmacology Ligand 13826 APL-2, Empaveli®
peginterferon alfa-2b Approved drug Immunopharmacology Ligand 7462 PegIntron®, Sylatron®
peginterferon beta-1a Approved drug Immunopharmacology Ligand 7637 interferon beta 1-alpha, PEG-INF-β-1a, Plegridy®
pembrolizumab Approved drug Immunopharmacology Ligand 7499 Keytruda®, lambrolizumab, MK-3475
penicillamine Approved drug PDB Ligand Immunopharmacology Ligand 7264 Cuprimine®
penpulimab Approved drug Immunopharmacology Ligand 12347 AK-105, AK105
PGE2 Approved drug PDB Ligand Immunopharmacology Ligand 1883 Cervidil®, minprositin E2, minprostin E2, Propess®, prostaglandin E2
phenylbutazone Approved drug PDB Ligand Immunopharmacology Ligand 7270 Butazolidine®
pirfenidone Approved drug Immunopharmacology Ligand 7532 AMR-69, Esbriet®
piroxicam Approved drug Immunopharmacology Ligand 7273 CP-16171, Feldene®
pirtobrutinib Approved drug PDB Ligand Immunopharmacology Ligand 11628 BTK inhibitor 16, Jaypirca®, LOXO-305, LOXO305, MCL-133, MCL133, RXC005
plerixafor Approved drug PDB Ligand Immunopharmacology Ligand 844 AMD 3100, AMD3100, bicyclam JM-2987, JM 3100, Mozobil®
polatuzumab vedotin Approved drug Immunopharmacology Ligand 8404 ACD79B-VCMMAE, polatuzumab vedotin-piiq, Polivy®, RG-7596, RG7596, RO5541077-000
polmacoxib Approved drug PDB Ligand Immunopharmacology Ligand 8316 Acelex® (S. Korea), CG-100649, CG100649
pomalidomide Approved drug Immunopharmacology Ligand 7348 CC-4047, IMID-3, Imnovid®, Pomalyst®
ponatinib Approved drug PDB Ligand Immunopharmacology Ligand 5890 AP24534, Iclusig®
ponesimod Approved drug Immunopharmacology Ligand 9320 ACT-128800, ACT128800, Compound 8bo [PMID:20446681], Ponvory®
pozelimab Approved drug Immunopharmacology Ligand 12900 pozelimab-bbfg, REGN-3918, REGN3918, Veopoz®
pranlukast Approved drug PDB Ligand Immunopharmacology Ligand 3634 ONO RS-411
prednicarbate Approved drug Immunopharmacology Ligand 7605 Dermatop®, Hoe 777, Hoe-777, S-770777
prednisolone Approved drug PDB Ligand Immunopharmacology Ligand 2866 DELTA.1-Cortisol, Orapred®, Pediapred®
prednisone Approved drug Immunopharmacology Ligand 7096 Lodotra®, Sterapred®
procaterol Approved drug Immunopharmacology Ligand 3464
 
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ravulizumab Approved drug Immunopharmacology Ligand 10168 ALXN-1210, ALXN1210, ravulizumab-cwvz, Ultomiris®
relatlimab Approved drug Immunopharmacology Ligand 9536 BMS-986016, BMS986016, ONO-4482, Opdualag® (nivolumab + relatlimab-rmbw), relatlimab-rmbw
reslizumab Approved drug Immunopharmacology Ligand 8091 CDP-835, CDP835, Cinqaero®, Cinqair®, JES1-39D10, SCH55700
retifanlimab Approved drug Immunopharmacology Ligand 11583 hPD-1 mAb 7(1.2), INCMGA0012, MGA012, retifanlimab-dlwr, Zynyz®
rilonacept Approved drug Immunopharmacology Ligand 6790 Arcalyst®, IL-1 Trap, interleukin-1 Trap
rimexolone Approved drug Immunopharmacology Ligand 7099 ORG-6216, Vexol®
risankizumab Approved drug Immunopharmacology Ligand 8922 ABBV-066, BI 655066, BI-655066, risankizumab-rzaa, Skyrizi®
ritlecitinib Approved drug Immunopharmacology Ligand 9559 compound 11 [PMID: 28139931], example 5 [WO2015083028], Litfulo®, PF-06651600, PF06651600
rituximab Approved drug Immunopharmacology Ligand 6780 HSDB 7455, IDEC-C2B8, MabThera®, Rituxan®
rofecoxib Approved drug PDB Ligand Immunopharmacology Ligand 2893 Ceoxx®, MK 966, Vioxx®
roflumilast Approved drug PDB Ligand Immunopharmacology Ligand 6962 ARQ-151/Zoryve® (roflumilast cream), BY-217, BYK-20869, Daliresp®, Daxas®
romiplostim Approved drug Immunopharmacology Ligand 6974 MG531, Nplate®
rozanolixizumab Approved drug Immunopharmacology Ligand 9801 CA170_01519.g57 IgG4P, rozanolixizumab-noli, Rystiggo®, UCB-7665, UCB7665
rupatadine Approved drug Immunopharmacology Ligand 10103 Rinialer®, Rupafin®, UR-12592, UR12592
ruxolitinib Approved drug PDB Ligand Immunopharmacology Ligand 5688 (R)-ruxolitinib, INC424, INCB 18424, INCB018424, Jakafi®, Jakavi®
 
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salbutamol Approved drug Immunopharmacology Ligand 558 albuterol, SCH-13949W, Ventolin®
salicylic acid Approved drug PDB Ligand Immunopharmacology Ligand 4306 Bazuka Extra Strength Gel®, salicylate
salmeterol Approved drug Immunopharmacology Ligand 559 GR 33343X, Serevent®
sapropterin Approved drug PDB Ligand Immunopharmacology Ligand 5276 Kuvan®, sapropterin dihydrochloride, SUN-0588, T-1401, tetrahydrobiopterin (THB)
sarilumab Approved drug Immunopharmacology Ligand 7999 Kevzara®, REGN88, SAR153191
satralizumab Approved drug Immunopharmacology Ligand 9093 Enspryng®, RG-6168, RG6168, SA-237, SA237, sapelizumab (deprecated INN), satralizumab-mwge
secukinumab Approved drug Immunopharmacology Ligand 8078 AIN 457, AIN457, Cosentyx®, NVP-AIN457
selinexor Approved drug Immunopharmacology Ligand 10036 compound 70 [WO2013019561A1], KPT-330, KPT330, Nexpovio®, Xpovio®
serplulimab Approved drug Immunopharmacology Ligand 13796 HANSIZHUANG® (China), Hetronifly®, HLX-10, HLX10
siltuximab Approved drug Immunopharmacology Ligand 7396 cLLB8, CNTO 328, Sylvant®
sintilimab Approved drug Immunopharmacology Ligand 12990 IBI 308, IBI-308, IBI308, Tyvyt®
siponimod Approved drug PDB Ligand Immunopharmacology Ligand 9289 BAF-312, BAF312, compound 32 [PMID: 24900670], Mayzent®
sirolimus Approved drug PDB Ligand Immunopharmacology Ligand 6031 AY-22989, Fyarro® (sirolimus albumin-bound particles), Rapamune®, rapamycin, WY-090217
sparsentan Approved drug Immunopharmacology Ligand 8448 DARA-a (Dual Acting Receptor Antagonist of angiotension and endothelin receptors), BMS-346567, compound 7 [PMID 15634011], Filspari®, RE-021, retrophin
spesolimab Approved drug Immunopharmacology Ligand 12169 BI-655130, BI655130, spesolimab-sbzo, Spevigo®
stapokibart Approved drug Immunopharmacology Ligand 13785 CM-310, CM310
sulindac Approved drug Immunopharmacology Ligand 5425 Clinoril®
suprofen Approved drug Immunopharmacology Ligand 7298 Profenal®, R-25061
sutimlimab Approved drug Immunopharmacology Ligand 9807 BIVV009, Enjaymo®, IPN-009, IPN009, sutimlimab-jome, TNT009
 
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tafasitamab Approved drug Immunopharmacology Ligand 11131 Minjuvi®, Monjuvi®, MOR-208, MOR00208, MOR208, tafasitamab-cxix, Xmab5574
tagitanlimab Approved drug Immunopharmacology Ligand 13795 A-167, Cotelet®, HBM-9167, KL-A167, KLA167
tapinarof Approved drug PDB Ligand Immunopharmacology Ligand 9686 benvitimod, GSK-2894512, GSK2894512, Vtama®, WB-1001, WBI 1001, WBI-1001
tauroursodeoxycholic acid Approved drug PDB Ligand Immunopharmacology Ligand 4746 TUDA, Relyvrio® (sodium phenylbutyrate + taurursodiol), tauroursodeoxycholate, taurursodiol, TUDCA, UR 906, ursodoxicoltaurine (INN)
tebentafusp Approved drug Immunopharmacology Ligand 7378 IMCgp100, Kimmtrak®, tebentafusp-tebn
teduglutide Approved drug Immunopharmacology Ligand 7049 ALX-0600, Gattex®, GLP2-2G, Revestive®
telitacicept Approved drug Immunopharmacology Ligand 11827 RC18, Tai'ai®
telotristat ethyl Approved drug Immunopharmacology Ligand 9490 LX-1606, LX1606, Xermelo®
teneligliptin Approved drug PDB Ligand Immunopharmacology Ligand 9906 compound 8g [PMID: 22959556], MP-513, MP513, Teneli
teplizumab Approved drug Immunopharmacology Ligand 12252 humanized OKT3, MGA031, PRV-031, teplizumab-mzwv, Tzield®
teprotumumab Approved drug Immunopharmacology Ligand 10612 R1507, RG-1507, RG1507, RV 001, RV-001, Tepezza®, teprotumumab-trbw
terfenadine Approved drug Immunopharmacology Ligand 2608 RMI-9918, Seldane®, Triludan®
teriflunomide Approved drug PDB Ligand Immunopharmacology Ligand 6844 A77 1726, Aubagio®, flucyamide, HMR-1726
tezepelumab Approved drug Immunopharmacology Ligand 8933 AMG 157, AMG-157, MEDI-9929, MEDI9929, tezepelumab-ekko, Tezspire®
thalidomide Approved drug Immunopharmacology Ligand 7327 K-17
theophylline Approved drug PDB Ligand Immunopharmacology Ligand 413 Nuelin®, Slo-Bid®, Theolair®
tildrakizumab Approved drug Immunopharmacology Ligand 8093 Ilumetri®, Ilumya®, MK-3222, MK3222, SCH-900222, SCH900222, SUNPG1623, tildrakizumab-asmn
tiotropium Approved drug Immunopharmacology Ligand 367 BA-679-BR, Spiriva®
tirabrutinib Approved drug Immunopharmacology Ligand 9265 GS-4059, ONO-4059, ONO4059, Velexbru®
tislelizumab Approved drug Immunopharmacology Ligand 9592 Bai Zean®, BGB-A317, BGBA317, hu317-1/IgG4mt2, Tevimbra®, tislelizumab-jsgr
tocilizumab Approved drug Immunopharmacology Ligand 6881 Actemra®, R-1569, RG-1569, RHPM-1, RoActemra®
tofacitinib Approved drug PDB Ligand Immunopharmacology Ligand 5677 CP-690,550, CP-690550, tasocitinib, Xeljanz®
tolmetin Approved drug PDB Ligand Immunopharmacology Ligand 7311 MCN-2559, McN-2559-21-98, Tolectin®
toripalimab Approved drug Immunopharmacology Ligand 12989 JS-001, JS001, Loqtorzi®, toripalimab-tpzi
tositumomab Approved drug Immunopharmacology Ligand 6781 Bexxar®, V10XA53
tralokinumab Approved drug Immunopharmacology Ligand 8001 Adbry®, Adtralza®, BAK1.1, CAT-354, tralokinumab-ldrm
tranilast Approved drug PDB Ligand Immunopharmacology Ligand 6326 MK-341, SB-252218
tremelimumab Approved drug Immunopharmacology Ligand 8462 CP-675, CP-675,206, CP-675206, Imjudo®, ticilimumab, tremelimumab-actl
triamcinolone Approved drug Immunopharmacology Ligand 2870 fluoxiprednisolone, Kenalog®, Nasacort®
triamcinolone acetonide Approved drug PDB Ligand Immunopharmacology Ligand 2867 Zilretta®
trifarotene Approved drug PDB Ligand Immunopharmacology Ligand 9962 Aklief®, CD5789, compound 15b [PMID: 29706423]
trilaciclib Approved drug Immunopharmacology Ligand 9626 Cosela®, G1T28
tripelennamine Approved drug Immunopharmacology Ligand 7318 Pyribenzamine®
 
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ublituximab Approved drug Immunopharmacology Ligand 8920 Briumvi®, LFB-R603, TG-1101, TGTX-1101, ublituximab-xiiy
ulinastatin Approved drug Immunopharmacology Ligand 10359 Miraclid®, Ulinase®, Urinastatin®
umbralisib Approved drug Immunopharmacology Ligand 8916 example A1 [US2014011819], RP-5264, RP5264, TGR-1202, TGR1202, Ukoniq®
umeclidinium Approved drug Immunopharmacology Ligand 7354 GSK573719A, Incruse Ellipta®
upadacitinib Approved drug Immunopharmacology Ligand 9246 ABT-494, Rinvoq®
ustekinumab Approved drug Immunopharmacology Ligand 6885 CNTO-1275, L04AC05, Stelara®, TT-20
 
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valdecoxib Approved drug PDB Ligand Immunopharmacology Ligand 2894 Bextra®, SC-65872
vamorolone Approved drug Immunopharmacology Ligand 9247 Agamree®, VBP-15, VBP15
vedolizumab Approved drug Immunopharmacology Ligand 7437 Entyvio®, LDP-02, LDP02, MLN-0002, MLN-002, MLN002
vemurafenib Approved drug PDB Ligand Immunopharmacology Ligand 5893 PLX4032, RG7204, Zelboraf®
venetoclax Approved drug PDB Ligand Immunopharmacology Ligand 8318 ABT-199, GDC-0199, Venclexta®, Venclyxto®
vilanterol Approved drug Immunopharmacology Ligand 7353 GW642444X
voclosporin Approved drug Immunopharmacology Ligand 11388 1,11-anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl- N-methyl-L-valyl-[(2S,3R,4R,6E)-3-hydroxy-4-methyl- 2-(methylamino)nona-6,8-dienoyl][(2S)-2-aminobutanoyl]- N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine], E-ISA247, ISA(TX)247, ISA-247, ISA247, ISATX247, Lupkynis®, R 1524, R-1524, R1524
vortioxetine Approved drug PDB Ligand Immunopharmacology Ligand 7351 Brintellix®, compound 5m [PMID: 21486038], Lu AA21004, Trintellix®
vunakizumab Approved drug Immunopharmacology Ligand 9296 AnDajing (Chinese trade name), SHR-1314
 
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xeligekimab Approved drug Immunopharmacology Ligand 13784 GR-1501, GR1501
 
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zafirlukast Approved drug PDB Ligand Immunopharmacology Ligand 3322 Accolate®, ICI-204219
zanubrutinib Approved drug Immunopharmacology Ligand 9861 BGB-3111, BGB3111, Brukinsa®, compound 27b [US9447106]
zileuton Approved drug Immunopharmacology Ligand 5297 A-64077, ZYFLO®
zilucoplan Approved drug Immunopharmacology Ligand 10404 RA-101495, RA101495, Zilbrysq®
zimberelimab Approved drug Immunopharmacology Ligand 12349 AB-122, AB122, GLS-010