ACTH [Ligand Id: 3633] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1201610 (Cortrophin, H.p. acthar gel, Corticotropin, Adrenomone, Cortigel, Corticotropin, repository, Adrenocorticotropin, Acth, Acthar, Repository corticotropin, Purified cortrophin gel, Acthar gel, Adrenocorticotropic Hormone)
  • MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
  • This target only has 1 pki data point
  • 8.6
1 CHEMBL1201610_lig_chart_1 MC1 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
  • This target only has 1 pki data point
  • 7.06
2 CHEMBL1201610_lig_chart_2 MC3 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
  • This target only has 1 pki data point
  • 6.16
3 CHEMBL1201610_lig_chart_3 MC4 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
  • This target only has 1 pki data point
  • 5
4 CHEMBL1201610_lig_chart_4 MC5 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
GtoPdb - - 8.6 pKi 2.5 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
GtoPdb - - 7.06 pKi 86.9 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]
MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
GtoPdb - - 6.16 pKi 693 nM Ki Pharmacol Toxicol (1996) 79: 161-5 [PMID:8884876]
MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
GtoPdb - - 5 pKi >10000 nM Ki Eur J Pharmacol (1995) 288: 311-317 [PMID:7774675]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]