RANK ligand   Click here for help

GtoPdb Ligand ID: 5066

Synonyms: receptor activator of nuclear factor κB ligand | osteoclast differentiation factor (ODF) | osteoprotegerin ligand | TNFSF11
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: RANK ligand (TNFSF11) is a member of the tumor necrosis factor (TNF) cytokine family. It can exist in both membrane-bound and soluble forms. It is a key factor for osteoclast differentiation and activation. Osteoprotegerin acts as a decoy receptor for RANK ligand.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands), Tumor necrosis factor superfamily ligands
Synonyms Click here for help
receptor activator of nuclear factor κB ligand | osteoclast differentiation factor (ODF) | osteoprotegerin ligand | TNFSF11
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF11 TNF superfamily member 11 Human prepro-tumor necrosis factor ligand superfamily member 11 CD254, ODF, OPGL, RANKL, TRANCE, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor superfamily member 11
Database Links Click here for help
CATH/Gene3D 2.60.120.40
DrugBank Target O14788 (Hs)
Ensembl Gene ENSG00000120659 (Hs)
GtoPdb PubChem SID 178101759
Human Protein Atlas ENSG00000120659 (Hs)
Immunopaedia Search RANK ligand
UniProtKB O14788 (Hs)
Wikipedia RANKL