cortistatin-14 [Ligand Id: 2007] activity data from GtoPdb

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  • MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1]
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  • SST1 receptor in Human [GtoPdb: 355] [UniProtKB: P30872]
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  • SST2 receptor in Human [GtoPdb: 356] [UniProtKB: P30874]
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  • SST3 receptor in Human [GtoPdb: 357] [UniProtKB: P32745]
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  • SST4 receptor in Human [GtoPdb: 358] [UniProtKB: P31391]
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  • SST5 receptor in Human [GtoPdb: 359] [UniProtKB: P35346]
  • SST5 receptor in Mouse [GtoPdb: 359] [UniProtKB: O08858]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MRGPRX2 in Human [GtoPdb: 157] [UniProtKB: Q96LB1]
GtoPdb - - 7.6 pEC50 25 nM EC50 J Biol Chem (2003) 278: 44400-4 [PMID:12915402];
Biochem Biophys Res Commun (2005) 330: 1146-52 [PMID:15823563];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314];
Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]
SST1 receptor in Human [GtoPdb: 355] [UniProtKB: P30872]
GtoPdb - - 9.1 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788]
SST2 receptor in Human [GtoPdb: 356] [UniProtKB: P30874]
GtoPdb - - 9 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788];
Eur J Pharmacol (1998) 348: 311-20 [PMID:9652348]
SST3 receptor in Human [GtoPdb: 357] [UniProtKB: P32745]
GtoPdb - - 9.9 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788]
SST4 receptor in Human [GtoPdb: 358] [UniProtKB: P31391]
GtoPdb - - 8.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788]
SST5 receptor in Human [GtoPdb: 359] [UniProtKB: P35346]
GtoPdb - - 9.7 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788];
Eur J Pharmacol (1998) 348: 311-20 [PMID:9652348]
SST5 receptor in Mouse [GtoPdb: 359] [UniProtKB: O08858]
GtoPdb - - 9.4 pKi - - - Neuropharmacology (2000) 39: 1451-62 [PMID:10818261]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.