GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

LIGHT   Click here for help

GtoPdb Ligand ID: 5070

Synonyms: Herpesvirus entry mediator-ligand | TR2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: LIGHT is a tumour necrosis factor superfamily protein that regulates T-cell-based inflammatory reactions, especially in mucosal membranes [1-2]. It exists as a membrane-anchored protein and as a soluble form in the serum. LIGHT's biological activity is mediated via binding to TNF superfamily receptors: lymphotoxin β receptor (LTβR; TNFRSF3), herpes virus entry mediator (HVEM; TNFRSF14), and decoy receptor 3 (DcR3; TNFRSF6B).
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands), Tumor necrosis factor superfamily ligands
Synonyms Click here for help
Herpesvirus entry mediator-ligand | TR2
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF14 TNF superfamily member 14 Human prepro-tumor necrosis factor ligand superfamily member 14 CD258, HVEM-L, LIGHT, LTg, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor superfamily member 14
Database Links Click here for help
CATH/Gene3D 2.60.120.40
Ensembl Gene ENSG00000125735 (Hs)
GtoPdb PubChem SID 178101763
Human Protein Atlas ENSG00000125735 (Hs)
UniProtKB O43557 (Hs)
Wikipedia TNFSF14