ChEMBL ligand: CHEMBL3343989
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2] Mas-related G-protein coupled receptor member X1 in Mouse [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3] Mas-related G-protein coupled receptor member X1 in Rat [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1] There should be some charts here, you may need to enable JavaScript!
MRGPRX2/Mas-related G-protein coupled receptor member X2 in Human [ChEMBL: CHEMBL5849] [GtoPdb: 157] [UniProtKB: Q96LB1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
GtoPdb	-	-	7.99	pKd	10.2	nM	Kd	Nat Neurosci (2002) 5: 201-9 [PMID:11850634]
GtoPdb	-	-	7.68	pKi	21	nM	Ki	Nat Neurosci (2002) 5: 201-9 [PMID:11850634]
ChEMBL	Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay	B	7.3	pEC50	50.12	nM	EC50	Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
ChEMBL	Agonist activity at human MrgprX1	B	7.3	pEC50	50	nM	EC50	J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
GtoPdb	-	-	7.8	pEC50	-	-	-	J Neurosci (2004) 24: 5044-53 [PMID:15163697]; Nat Neurosci (2002) 5: 201-9 [PMID:11850634]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
Mas-related G-protein coupled receptor member X1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
ChEMBL	Agonist activity at mouse MRGPRC11	B	6.52	pEC50	300	nM	EC50	J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
ChEMBL	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	B	6.6	pEC50	251.19	nM	EC50	Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
Mas-related G-protein coupled receptor member X1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
ChEMBL	Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay	B	6.5	pEC50	316.23	nM	EC50	Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
ChEMBL	Agonist activity at rat MRGPRC	B	6.52	pEC50	300	nM	EC50	J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
MRGPRX2/Mas-related G-protein coupled receptor member X2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5849] [GtoPdb: 157] [UniProtKB: Q96LB1]
ChEMBL	Agonist activity at MRGPRX2 (unknown origin) expressed in HTLA cells assessed as induction of beta-arrestin 2 recruitment incubated for 18 to 24 hrs by PRESTO-Tango assay	F	4.95	pEC50	11220.18	nM	EC50	Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]
ChEMBL	Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in tetracycline-induced FLP-IN/T-REX 293 cells assessed as increase in intracellular calcium release by FLIPR assay	F	5.05	pEC50	8912.51	nM	EC50	Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]