APRIL   Click here for help

GtoPdb Ligand ID: 5068

Synonyms: A proliferation-inducing ligand | TALL2 | TNF- and APOL-related leukocyte expressed ligand 2 | TNF-related death ligand 1 | TRDL-1 | ZTNF2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: APRIL (also known as tumor necrosis factor ligand superfamily member 13; TNFSF13) is a protein of the TNF superfamily recognized by the cell surface catalytic receptor TACI [9] and other TNF family receptors [3]. Three APRIL isoforms have bee reported [1]. We provide the amino acid sequence for the mature peptide chain (i.e. without the 104 amino acid propeptide leader sequence which is cleaved by furin convertase in the Golgi apparatus prior to secretion [4]).
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands), Tumor necrosis factor superfamily ligands
Synonyms Click here for help
A proliferation-inducing ligand | TALL2 | TNF- and APOL-related leukocyte expressed ligand 2 | TNF-related death ligand 1 | TRDL-1 | ZTNF2
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF13 TNF superfamily member 13 Human prepro-tumor necrosis factor ligand superfamily member 13 APRIL, CD256, tumor necrosis factor (ligand) superfamily, member 13, tumor necrosis factor superfamily member 13
Database Links Click here for help
CATH/Gene3D 2.60.120.40
Ensembl Gene ENSG00000161955 (Hs)
GtoPdb PubChem SID 178101761
Human Protein Atlas ENSG00000161955 (Hs)
UniProtKB O75888 (Hs)
Wikipedia TNFSF13