ICAM-1   Click here for help

GtoPdb Ligand ID: 6757

Comment: ICAM-1 is a cell-adhesion molecule that is overexpressed on the surface of a number of cancer cells types [1,5], and this may be correlated with metastasis and poor prognosis [3]. These findings suggest ICAM-1 as an ideal target for oncology therapeutic development [2]. Monoclonal antibodies (and antibody-drug conjugates) that target ICAM-1 are being explored for anti-tumour potential [4,6-7], and there is a report of the experimental effect of ICAM-1 targeting CAR-T cells in triple-negative breast cancer [8].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ICAM1 intercellular adhesion molecule 1 Human prepro-intercellular adhesion molecule 1 BB2, CD54, human rhinovirus receptor
Database Links Click here for help
DrugBank Target P05362 (Hs)
Ensembl Gene ENSG00000090339 (Hs)
Entrez Gene 3383 (Hs)
GtoPdb PubChem SID 178103368
Human Protein Atlas ENSG00000090339 (Hs)
Immunopaedia Search ICAM-1
UniProtKB P05362 (Hs)
Wikipedia ICAM1