apelin receptor early endogenous ligand   Click here for help

GtoPdb Ligand ID: 7930

Abbreviated name: ELA
Synonyms: ELABELA | Ende | tdl | toddler
Compound class: Endogenous peptide in human, mouse or rat
Comment: ELA signals via the apelin receptor to mediate endoderm differentiation and embryonic heart morphogenesis, and is present prior to the expression of apelin, making this the earliest ligand recognised by the apelin receptor [1]. More recently (Apr 2017) the activity as an endogenous agonist of the Apelin APJ receptor in the adult cardiovascular system was demonstracted [3].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
ELABELA | Ende | tdl | toddler
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
APELA apelin receptor early endogenous ligand Human prepro-apelin receptor early endogenous ligand -
Database Links Click here for help
Specialist databases
GPCRdb Ligand apelin receptor early endogenous ligand
Other databases
Ensembl Gene ENSG00000248329 (Hs)
GtoPdb PubChem SID 249565613
Human Protein Atlas ENSG00000248329 (Hs)
UniProtKB P0DMC3 (Hs)