ACTH | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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ACTH (Human)
Ligand Activity Charts

ACTH [Ligand Id: 3633] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201610
MC₁ receptor in Human [GtoPdb: 282] [UniProtKB: Q01726] There should be some charts here, you may need to enable JavaScript!
MC₃ receptor in Human [GtoPdb: 284] [UniProtKB: P41968] There should be some charts here, you may need to enable JavaScript!
MC₄ receptor in Human [GtoPdb: 285] [UniProtKB: P32245] There should be some charts here, you may need to enable JavaScript!
MC₅ receptor in Human [GtoPdb: 286] [UniProtKB: P33032] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MC₁ receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
GtoPdb	-	-	8.6	pKi	2.5	nM	Ki	Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC₃ receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
GtoPdb	-	-	7.06	pKi	86.9	nM	Ki	Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC₄ receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
GtoPdb	-	-	6.16	pKi	693	nM	Ki	Pharmacol. Toxicol. (1996) 79: 161-5 [PMID:8884876]
MC₅ receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
GtoPdb	-	-	5	pKi	>10000	nM	Ki	Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]