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The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

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GtoImmuPdb antibodies only: Includes therapeutic monoclonal antibodies.
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Ligand name ID Synonyms
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ABBV-3373 Immunopharmacology Ligand 12917 ADC 122
AbGn-168H Immunopharmacology Ligand 10013 AbGn-168, neihulizumab
abrezekimab Immunopharmacology Ligand 9806 CDP7766, UCB-4144, UCB4144, VR-942
abrilumab Immunopharmacology Ligand 11531 AMG 181, AMG-181, MEDI-7183, MEDI7183
adalimumab Approved drug Immunopharmacology Ligand 4860 D2E7, Humira®
AFM13 Immunopharmacology Ligand 10067 AFM 13, AFM-13
alemtuzumab Approved drug Immunopharmacology Ligand 6770 campath 1H, Campath®, campath-1H, Lemtrada®
ALT-803 Immunopharmacology Ligand 9615 IL-15 N72D:IL-15RαSu/Fc, IL-15SA, N-803
AMG820 Immunopharmacology Ligand 9106
AMY109 Immunopharmacology Ligand 12789 AMY-109, H1009/L395-F1974m
anatumomab mafenatox Immunopharmacology Ligand 9947 5T4FabV13SEAD227A, ABR 214936, ABR-214936, ABR214936, pMB125, PNU 214936, PNU-214936, PNU214936, TTS-CD2
andecaliximab Immunopharmacology Ligand 9510 GS-5745, GS5745
anifrolumab Approved drug Immunopharmacology Ligand 8258 anifrolumab-fnia, MDX-1333, MEDI-546, Saphnelo®
atezolizumab Approved drug Immunopharmacology Ligand 7990 MPDL3280A, Tecentriq®
atibuclimab Immunopharmacology Ligand 11326 IC14
avdoralimab Immunopharmacology Ligand 11345 anti-hC5aR-32F3A6 GL, IPH-5401, NN-8210, NNC-0215-0384
avelumab Approved drug Immunopharmacology Ligand 8735 Bavencio®, MSB-0010718C, MSB0010718C
 
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balertatug Immunopharmacology Ligand 13800
basiliximab Approved drug Immunopharmacology Ligand 6879 CHI-621, L04AC02, SDZ-CHI-621, Simulect®
batoclimab Immunopharmacology Ligand 13805 HBM9161, HL161, HL161ANS, IMVT-1401, RVT-1401
begelomab Immunopharmacology Ligand 8691 Begendina&rg; (proprietary name), BT 5/9, SAND 26
belantamab mafodotin Approved drug Immunopharmacology Ligand 11117 belamaf, belantamab mafodotin-blmf, Blenrep®, GSK-2857916, GSK2857916
belimumab Approved drug Immunopharmacology Ligand 6887 Benlysta®, hBlySmAb-1.1, LimphoStat-B, lymphostat-B
bempikibart Immunopharmacology Ligand 13725 ADX-914, ADX914
benralizumab Approved drug Immunopharmacology Ligand 7674 BIW-8405, Fasenra®, KHK4563, MEDI-563
bexmarilimab Immunopharmacology Ligand 12907 Clevegen, FP-1305, FP1305
bifikafusp alfa Immunopharmacology Ligand 9756 Daramun (bifikafusp alfa and onfekafusp alfa), Darleukin, L19-IL2, L19IL2, Nidlegy (bifikafusp alfa and onfekafusp alfa)
bimekizumab Approved drug Immunopharmacology Ligand 9411 bimekizumab-bkzx, Bimzelx®, CA028_0496, CDP4940, gL7gH9, UCB-4940, UCB4940, Zu-G1
blinatumomab Approved drug Immunopharmacology Ligand 7384 Blincyto®, bscCD19xCD3, MEDI-538, MT-103, MT103
brazikumab Immunopharmacology Ligand 9293 AMG 139, AMG-139, MEDI2070
brentuximab vedotin Approved drug Immunopharmacology Ligand 6772 Adcetris®, anti-CD30 ADC SGN-35, SGN 35
briakinumab Immunopharmacology Ligand 9213 ABT-874, J-695, J695, Ozespa
briquilimab Immunopharmacology Ligand 13450 AMG-191, AMG191, JSP-191, JSP191
brodalumab Approved drug Immunopharmacology Ligand 7540 AMG-827, AMG827, Kyntheum®, Lumicef®, Siliq®
BsAb (CD89-CD20) Immunopharmacology Ligand 9833
 
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cabiralizumab Immunopharmacology Ligand 9107 BMS-986227, FPA-008, FPA008
cadonilimab Approved drug Immunopharmacology Ligand 12966 AK-104, AK104
camoteskimab Immunopharmacology Ligand 13187 AEVI 007, AEVI-007, AVTX 007, AVTX-007, CERC 007, CERC-007, MEDI 2338
camrelizumab Approved drug Immunopharmacology Ligand 9758 INCSHR1210, SHR-1210
canakinumab Approved drug Immunopharmacology Ligand 6773 ACZ 885, ACZ885, Ilaris®
cemiplimab Approved drug Immunopharmacology Ligand 10090 cemiplimab-rwlc, Libtayo®, REGN-2810, REGN2810, SAR-439684, SAR439684
certolizumab pegol Approved drug Immunopharmacology Ligand 6774 CDP870, Cimzia®, PHA 738144
CFZ533 Immunopharmacology Ligand 9802 CFZ-533, iscalimab (proposed INN), NVP-CFZ533, OM11-62MF
clazakizumab Immunopharmacology Ligand 9195 ALD-518, ALD518, BMS-945429
COVA322 Immunopharmacology Ligand 10469
crovalimab Approved drug Immunopharmacology Ligand 12790 crovalimab-akkz, Piasky®, RG-6107, RG6107, Senkai® (China), SKY59
cusatuzumab Immunopharmacology Ligand 9778 ARGX-110, ARGX110, clone 41D12
 
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daclizumab Approved drug Immunopharmacology Ligand 6880 L04AC01, RO-24-7375, Ro-247375, Zenapax®
dapirolizumab pegol Immunopharmacology Ligand 11123 CDP-7657, CDP7657, DZP
daratumumab Approved drug Immunopharmacology Ligand 7395 3003-005, Darzalex®, HuMax-CD38, JNJ-54767414
dectrekumab Immunopharmacology Ligand 8714 QAX-576, QAX576
divozilimab Approved drug Immunopharmacology Ligand 13087 BCD 132, BCD-132, Ivlizi®
dostarlimab Approved drug Immunopharmacology Ligand 11518 ANB-011, dostarlimab-gxly, Jemperli®, TSR-042, WBP-285
dupilumab Approved drug Immunopharmacology Ligand 7574 Dupixent®, REGN668, SAR231893
durvalumab Approved drug Immunopharmacology Ligand 7985 anti-B7H1 monoclonal antibody, Imfinzi®, MEDI-4736, MEDI4736
DX-2507 Immunopharmacology Ligand 9959
 
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eculizumab Approved drug Immunopharmacology Ligand 6884 h5G1.1, h5G1.1VHC, Soliris®
efalizumab Approved drug Immunopharmacology Ligand 6593 anti alphaL integrin, antiCD11 alpha, hu1124, Raptiva®
efgartigimod alfa Approved drug Immunopharmacology Ligand 9777 ARGX-113, efgartigimod alfa-fcab, Vyvgart®
eldelumab Immunopharmacology Ligand 9047 BMS-936557, MDX-1100
elezanumab Immunopharmacology Ligand 9290 ABT-555, AE12-1Y-QL
elotuzumab Approved drug Immunopharmacology Ligand 8361 BMS-901608, Empliciti®, HuLuc63
elranatamab Approved drug Immunopharmacology Ligand 12889 elranatamab-bcmm, Elrexfio®, PF-06863135, PF06863135
emactuzumab Immunopharmacology Ligand 8944 RG7155, RO5509554
emapalumab Approved drug Immunopharmacology Ligand 9295 emapalumab-lzsg, Gamifant®, NI-0501, NI0501
enoblituzumab Immunopharmacology Ligand 9589 MGA-271, MGA271
enokizumab Immunopharmacology Ligand 8934 7F3com-2H2, MEDI-528, MEDI528
envafolimab Approved drug Immunopharmacology Ligand 10492 Envida®, KN-035, KN035
epcoritamab Approved drug Immunopharmacology Ligand 11442 epcoritamab-bysp, Epkinly®, GEN-3013, GEN3013, Tepkinly®
epratuzumab Immunopharmacology Ligand 8088 90Y-DOTA-hLL2, 90Y-epratuzumab tetraxetan, 90Y-hLL2, AMG-412, IMMU-hLL2, LymphoCide® (proposed proprietary name)
etrolizumab Immunopharmacology Ligand 8407 PRO145223, RG-7413, RG7413, rhuMAb Beta7
 
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felzartamab Immunopharmacology Ligand 13455 MOR-03087, MOR-202, MOR03087, MOR202
fezakinumab Immunopharmacology Ligand 9281 ILV-094
fontolizumab Immunopharmacology Ligand 9847 HuZAF
 
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galcanezumab Approved drug Immunopharmacology Ligand 8967 clone III, Emgality®, galcanezumab-gnlm, LY-2951742, LY2951742
gemtuzumab ozogamicin Approved drug Immunopharmacology Ligand 6775 CDP 771, CMA 676, hP67.6-calicheamicin, Mylotarg®, WAY-CMA 676
gevokizumab Immunopharmacology Ligand 7394 XOMA 052, XOMA-052
gimsilumab Immunopharmacology Ligand 9624 MORAb-022
golimumab Approved drug Immunopharmacology Ligand 6776 CNTO-148, CNTO148, Simponi®
GSK3050002 Immunopharmacology Ligand 9623 E6071, KANAb071
guselkumab Approved drug Immunopharmacology Ligand 7998 CNTO-1959, Tremfya®
 
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ianalumab Immunopharmacology Ligand 10656 VAY-736, VAY736
ibalizumab Approved drug Immunopharmacology Ligand 10208 Hu5A8, ibalizumab-uiyk, TMB-355, TMB355, TNX-355, Trogarzo®
ibritumomab tiuxetan Approved drug Immunopharmacology Ligand 6777 IDEC-2B8, IDEC-Y2B8-yttrium ibritumomab tiuxetan, NSC-715848, Zevalin®
imaprelimab Immunopharmacology Ligand 9805 PRX-003, PRX003
inclacumab Immunopharmacology Ligand 12312 HuMab 002, LC1004-002, RO-4905417, RO4905417
infliximab Approved drug Immunopharmacology Ligand 5004 cA2, Inflectra®, Remicade®, Remsima®, SB2, TA-650, Zymfentra® (subcutaneous formulation)
inotuzumab ozogamicin Approved drug Immunopharmacology Ligand 8266 Besponsa®, CMC-544
ipilimumab Approved drug Immunopharmacology Ligand 6888 MDX-010, MDX-101, MDX-CTLA-4, Yervoy®
itolizumab Approved drug Immunopharmacology Ligand 9421 Alzumab®, T1h
ivonescimab Approved drug Immunopharmacology Ligand 13396 AK-112, AK112, Idafang® (China), SMT-112, SMT112
ixekizumab Approved drug Immunopharmacology Ligand 7541 LY-2439821, LY2439821, Taltz®
 
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lebrikizumab Approved drug Immunopharmacology Ligand 7684 Ebglyss®, lebrikizumab-lbkz, MILR1444A, RG3637, TNX-650
lenzilumab Immunopharmacology Ligand 8935 KB-003, KB003
leronlimab Immunopharmacology Ligand 10752 PRO 140, PRO-140, PRO140, Vyrologix®
ligelizumab Immunopharmacology Ligand 8997 CL-2C, NVP-QGE031, QGE031
lilotomab Immunopharmacology Ligand 9950 Betalutin®, HH1, tetulomab
lintuzumab Immunopharmacology Ligand 7983 ACTIMAB®, HuM195, SGN-33, SMART M195
lirilumab Immunopharmacology Ligand 9310 1-7F9, BMS-986015, IPH2102
litifilimab Immunopharmacology Ligand 11122 BIIB-059, BIIB059
lulizumab pegol Immunopharmacology Ligand 8460 BMS-931699, BMS931699
lutikizumab Immunopharmacology Ligand 9297 ABT-981, E26.13-SS-X3
LY3022855 Immunopharmacology Ligand 9109 IMC-CS4
 
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MAB92 Immunopharmacology Ligand 9665
magrolimab Immunopharmacology Ligand 12652 Hu5F9-G4
mavrilimumab Immunopharmacology Ligand 7785 CAM-3001, KPL-301
MCS110 Immunopharmacology Ligand 9110
mepolizumab Approved drug Immunopharmacology Ligand 7685 Nucala®, SB-240563
mezagitamab Immunopharmacology Ligand 10609 TAK-079, TAK079
milatuzumab Immunopharmacology Ligand 8267 hLL1, IMMU-115
mirikizumab Approved drug Immunopharmacology Ligand 9846 Antibody I [US9023358], LY-3074828, LY3074828, mirikizumab-mrkz, Omvoh®
mogamulizumab Approved drug Immunopharmacology Ligand 6477 KW-0761, mogamulizumab-kpkc, Poteligeo®
monalizumab Immunopharmacology Ligand 8323 humZ270, IPH-2201, NN8765-3658
moxetumomab pasudotox Approved drug Immunopharmacology Ligand 7675 CAT-8015, GCR-8015, HA22, Lumoxiti®, moxetumomab pasudotox-tdfk
muromonab-CD3 Approved drug Immunopharmacology Ligand 6889 L04AA02, OKT-3, Orthoclone Okt3®
 
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namilumab Immunopharmacology Ligand 10370 AMG203, MT203
naptumomab estafenatox Immunopharmacology Ligand 9948 ABR-217620, ABR217620, Anyara (proposed trade name), TTS CD3, TTS-CD3
naratuximab emtansine Immunopharmacology Ligand 9949 IMGN-529, IMGN529, K7153A-SMCC-DM1
natalizumab Approved drug Immunopharmacology Ligand 6591 AN100226, anti-alpha4 integrin, anti-VLA4, Tysabri®
nemolizumab Approved drug Immunopharmacology Ligand 8720 CD14152, CIM 331, CIM331, Mitchga®, Nemluvio®
nivolumab Approved drug Immunopharmacology Ligand 7335 BMS-936558, MDX-1106, ONO-4538, Opdivo®
nurulimab Immunopharmacology Ligand 12992 BCD-145, BCD145
 
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obinutuzumab Approved drug Immunopharmacology Ligand 6941 GA-101, GA101, Gazyva®
ocrelizumab Approved drug Immunopharmacology Ligand 7580 2H7, Ocrevus®, PRO70769, RG1594
ofatumumab Approved drug Immunopharmacology Ligand 6778 Arzerra®, GSK 1841157, GSK1841157, humax-CD20, Kesimpta® (subcutaneous), OMB-157, OMB157
oleclumab Immunopharmacology Ligand 9596 MEDI 9447, MEDI-9447
omalizumab Approved drug Immunopharmacology Ligand 6890 IGE25, olizumab, R03DX05, RG-3648, rhumab-E25, Xolair®
onfekafusp alfa Immunopharmacology Ligand 9757 Daramun (bifikafusp alfa and onfekafusp alfa), Fibronum, L19TNF-alpha, Nidlegy (bifikafusp alfa and onfekafusp alfa)
ontamalimab Immunopharmacology Ligand 9340 PF-00547659, PF-547659, SHP647
ordesekimab Immunopharmacology Ligand 13046 AMG-714, AMG714, MAb146B7, PRV-015
OSE-127 Immunopharmacology Ligand 9604 Effi-7
otilimab Immunopharmacology Ligand 11132 GSK-3196165, GSK3196165, MOR-103, MOR103
otlertuzumab Immunopharmacology Ligand 9951 CD37-SMIP, TRU-016, TRU016
ozoralizumab Immunopharmacology Ligand 9638 ATN-103, PF-5230896
 
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paridiprubart Immunopharmacology Ligand 13714 EB05, NI 0101, NI-0101
pascolizumab Immunopharmacology Ligand 7786 SB-240683
pateclizumab Immunopharmacology Ligand 9854 MLTA3698A, PRO283698, RG7416
pembrolizumab Approved drug Immunopharmacology Ligand 7499 Keytruda®, lambrolizumab, MK-3475
penpulimab Approved drug Immunopharmacology Ligand 12347 AK-105, AK105
perenostobart Immunopharmacology Ligand 12103 SRF-617, SRF617
plonmarlimab Immunopharmacology Ligand 11644 TJ 003234, TJ003234, TJM2
plozalizumab Immunopharmacology Ligand 8921 hu1D9, MLN-1202, MLN1202
polatuzumab vedotin Approved drug Immunopharmacology Ligand 8404 ACD79B-VCMMAE, polatuzumab vedotin-piiq, Polivy®, RG-7596, RG7596, RO5541077-000
pozelimab Approved drug Immunopharmacology Ligand 12900 pozelimab-bbfg, REGN-3918, REGN3918, Veopoz®
prolgolimab Immunopharmacology Ligand 12991 BCD-100, BCD100
 
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quilizumab Immunopharmacology Ligand 8998 47H4 v5 hulgG1, MEMP1972A, RG-7449
 
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ravulizumab Approved drug Immunopharmacology Ligand 10168 ALXN-1210, ALXN1210, ravulizumab-cwvz, Ultomiris®
relatlimab Approved drug Immunopharmacology Ligand 9536 BMS-986016, BMS986016, ONO-4482, Opdualag® (nivolumab + relatlimab-rmbw), relatlimab-rmbw
remtolumab Immunopharmacology Ligand 9597 A-1230717, ABT-122
reslizumab Approved drug Immunopharmacology Ligand 8091 CDP-835, CDP835, Cinqaero®, Cinqair®, JES1-39D10, SCH55700
retifanlimab Approved drug Immunopharmacology Ligand 11583 hPD-1 mAb 7(1.2), INCMGA0012, MGA012, retifanlimab-dlwr, Zynyz®
risankizumab Approved drug Immunopharmacology Ligand 8922 ABBV-066, BI 655066, BI-655066, risankizumab-rzaa, Skyrizi®
rituximab Approved drug Immunopharmacology Ligand 6780 HSDB 7455, IDEC-C2B8, MabThera®, Rituxan®
rocatinlimab Immunopharmacology Ligand 13045 AMG-451, AMG451, KHK-4083, KHK4083
rontalizumab Immunopharmacology Ligand 9640 9F3v13, RhuMAB IFNalpha, rhuMAb interferon-α
rovelizumab Immunopharmacology Ligand 9598 Hu23F2G, LeukArrest
rozanolixizumab Approved drug Immunopharmacology Ligand 9801 CA170_01519.g57 IgG4P, rozanolixizumab-noli, Rystiggo®, UCB-7665, UCB7665
 
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sarilumab Approved drug Immunopharmacology Ligand 7999 Kevzara®, REGN88, SAR153191
satralizumab Approved drug Immunopharmacology Ligand 9093 Enspryng®, RG-6168, RG6168, SA-237, SA237, sapelizumab (deprecated INN), satralizumab-mwge
secukinumab Approved drug Immunopharmacology Ligand 8078 AIN 457, AIN457, Cosentyx®, NVP-AIN457
serplulimab Approved drug Immunopharmacology Ligand 13796 HANSIZHUANG® (China), Hetronifly®, HLX-10, HLX10
sibeprenlimab Immunopharmacology Ligand 12102 VIS-649, VIS649
sifalimumab Immunopharmacology Ligand 8257 MDX-1103, MEDI-545, MEDI545
siltuximab Approved drug Immunopharmacology Ligand 7396 cLLB8, CNTO 328, Sylvant®
sintilimab Approved drug Immunopharmacology Ligand 12990 IBI 308, IBI-308, IBI308, Tyvyt®
sirukumab Immunopharmacology Ligand 7989 CNTO 136, CNTO-136, Plivensia (proposed trade name)
sonelokimab Immunopharmacology Ligand 10491 IL17-MS3086, IL17MS3086, SEQ ID 836 [WO2012156219A1]
spartalizumab Immunopharmacology Ligand 10140 NPV-PDR001, NPVPDR001, PDR-001, PDR001
spesolimab Approved drug Immunopharmacology Ligand 12169 BI-655130, BI655130, spesolimab-sbzo, Spevigo®
stapokibart Approved drug Immunopharmacology Ligand 13785 CM-310, CM310
sutimlimab Approved drug Immunopharmacology Ligand 9807 BIVV009, Enjaymo®, IPN-009, IPN009, sutimlimab-jome, TNT009
 
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tabalumab Immunopharmacology Ligand 8000 LY 2127399, LY2127399
tafasitamab Approved drug Immunopharmacology Ligand 11131 Minjuvi®, Monjuvi®, MOR-208, MOR00208, MOR208, tafasitamab-cxix, Xmab5574
tagitanlimab Approved drug Immunopharmacology Ligand 13795 A-167, Cotelet®, HBM-9167, KL-A167, KLA167
tebentafusp Approved drug Immunopharmacology Ligand 7378 IMCgp100, Kimmtrak®, tebentafusp-tebn
temelimab Immunopharmacology Ligand 11530 GNbAC1
teplizumab Approved drug Immunopharmacology Ligand 12252 humanized OKT3, MGA031, PRV-031, teplizumab-mzwv, Tzield®
tepoditamab Immunopharmacology Ligand 10353 MCLA-117, MCLA117, PB9122
teprotumumab Approved drug Immunopharmacology Ligand 10612 R1507, RG-1507, RG1507, RV 001, RV-001, Tepezza®, teprotumumab-trbw
tezepelumab Approved drug Immunopharmacology Ligand 8933 AMG 157, AMG-157, MEDI-9929, MEDI9929, tezepelumab-ekko, Tezspire®
tibulizumab Immunopharmacology Ligand 10350 LY-3090106, LY3090106
tildrakizumab Approved drug Immunopharmacology Ligand 8093 Ilumetri®, Ilumya®, MK-3222, MK3222, SCH-900222, SCH900222, SUNPG1623, tildrakizumab-asmn
timolumab Immunopharmacology Ligand 9097 8c10, BTT-1023, BTT1023, r8c10, SI-3106, SI-636
tislelizumab Approved drug Immunopharmacology Ligand 9592 Bai Zean®, BGB-A317, BGBA317, hu317-1/IgG4mt2, Tevimbra®, tislelizumab-jsgr
tocilizumab Approved drug Immunopharmacology Ligand 6881 Actemra®, R-1569, RG-1569, RHPM-1, RoActemra®
tomaralimab Immunopharmacology Ligand 9408 OPN-305, OPN305, VK5A/H4
toripalimab Approved drug Immunopharmacology Ligand 12989 JS-001, JS001, Loqtorzi®, toripalimab-tpzi
tositumomab Approved drug Immunopharmacology Ligand 6781 Bexxar®, V10XA53
tozorakimab Immunopharmacology Ligand 12964 MEDI-3506, MEDI3506
tralokinumab Approved drug Immunopharmacology Ligand 8001 Adbry®, Adtralza®, BAK1.1, CAT-354, tralokinumab-ldrm
tregalizumab Immunopharmacology Ligand 9864 BT-061, hB-F5
tremelimumab Approved drug Immunopharmacology Ligand 8462 CP-675, CP-675,206, CP-675206, Imjudo®, ticilimumab, tremelimumab-actl
 
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ublituximab Approved drug Immunopharmacology Ligand 8920 Briumvi®, LFB-R603, TG-1101, TGTX-1101, ublituximab-xiiy
ulocuplumab Immunopharmacology Ligand 9161 BMS-936564, MDX-1338
urelumab Immunopharmacology Ligand 9311 BMS 663513, BMS-663513
ustekinumab Approved drug Immunopharmacology Ligand 6885 CNTO-1275, L04AC05, Stelara®, TT-20
utomilumab Immunopharmacology Ligand 9244 PF-05082566
 
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vadastuximab talirine Immunopharmacology Ligand 9434 SGN-CD33A
varokibart Immunopharmacology Ligand 12187
vedolizumab Approved drug Immunopharmacology Ligand 7437 Entyvio®, LDP-02, LDP02, MLN-0002, MLN-002, MLN002
veltuzumab Immunopharmacology Ligand 8268 hA20, IMMU-106
vixarelimab Immunopharmacology Ligand 13451 KPL-716, KPL716
vobarilizumab Immunopharmacology Ligand 8363 ALX-0061
vunakizumab Approved drug Immunopharmacology Ligand 9296 AnDajing (Chinese trade name), SHR-1314
 
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xeligekimab Approved drug Immunopharmacology Ligand 13784 GR-1501, GR1501
Xilonix TN Immunopharmacology Ligand 8528
 
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zadoprubart Immunopharmacology Ligand 13799
zigakibart Immunopharmacology Ligand 12101 BION-1301, BION1301, clone 14_1G.15
ziltivekimab Immunopharmacology Ligand 11552 COR-001, COR001, MEDI-5117, MEDI5117, ZILTI
zimberelimab Approved drug Immunopharmacology Ligand 12349 AB-122, AB122, GLS-010