Synonyms: Tumor necrosis factor ligand superfamily member 15, membrane form
Compound class:
Endogenous peptide in human, mouse or rat
Comment: TL1A occurs as both membrane‐bound and soluble forms. It principally functions as a negative modulator of epithelial cell proliferation. Inhibiting the TL1A/death receptor 3 (TNFRSF25) pathway has been proposed as mechanism to treat inflammatory bowel disease [1]. In addition, TL1A has been associated with tumourigenesis and progression of some gastrointestinal malignancies [3,5,7], making it a target of interest for the development of novel anti-cancer drugs.
Species: Human
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Classification | |
Compound class | Endogenous peptide in human, mouse or rat |
Ligand families/groups | Tumor necrosis factor superfamily ligands |
Synonyms |
Tumor necrosis factor ligand superfamily member 15, membrane form |
Gene/Precursor | ||||||||||
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Database Links | |
CATH/Gene3D | 2.60.120.40 |
Ensembl Gene | ENSG00000181634 (Hs) |
GtoPdb PubChem SID | 178101764 |
Human Protein Atlas | ENSG00000181634 (Hs) |
UniProtKB | O95150 (Hs) |
Wikipedia | TNFSF15 |