amyloid β   Click here for help

GtoPdb Ligand ID: 4865

Synonyms: amyloid β-peptide | beta-amyloid protein
Compound class: Endogenous peptide in human, mouse or rat
Comment: We give the sequence for the 42 amino acid peptide here, but note that use of the name β-amyloid generally refers to the ensemble of peptides of 40 to 43 residues excised from the precursor APP protein by the combined action of β- and γ-secretases. These peptides may be soluble monomers or oligomers and contribute to the formation of fibrils and plaques that are associated with Alzheimer's disease.

The amino acid sequences of alternative forms are;
1-40 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
1-42 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
1-43 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIAT

So far we have annotated three types of target relationships for β-amyloid:
1) antibodies directed against the peptide forms for depletion
2) aggregation antagonists
3) imaging reagents for detection
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
amyloid β-peptide | beta-amyloid protein
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
APP amyloid beta precursor protein Human prepro-amyloid beta A4 protein AD1, Alzheimer disease, amyloid beta (A4) precursor protein, peptidase nexin-II
Database Links Click here for help
Specialist databases
GPCRdb Ligand amyloid beta
Other databases
CATH/Gene3D 4.10.230.10, 4.10.410.10, 3.30.1490.140, 3.90.570.10
Ensembl Gene ENSG00000142192 (Hs)
GtoPdb PubChem SID 178101566
Human Protein Atlas ENSG00000142192 (Hs)
UniProtKB P05067 (Hs)
Wikipedia Amyloid_beta