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ChEMBL ligand: CHEMBL438945 (Human neuropeptide y) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] | ||||||||
ChEMBL | Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2013) 56: 8422-8431 [PMID:24090364] |
ChEMBL | Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins | B | 9.68 | pKi | 0.21 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
ChEMBL | Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay | B | 10.02 | pKi | 0.1 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN | B | 8.59 | pIC50 | 2.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 687-692 [PMID:23265893] |
ChEMBL | Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Nat Prod (2009) 72: 2172-2176 [PMID:19916528] |
ChEMBL | Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins | B | 9.66 | pIC50 | 0.22 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
ChEMBL | Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method | B | 9.68 | pIC50 | 0.21 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
ChEMBL | Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay | B | 9.85 | pIC50 | 0.14 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assay | B | 10.15 | pIC50 | 0.07 | nM | IC50 | Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449] |
Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555] | ||||||||
GtoPdb | - | - | 10.5 | pKi | - | - | - | Peptides (1997) 18: 397-401 [PMID:9145427] |
GtoPdb | - | - | 8.8 | pIC50 | - | - | - | Mol Pharmacol (1992) 41: 817-21 [PMID:1316999] |
Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] | ||||||||
ChEMBL | Displacement of Cy5-pNPY from human Y2 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2013) 56: 8422-8431 [PMID:24090364] |
GtoPdb | - | - | 9.5 | pKi | - | - | - |
Mol Pharmacol (1996) 49: 224-8 [PMID:8632753]; J Biol Chem (1995) 270: 26758-61 [PMID:7592910] |
ChEMBL | Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay | B | 10.12 | pKi | 0.08 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Compound was evaluated for its inhibitory activity against Y2 receptor of rabbit kidney membrane | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 937-942 |
ChEMBL | Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay | B | 9.72 | pIC50 | 0.19 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Binding affinity to human neuropeptide Y2 receptor by radioligand displacement assay | B | 10.05 | pIC50 | 0.09 | nM | IC50 | Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449] |
ChEMBL | Displacement of [125I]peptide YY from Y2 receptor in human KAN-TS cells measured after 60 mins by scintillation counting method | B | 10.55 | pIC50 | 0.03 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
Y2 receptor in Rat [GtoPdb: 306] [UniProtKB: Q9ERC0] | ||||||||
GtoPdb | - | - | 9.4 | pKi | - | - | - | Mol Pharmacol (2001) 60: 124-34 [PMID:11408607] |
Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] | ||||||||
ChEMBL | Displacement of Cy5-[K4]hPP from human Y4 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry | B | 6.55 | pKi | 282 | nM | Ki | J Med Chem (2013) 56: 8422-8431 [PMID:24090364] |
GtoPdb | - | - | 8 | pKi | - | - | - | J Biol Chem (1995) 270: 29123-8 [PMID:7493937] |
ChEMBL | Agonist activity at human Y4 receptor expressed in sf9 cells assessed as hydrolysis of [gamma-33P]GTP after 2 mins by scintillation counting analysis | B | 6.38 | pEC50 | 417 | nM | EC50 | J Med Chem (2013) 56: 8422-8431 [PMID:24090364] |
Y4 receptor in Rat [GtoPdb: 307] [UniProtKB: Q63447] | ||||||||
GtoPdb | - | - | 6.4 | pKi | - | - | - | Peptides (1997) 18: 609-12 [PMID:9210181] |
GtoPdb | - | - | 8.8 | pKi | - | - | - |
Peptides (1997) 18: 397-401 [PMID:9145427]; Peptides (1997) 18: 609-12 [PMID:9210181] |
Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] | ||||||||
ChEMBL | Displacement of Cy5-pNPY from human Y5 receptor expressed in human HEC-1B cells after 90 to 120 mins by flow cytometry | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (2013) 56: 8422-8431 [PMID:24090364] |
GtoPdb | - | - | 9.1 | pKi | - | - | - | J Biol Chem (1996) 271: 26315-9 [PMID:8824284] |
ChEMBL | Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK293 cell membranes. | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2000) 43: 346-350 [PMID:10669561] |
Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634] | ||||||||
GtoPdb | - | - | 9.3 | pKi | - | - | - | J Biol Chem (1996) 271: 26315-9 [PMID:8824284] |
PrRP receptor in Human [GtoPdb: 337] [UniProtKB: P49683] | ||||||||
GtoPdb | - | - | 5.4 | pKi | - | - | - | Genomics (2005) 85: 688-703 [PMID:15885496] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]