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Target not currently curated in GtoImmuPdb
Target id: 1541
Nomenclature: protein kinase AMP-activated catalytic subunit alpha 1
Abbreviated Name: AMPKA1
Family: AMPK subfamily
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 559 | 5p13.1 | PRKAA1 | protein kinase AMP-activated catalytic subunit alpha 1 | |
Mouse | - | 559 | 15 A1 | Prkaa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | |
Rat | - | 559 | 2q16 | Prkaa1 | protein kinase AMP-activated catalytic subunit alpha 1 |
Database Links | |
Alphafold | Q13131 (Hs), Q5EG47 (Mm), P54645 (Rn) |
BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL4045 (Hs), CHEMBL1075161 (Mm), CHEMBL4533 (Rn) |
DrugBank Target | Q13131 (Hs) |
Ensembl Gene | ENSG00000132356 (Hs), ENSMUSG00000050697 (Mm), ENSRNOG00000012799 (Rn) |
Entrez Gene | 5562 (Hs), 105787 (Mm), 65248 (Rn) |
Human Protein Atlas | ENSG00000132356 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:5562 (Hs), mmu:105787 (Mm), rno:65248 (Rn) |
OMIM | 602739 (Hs) |
Pharos | Q13131 (Hs) |
RefSeq Nucleotide | NM_006251 (Hs), NM_001013367 (Mm), NM_019142 (Rn) |
RefSeq Protein | NP_006242 (Hs), NP_001013385 (Mm), NP_062015 (Rn) |
UniProtKB | Q13131 (Hs), Q5EG47 (Mm), P54645 (Rn) |
Wikipedia | PRKAA1 (Hs) |
Enzyme Reaction | ||||
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DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: AMPK-alpha1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 2... |
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Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: AMPKα1/nd | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
AMPK subfamily: protein kinase AMP-activated catalytic subunit alpha 1. Last modified on 30/03/2016. Accessed on 14/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1541.