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Target not currently curated in GtoImmuPdb
Target id: 1477
Nomenclature: protein kinase, cAMP-dependent, catalytic, beta subunit
Abbreviated Name: PKACb
Family: Protein kinase A (PKA) family
Quaternary Structure: Complexes |
protein kinase A |
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 351 | 1p31.1 | PRKACB | protein kinase cAMP-activated catalytic subunit beta | |
Mouse | - | 351 | 3 H2 | Prkacb | protein kinase, cAMP dependent, catalytic, beta | |
Rat | - | 351 | 2q44 | Prkacb | protein kinase cAMP-activated catalytic subunit beta |
Database Links | |
Alphafold | P22694 (Hs), P68181 (Mm), P68182 (Rn) |
BRENDA | 2.7.11.11 |
ChEMBL Target | CHEMBL2918 (Hs) |
Ensembl Gene | ENSG00000142875 (Hs), ENSMUSG00000005034 (Mm), ENSRNOG00000004978 (Rn) |
Entrez Gene | 5567 (Hs), 18749 (Mm), 293508 (Rn) |
Human Protein Atlas | ENSG00000142875 (Hs) |
KEGG Enzyme | 2.7.11.11 |
KEGG Gene | hsa:5567 (Hs), mmu:18749 (Mm), rno:293508 (Rn) |
OMIM | 176892 (Hs) |
Pharos | P22694 (Hs) |
RefSeq Nucleotide | NM_001242857 (Hs), NM_011100 (Mm), NM_001077645 (Rn) |
RefSeq Protein | NP_002722 (Hs), NP_035230 (Mm), NP_001157670 (Mm), NP_001157671 (Mm), NP_001157672 (Mm), NP_001071113 (Rn) |
UniProtKB | P22694 (Hs), P68181 (Mm), P68182 (Rn) |
Wikipedia | PRKACB (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
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Target used in screen: PKAC-beta | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Djung JF, Mears RJ, Montalbetti CA, Coulter TS, Golebiowski A, Carr AN, Barker O, Greis KD, Zhou S, Dolan E et al.. (2011) The synthesis and evaluation of indolylureas as PKCα inhibitors. Bioorg Med Chem, 19 (8): 2742-50. [PMID:21435888]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
Protein kinase A (PKA) family: protein kinase, cAMP-dependent, catalytic, beta subunit. Last modified on 12/04/2019. Accessed on 10/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1477.