Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	476	1q32.2	CAMK1G	calcium/calmodulin dependent protein kinase IG
Mouse	-	477	1 97.74 cM	Camk1g	calcium/calmodulin-dependent protein kinase I gamma
Rat	-	476	13q27	Camk1g	calcium/calmodulin-dependent protein kinase IG

Previous and Unofficial Names

caM kinase I gamma | caMK-like CREB kinase III | CLICK III

Database Links
Alphafold	Q96NX5 (Hs), Q91VB2 (Mm), Q7TNJ7 (Rn)
BRENDA	2.7.11.17
ChEMBL Target	CHEMBL5258 (Hs)
Ensembl Gene	ENSG00000008118 (Hs), ENSMUSG00000016179 (Mm), ENSRNOG00000006470 (Rn)
Entrez Gene	57172 (Hs), 215303 (Mm), 171358 (Rn)
Human Protein Atlas	ENSG00000008118 (Hs)
KEGG Enzyme	2.7.11.17
KEGG Gene	hsa:57172 (Hs), mmu:215303 (Mm), rno:171358 (Rn)
OMIM	614994 (Hs)
Pharos	Q96NX5 (Hs)
RefSeq Nucleotide	NM_020439 (Hs), NM_144817 (Mm), NM_182842 (Rn)
RefSeq Protein	NP_065172 (Hs), NP_659066 (Mm), NP_878262 (Rn)
UniProtKB	Q96NX5 (Hs), Q91VB2 (Mm), Q7TNJ7 (Rn)
Wikipedia	CAMK1G (Hs)

Selected 3D Structures
	Description:  Crystal structure of human calmodulin-dependent protein kinase IG PDB Id:  2JAM Resolution:  1.7Å Species:  Human References:

Enzyme Reaction
EC Number: 2.7.11.17

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2-3
Key to terms and symbols		Click column headers to sort
Target used in screen: CAMK1G
Ligand Sp. Type Action Value Parameter staurosporine Hs Inhibitor Inhibition 7.6 pKd sunitinib Hs Inhibitor Inhibition 6.4 pKd tamatinib Hs Inhibitor Inhibition 6.3 pKd lestaurtinib Hs Inhibitor Inhibition 6.3 pKd SU-14813 Hs Inhibitor Inhibition 6.0 pKd midostaurin Hs Inhibitor Inhibition 5.7 pKd KW-2449 Hs Inhibitor Inhibition 5.7 pKd ruxolitinib Hs Inhibitor Inhibition 5.7 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/CAMK1g
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 4.7 PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 28.5 K-252a Hs Inhibitor Inhibition 42.5 SU11652 Hs Inhibitor Inhibition 49.5 SB 218078 Hs Inhibitor Inhibition 56.5 sunitinib Hs Inhibitor Inhibition 67.0 Syk inhibitor II Hs Inhibitor Inhibition 74.0 bosutinib Hs Inhibitor Inhibition 82.7 PKCbeta inhibitor Hs Inhibitor Inhibition 84.6 Syk inhibitor Hs Inhibitor Inhibition 89.2
Displaying the top 10 most potent ligands  View all ligands in screen »