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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 221 | 15q21.3 | RAB27A | RAB27A, member RAS oncogene family | |
Mouse | - | 221 | 9 40.08 cM | Rab27a | RAB27A, member RAS oncogene family | |
Rat | - | 221 | 8q24 | Rab27a | RAB27A, member RAS oncogene family |
Previous and Unofficial Names |
RAB27A |
Database Links | |
Alphafold | P51159 (Hs), Q9ERI2 (Mm), P23640 (Rn) |
ChEMBL Target | CHEMBL4105702 (Hs) |
Ensembl Gene | ENSG00000069974 (Hs), ENSMUSG00000032202 (Mm), ENSRNOG00000052499 (Rn) |
Entrez Gene | 5873 (Hs), 11891 (Mm), 50645 (Rn) |
Human Protein Atlas | ENSG00000069974 (Hs) |
KEGG Gene | hsa:5873 (Hs), mmu:11891 (Mm), rno:50645 (Rn) |
OMIM | 607624 (Hs) |
Pharos | P51159 (Hs) |
RefSeq Nucleotide | NM_004580 (Hs), NM_001301230 (Mm), NM_017317 (Rn) |
RefSeq Protein | NP_004571 (Hs), NP_001288159 (Mm), NM_017317 (Rn) |
UniProtKB | P51159 (Hs), Q9ERI2 (Mm), P23640 (Rn) |
Wikipedia | RAB27A (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Small molecule inhibitors of Rab27a-JFC1 binding, termed Nexinhibs (neutrophil exocytosis inhibitors) demonstrate the druggability of Rab GTPases and inhibition of exocytosis of azurophilic granules in human neutrophils without affecting other important innate immune responses, including phagocytosis and neutrophil extracellular trap production. These thus have potential use as an inhibitor of systemic inflammation [4]. |
Cell Type Associations | ||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||
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1. Brzezinska AA, Johnson JL, Munafo DB, Crozat K, Beutler B, Kiosses WB, Ellis BA, Catz SD. (2008) The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic, 9 (12): 2151-64. [PMID:18939952]
2. Catz SD. (2014) The role of Rab27a in the regulation of neutrophil function. Cell Microbiol, 16 (9): 1301-10. [PMID:24964030]
3. Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD. (2012) Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Mol Biol Cell, 23 (10): 1902-16. [PMID:22438581]
4. Johnson JL, Ramadass M, He J, Brown SJ, Zhang J, Abgaryan L, Biris N, Gavathiotis E, Rosen H, Catz SD. (2016) Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem, 291 (50): 25965-25982. [PMID:27702998]