lestaurtinib [Ligand Id: 5672] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL603469 (A-154475, A-154475.0, Cep-701, CEP-701, KT-555, KT-5555, KT5555, Lestaurtinib, SP-924, SP924, SPM-924)
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  • 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
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  • activin A receptor type 1/Activin receptor type-1 in Human [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
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  • activin A receptor type 1B/Activin receptor type-1B in Human [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
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  • activin A receptor type 2A/Activin receptor type-2A in Human [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037]
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  • activin A receptor type 2B/Activin receptor type-2B in Human [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705]
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  • AP2 associated kinase 1/Adaptor-associated kinase in Human [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8]
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  • Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141]
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  • Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236]
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  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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  • protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
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  • protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
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  • protein kinase AMP-activated non-catalytic subunit gamma 1/AMP-activated protein kinase, gamma-1 subunit in Human [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619]
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  • protein kinase AMP-activated non-catalytic subunit gamma 2/AMP-activated protein kinase, gamma-2 subunit in Human [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0]
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  • ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2]
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  • ATP-dependent RNA helicase DDX3X in Human [ChEMBL: CHEMBL5553] [UniProtKB: O00571]
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  • BMP2 inducible kinase/BMP-2-inducible protein kinase in Human [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1]
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  • bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
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  • bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
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  • bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
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  • Brain glycogen phosphorylase in Human [ChEMBL: CHEMBL3856] [UniProtKB: P11216]
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  • BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274]
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  • BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
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  • BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
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  • Calcium-dependent protein kinase 1 in Plasmodium falciparum [ChEMBL: CHEMBL1908387] [UniProtKB: P62344]
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  • calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
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  • calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
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  • calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5]
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  • calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
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  • calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554]
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  • calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
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  • calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
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  • calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
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  • calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
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  • calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4]
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  • protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
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  • protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
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  • protein kinase, cAMP-dependent, regulatory, type II, alpha subunit/cAMP-dependent protein kinase type II-alpha regulatory subunit in Human [ChEMBL: CHEMBL2221] [GtoPdb: 1474] [UniProtKB: P13861]
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  • casein kinase 1 alpha 1/Casein kinase I alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
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  • casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
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  • casein kinase 1 epsilon/Casein kinase I epsilon in Human [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
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  • casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
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  • casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
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  • casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
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  • casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752]
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  • casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4]
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  • Cell division control protein 2 homolog in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL1908388] [UniProtKB: P61075]
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  • cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1]
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  • cell division cycle 7/Cell division cycle 7-related protein kinase in Human [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
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  • cyclin dependent kinase 8/Cell division protein kinase 8 in Human [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336]
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  • Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
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  • Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
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  • coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60]
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  • Choline-phosphate cytidylyltransferase A in Human [ChEMBL: CHEMBL4105855] [UniProtKB: P49585]
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  • Chromodomain-helicase-DNA-binding protein 4 in Human [ChEMBL: CHEMBL4105742] [UniProtKB: Q14839]
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  • citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
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  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 10/Cyclin-dependent kinase 10 in Human [ChEMBL: CHEMBL1795191] [GtoPdb: 1962] [UniProtKB: Q15131]
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  • cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4]
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  • cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526]
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  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
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  • cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
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  • cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
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  • cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
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  • cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
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  • cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772]
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  • cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4]
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  • cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039]
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  • Cytochrome c1, heme protein, mitochondrial in Human [ChEMBL: CHEMBL4105975] [UniProtKB: P08574]
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  • death associated protein kinase 1/Death-associated protein kinase 1 in Human [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
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  • death associated protein kinase 2/Death-associated protein kinase 2 in Human [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
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  • death associated protein kinase 3/Death-associated protein kinase 3 in Human [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
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  • discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
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  • dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3]
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  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
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  • mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
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  • mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
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  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
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  • mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163]
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  • mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
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  • mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
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  • CDC like kinase 1/Dual specificity protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
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  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
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  • CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
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  • TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
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  • testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
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  • testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
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  • dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
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  • dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
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  • Dynamin-like 120 kDa protein, mitochondrial in Human [ChEMBL: CHEMBL4105705] [UniProtKB: O60313]
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  • Electron transfer flavoprotein subunit beta in Human [ChEMBL: CHEMBL4105744] [UniProtKB: P38117]
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  • EPH receptor A1/Ephrin type-A receptor 1 in Human [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
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  • EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
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  • EPH receptor A3/Ephrin type-A receptor 3 in Human [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
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  • EPH receptor A4/Ephrin type-A receptor 4 in Human [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
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  • EPH receptor A5/Ephrin type-A receptor 5 in Human [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
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  • EPH receptor A6/Ephrin type-A receptor 6 in Human [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33]
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  • EPH receptor A7/Ephrin type-A receptor 7 in Human [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
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  • EPH receptor A8/Ephrin type-A receptor 8 in Human [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
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  • EPH receptor B1/Ephrin type-B receptor 1 in Human [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
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  • EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
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  • EPH receptor B3/Ephrin type-B receptor 3 in Human [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
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  • EPH receptor B4/Ephrin type-B receptor 4 in Human [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
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  • EPH receptor B6/Ephrin type-B receptor 6 in Human [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
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  • eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3]
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  • eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
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  • Eukaryotic translation initiation factor 5B in Human [ChEMBL: CHEMBL4105852] [UniProtKB: O60841]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
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  • fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
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  • fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
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  • protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
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  • General transcription and DNA repair factor IIH helicase subunit XPD in Human [ChEMBL: CHEMBL4105743] [UniProtKB: P18074]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
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  • G protein-coupled receptor kinase 4 in Human [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298]
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  • G protein-coupled receptor kinase 6 in Human [ChEMBL: CHEMBL6144] [GtoPdb: 1470] [UniProtKB: P43250]
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  • Guanine nucleotide-binding protein G(i) subunit alpha-2 in Human [ChEMBL: CHEMBL4105887] [UniProtKB: P04899]
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  • Haem oxygenase 2/Heme oxygenase 2 in Human [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02]
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  • homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
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  • homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
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  • homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63]
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  • hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058]
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  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
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  • inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
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  • inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
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  • inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • Insulin receptor-related receptor/Insulin receptor-related protein in Human [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616]
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  • eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
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  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616]
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  • interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
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  • leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
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  • leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376]
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  • Liver glycogen phosphorylase in Human [ChEMBL: CHEMBL2568] [UniProtKB: P06737]
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  • colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
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  • macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • mitogen-activated protein kinase 11/MAP kinase p38 beta in Human [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
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  • mitogen-activated protein kinase 13/MAP kinase p38 delta in Human [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264]
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  • mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778]
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  • MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
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  • microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
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  • microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34]
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  • maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
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  • Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9]
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There should be some charts here, you may need to enable JavaScript!
  • misshapen like kinase 1/Misshapen-like kinase 1 in Human [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
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  • mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08]
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  • mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
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  • mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
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  • mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
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  • mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233]
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  • mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
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  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
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  • mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852]
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  • mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283]
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  • mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16]
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  • mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5]
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  • mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759]
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  • mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
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  • mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
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  • mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382]
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  • mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
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  • mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
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  • mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918]
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  • mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
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  • mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8]
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  • mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819]
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  • mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
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  • BUB1 mitotic checkpoint serine/threonine kinase/Mitotic checkpoint serine/threonine-protein kinase BUB1 in Human [ChEMBL: CHEMBL1772932] [GtoPdb: 1949] [UniProtKB: O43683]
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  • ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
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  • Multifunctional protein ADE2 in Human [ChEMBL: CHEMBL5922] [UniProtKB: P22234]
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  • muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
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There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • myosin light chain kinase 3/Myosin light chain kinase in Human [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0]
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There should be some charts here, you may need to enable JavaScript!
  • myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6]
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  • myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
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  • DM1 protein kinase/Myotonin-protein kinase in Human [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
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  • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0]
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  • neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
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  • neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
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  • tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
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  • neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
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  • NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285]
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  • NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093]
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There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
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  • calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936]
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There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Phosphatidylethanolamine-binding protein 1 in Human [ChEMBL: CHEMBL4105856] [UniProtKB: P30086]
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma in Human [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747]
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  • phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755]
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  • phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma in Human [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 alpha/Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha in Human [ChEMBL: CHEMBL1795194] [GtoPdb: 2858] [UniProtKB: P48426]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8]
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  • Phosphofructokinase platelet type in Human [ChEMBL: CHEMBL2972] [UniProtKB: Q01813]
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  • phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816]
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  • phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
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  • phosphatidylinositol 4-kinase beta/PI4-kinase beta subunit in Human [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
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  • cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
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  • cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88]
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  • platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • Probable ATP-dependent RNA helicase DDX6 in Human [ChEMBL: CHEMBL4105783] [UniProtKB: P26196]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
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  • protein kinase C iota/Protein kinase C iota in Human [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • protein kinase D3/Protein kinase C nu in Human [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
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  • protein kinase C theta/Protein kinase C theta in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
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  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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  • protein kinase N1/Protein kinase N1 in Human [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512]
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  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
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  • protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
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  • MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
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  • c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
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  • sugen kinase 110/Putative uncharacterized serine/threonine-protein kinase SgK110 in Human [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264]
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  • RAB27A, member RAS oncogene family/Ras-related protein Rab-27A in Human [ChEMBL: CHEMBL4105702] [GtoPdb: 2916] [UniProtKB: P51159]
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  • receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
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  • receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572]
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  • receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078]
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
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  • erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
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  • fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
  • fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342]
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  • erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860]
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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  • G protein-coupled receptor kinase 1/Rhodopsin kinase in Human [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835]
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  • ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
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  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
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  • ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
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  • ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
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  • ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676]
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  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
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  • ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
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  • S-adenosylmethionine synthase isoform type-2 in Human [ChEMBL: CHEMBL3313835] [UniProtKB: P31153]
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  • ATR checkpoint kinase/Serine-protein kinase ATR in Human [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
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  • serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
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  • serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
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  • serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
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  • serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5]
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  • serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768]
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  • STE20 like kinase/Serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
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  • serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
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  • serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506]
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  • serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08]
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  • serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57]
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  • serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6]
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  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
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  • serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2]
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  • serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7]
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  • Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208]
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  • Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
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  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
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  • AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
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  • AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
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  • A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398]
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  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
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  • aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
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  • B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
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  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
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  • checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
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  • microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
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  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
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  • doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
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  • doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
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  • doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098]
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  • endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460]
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  • endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5]
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  • cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976]
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  • ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9]
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  • integrin linked kinase/Serine/threonine-protein kinase ILK-1 in Human [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418]
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  • large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
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  • large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
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  • male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794]
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  • microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
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  • CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
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  • CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
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  • CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37]
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  • serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
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  • serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
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  • serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289]
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  • mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
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  • protein kinase N3/Serine/threonine-protein kinase N3 in Human [ChEMBL: CHEMBL3627581] [GtoPdb: 1522] [UniProtKB: Q6P5Z2]
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  • NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
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  • NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66]
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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  • NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956]
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  • NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957]
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  • NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8]
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  • NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
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  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
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  • NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
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  • serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84]
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  • nemo like kinase/Serine/threonine protein kinase NLK in Human [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
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  • oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747]
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  • p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
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  • p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
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  • p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
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  • p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013]
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  • p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
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  • p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286]
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  • cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
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  • cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537]
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  • cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002]
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  • cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921]
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  • cyclin dependent kinase 15/Serine/threonine-protein kinase PFTAIRE-2 in Human [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
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  • Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
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  • Serine/threonine-protein kinase pknB in Mycobacterium tuberculosis [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3]
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  • polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
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  • polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
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  • protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817]
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  • pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523]
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  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
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  • activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
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  • RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2]
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  • RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4]
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  • RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730]
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  • receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
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  • SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2]
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  • serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
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  • salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059]
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  • salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1]
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  • SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2]
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  • SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
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  • SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362]
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  • SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
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  • TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
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  • TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54]
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  • TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8]
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  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
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  • TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18]
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  • tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
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  • tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
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  • unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385]
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  • unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
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  • unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2]
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  • VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
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  • WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
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  • Signal recognition particle receptor subunit alpha in Human [ChEMBL: CHEMBL4105934] [UniProtKB: P08240]
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  • signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
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  • signal transducer and activator of transcription 5A/Signal transducer and activator of transcription 5A in Human [ChEMBL: CHEMBL5403] [GtoPdb: 3221] [UniProtKB: P42229]
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  • SNF related kinase/SNF-related serine/threonine-protein kinase in Human [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2]
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  • mitogen-activated protein kinase kinase kinase 19/SPS1/STE20-related protein kinase YSK4 in Human [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5]
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  • STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6]
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  • serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8]
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  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
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  • Structural maintenance of chromosomes protein 1A in Human [ChEMBL: CHEMBL4105747] [UniProtKB: Q14683]
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  • Structural maintenance of chromosomes protein 2 in Human [ChEMBL: CHEMBL4105890] [UniProtKB: O95347]
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  • Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial in Human [ChEMBL: CHEMBL4105973] [UniProtKB: Q9P2R7]
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  • testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
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  • transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
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  • transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
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  • Thyroid hormone receptor-associated protein 3 in Human [ChEMBL: CHEMBL4105820] [UniProtKB: Q9Y2W1]
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  • TP53 regulating kinase/TP53-regulating kinase in Human [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44]
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  • TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5]
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  • TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84]
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  • protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640]
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  • tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
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  • BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
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  • BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813]
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  • protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
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  • Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • megakaryocyte-associated tyrosine kinase/Tyrosine-protein kinase CTK in Human [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679]
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  • FER tyrosine kinase/Tyrosine-protein kinase FER in Human [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
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  • FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
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  • FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
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  • fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685]
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
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  • HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
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  • IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
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  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
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  • tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590]
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  • TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
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  • AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6]
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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  • tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680]
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  • TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
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  • TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
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  • tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
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  • YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • U5 small nuclear ribonucleoprotein 200 kDa helicase in Human [ChEMBL: CHEMBL4105972] [UniProtKB: O75643]
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  • aarF domain containing kinase 1/Uncharacterized aarF domain-containing protein kinase 1 in Human [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2]
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  • coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53]
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  • aarF domain containing kinase 5/Uncharacterized aarF domain-containing protein kinase 5 in Human [ChEMBL: CHEMBL4105886] [GtoPdb: 1929] [UniProtKB: Q3MIX3]
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  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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  • fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
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  • Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human [ChEMBL: CHEMBL4105892] [UniProtKB: P49748]
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  • WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
26S protease regulatory subunit 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831205] [UniProtKB: P43686]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
ChEMBL Binding affinity to PDPK1 B 8.47 pKd 3.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PDPK1 kinase domain B 8.47 pKd 3.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Actin-related protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6090] [UniProtKB: P61160]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Actin-related protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105857] [UniProtKB: P61158]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.71 pKd 1949 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ACVR1 B 7.12 pKd 75 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ACVR1 kinase domain B 7.12 pKd 75 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.18 pKd 660 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ACVR1B B 7.07 pKd 86 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ACVR1B kinase domain B 7.07 pKd 86 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037]
ChEMBL Binding affinity to ACVR2A B 5.6 pKd 2500 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ACVR2A kinase domain B 5.6 pKd 2500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ACVR2B B 5.42 pKd 3800 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ACVR2B kinase domain B 5.42 pKd 3800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Acyl-CoA dehydrogenase family member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105816] [UniProtKB: Q6JQN1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Acyl-CoA dehydrogenase family member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105707] [UniProtKB: Q709F0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
AP2 associated kinase 1/Adaptor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.18 pKd 66 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AAK1 B 8.51 pKd 3.1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AAK1 kinase domain B 8.51 pKd 3.1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Adenine phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105819] [UniProtKB: P07741]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Adenylate kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4938] [UniProtKB: P54819]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Binding affinity to ALK B 7.15 pKd 71 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ALK kinase domain B 7.15 pKd 71 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.08 pKd 840 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AMPK-alpha1 B 7.6 pKd 25 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AMPK-alpha1 kinase domain B 7.6 pKd 25 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
ChEMBL Binding affinity to AMPK-alpha2 B 7.25 pKd 56 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AMPK-alpha2 kinase domain B 7.25 pKd 56 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase AMP-activated non-catalytic subunit gamma 1/AMP-activated protein kinase, gamma-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.05 pKd 885 nM Kd Science (2017) 358: null-null [PMID:29191878]
protein kinase AMP-activated non-catalytic subunit gamma 2/AMP-activated protein kinase, gamma-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.05 pKd 890 nM Kd Science (2017) 358: null-null [PMID:29191878]
ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2]
ChEMBL Binding affinity to ANKK1 B 7.49 pKd 32 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ANKK1 kinase domain B 7.49 pKd 32 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ATP-dependent RNA helicase DDX1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010634] [UniProtKB: Q92499]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATP-dependent RNA helicase DDX3X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5553] [UniProtKB: O00571]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATP-dependent RNA helicase DDX42 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105782] [UniProtKB: Q86XP3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATP-dependent RNA helicase DHX30 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105814] [UniProtKB: Q7L2E3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.67 pKd 214 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BIKE B 7.8 pKd 16 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BIKE kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BMPR1A B 6.02 pKd 950 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BMPR1A kinase domain B 6.02 pKd 950 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BMPR1B B 7.24 pKd 57 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BMPR1B kinase domain B 7.24 pKd 57 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BMPR2 B 5.82 pKd 1500 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BMPR2 kinase domain B 5.82 pKd 1500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to recombinant BMPR2 (unknown origin) assessed as dissociation constant by DSF assay B 5.82 pKd 1500 nM Kd ACS Med Chem Lett (2023) 14: 833-840 [PMID:37312836]
Brain glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3856] [UniProtKB: P11216]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
ChEMBL Binding affinity to BRSK1 B 7.6 pKd 25 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BRSK1 kinase domain B 7.6 pKd 25 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
ChEMBL Binding affinity to BRSK2 B 7.8 pKd 16 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BRSK2 kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Calcium-dependent protein kinase 1 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908387] [UniProtKB: P62344]
ChEMBL Binding constant for PFCDPK1(P.falciparum) kinase domain B 8.25 pKd 5.6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
ChEMBL Binding affinity to CAMK1 B 6.89 pKd 130 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK1 kinase domain B 6.89 pKd 130 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
ChEMBL Binding affinity to CAMK1D B 7.33 pKd 47 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK1D kinase domain B 7.33 pKd 47 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5]
ChEMBL Binding constant for CAMK1G kinase domain B 6.33 pKd 470 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
ChEMBL Binding affinity to CAMK2A B 8 pKd 10 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK2A kinase domain B 8 pKd 10 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554]
ChEMBL Binding affinity to CAMK2B B 7.23 pKd 59 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK2B kinase domain B 7.23 pKd 59 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.48 pKd 332 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CAMK2D B 8.06 pKd 8.8 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK2D kinase domain B 8.06 pKd 8.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
ChEMBL Binding affinity to CAMK1G B 6.33 pKd 470 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.51 pKd 306 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CAMK2G B 7.59 pKd 26 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK2G kinase domain B 7.59 pKd 26 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CAMK4 B 5.52 pKd 3000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMK4 kinase domain B 5.52 pKd 3000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
ChEMBL Binding affinity to CAMKK1 B 7.64 pKd 23 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMKK1 kinase domain B 7.64 pKd 23 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.86 pKd 1381 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CAMKK2 B 7.82 pKd 15 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CAMKK2 kinase domain B 7.82 pKd 15 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PKAC-alpha kinase domain B 6.66 pKd 220 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PKAC-beta B 6.8 pKd 160 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PKAC-beta kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, cAMP-dependent, regulatory, type II, alpha subunit/cAMP-dependent protein kinase type II-alpha regulatory subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2221] [GtoPdb: 1474] [UniProtKB: P13861]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSNK1A1L B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSNK1A1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSNK1D B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSNK1D kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSNK1E B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSNK1E kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSNK1G1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSNK1G1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSNK1G2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSNK1G2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Binding constant for CSNK2A1 kinase domain B 5.59 pKd 2600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to CSNK2A1 B 7.16 pKd 69 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CSNK2A2 kinase domain B 6.01 pKd 970 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to CSNK2A2 B 6.74 pKd 180 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752]
ChEMBL Binding constant for CSNK1A1L kinase domain B 5.15 pKd 7100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSNK1G3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSNK1G3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Cell division control protein 2 homolog in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908388] [UniProtKB: P61075]
ChEMBL Binding constant for PFPK5(P.falciparum) kinase domain B 5.25 pKd 5600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1]
ChEMBL Binding affinity to CDK11 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK11 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336]
ChEMBL Binding affinity to CDK8 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK8 kinase domain B 5.1 pKd 8000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PRKG1 B 6.43 pKd 370 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKG1 kinase domain B 6.43 pKd 370 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
ChEMBL Binding affinity to PRKG2 B 7.6 pKd 25 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKG2 kinase domain B 7.6 pKd 25 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ADCK3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ADCK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Choline-phosphate cytidylyltransferase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105855] [UniProtKB: P49585]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Chromodomain-helicase-DNA-binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105742] [UniProtKB: Q14839]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CIT B 7.07 pKd 85 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CIT kinase domain B 7.07 pKd 85 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.11 pKd 783 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to JNK1 B 7.96 pKd 11 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JNK1 kinase domain B 7.96 pKd 11 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.76 pKd 1729 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to JNK2 B 6.49 pKd 320 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JNK2 kinase domain B 6.49 pKd 320 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.55 pKd 28 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to JNK3 B 7.92 pKd 12 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JNK3 kinase domain B 7.92 pKd 12 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 10/Cyclin-dependent kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795191] [GtoPdb: 1962] [UniProtKB: Q15131]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CDC2L5 kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.48 pKd 330 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CDK2 B 7.7 pKd 20 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK2 kinase domain B 7.7 pKd 20 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526]
ChEMBL Binding affinity to CDK3 B 6.38 pKd 420 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK3 kinase domain B 6.38 pKd 420 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.43 pKd 37 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.06 pKd 866 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CDK4-cyclinD3 kinase domain B 7.46 pKd 35 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for CDK4-cyclinD1 kinase domain B 7.52 pKd 30 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.81 pKd 1564 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CDK5 B 6.39 pKd 410 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK5 kinase domain B 6.39 pKd 410 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.76 pKd 1757 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CDK7 B 7.06 pKd 87 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK7 kinase domain B 7.06 pKd 87 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CDK9 B 6.28 pKd 530 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDK9 kinase domain B 6.28 pKd 530 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
ChEMBL Binding constant for CDKL1 kinase domain B 6.31 pKd 490 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772]
ChEMBL Binding affinity to CDKL2 B 7.37 pKd 43 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDKL2 kinase domain B 7.37 pKd 43 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4]
ChEMBL Binding affinity to CDKL3 B 6.37 pKd 430 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDKL3 kinase domain B 6.37 pKd 430 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CDKL5 B 8 pKd 10 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDKL5 kinase domain B 8 pKd 10 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Cysteine--tRNA ligase, cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105937] [UniProtKB: P49589]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Cytochrome c1, heme protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105975] [UniProtKB: P08574]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
dCTP pyrophosphatase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769292] [UniProtKB: Q9H773]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
ChEMBL Binding affinity to DAPK1 B 7.1 pKd 80 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DAPK1 kinase domain B 7.1 pKd 80 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
ChEMBL Binding affinity to DAPK2 B 7.2 pKd 63 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DAPK2 kinase domain B 7.2 pKd 63 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
ChEMBL Binding affinity to DAPK3 B 7.09 pKd 82 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DAPK3 kinase domain B 7.09 pKd 82 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Delta(24)-sterol reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331059] [UniProtKB: Q15392]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Deoxycytidine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2447] [UniProtKB: P27707]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to DDR2 B 6.4 pKd 400 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DDR2 kinase domain B 6.4 pKd 400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
DnaJ homolog subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189122] [UniProtKB: P31689]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
DNA replication licensing factor MCM4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105745] [UniProtKB: P33991]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
DNA topoisomerase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3]
ChEMBL Binding constant for RIPK5 kinase domain B 8.28 pKd 5.3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.93 pKd 1162 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MEK1 B 8.46 pKd 3.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MEK1 kinase domain B 8.46 pKd 3.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.24 pKd 569 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MEK2 B 8.41 pKd 3.9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MEK2 kinase domain B 8.41 pKd 3.9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.92 pKd 120 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MEK3 B 8.3 pKd 5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MEK3 kinase domain B 8.3 pKd 5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.1 pKd 790 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MEK4 B 8.42 pKd 3.8 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MEK4 kinase domain B 8.42 pKd 3.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.75 pKd 1794 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MEK5 kinase domain B 8.15 pKd 7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.06 pKd 87 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MEK6 B 7.36 pKd 44 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MEK6 kinase domain B 7.36 pKd 44 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL Binding constant for MKK7 kinase domain B 7.1 pKd 80 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.75 pKd 179 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CLK1 B 8.02 pKd 9.6 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CLK1 kinase domain B 8.02 pKd 9.6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CLK2 B 7.36 pKd 44 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CLK2 kinase domain B 7.36 pKd 44 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CLK3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CLK4 B 8.52 pKd 3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CLK4 kinase domain B 8.52 pKd 3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL Binding affinity to TTK B 8.19 pKd 6.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TTK kinase domain B 8.19 pKd 6.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TESK1 B 6.54 pKd 290 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TESK1 kinase domain B 6.54 pKd 290 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.73 pKd 1858 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to DYRK1A B 7.7 pKd 20 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DYRK1A kinase domain B 7.7 pKd 20 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of NanoLuc-fused DYRK1A (unknown origin) transfected in HEK293 cells using tracer K10 incubated for 1 hr by NanoBRET assay B 7.92 pIC50 12 nM IC50 Eur J Med Chem (2022) 229: 114054-114054 [PMID:34959172]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
ChEMBL Binding affinity to DYRK1B B 7.54 pKd 29 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DYRK1B kinase domain B 7.54 pKd 29 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL Binding affinity to DYRK2 B 7.66 pKd 22 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DYRK2 kinase domain B 7.66 pKd 22 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Dynamin-like 120 kDa protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105705] [UniProtKB: O60313]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Electron transfer flavoprotein subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105744] [UniProtKB: P38117]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Elongation factor Tu, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105970] [UniProtKB: P49411]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHA1 B 6.42 pKd 380 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA1 kinase domain B 6.42 pKd 380 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHA2 B 6.1 pKd 790 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA2 kinase domain B 6.1 pKd 790 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
ChEMBL Binding affinity to EPHA3 B 6.8 pKd 160 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA3 kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHA4 B 5.77 pKd 1700 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA4 kinase domain B 5.77 pKd 1700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHA5 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA5 kinase domain B 5.23 pKd 5900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33]
ChEMBL Binding affinity to EPHA6 B 5.92 pKd 1200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA6 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHA7 B 6.59 pKd 260 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA7 kinase domain B 6.59 pKd 260 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
ChEMBL Binding affinity to EPHA8 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHA8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
ChEMBL Binding affinity to EPHB1 B 5.28 pKd 5200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHB1 kinase domain B 5.28 pKd 5200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHB2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHB2 kinase domain B 5.16 pKd 6900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHB3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHB3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHB4 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHB4 kinase domain B 5.16 pKd 6900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to EPHB6 B 7.01 pKd 98 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EPHB6 kinase domain B 7.01 pKd 98 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EGFR(L747-S752del, P753S) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(S752-I759del) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to EGFR G719C mutant B 5.92 pKd 1200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EGFR(G719C) kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(G719S) kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to EGFR G719S mutant B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EGFR kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to EGFR B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to EGFR L858R mutant B 6.07 pKd 860 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EGFR(L858R) kinase domain B 6.07 pKd 860 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L861Q) kinase domain B 6.1 pKd 800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to EGFR L861Q mutant B 6.1 pKd 800 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EGFR(L747-T751del,Sins) kinase domain B 6.25 pKd 560 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(E746-A750del) kinase domain B 6.4 pKd 400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L747-E749del, A750P) kinase domain B 6.49 pKd 320 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to EGFR L858R,T790M mutant B 7.52 pKd 30 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for EGFR(T790M) kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L858R,T790M) kinase domain B 8.11 pKd 7.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to DDR1 B 6.29 pKd 510 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DDR1 kinase domain B 6.29 pKd 510 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EIF2AK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
ChEMBL Binding affinity to GCN2 Kin.Dom.2, S808G mutant B 8.39 pKd 4.1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain B 8.39 pKd 4.1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Eukaryotic translation initiation factor 5B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105852] [UniProtKB: O60841]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Exosome RNA helicase MTR4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105889] [UniProtKB: P42285]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Ferrochelatase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879831] [UniProtKB: P22830]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FGFR1 B 6.51 pKd 310 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FGFR1 kinase domain B 6.51 pKd 310 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Binding affinity to FGFR2 B 6.18 pKd 660 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FGFR2 kinase domain B 6.18 pKd 660 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL Binding affinity to FGFR3 G697C mutant B 6.14 pKd 730 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FGFR3(G697C) kinase domain B 6.14 pKd 730 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to FGFR3 B 6.24 pKd 580 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FGFR3 kinase domain B 6.24 pKd 580 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL Binding affinity to FGFR4 B 5.74 pKd 1800 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FGFR4 kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FAK B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FAK kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
General transcription and DNA repair factor IIH helicase subunit XPD in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105743] [UniProtKB: P18074]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Glycine--tRNA ligase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105815] [UniProtKB: P41250]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to GSK3A B 5.64 pKd 2300 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GSK3A kinase domain B 5.64 pKd 2300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to GSK3B B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GSK3B kinase domain B 5.89 pKd 1300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
G protein-coupled receptor kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298]
ChEMBL Binding affinity to GRK4 B 7.92 pKd 12 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GRK4 kinase domain B 7.92 pKd 12 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
G protein-coupled receptor kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6144] [GtoPdb: 1470] [UniProtKB: P43250]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
G protein-coupled receptor kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075133] [GtoPdb: 1471] [UniProtKB: Q8WTQ7]
ChEMBL Binding affinity to GRK7 B 8.14 pKd 7.2 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GRK7 kinase domain B 8.14 pKd 7.2 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
GTP-binding nuclear protein Ran in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741190] [UniProtKB: P62826]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Guanine nucleotide-binding protein G(i) subunit alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105887] [UniProtKB: P04899]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Haem oxygenase 2/Heme oxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MET(M1250T) kinase domain B 6.32 pKd 480 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to MET M1250T mutant B 6.48 pKd 330 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MET kinase domain B 6.54 pKd 290 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to MET B 6.64 pKd 230 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MET(Y1235D) kinase domain B 7.39 pKd 41 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to MET Y1235D mutant B 7.52 pKd 30 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02]
ChEMBL Binding affinity to HIPK1 B 6.23 pKd 590 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HIPK1 kinase domain B 6.23 pKd 590 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
ChEMBL Binding affinity to HIPK2 B 6.43 pKd 370 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HIPK2 kinase domain B 6.43 pKd 370 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
ChEMBL Binding affinity to HIPK3 B 6.6 pKd 250 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HIPK3 kinase domain B 6.6 pKd 250 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63]
ChEMBL Binding affinity to HIPK4 B 6.82 pKd 150 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HIPK4 kinase domain B 6.82 pKd 150 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058]
ChEMBL Binding affinity to HUNK B 6.24 pKd 570 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HUNK kinase domain B 6.24 pKd 570 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Binding affinity to IKK-alpha B 8.05 pKd 9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for IKK-alpha kinase domain B 8.05 pKd 9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
ChEMBL Binding affinity to IKK-beta B 7.92 pKd 12 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for IKK-beta kinase domain B 7.92 pKd 12 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.19 pKd 642 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to IKK-epsilon B 7.96 pKd 11 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for IKK-epsilon kinase domain B 7.96 pKd 11 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to IGF1R B 5.38 pKd 4200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for IGF1R kinase domain B 5.38 pKd 4200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to INSR B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for INSR kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616]
ChEMBL Binding affinity to INSRR B 5.74 pKd 1800 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for INSRR kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL Binding affinity to PRKR B 6.92 pKd 120 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKR kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to IRAK1 B 8.21 pKd 6.1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for IRAK1 kinase domain B 8.21 pKd 6.1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.83 pKd 147 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to IRAK3 B 7.8 pKd 16 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for IRAK3 kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.06 pKd 88 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for IRAK4 kinase domain B 8.77 pKd 1.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Isoleucine--tRNA ligase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105821] [UniProtKB: Q9NSE4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL Binding constant for LRRK2 kinase domain B 8.44 pKd 3.6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for LRRK2(G2019S) kinase domain B 8.6 pKd 2.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376]
ChEMBL Binding affinity to LTK B 6.31 pKd 490 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LTK kinase domain B 6.31 pKd 490 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to LIMK1 B 5.8 pKd 1600 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LIMK1 kinase domain B 5.8 pKd 1600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to LIMK2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LIMK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Liver glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2568] [UniProtKB: P06737]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Long-chain-fatty-acid--CoA ligase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105818] [UniProtKB: Q9ULC5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
ChEMBL Binding affinity to CSF1R B 6.96 pKd 110 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSF1R kinase domain B 6.96 pKd 110 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay B 1.49 pIC50 1.49 - logIC50 Bioorg Med Chem (2010) 18: 1789-1797 [PMID:20156689]
ChEMBL Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay B 7.51 pIC50 31 nM IC50 Bioorg Med Chem (2010) 18: 1789-1797 [PMID:20156689]
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MST1R B 5.09 pKd 8200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MST1R kinase domain B 5.09 pKd 8200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAPKAPK2 B 6.64 pKd 230 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAPKAPK2 kinase domain B 6.64 pKd 230 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAPKAPK5 B 6.03 pKd 930 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAPKAPK5 kinase domain B 6.03 pKd 930 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ERK1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERK1 kinase domain B 5.01 pKd 9800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ERK2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL Binding affinity to MKNK1 B 7.25 pKd 56 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MKNK1 kinase domain B 7.25 pKd 56 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to p38-alpha B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for p38-alpha kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to p38-beta B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for p38-beta kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264]
ChEMBL Binding affinity to p38-delta B 5.46 pKd 3500 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for p38-delta kinase domain B 5.46 pKd 3500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778]
ChEMBL Binding affinity to p38-gamma B 6.43 pKd 370 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for p38-gamma kinase domain B 6.43 pKd 370 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL Binding affinity to MKNK2 B 8.85 pKd 1.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MKNK2 kinase domain B 8.85 pKd 1.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.8 pKd 157 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MARK2 B 7.85 pKd 14 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MARK2 kinase domain B 7.85 pKd 14 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34]
ChEMBL Binding affinity to MARK4 B 6.92 pKd 120 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MARK4 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.14 pKd 73 nM Kd Science (2017) 358: null-null [PMID:29191878]
maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.73 pKd 185 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MELK B 7.59 pKd 26 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MELK kinase domain B 7.59 pKd 26 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9]
ChEMBL Binding affinity to MAST1 B 7.72 pKd 19 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAST1 kinase domain B 7.72 pKd 19 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Midasin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105779] [UniProtKB: Q9NU22]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.39 pKd 41 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MINK B 8.44 pKd 3.6 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MINK kinase domain B 8.44 pKd 3.6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ERK8 B 8.31 pKd 4.9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERK8 kinase domain B 8.31 pKd 4.9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
ChEMBL Binding affinity to ERK4 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
ChEMBL Binding affinity to ERK3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ERK5 B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERK5 kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP3K1 B 5.36 pKd 4400 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP3K1 kinase domain B 5.36 pKd 4400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
ChEMBL Binding affinity to MLK2 B 7.82 pKd 15 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MLK2 kinase domain B 7.82 pKd 15 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.81 pKd 154 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MLK3 B 7.74 pKd 18 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MLK3 kinase domain B 7.74 pKd 18 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to human MLK3 B 7.74 pKd 18 nM Kd J Med Chem (2013) 56: 8032-8048 [PMID:24044867]
mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852]
ChEMBL Binding constant for DLK kinase domain B 6.08 pKd 840 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283]
ChEMBL Binding affinity to LZK B 6.47 pKd 340 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LZK kinase domain B 6.47 pKd 340 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16]
ChEMBL Binding affinity to MAP3K15 B 8.47 pKd 3.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP3K15 kinase domain B 8.47 pKd 3.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.65 pKd 2260 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP3K2 B 8.32 pKd 4.8 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP3K2 kinase domain B 8.32 pKd 4.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.62 pKd 2386 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP3K3 B 8.22 pKd 6 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP3K3 kinase domain B 8.22 pKd 6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP3K4 B 5.59 pKd 2600 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP3K4 kinase domain B 5.59 pKd 2600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.2 pKd 631 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ASK1 B 7.15 pKd 70 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ASK1 kinase domain B 7.15 pKd 70 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.42 pKd 378 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ASK2 B 6.77 pKd 170 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ASK2 kinase domain B 6.77 pKd 170 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
ChEMBL Binding affinity to TAK1 B 8.54 pKd 2.9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TAK1 kinase domain B 8.54 pKd 2.9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
ChEMBL Binding affinity to MLK1 B 8.46 pKd 3.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MLK1 kinase domain B 8.46 pKd 3.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.6 pKd 252 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to HPK1 B 7.42 pKd 38 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HPK1 kinase domain B 7.42 pKd 38 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.2 pKd 63 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP4K2 B 8.33 pKd 4.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP4K2 kinase domain B 8.33 pKd 4.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.81 pKd 1565 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP4K3 B 6.96 pKd 110 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP4K3 kinase domain B 6.96 pKd 110 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.04 pKd 91 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP4K4 B 7.64 pKd 23 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP4K4 kinase domain B 7.64 pKd 23 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.76 pKd 173 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MAP4K5 B 7.37 pKd 43 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAP4K5 kinase domain B 7.37 pKd 43 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BUB1 mitotic checkpoint serine/threonine kinase/Mitotic checkpoint serine/threonine-protein kinase BUB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1772932] [GtoPdb: 1949] [UniProtKB: O43683]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ZAK B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ZAK kinase domain B 5.17 pKd 6700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Multifunctional protein ADE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5922] [UniProtKB: P22234]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
ChEMBL Binding affinity to MUSK B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MUSK kinase domain B 5.39 pKd 4100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Myosin-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105746] [UniProtKB: P35580]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Myosin-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105888] [UniProtKB: Q7Z406]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
myosin IIIA/Myosin IIIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4]
ChEMBL Binding affinity to MYO3A B 6.59 pKd 260 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MYO3A kinase domain B 6.59 pKd 260 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin IIIB/Myosin-IIIB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4]
ChEMBL Binding affinity to MYO3B B 6.11 pKd 770 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MYO3B kinase domain B 6.11 pKd 770 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase 3/Myosin light chain kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.02 pKd 95 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MLCK kinase domain B 7.92 pKd 12 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3]
ChEMBL Binding affinity to MYLK2 B 7.25 pKd 56 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MYLK2 kinase domain B 7.25 pKd 56 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6]
ChEMBL Binding affinity to SgK085 B 7.54 pKd 29 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MYLK4 kinase domain B 7.54 pKd 29 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MYLK B 7.89 pKd 13 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MYLK kinase domain B 7.89 pKd 13 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to MLCK B 7.92 pKd 12 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
ChEMBL Binding affinity to DMPK B 6.62 pKd 240 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DMPK kinase domain B 6.62 pKd 240 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.25 pKd 561 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TRKA B 8.08 pKd 8.3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TRKA kinase domain B 8.08 pKd 8.3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL Binding affinity to TRKB B 7.85 pKd 14 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TRKB kinase domain B 7.85 pKd 14 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.97 pKd 108 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TNK1 B 8.03 pKd 9.3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TNK1 kinase domain B 8.03 pKd 9.3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
ChEMBL Binding affinity to TRKC B 7.85 pKd 14 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TRKC kinase domain B 7.85 pKd 14 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285]
ChEMBL Binding affinity to ARK5 B 8.43 pKd 3.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ARK5 kinase domain B 8.43 pKd 3.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.14 pKd 72 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SNARK B 9 pKd 1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SNARK kinase domain B 9 pKd 1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Nucleolar GTP-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105780] [UniProtKB: Q9BZE4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Obg-like ATPase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105704] [UniProtKB: Q9NTK5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936]
ChEMBL Binding constant for CASK kinase domain B 6.48 pKd 330 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Peroxisomal acyl-coenzyme A oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105748] [UniProtKB: Q15067]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Peroxisomal acyl-coenzyme A oxidase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105817] [UniProtKB: O15254]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Phenylalanine--tRNA ligase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105969] [UniProtKB: Q9NSD9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Phosphatidylethanolamine-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105856] [UniProtKB: P30086]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
ChEMBL Binding affinity to PIK3C2B B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3C2B kinase domain B 5.28 pKd 5200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747]
ChEMBL Binding affinity to PIK3C2G B 6.64 pKd 230 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3C2G kinase domain B 6.64 pKd 230 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755]
ChEMBL Binding affinity to PIP5K1A B 7.44 pKd 36 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIP5K1A kinase domain B 7.44 pKd 36 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331]
ChEMBL Binding constant for PIP5K1C kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha/Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795194] [GtoPdb: 2858] [UniProtKB: P48426]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
ChEMBL Binding affinity to PIP5K2B B 7.74 pKd 18 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIP5K2B kinase domain B 7.74 pKd 18 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PIP5K2C kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Phosphofructokinase platelet type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2972] [UniProtKB: Q01813]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816]
ChEMBL Binding affinity to PHKG1 B 9.41 pKd 0.39 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PHKG1 kinase domain B 9.41 pKd 0.39 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.91 pKd 122 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PHKG2 B 8.77 pKd 1.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PHKG2 kinase domain B 8.77 pKd 1.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL Binding constant for PIK3CA(I800L) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PIK3CA B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to PIK3CA E542K mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to PIK3CA E545A mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to PIK3CA E545K mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CA(E545K) kinase domain B 5.13 pKd 7400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(E542K) kinase domain B 5.23 pKd 5900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(E545A) kinase domain B 5.25 pKd 5600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(Q546K) kinase domain B 5.27 pKd 5400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PIK3CA Q546K mutant B 5.27 pKd 5400 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CA kinase domain B 5.31 pKd 4900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PIK3CA C420R mutant B 5.31 pKd 4900 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CA(C420R) kinase domain B 5.31 pKd 4900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PIK3CA M1043I mutant B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CA(M1043I) kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(H1047Y) kinase domain B 6.19 pKd 650 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PIK3CA H1047Y mutant B 6.19 pKd 650 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CA(H1047L) kinase domain B 7.31 pKd 49 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PIK3CA H1047L mutant B 7.31 pKd 49 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL Binding affinity to PIK3CB B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CB kinase domain B 5.17 pKd 6700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL Binding affinity to PIK3CD B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CD kinase domain B 5.4 pKd 4000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL Binding affinity to PIK3CG B 6.46 pKd 350 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK3CG kinase domain B 6.46 pKd 350 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol 4-kinase beta/PI4-kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
ChEMBL Binding affinity to PIK4CB B 6.54 pKd 290 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIK4CB kinase domain B 6.54 pKd 290 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
ChEMBL Binding affinity to CDC2L1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDC2L1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88]
ChEMBL Binding affinity to CDC2L2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CDC2L2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL Binding affinity to PDGFRA B 6.42 pKd 380 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PDGFRA kinase domain B 6.46 pKd 350 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.76 pKd 1735 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PDGFRB kinase domain B 7.54 pKd 29 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to PDGFRB B 7.55 pKd 28 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
Probable ATP-dependent RNA helicase DDX6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105783] [UniProtKB: P26196]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Protein delta homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5671] [UniProtKB: P80370]
ChEMBL Binding affinity to DLK B 6.08 pKd 840 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to DLK (unknown origin) assessed as dissociation constant B 6.08 pKd 840 nM Kd Eur J Med Chem (2023) 255: 115404-115404 [PMID:37098296]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.74 pKd 1799 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PKAC-alpha B 6.66 pKd 220 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PRKCD B 6.62 pKd 240 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKCD kinase domain B 6.62 pKd 240 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Binding affinity to PRKCE B 6.8 pKd 160 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKCE kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Binding affinity to PRKCH B 6.85 pKd 140 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKCH kinase domain B 6.85 pKd 140 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKCI kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Binding affinity to PRKD1 B 7.85 pKd 14 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKD1 kinase domain B 7.85 pKd 14 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.28 pKd 53 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PRKD3 B 8.05 pKd 8.9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKD3 kinase domain B 8.05 pKd 8.9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PRKCQ B 7 pKd 100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKCQ kinase domain B 7 pKd 100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
protein kinase N1/Protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.7 pKd 198 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PKN1 B 8.28 pKd 5.3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PKN1 kinase domain B 8.28 pKd 5.3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.79 pKd 164 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PKN2 B 8.74 pKd 1.8 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PKN2 kinase domain B 8.74 pKd 1.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.96 pKd 1088 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PYK2 B 7.39 pKd 41 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PYK2 kinase domain B 7.39 pKd 41 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
ChEMBL Binding affinity to MERTK B 7.49 pKd 32 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MERTK kinase domain B 7.49 pKd 32 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
ChEMBL Binding affinity to ROS1 B 7.59 pKd 26 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ROS1 kinase domain B 7.59 pKd 26 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
sugen kinase 110/Putative uncharacterized serine/threonine-protein kinase SgK110 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264]
ChEMBL Binding affinity to SgK110 B 6.92 pKd 120 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SgK110 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.49 pKd 3257 nM Kd Science (2017) 358: null-null [PMID:29191878]
Ras-related protein Rab-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105971] [UniProtKB: P61026]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
RAB27A, member RAS oncogene family/Ras-related protein Rab-27A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105702] [GtoPdb: 2916] [UniProtKB: P51159]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Ras-related protein Rab-6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105703] [UniProtKB: P20340]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
ChEMBL Binding affinity to RIPK1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RIPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078]
ChEMBL Binding affinity to RIPK4 B 7.89 pKd 13 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RIPK4 kinase domain B 7.89 pKd 13 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL Binding affinity to ERBB2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERBB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
ChEMBL Binding affinity to ERBB4 B 5.85 pKd 1400 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERBB4 kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
GtoPdb - - 8.07 pKd 8.5 nM Kd Nat Biotechnol (2011) 29: 1046-51 [PMID:22037378]
fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342]
ChEMBL Inhibition of FLT3 autophosphorylation in mouse BaF3/ITD cells after 1 hr by immunoblotting analysis B 8.82 pIC50 1.5 nM IC50 Medchemcomm (2012) 3: 22-27
erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860]
ChEMBL Binding affinity to ERBB3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERBB3 kinase domain B 5.26 pKd 5500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ROCK1 B 7.25 pKd 56 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ROCK1 kinase domain B 7.25 pKd 56 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ROCK2 B 7.15 pKd 71 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ROCK2 kinase domain B 7.15 pKd 71 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
G protein-coupled receptor kinase 1/Rhodopsin kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835]
ChEMBL Binding affinity to GRK1 B 7.62 pKd 24 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GRK1 kinase domain B 7.62 pKd 24 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SBK1 B 6.7 pKd 200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for S6K1 kinase domain B 7.16 pKd 69 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.61 pKd 2477 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain B 5.62 pKd 2400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA3(Kin.Dom.1-N-terminal) B 6.54 pKd 290 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to RPS6KA4(Kin.Dom.1-N-terminal) B 7.21 pKd 62 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain B 7.55 pKd 28 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
ChEMBL Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA5(Kin.Dom.2-C-terminal) B 6.02 pKd 960 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain B 7.06 pKd 88 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA5(Kin.Dom.1-N-terminal) B 7.38 pKd 42 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.69 pKd 2022 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal) B 5.89 pKd 1300 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain B 6.54 pKd 290 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676]
ChEMBL Binding affinity to RPS6KA1(Kin.Dom.2-C-terminal) B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain B 5.89 pKd 1300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.49 pKd 324 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain B 7.21 pKd 62 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA1(Kin.Dom.1-N-terminal) B 7.55 pKd 28 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to RPS6KA2(Kin.Dom.2-C-terminal) B 5.92 pKd 1200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain B 6.02 pKd 960 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA2(Kin.Dom.1-N-terminal) B 7.06 pKd 88 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain B 7.38 pKd 42 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
ChEMBL Binding affinity to RPS6KA6(Kin.Dom.2-C-terminal) B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain B 5.04 pKd 9100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.01 pKd 981 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to RPS6KA6(Kin.Dom.1-N-terminal) B 6.96 pKd 110 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain B 6.96 pKd 110 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RNA cytidine acetyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105935] [UniProtKB: Q9H0A0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
S-adenosylmethionine synthase isoform type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313835] [UniProtKB: P31153]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Septin-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105891] [UniProtKB: Q9UHD8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATR checkpoint kinase/Serine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.01 pKd 98 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to LOK B 8.24 pKd 5.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LOK kinase domain B 8.24 pKd 5.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to LKB1 B 7.24 pKd 57 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LKB1 kinase domain B 7.24 pKd 57 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to STK16 B 7.72 pKd 19 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for STK16 kinase domain B 7.72 pKd 19 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5]
ChEMBL Binding affinity to DRAK1 B 8.47 pKd 3.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DRAK1 kinase domain B 8.47 pKd 3.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768]
ChEMBL Binding affinity to DRAK2 B 8.3 pKd 5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DRAK2 kinase domain B 8.3 pKd 5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.12 pKd 750 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SLK B 7.46 pKd 35 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SLK kinase domain B 7.46 pKd 35 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
ChEMBL Binding affinity to MST3 B 6.12 pKd 760 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MST3 kinase domain B 6.12 pKd 760 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506]
ChEMBL Binding affinity to YSK1 B 7.01 pKd 97 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for YSK1 kinase domain B 7.01 pKd 97 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08]
ChEMBL Binding constant for YANK1 kinase domain B 5.68 pKd 2100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57]
ChEMBL Binding affinity to YANK2 B 5.23 pKd 5900 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for YANK2 kinase domain B 5.23 pKd 5900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6]
ChEMBL Binding affinity to YANK3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for YANK3 kinase domain B 5.1 pKd 8000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
ChEMBL Binding affinity to STK33 B 7.59 pKd 26 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for STK33 kinase domain B 7.59 pKd 26 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2]
ChEMBL Binding affinity to STK35 B 6.09 pKd 810 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for STK35 kinase domain B 6.09 pKd 810 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7]
ChEMBL Binding affinity to STK36 B 5.42 pKd 3800 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for STK36 kinase domain B 5.42 pKd 3800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208]
ChEMBL Binding affinity to NDR1 B 6.66 pKd 220 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NDR1 kinase domain B 6.66 pKd 220 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
ChEMBL Binding affinity to NDR2 B 6.43 pKd 370 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NDR2 kinase domain B 6.43 pKd 370 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AKT1 B 5.36 pKd 4400 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AKT1 kinase domain B 5.36 pKd 4400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AKT2 B 5.68 pKd 2100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AKT2 kinase domain B 5.68 pKd 2100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AKT3 B 5.21 pKd 6200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AKT3 kinase domain B 5.21 pKd 6200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.6 pKd 25 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AURKA B 7.8 pKd 16 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AURKA kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.88 pKd 131 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to AURKB B 7.8 pKd 16 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AURKB kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
ChEMBL Binding affinity to AURKC B 8.39 pKd 4.1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AURKC kinase domain B 8.39 pKd 4.1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BRAF B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to BRAF V600E mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BRAF kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for BRAF(V600E) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.14 pKd 72 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CHEK1 B 8.55 pKd 2.8 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CHEK1 kinase domain B 8.55 pKd 2.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL Binding affinity to CHEK2 B 6.68 pKd 210 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CHEK2 kinase domain B 6.68 pKd 210 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.99 pKd 103 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MARK3 B 7.31 pKd 49 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MARK3 kinase domain B 7.31 pKd 49 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.34 pKd 46 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PRKD2 B 8.09 pKd 8.1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKD2 kinase domain B 8.09 pKd 8.1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
ChEMBL Binding affinity to DCAMKL1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DCAMKL1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
ChEMBL Binding affinity to DCAMKL2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DCAMKL2 kinase domain B 5.35 pKd 4500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098]
ChEMBL Binding affinity to DCAMKL3 B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DCAMKL3 kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.38 pKd 42 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ERN1 B 8.24 pKd 5.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ERN1 kinase domain B 8.24 pKd 5.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.53 pKd 292 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.16 pKd 694 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to GAK B 8.14 pKd 7.3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for GAK kinase domain B 8.14 pKd 7.3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ICK B 7.41 pKd 39 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ICK kinase domain B 7.41 pKd 39 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
integrin linked kinase/Serine/threonine-protein kinase ILK-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
GtoPdb - - 7.52 pKd 30 nM Kd Blood (2009) 114: 2984-92 [PMID:19654408]
ChEMBL Binding affinity to LATS1 B 7.52 pKd 30 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LATS1 kinase domain B 7.52 pKd 30 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.6 pKd 25 nM Kd Science (2017) 358: null-null [PMID:29191878]
large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
GtoPdb - - 9 pKd 1 nM Kd Blood (2009) 114: 2984-92 [PMID:19654408]
ChEMBL Binding affinity to LATS2 B 9 pKd 1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LATS2 kinase domain B 9 pKd 1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794]
ChEMBL Binding affinity to MAK B 5.77 pKd 1700 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MAK kinase domain B 5.77 pKd 1700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
ChEMBL Binding affinity to MARK1 B 7.08 pKd 83 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MARK1 kinase domain B 7.08 pKd 83 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MRCKA B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MRCKA kinase domain B 5.04 pKd 9200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MRCKB B 6 pKd 1000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MRCKB kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to DMPK2 B 5.6 pKd 2500 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for DMPK2 kinase domain B 5.6 pKd 2500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.35 pKd 45 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MST1 B 8.52 pKd 3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MST1 kinase domain B 8.52 pKd 3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.52 pKd 30 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MST2 B 8.62 pKd 2.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MST2 kinase domain B 8.62 pKd 2.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to MST4 B 6.64 pKd 230 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for MST4 kinase domain B 6.64 pKd 230 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
ChEMBL Binding constant for MTOR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase N3/Serine/threonine-protein kinase N3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3627581] [GtoPdb: 1522] [UniProtKB: Q6P5Z2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.86 pKd 1374 nM Kd Science (2017) 358: null-null [PMID:29191878]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to NEK1 B 5.6 pKd 2500 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NEK1 kinase domain B 5.6 pKd 2500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66]
ChEMBL Binding constant for NEK11 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to NEK2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NEK2 kinase domain B 5.31 pKd 4900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for NEK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957]
ChEMBL Binding constant for NEK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8]
ChEMBL Binding affinity to NEK5 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NEK5 kinase domain B 5.25 pKd 5600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
ChEMBL Binding affinity to NEK6 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NEK6 kinase domain B 5.36 pKd 4400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Binding affinity to NEK7 B 5.4 pKd 4000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NEK7 kinase domain B 5.4 pKd 4000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to NEK9 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NEK9 kinase domain B 5.27 pKd 5400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84]
ChEMBL Binding affinity to NIM1 B 5.74 pKd 1800 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NIM1 kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to NLK B 6.11 pKd 770 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for NLK kinase domain B 6.11 pKd 770 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747]
ChEMBL Binding affinity to OSR1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for OSR1 kinase domain B 5.1 pKd 8000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
ChEMBL Binding affinity to PAK1 B 7.52 pKd 30 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PAK1 kinase domain B 7.52 pKd 30 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PAK2 B 7.37 pKd 43 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PAK2 kinase domain B 7.37 pKd 43 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
ChEMBL Binding affinity to PAK3 B 7.46 pKd 35 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PAK3 kinase domain B 7.46 pKd 35 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.54 pKd 29 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PAK4 B 7.62 pKd 24 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PAK4 kinase domain B 7.62 pKd 24 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PAK6 B 8 pKd 9.9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PAK6 kinase domain B 8 pKd 9.9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286]
ChEMBL Binding affinity to PAK7 B 7.62 pKd 24 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PAK7 kinase domain B 7.62 pKd 24 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PCTK1 B 7.57 pKd 27 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PCTK1 kinase domain B 7.57 pKd 27 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PCTK2 B 6.14 pKd 720 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PCTK2 kinase domain B 6.14 pKd 720 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PCTK3 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PCTK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921]
ChEMBL Binding affinity to PFTK1 B 6.14 pKd 720 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PFTK1 kinase domain B 6.14 pKd 720 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 15/Serine/threonine-protein kinase PFTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40]
ChEMBL Binding affinity to PFTAIRE2 B 5.89 pKd 1300 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PFTAIRE2 kinase domain B 5.89 pKd 1300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PIM1 B 6.7 pKd 200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIM1 kinase domain B 6.7 pKd 200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PIM2 B 6.6 pKd 250 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIM2 kinase domain B 6.6 pKd 250 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
ChEMBL Binding affinity to PIM3 B 7.74 pKd 18 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PIM3 kinase domain B 7.74 pKd 18 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Serine/threonine-protein kinase pknB in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81]
ChEMBL Binding constant for PKNB(M.tuberculosis) kinase domain B 7.26 pKd 55 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PLK1 B 6.66 pKd 220 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PLK1 kinase domain B 6.66 pKd 220 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3]
ChEMBL Binding affinity to PLK2 B 6.48 pKd 330 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PLK2 kinase domain B 6.48 pKd 330 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
ChEMBL Binding affinity to PLK3 B 5.64 pKd 2300 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PLK3 kinase domain B 5.64 pKd 2300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.05 pKd 90 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PLK4 B 8.82 pKd 1.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PLK4 kinase domain B 8.82 pKd 1.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.89 pKd 1282 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PRKX B 7.38 pKd 42 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRKX kinase domain B 7.38 pKd 42 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523]
ChEMBL Binding affinity to PRP4 B 6.26 pKd 550 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PRP4 kinase domain B 6.26 pKd 550 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Binding affinity to RAF1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RAF1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
ChEMBL Binding affinity to ACVRL1 B 5.66 pKd 2200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ACVRL1 kinase domain B 5.66 pKd 2200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2]
ChEMBL Binding affinity to RIOK1 B 8.05 pKd 9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RIOK1 kinase domain B 8.05 pKd 9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4]
ChEMBL Binding affinity to RIOK2 B 5.17 pKd 6700 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RIOK2 kinase domain B 5.17 pKd 6700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730]
ChEMBL Binding affinity to RIOK3 B 8.11 pKd 7.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RIOK3 kinase domain B 8.11 pKd 7.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to RIPK2 B 6.19 pKd 640 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RIPK2 kinase domain B 6.19 pKd 640 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2]
ChEMBL Binding constant for SBK1 kinase domain B 6.7 pKd 200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
ChEMBL Binding constant for SGK3 kinase domain B 8.24 pKd 5.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059]
ChEMBL Binding affinity to SIK B 7.09 pKd 82 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SIK kinase domain B 7.09 pKd 82 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.26 pKd 55 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SIK2 B 7.82 pKd 15 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SIK2 kinase domain B 7.82 pKd 15 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.07 pKd 848 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to QSK B 6.92 pKd 120 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for QSK kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
ChEMBL Binding affinity to SRPK1 B 8 pKd 10 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SRPK1 kinase domain B 8 pKd 10 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362]
ChEMBL Binding affinity to SRPK2 B 7.29 pKd 51 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SRPK2 kinase domain B 7.29 pKd 51 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
ChEMBL Binding affinity to SRPK3 B 7.89 pKd 13 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SRPK3 kinase domain B 7.89 pKd 13 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TAO1 B 6.3 pKd 500 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to TAOK1 B 7.15 pKd 70 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TAOK1 kinase domain B 7.15 pKd 70 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TAOK2 kinase domain B 6.3 pKd 500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TAOK3 B 7.07 pKd 86 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TAOK3 kinase domain B 7.07 pKd 86 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.01 pKd 977 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TBK1 B 7.74 pKd 18 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TBK1 kinase domain B 7.74 pKd 18 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18]
ChEMBL Binding affinity to TNNI3K B 5.68 pKd 2100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TNNI3K kinase domain B 5.68 pKd 2100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
ChEMBL Binding affinity to TLK1 B 6.96 pKd 110 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TLK1 kinase domain B 6.96 pKd 110 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
ChEMBL Binding affinity to TLK2 B 7.19 pKd 64 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TLK2 kinase domain B 7.19 pKd 64 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ULK1 B 6 pKd 1000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ULK1 kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL Binding affinity to ULK2 B 7.22 pKd 60 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ULK2 kinase domain B 7.22 pKd 60 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.67 pKd 212 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ULK3 B 8.31 pKd 4.9 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ULK3 kinase domain B 8.31 pKd 4.9 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
ChEMBL Binding constant for VRK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to WEE1 B 5.92 pKd 1200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for WEE1 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Signal recognition particle receptor subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105934] [UniProtKB: P08240]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
ChEMBL Inhibition of STAT3 phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysis B 8 pIC50 10 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
signal transducer and activator of transcription 5A/Signal transducer and activator of transcription 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5403] [GtoPdb: 3221] [UniProtKB: P42229]
ChEMBL Inhibition of STAT5 phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysis B 8 pIC50 10 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
SNF related kinase/SNF-related serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2]
ChEMBL Binding constant for SNRK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 19/SPS1/STE20-related protein kinase YSK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5]
ChEMBL Binding affinity to YSK4 B 9.28 pKd 0.52 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for YSK4 kinase domain B 9.28 pKd 0.52 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8]
ChEMBL Binding affinity to STK39 B 5.96 pKd 1100 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for STK39 kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL Binding affinity to KIT V559D,V654A mutant B 6.42 pKd 380 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for KIT(V559D,V654A) kinase domain B 6.42 pKd 380 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to KIT B 6.82 pKd 150 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for KIT kinase domain B 6.82 pKd 150 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(V559D) kinase domain B 7.12 pKd 76 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to KIT V559D mutant B 7.12 pKd 76 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to KIT V559D,T670I mutant B 7.35 pKd 45 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for KIT(V559D,T670I) kinase domain B 7.35 pKd 45 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(L576P) kinase domain B 7.4 pKd 40 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to KIT L576P mutant B 7.4 pKd 40 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for KIT(A829P) kinase domain B 7.46 pKd 35 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(D816H) kinase domain B 7.96 pKd 11 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(D816V) kinase domain B 8.15 pKd 7.1 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to KIT D816V mutant B 8.15 pKd 7.1 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
Structural maintenance of chromosomes protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105747] [UniProtKB: Q14683]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Structural maintenance of chromosomes protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105890] [UniProtKB: O95347]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105973] [UniProtKB: Q9P2R7]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
tankyrase 2/Tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2]
ChEMBL Binding affinity to TNK2 B 8.18 pKd 6.6 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
ChEMBL Binding affinity to TSSK1B B 7.01 pKd 98 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TSSK1B kinase domain B 7.01 pKd 98 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.02 pKd 966 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TGFBR1 B 6.92 pKd 120 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TGFBR1 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.89 pKd 1280 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TGFBR2 B 6.27 pKd 540 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TGFBR2 kinase domain B 6.27 pKd 540 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Thyroid hormone receptor-associated protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105820] [UniProtKB: Q9Y2W1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
TP53 regulating kinase/TP53-regulating kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TNIK B 8.27 pKd 5.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TNIK kinase domain B 8.27 pKd 5.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84]
ChEMBL Binding constant for TRPM6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to PKMYT1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for PKMYT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.19 pKd 64 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TNK2 kinase domain B 8.18 pKd 6.6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ABL1 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to ABL1 E255K mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to ABL1 F317I mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to ABL1 F317L mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to ABL1 H396P mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to ABL1 Q252H mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ABL1(F317I)-non phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to ABL1 Y253F mutant B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ABL1(F317L)-non phosphorylated kinase domain B 5.12 pKd 7600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(F317I)-phosphorylated kinase domain B 5.31 pKd 4900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to ABL1 M351T mutant B 5.48 pKd 3300 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ABL1-non phosphorylated kinase domain B 5.49 pKd 3200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(Q252H)-non phosphorylated kinase domain B 5.6 pKd 2500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(F317L)-phosphorylated kinase domain B 5.66 pKd 2200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(H396P)-non phosphorylated kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1-phosphorylated kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(T315I)-non phosphorylated kinase domain B 6.02 pKd 950 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(Y253F)-phosphorylated kinase domain B 6.04 pKd 910 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(H396P)-phosphorylated kinase domain B 6.06 pKd 870 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(E255K)-phosphorylated kinase domain B 6.08 pKd 840 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(Q252H)-phosphorylated kinase domain B 6.08 pKd 830 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(M351T)-phosphorylated kinase domain B 6.11 pKd 780 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to ABL1 T315I mutant B 6.46 pKd 350 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ABL1(T315I)-phosphorylated kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to ABL2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ABL2 kinase domain B 5.19 pKd 6500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
ChEMBL Binding affinity to BLK B 6.8 pKd 160 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BLK kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813]
ChEMBL Binding affinity to BMX B 6.7 pKd 200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BMX kinase domain B 6.7 pKd 200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.84 pKd 14295 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BRK B 5.77 pKd 1700 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BRK kinase domain B 5.77 pKd 1700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.93 pKd 1179 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to BTK B 7.18 pKd 66 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for BTK kinase domain B 7.18 pKd 66 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to CSK B 6.59 pKd 260 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CSK kinase domain B 6.59 pKd 260 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
megakaryocyte-associated tyrosine kinase/Tyrosine-protein kinase CTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679]
ChEMBL Binding affinity to CTK B 6.01 pKd 970 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for CTK kinase domain B 6.01 pKd 970 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FER tyrosine kinase/Tyrosine-protein kinase FER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.63 pKd 235 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FER B 7.55 pKd 28 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FER kinase domain B 7.55 pKd 28 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.93 pKd 1186 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FES B 6.43 pKd 370 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FES kinase domain B 6.43 pKd 370 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FGR B 7.28 pKd 52 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FGR kinase domain B 7.28 pKd 52 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FRK B 6.13 pKd 740 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FRK kinase domain B 6.13 pKd 740 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to FYN B 7.08 pKd 84 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FYN kinase domain B 7.08 pKd 84 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to HCK B 6.57 pKd 270 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for HCK kinase domain B 6.57 pKd 270 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
ChEMBL Binding affinity to ITK B 6.54 pKd 290 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ITK kinase domain B 6.54 pKd 290 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to JAK1 JH2 domain B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JAK1(JH2domain-pseudokinase) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to JH1 catalytic domain JAK1 B 8.06 pKd 8.8 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JAK1(JH1domain-catalytic) kinase domain B 8.06 pKd 8.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Binding affinity to JH1 catalytic domain JAK2 B 8.43 pKd 3.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JAK2(JH1domain-catalytic) kinase domain B 8.43 pKd 3.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of JAK2 V617F mutant phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysis B 8 pIC50 10 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of JAK2 (unknown origin) in presence of ATP B 8.54 pIC50 2.9 nM IC50 J Med Chem (2020) 63: 12403-12428 [PMID:32659083]
ChEMBL Inhibition of JAK2 (unknown origin) B 9 pIC50 1 nM IC50 RSC Med Chem (2022) 13: 798-816 [PMID:35923716]
ChEMBL Inhibition of JAK 2 (unknown origin) B 9.05 pIC50 0.9 nM IC50 J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL Inhibition of wild-type JAK2 (unknown origin) expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated with substrate for 60 mins followed by compound addition and measured after 20 mins by time-resolve fluorescence assay B 9.05 pIC50 0.9 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Binding affinity to JH1 catalytic domain of JAK3 B 8.64 pKd 2.3 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for JAK3(JH1domain-catalytic) kinase domain B 8.64 pKd 2.3 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to LCK B 6.37 pKd 430 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LCK kinase domain B 6.37 pKd 430 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to LYN B 6.72 pKd 190 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for LYN kinase domain B 6.72 pKd 190 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.91 pKd 122 nM Kd Science (2017) 358: null-null [PMID:29191878]
GtoPdb - - 8.07 pKd 8.5 nM Kd Nat Biotechnol (2011) 29: 1046-51 [PMID:22037378]
ChEMBL Binding affinity to FLT3 B 8.07 pKd 8.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assay B 8.07 pKd 8.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FLT3 kinase domain B 8.07 pKd 8.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to human FLT3 B 8.07 pKd 8.5 nM Kd J Med Chem (2013) 56: 8032-8048 [PMID:24044867]
ChEMBL Binding constant for FLT3(R834Q) kinase domain B 8.15 pKd 7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(K663Q) kinase domain B 8.27 pKd 5.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to FLT3 K663Q mutant B 8.27 pKd 5.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FLT3(ITD) kinase domain B 8.82 pKd 1.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(N841I) kinase domain B 8.85 pKd 1.4 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to FLT3 N841I mutant B 8.85 pKd 1.4 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FLT3(D835H) kinase domain B 9.18 pKd 0.66 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to FLT3 D835H mutant B 9.18 pKd 0.66 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FLT3(D835Y) kinase domain B 9.24 pKd 0.57 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to FLT3 D835Y mutant B 9.24 pKd 0.57 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Inhibition of FLT3 D835H mutant (unknown origin) B 7.92 pIC50 11.9 nM IC50 J Med Chem (2020) 63: 12403-12428 [PMID:32659083]
ChEMBL Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay B 8.09 pIC50 8.2 nM IC50 Bioorg Med Chem Lett (2013) 23: 1768-1770 [PMID:23411073]
ChEMBL Inhibition of FLT3 by HTRF assay B 8.3 pIC50 5 nM IC50 Bioorg Med Chem Lett (2010) 20: 2033-2037 [PMID:20153646]
ChEMBL Inhibition of FLT3-WT (unknown origin) B 8.52 pIC50 3 nM IC50 Bioorg Med Chem (2022) 56: 116596-116596 [PMID:35033885]
ChEMBL Inhibition of recombinant His-tagged human FLT3 expressed in baculovirus expression system using peptide substrate incubated for 30 mins in presence of ATP by HTRF assay B 8.52 pIC50 3 nM IC50 Eur J Med Chem (2020) 195: 112205-112205 [PMID:32272419]
ChEMBL Inhibition of FLT3 (unknown origin) B 8.52 pIC50 3 nM IC50 RSC Med Chem (2022) 13: 798-816 [PMID:35923716]
ChEMBL Inhibition of human FLT3 B 8.52 pIC50 3 nM IC50 RSC Med Chem (2022) 13: 798-816 [PMID:35923716]
ChEMBL Inhibition of FLT3 (unknown origin) B 8.52 pIC50 3 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay B 8.59 pIC50 2.6 nM IC50 Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Inhibition of FLT3-mediated STAT5 phosphorylation in human MV411 cells after 1 hr by immunoblotting analysis B 8.6 pIC50 2.5 nM IC50 Medchemcomm (2012) 3: 22-27
ChEMBL Inhibition of FLT3 (unknown origin) autophosphorylation B 8.7 pIC50 2 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of FLT3 ITD mutant autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay B 8.82 pIC50 1.5 nM IC50 Blood (2009) 114: 2984-2992 [PMID:19654408]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.69 pKd 205 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RET kinase domain B 7.7 pKd 20 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RET B 7.7 pKd 20 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to RET M918T mutant B 7.85 pKd 14 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RET(M918T) kinase domain B 7.85 pKd 14 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RET(V804L) kinase domain B 8.17 pKd 6.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RET(V804L) B 8.17 pKd 6.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding affinity to RET V804M mutant B 8.33 pKd 4.7 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for RET(V804M) kinase domain B 8.33 pKd 4.7 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590]
ChEMBL Binding affinity to TIE1 B 6.17 pKd 680 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TIE1 kinase domain B 6.17 pKd 680 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
ChEMBL Binding affinity to TYRO3 B 6.19 pKd 650 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TYRO3 kinase domain B 6.19 pKd 650 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL Binding affinity to AXL B 7.46 pKd 35 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for AXL kinase domain B 7.46 pKd 35 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SRC B 6.19 pKd 640 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SRC kinase domain B 6.19 pKd 640 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6]
ChEMBL Binding affinity to SRMS B 6.09 pKd 820 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SRMS kinase domain B 6.09 pKd 820 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.58 pKd 265 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SYK B 8.02 pKd 9.5 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for SYK kinase domain B 8.02 pKd 9.5 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TEC B 5.92 pKd 1200 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TEC kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL Binding affinity to TIE2 B 6.2 pKd 630 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TIE2 kinase domain B 6.2 pKd 630 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
ChEMBL Binding affinity to TXK B 6.18 pKd 660 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TXK kinase domain B 6.18 pKd 660 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to TYK2(JH2domain-pseudokinase) B 6.04 pKd 910 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TYK2(JH2domain-pseudokinase) kinase domain B 6.04 pKd 910 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to TYK2(JH1domain-catalytic) B 7.82 pKd 15 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for TYK2(JH1domain-catalytic) kinase domain B 7.82 pKd 15 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to YES B 6.8 pKd 160 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for YES kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Binding affinity to ZAP70 B 7.8 pKd 16 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ZAP70 kinase domain B 7.8 pKd 16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Tyrosyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3179] [UniProtKB: P54577]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
U5 small nuclear ribonucleoprotein 200 kDa helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105972] [UniProtKB: O75643]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
UMP-CMP kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5681] [UniProtKB: P30085]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
aarF domain containing kinase 1/Uncharacterized aarF domain-containing protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53]
ChEMBL Binding affinity to ADCK4 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for ADCK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
aarF domain containing kinase 5/Uncharacterized aarF domain-containing protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105886] [GtoPdb: 1929] [UniProtKB: Q3MIX3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Uncharacterized protein FLJ45252 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105933] [UniProtKB: Q6ZSR9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.1 pKd 80 nM Kd Science (2017) 358: null-null [PMID:29191878]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Binding affinity to FLT1 B 6.92 pKd 120 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FLT1 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Binding affinity to VEGFR2 B 6.66 pKd 220 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for VEGFR2 kinase domain B 6.66 pKd 220 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
ChEMBL Binding affinity to FLT4 B 7.77 pKd 17 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for FLT4 kinase domain B 7.77 pKd 17 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105892] [UniProtKB: P49748]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8]
ChEMBL Binding affinity to WEE2 B 5 pKd >10000 nM Kd Blood (2009) 114: 2984-2992 [PMID:19654408]
ChEMBL Binding constant for WEE2 kinase domain B 5.1 pKd 7900 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]