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Target has curated data in GtoImmuPdb
Target id: 1955
Nomenclature: calcium/calmodulin dependent protein kinase IV
Abbreviated Name: CaMK4
Family: CAMK1 family
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 473 | 5q22.1 | CAMK4 | calcium/calmodulin dependent protein kinase IV | |
Mouse | - | 469 | 18 18.15 cM | Camk4 | calcium/calmodulin-dependent protein kinase IV | |
Rat | - | 474 | 18p12 | Camk4 | calcium/calmodulin-dependent protein kinase IV |
Previous and Unofficial Names |
brain Ca++-calmodulin-dependent protein kinase type IV | Ca2+/calmodulin-dependent protein kinase type IV/Gr | calspermin | CAM kinase IV | CAM kinase-GR | caMK IV |
Database Links | |
Alphafold | Q16566 (Hs), P08414 (Mm), P13234 (Rn) |
BRENDA | 2.7.11.17 |
ChEMBL Target | CHEMBL2494 (Hs) |
Ensembl Gene | ENSG00000152495 (Hs), ENSMUSG00000038128 (Mm), ENSRNOG00000020478 (Rn) |
Entrez Gene | 814 (Hs), 12326 (Mm), 25050 (Rn) |
Human Protein Atlas | ENSG00000152495 (Hs) |
KEGG Enzyme | 2.7.11.17 |
KEGG Gene | hsa:814 (Hs), mmu:12326 (Mm), rno:25050 (Rn) |
OMIM | 114080 (Hs) |
Pharos | Q16566 (Hs) |
RefSeq Nucleotide | NM_001744 (Hs), NM_009793 (Mm), NM_012727 (Rn) |
RefSeq Protein | NP_001735 (Hs), NP_033923 (Mm), NP_036859 (Rn) |
UniProtKB | Q16566 (Hs), P08414 (Mm), P13234 (Rn) |
Wikipedia | CAMK4 (Hs) |
Selected 3D Structures | |||||||||||
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Enzyme Reaction | ||||
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DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,5 |
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: CAMK4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3 |
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Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: CaMKIV/CAMK4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Immunopharmacology Comments |
CAMKIV has been implicated in the differentiation of Th17 cells, suggesting CAMKIV as a target for therapeutic intervention in Th17-driven autoimmune diseases [4]. |
Immuno Process Associations | ||
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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
4. Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC. (2014) CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. J Clin Invest, 124 (5): 2234-45. [PMID:24667640]
5. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
CAMK1 family: calcium/calmodulin dependent protein kinase IV. Last modified on 16/02/2017. Accessed on 03/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1955.