erythropoietin   Click here for help

GtoPdb Ligand ID: 4921

Synonyms: Epogen® | Procrit®
Approved drug
erythropoietin is an approved drug (FDA (no history prior to 1989 available))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Recombinant forms of human erythropoietin (epoetins), are contained in various approved drugs with INNs that reflect the different glycoform structures formed by different manufacturing processes. The table below provides details of the epoetin alpha originator drug and biosimilars that are currently approved for use by the US FDA and/or the European Medicines Agency (EMA).

Epoetin alpha and biosimilar drugs.

INNTrade names (authorisation holder)First FDA approvalFirst EMA approval
epoetin alfaBinocrit (Sandoz), Abseamed (Medice Arzneimittel Pütter), Epogen (Amgen), Procrit (Janssen)19892007
epoetin betaNeoRecormon, Recormon (both Roche)n/a1997
epoetin zeta (a.k.a. epoetin alfa-epbx)Silapo (Stada Arzneimitte), Retacrit (Hospira)20182007
epoetin thetaBiopoin (Teva), Eporatio (Ratiopharm)n/a2009
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: erythropoietin

Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (FDA (no history prior to 1989 available))
International Nonproprietary Names Click here for help
INN number INN
6384 epoetin alfa
Synonyms Click here for help
Epogen® | Procrit®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
EPO erythropoietin Human prepro-erythropoietin EP
Database Links Click here for help
ChEMBL Ligand CHEMBL1201565
DrugBank Ligand DB00016
Ensembl Gene ENSG00000130427 (Hs)
GtoPdb PubChem SID 178101620
Human Protein Atlas ENSG00000130427 (Hs)
Search PubMed clinical trials epoetin alfa
Search PubMed titles epoetin alfa
Search PubMed titles/abstracts epoetin alfa
UniProtKB P01588 (Hs)
Wikipedia Erythropoietin, Epoetin alfa