ChEMBL ligand: CHEMBL373742 (Arginine vasopressin, Arginine Vasopressin, Argipressin or lypressin, Beta-Hypophamine, Leiormone, Pitressin, Vasophysin, Vasopressin, Vasopressin injection, Vasopressin, unspecified, Vasostrict)
OT receptor/Oxytocin receptor in Human [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] OT receptor/Oxytocin receptor in Rat [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] There should be some charts here, you may need to enable JavaScript!
V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] V1A receptor/Vasopressin V1a receptor in Rat [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] There should be some charts here, you may need to enable JavaScript!
V1B receptor/Vasopressin V1b receptor in Human [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] V1B receptor/Vasopressin V1b receptor in Rat [ChEMBL: CHEMBL2659] [GtoPdb: 367] [UniProtKB: P48974] There should be some charts here, you may need to enable JavaScript!
V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] Vasopressin V2 receptor in Pig [ChEMBL: CHEMBL3944] [UniProtKB: P32307] Vasopressin V2 receptor in Bovine [ChEMBL: CHEMBL2344] [UniProtKB: P48044] V2 receptor/Vasopressin V2 receptor in Rat [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559]
ChEMBL	Displacement of [3H]OT from oxytocin receptor expressed in COS1 cells	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 8585-8596 [PMID:21117646]
ChEMBL	Displacement of [3H]OT from human mammary gland oxytocin receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting method	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2018) 26: 3039-3045 [PMID:29602673]
ChEMBL	Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hr	B	8.7	pKi	2	nM	Ki	J Med Chem (2019) 62: 3297-3310 [PMID:30896946]
ChEMBL	Displacement of [3H]AVP from human oxytocin receptor expressed CHO cells after 60 mins	B	8.77	pKi	1.7	nM	Ki	J Med Chem (2011) 54: 2864-2877 [PMID:21428295]
ChEMBL	Displacement of [3H]-AVP from human oxytocin receptor expressed in CHO cells after 30 mins	B	8.78	pKi	1.65	nM	Ki	J Med Chem (2012) 55: 8588-8602 [PMID:22984902]
GtoPdb	-	-	9.3	pKi	-	-	-	Life Sci (1995) 57: 2253-61 [PMID:7475979]; EMBO J (1995) 14: 2176-82 [PMID:7774575]; FEBS Lett (1996) 397: 201-6 [PMID:8955347]; J Biol Chem (2001) 276: 26931-41 [PMID:11337500]; Endocrinology (2002) 143: 4655-64 [PMID:12446593]; J Med Chem (2004) 47: 2375-2388 [PMID:15084136]; Br J Pharmacol (2005) 146: 744-751 [PMID:16158071]; Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]
ChEMBL	Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay	B	7.39	pEC50	41	nM	EC50	J Med Chem (2010) 53: 8585-8596 [PMID:21117646]
ChEMBL	Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay	B	7.66	pEC50	22	nM	EC50	J Med Chem (2014) 57: 5306-5317 [PMID:24874785]
ChEMBL	Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay	F	7.82	pEC50	15.14	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay	F	7.82	pEC50	15	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay	F	8.08	pEC50	8.3	nM	EC50	J Med Chem (2011) 54: 2864-2877 [PMID:21428295]
ChEMBL	Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	F	10	pEC50	0.1	nM	EC50	J Med Chem (2019) 62: 3297-3310 [PMID:30896946]
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536]
ChEMBL	Displacement of [3H]AVP from rat OT receptor expressed in CHO cells	B	8.93	pKi	1.17	nM	Ki	J Med Chem (2007) 50: 835-847 [PMID:17300166]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes	B	8.4	pKi	3.95	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Displacement of [3H]AVP from human liver vasopressin V1a receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting method	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem (2018) 26: 3039-3045 [PMID:29602673]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes	B	8.82	pKi	1.53	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells	B	8.87	pKi	1.35	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes	B	8.89	pKi	1.3	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes	B	8.95	pKi	1.13	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins	B	8.96	pKi	1.1	nM	Ki	J Med Chem (2011) 54: 2864-2877 [PMID:21428295]
ChEMBL	Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins	B	9.15	pKi	0.7	nM	Ki	J Med Chem (2012) 55: 8588-8602 [PMID:22984902]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
GtoPdb	-	-	9.3	pKi	-	-	-	Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; J Med Chem (2004) 47: 2375-2388 [PMID:15084136]; Eur J Biochem (2000) 267: 4253-63 [PMID:10866830]; Endocrinology (2002) 143: 4655-64 [PMID:12446593]; Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976]; J Biol Chem (1997) 272: 26536-44 [PMID:9334232]; Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]; Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 63-9 [PMID:9459574]; J Biol Chem (1994) 269: 3304-10 [PMID:8106369]; Endocrinology (1997) 138: 4109-22 [PMID:9322919]; J Pharmacol Exp Ther (1998) 287: 860-7 [PMID:9864265]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes	B	9.46	pKi	0.35	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes	B	9.59	pKi	0.26	nM	Ki	J Med Chem (2007) 50: 4976-4985 [PMID:17850055]
ChEMBL	Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	F	9.62	pEC50	0.24	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	B	9.62	pEC50	0.24	nM	EC50	J Med Chem (2014) 57: 5306-5317 [PMID:24874785]
ChEMBL	Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	F	9.63	pEC50	0.23	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560]
ChEMBL	Negative log of Kd.	B	9.19	pKd	0.65	nM	Kd	J Med Chem (1992) 35: 151-157 [PMID:1732523]
ChEMBL	Binding potency against V1 receptor in rat liver cells	B	9.19	pKd	0.64	nM	Kd	J Med Chem (1992) 35: 151-157 [PMID:1732523]
GtoPdb	-	-	8.4	pKi	-	-	-	EMBO J (1995) 14: 2176-82 [PMID:7774575]
ChEMBL	Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane	B	8.81	pKi	1.54	nM	Ki	J Med Chem (2007) 50: 835-847 [PMID:17300166]
ChEMBL	Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	F	10.15	pEC50	0.07	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	F	10.2	pEC50	0.06	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901]
ChEMBL	Displacement of [3H]AVP from human vasopressin V1b receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting method	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem (2018) 26: 3039-3045 [PMID:29602673]
ChEMBL	Displacement of [3H]AVP from human vasopressin V1b receptor expressed CHO cells after 60 mins	B	9.17	pKi	0.68	nM	Ki	J Med Chem (2011) 54: 2864-2877 [PMID:21428295]
ChEMBL	Displacement of [3H]-AVP from human vasopressin V1b receptor expressed in CHO cells after 30 mins	B	9.31	pKi	0.49	nM	Ki	J Med Chem (2012) 55: 8588-8602 [PMID:22984902]
GtoPdb	-	-	9.5	pKi	-	-	-	Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; J Med Chem (2004) 47: 2375-2388 [PMID:15084136]; Endocrinology (2002) 143: 4655-64 [PMID:12446593]; Br J Pharmacol (2005) 146: 744-751 [PMID:16158071]; Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976]; Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]; Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 63-9 [PMID:9459574]; Endocrinology (1997) 138: 4109-22 [PMID:9322919]; J Pharmacol Exp Ther (1998) 287: 860-7 [PMID:9864265]
ChEMBL	Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay	F	8.37	pEC50	4.3	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	B	8.37	pEC50	4.3	nM	EC50	J Med Chem (2014) 57: 5306-5317 [PMID:24874785]
ChEMBL	Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay	F	8.37	pEC50	4.27	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay	F	8.7	pEC50	2	nM	EC50	J Med Chem (2011) 54: 2864-2877 [PMID:21428295]
V1B receptor/Vasopressin V1b receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2659] [GtoPdb: 367] [UniProtKB: P48974]
ChEMBL	Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in At-T20 cells	B	9.54	pKi	0.29	nM	Ki	J Med Chem (2007) 50: 835-847 [PMID:17300166]
GtoPdb	-	-	9.9	pKi	-	-	-	Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
ChEMBL	Displacement of [3H]AVP from human kidney vasopressin V2 receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting method	B	7.49	pKi	32	nM	Ki	Bioorg Med Chem (2018) 26: 3039-3045 [PMID:29602673]
ChEMBL	Displacement of [3H]-AVP from human vasopressin V2 receptor expressed in CHO cells after 30 mins	B	8.83	pKi	1.48	nM	Ki	J Med Chem (2012) 55: 8588-8602 [PMID:22984902]
ChEMBL	Displacement of [3H]-AVP from human vasopressin V2 receptor expressed in CHO cells after 30 mins by saturation binding assay	B	8.87	pKi	1.36	nM	Ki	J Med Chem (2012) 55: 8588-8602 [PMID:22984902]
ChEMBL	Displacement of [3H]AVP from human vasopressin V2 receptor expressed CHO cells after 60 mins	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2011) 54: 2864-2877 [PMID:21428295]
GtoPdb	-	-	9.1	pKi	-	-	-	Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; J Med Chem (2004) 47: 2375-2388 [PMID:15084136]; EMBO J (1995) 14: 2176-82 [PMID:7774575]; Endocrinology (2002) 143: 4655-64 [PMID:12446593]; Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976]; Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]; Kidney Int (2000) 58: 1613-22 [PMID:11012895]; Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 63-9 [PMID:9459574]; Endocrinology (1997) 138: 4109-22 [PMID:9322919]; J Pharmacol Exp Ther (1998) 287: 860-7 [PMID:9864265]
ChEMBL	Binding affinity to vasopression V2 receptor (unknown origin) on isolated cell membrane by vasopression-self competition binding assay	B	6.62	pIC50	242	nM	IC50	Bioorg Med Chem Lett (2013) 23: 989-995 [PMID:23312470]
ChEMBL	Binding to human V2 receptor expressed in LV2 cells by cAMP production	F	10.28	pEC50	0.05	nM	EC50	Bioorg Med Chem Lett (2006) 16: 954-959 [PMID:16297621]
ChEMBL	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	F	10.3	pEC50	0.05	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	F	10.3	pEC50	0.05	nM	EC50	J Med Chem (2011) 54: 4388-4398 [PMID:21688787]
ChEMBL	Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	B	10.3	pEC50	0.05	nM	EC50	J Med Chem (2014) 57: 5306-5317 [PMID:24874785]
Vasopressin V2 receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3944] [UniProtKB: P32307]
ChEMBL	Tested for the inhibition to V2 subtype receptor using [3H]- (VS2) as radioligand at 3 nM and arginine-vasopressin at 2 uM in LLCPKI cells	B	8.48	pIC50	3.3	nM	IC50	Bioorg Med Chem Lett (1997) 7: 719-724
Vasopressin V2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2344] [UniProtKB: P48044]
ChEMBL	Inhibition of radioligand [3H]AVP binding to V2 receptor in bovine kidney inner medulla membrane	B	8.82	pKd	1.5	nM	Kd	J Med Chem (1994) 37: 255-259 [PMID:7507528]
V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788]
ChEMBL	Compound was evaluated for its dissociation constant (Kd) to rat kidney Vasopressin V2 receptor	B	8.82	pKd	1.5	nM	Kd	Bioorg Med Chem Lett (1999) 9: 667-672 [PMID:10201826]
ChEMBL	Displacement of [3H]AVP from vasopressin V2 receptor in rat kidney membranes	B	9.35	pKi	0.45	nM	Ki	J Med Chem (2007) 50: 835-847 [PMID:17300166]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]