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cyclin dependent kinase 17

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Target not currently curated in GtoImmuPdb

Target id: 1970

Nomenclature: cyclin dependent kinase 17

Abbreviated Name: CDK17

Family: TAIRE subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 523 12q23.1 CDK17 cyclin dependent kinase 17
Mouse - 523 10 C2 Cdk17 cyclin dependent kinase 17
Rat - 523 7q13 Cdk17 cyclin-dependent kinase 17
Previous and Unofficial Names Click here for help
PCTAIRE protein kinase 2 | PCTAIRE2 | cyclin-dependent kinase 17
Database Links Click here for help
Alphafold Q00537 (Hs), Q8K0D0 (Mm), O35831 (Rn)
BRENDA 2.7.11.22
ChEMBL Target CHEMBL5790 (Hs)
Ensembl Gene ENSG00000059758 (Hs), ENSMUSG00000020015 (Mm), ENSRNOG00000004148 (Rn)
Entrez Gene 5128 (Hs), 237459 (Mm), 314743 (Rn)
Human Protein Atlas ENSG00000059758 (Hs)
KEGG Enzyme 2.7.11.22
KEGG Gene hsa:5128 (Hs), mmu:237459 (Mm), rno:314743 (Rn)
OMIM 603440 (Hs)
Pharos Q00537 (Hs)
RefSeq Nucleotide NM_001170464 (Hs), NM_146239 (Mm), NM_001108082 (Rn)
RefSeq Protein NP_002586 (Hs), NP_666351 (Mm), NP_001101552 (Rn)
UniProtKB Q00537 (Hs), Q8K0D0 (Mm), O35831 (Rn)
Wikipedia CDK17 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: PCTK2
Ligand Sp. Type Action Value Parameter
R547 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.1 pKd
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.0 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.9 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 7.8 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.5 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
alvocidib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

TAIRE subfamily: cyclin dependent kinase 17. Last modified on 20/03/2013. Accessed on 01/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1970.