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Target not currently curated in GtoImmuPdb
Target id: 1847
Nomenclature: muscle associated receptor tyrosine kinase
Abbreviated Name: MuSK
Family: Type IX RTKs: MuSK
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 869 | 9q31.3 | MUSK | muscle associated receptor tyrosine kinase | |
Mouse | 1 | 868 | 4 31.87 cM | Musk | muscle, skeletal, receptor tyrosine kinase | |
Rat | 1 | 868 | 5q24 | Musk | muscle associated receptor tyrosine kinase |
Database Links ![]() |
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Alphafold | O15146 (Hs), Q61006 (Mm), Q62838 (Rn) |
BRENDA | 2.7.10.1 |
CATH/Gene3D | 1.10.2000.10, 2.60.40.10 |
ChEMBL Target | CHEMBL5684 (Hs) |
Ensembl Gene | ENSG00000030304 (Hs), ENSMUSG00000057280 (Mm), ENSRNOG00000033567 (Rn) |
Entrez Gene | 4593 (Hs), 18198 (Mm), 81725 (Rn) |
Human Protein Atlas | ENSG00000030304 (Hs) |
KEGG Enzyme | 2.7.10.1 |
KEGG Gene | hsa:4593 (Hs), mmu:18198 (Mm), rno:81725 (Rn) |
OMIM | 601296 (Hs) |
Orphanet | ORPHA160311 (Hs) |
Pharos | O15146 (Hs) |
RefSeq Nucleotide | NM_001166280 (Hs), NM_001037127 (Mm), NM_031061 (Rn) |
RefSeq Protein | NP_005583 (Hs), NP_001032207 (Mm), NP_001159468 (Mm), NP_035074 (Mm), NP_001032204 (Mm), NP_001032205 (Mm), NP_001032206 (Mm), NP_112323 (Rn) |
UniProtKB | O15146 (Hs), Q61006 (Mm), Q62838 (Rn) |
Wikipedia | MUSK (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Compound 25 [PMID 17935989] is a CHK1 inhibitor and interacts with MUSK as an off-target. Inhibiton of CHK1 is >400 times more potent than inhibition of MUSK [4]. Similarly MUSK is an off-target of the JAK2 inhibitor compound 1d [PMID 21493067] [6]. |
DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,7 |
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Target used in screen: MUSK | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3 |
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Target used in screen: MuSK/MUSK | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
4. Tao ZF, Chen Z, Bui MH, Kovar P, Johnson E, Bouska J, Zhang H, Rosenberg S, Sowin T, Lin NH. (2007) Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. Bioorg Med Chem Lett, 17 (23): 6593-601. [PMID:17935989]
5. Till JH, Becerra M, Watty A, Lu Y, Ma Y, Neubert TA, Burden SJ, Hubbard SR. (2002) Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Structure, 10 (9): 1187-96. [PMID:12220490]
6. Wang T, Ioannidis S, Almeida L, Block MH, Davies AM, Lamb ML, Scott DA, Su M, Zhang HJ, Alimzhanov M et al.. (2011) In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett, 21 (10): 2958-61. [PMID:21493067]
7. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
Type IX RTKs: MuSK: muscle associated receptor tyrosine kinase. Last modified on 05/05/2015. Accessed on 13/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1847.