Synonyms: fibroblast growth factor 23
Compound class:
Endogenous peptide in human, mouse or rat
Comment: FGF-23 regulates phosphate homeostasis and calcium transport in the kidney [3]. The full-length 327 amino acid protein is functional, and is deactivated by proteolytic cleavage which generates N-terminal and C-terminal chains. Mutation of the cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR), and other gene alterations are associated with hyperphosphatemic familial tumoral calcinosis (HFTC). Antibody-driven inactivation of FGF-23 is being investigated as a pharmacological intervention in these indications. Burosumab (KRN23) is one such FGF-23 neutralising antibody in clinical development.
A FGFR1 isoform [FGFR1(IIIc)] in complex with the Klotho protein (KL; Q9UEF7) forms a high affinity receptor for FGF-23 [1-2,4].
Species: Human
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Classification | |
Compound class | Endogenous peptide in human, mouse or rat |
Ligand families/groups | Fibroblast growth factor (FGF) family ligands |
Synonyms |
fibroblast growth factor 23 |
Gene/Precursor | ||||||||||
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Database Links | |
Ensembl Gene | ENSG00000118972 (Hs) |
Entrez Gene | 8074 (Hs) |
GtoPdb PubChem SID | 318164810 |
Human Protein Atlas | ENSG00000118972 (Hs) |
UniProtKB | Q9GZV9 (Hs) |
Wikipedia | Fibroblast_growth_factor_23 |