CCL3   Click here for help

GtoPdb Ligand ID: 756

Synonyms: macrophage inflammatory protein-1α | MIP-1α
Immunopharmacology Ligand
Comment: CCL3 is a CC family chemokine more commonly referred to as macrophage inflammatory protein-1α or MIP-1α. It acts in a dimer with CCL4 (MIP-1β) [1].
Species: Human
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms Click here for help
macrophage inflammatory protein-1α | MIP-1α
Medical Relevance
A variation in the MIP-1α gene (specifically, a polymorphism MIP-1α -906 (TA)(6)/(TA)(6) ) may increase susceptibility to ulcerative colitis [5]
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CCL3 C-C motif chemokine ligand 3 Human C-C motif chemokine 3 chemokine (C-C motif) ligand 3, G0S19-1, LD78ALPHA, MIP-1-alpha, SCYA3, small inducible cytokine A3 (homologous to mouse Mip-1a)
Database Links Click here for help
Specialist databases
GPCRdb Ligand CCL3
Other databases
Ensembl Gene ENSG00000006075 (Hs)
Entrez Gene 6348 (Hs)
GtoPdb PubChem SID 135651684
Human Protein Atlas ENSG00000006075 (Hs)
Immunopaedia Search CCL3
OMIM 182283
RefSeq Protein NP_002974
UniProtKB P10147 (Hs)
Wikipedia CCL3 (Hs)