Hot Topics in Pharmacology

Coronavrius Information

We are currently collating information related to SARS-CoV-2 and COVID-19 at a dedicated coronavirus information page. This contains details of ligands and targets relevant to COVID-19 and links to useful resources and publications.

Recent publications of interest recommended by NC-IUPHAR

2021: Jul | Jun | May | Apr | Mar | Feb | Jan
2020: Dec | Nov | Oct | Sep | Aug

    July 2021


  • The PROTACtable genome.
    Schneider M, Radoux CJ, Hercules A, Ochoa D, Dunham I, Zalmas LP, Hessler G, Ruf S, Shanmugasundaram V, Hann MM et al.. The PROTACtable genome. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:34285415]

  • Identifying the core concepts of pharmacology education.
    White PJ, Davis EA, Santiago M, Angelo T, Shield A, Babey AM, Kemp-Harper B, Maynard G, Al-Sallami HS, Musgrave IF et al.. Identifying the core concepts of pharmacology education. (2021)  Pharmacol Res Perspect, 9 (4): e00836. [PMID:34288559]

  • Sulfatides are endogenous ligands for the TLR4-MD-2 complex.
    Su L, Athamna M, Wang Y, Wang J, Freudenberg M, Yue T, Wang J, Moresco EMY, He H, Zor T et al.. Sulfatides are endogenous ligands for the TLR4-MD-2 complex. (2021)  Proc Natl Acad Sci U S A, 118 (30). [PMID:34290146]

  • Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
    Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S et al.. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. (2021)  Science, [Epub ahead of print]. [PMID:34285133]

  • Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data.
    van der Lee M, Allard WG, Vossen RHAM, Baak-Pablo RF, Menafra R, Deiman BALM, Deenen MJ, Neven P, Johansson I, Gastaldello S et al.. Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data. (2021)  Sci Transl Med, 13 (603). [PMID:34290055]

  • The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
    Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S et al.. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. (2021)  Sci Transl Med, 13 (603). [PMID:34290058]

  • Molecular topography of an entire nervous system.
    Taylor SR, Santpere G, Weinreb A, Barrett A, Reilly MB, Xu C, Varol E, Oikonomou P, Glenwinkel L, McWhirter R et al.. Molecular topography of an entire nervous system. (2021)  Cell, [Epub ahead of print]. [PMID:34237253]

  • Structure of human Cav2.2 channel blocked by the painkiller ziconotide.
    Gao S, Yao X, Yan N. Structure of human Cav2.2 channel blocked by the painkiller ziconotide. (2021)  Nature, [Epub ahead of print]. [PMID:34234349]

  • Mapping the human genetic architecture of COVID-19.
    COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. (2021)  Nature, [Epub ahead of print]. [PMID:34237774]

  • Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
    Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI. Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. (2021)  Nat Struct Mol Biol, 28 (7): 564-572. [PMID:34239124]

  • Heat-dependent opening of TRPV1 in the presence of capsaicin.
    Kwon DH, Zhang F, Suo Y, Bouvette J, Borgnia MJ, Lee SY. Heat-dependent opening of TRPV1 in the presence of capsaicin. (2021)  Nat Struct Mol Biol, 28 (7): 554-563. [PMID:34239123]

  • 2020 in review: FDA approvals of new medicines.
    Kinch MS, Kraft Z, Schwartz T. 2020 in review: FDA approvals of new medicines. (2021)  Drug Discov Today, [Epub ahead of print]. [PMID:34252611]

  • Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
    Szustakowski JD, Balasubramanian S, Kvikstad E, Khalid S, Bronson PG, Sasson A, Wong E, Liu D, Wade Davis J, Haefliger C et al.. Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank. (2021)  Nat Genet, 53 (7): 942-948. [PMID:34183854]

  • Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
    Schmidl S, Ursu O, Iancu CV, Oreb M, Oprea TI, Choe JY. Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems. (2021)  Sci Rep, 11 (1): 13751. [PMID:34215797]

  • Research Article Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
    Lowe D. Drug Repurposing for Coronaviruses: Be Careful.  In the Pipeline, https://blogs.sciencemag.org/pipeline/archives/2021/06/25/drug-repurposing-for-coronaviruses-be-careful
    Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, Zhang Z, Alon A, O'Donnell HR et al.. Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. (2021)  bioRxiv,. [PMID:33791693]

  • The language of race, ethnicity, and ancestry in human genetic research.
    Birney E, Inouye M, Raff J, Rutherford A, Scally A. The language of race, ethnicity, and ancestry in human genetic research. (2021)  arXiv, Preprint.

  • June 2021


  • Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4.
    Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X et al.. Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4. (2021)  Nature, [Epub ahead of print]. [PMID:34135510]

  • Structures of human mGlu2 and mGlu7 homo- and heterodimers.
    Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T et al.. Structures of human mGlu2 and mGlu7 homo- and heterodimers. (2021)  Nature, [Epub ahead of print]. [PMID:34135509]

  • SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation.
    Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T et al.. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. (2021)  Elife, 10. [PMID:33890572]

  • Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
    Cater RJ, Chua GL, Erramilli SK, Keener JE, Choy BC, Tokarz P, Chin CF, Quek DQY, Kloss B, Pepe JG et al.. Structural basis of omega-3 fatty acid transport across the blood-brain barrier. (2021)  Nature, [Epub ahead of print]. [PMID:34135507]

  • A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects.
    Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L et al.. A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects. (2021)  Neuropharmacology, In Press. DOI: 10.1016/j.neuropharm.2021.108673

  • The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration.
    Hoare SRJ. The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration. (2021)  SLAS Discov,: 24725552211019653 [Epub ahead of print]. [PMID:34112012]

  • Landmark Alzheimer's drug approval confounds research community.
    Mullard A. Landmark Alzheimer's drug approval confounds research community. (2021)  Nature, [Epub ahead of print]. [PMID:34103732]

  • Rationality over fashion and hype in drug design.
    Medina-Franco JL, Martinez-Mayorga K, Fernández-de Gortari E, Kirchmair J, Bajorath J. Rationality over fashion and hype in drug design. (2021)  F1000Res, Preprint. DOI: 10.12688/f1000research.52676.1

  • Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.
    Hodcroft EB, Zuber M, Nadeau S, Vaughan TG, Crawford KHD, Althaus CL, Reichmuth ML, Bowen JE, Walls AC, Corti D et al.. Spread of a SARS-CoV-2 variant through Europe in the summer of 2020. (2021)  Nature, [Epub ahead of print]. [PMID:34098568]

  • Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.
    Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB et al.. Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease. (2021)  medrxiv, Preprint. DOI: 10.1101/2020.12.14.20248176

  • May 2021


  • Pharmacogenetics at Scale: An Analysis of the UK Biobank.
    McInnes G, Lavertu A, Sangkuhl K, Klein TE, Whirl-Carrillo M, Altman RB. Pharmacogenetics at Scale: An Analysis of the UK Biobank. (2021)  Clin Pharmacol Ther, 109 (6): 1528-1537. [PMID:33237584]

  • Assessing the functional relevance of splice isoforms.
    Pozo F, Martinez-Gomez L, Walsh TA, Rodriguez JM, Di Domenico T, Abascal F, Vazquez J, Tress ML. Assessing the functional relevance of splice isoforms. (2021)  NAR Genom Bioinform, 3 (2): lqab044. [PMID:34046593]

  • Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
    Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C et al.. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. (2021)  Nat Neurosci, [Epub ahead of print]. [PMID:34045744]

  • Next generation plasma proteome profiling to monitor health and disease.
    Zhong W, Edfors F, Gummesson A, Bergström G, Fagerberg L, Uhlén M. Next generation plasma proteome profiling to monitor health and disease. (2021)  Nat Commun, 12 (1): 2493. [PMID:33941778]

  • The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin.
    Peacock TP, Sheppard CM, Brown JC, Goonawardane N, Zhou J, Whiteley M, PHE Virology Consortium, de Silva TI, Barclay WS. The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin.   bioRxiv, Preprint. DOI: 10.1101/2021.05.28.446163

  • The complete sequence of a human genome.
    Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A et al.. The complete sequence of a human genome. (2021)  bioRxiv, Preprint. DOI: 10.1101/2021.05.26.445798

  • Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries.
    Islam N, Shkolnikov VM, Acosta RJ, Klimkin I, Kawachi I, Irizarry RA, Alicandro G, Khunti K, Yates T, Jdanov DA et al.. Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries. (2021)  BMJ, 373: n1137. [PMID:34011491]

  • Will the chemical probes please stand up?.
    Škuta C, Southan C, Bartůněk P. Will the chemical probes please stand up?. (2021)  RSC Med. Chem., Epub ahead of print. DOI: 10.1039/D1MD00138H

  • April 2021


  • RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape.
    Mullard A. RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:33864035]

  • Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
    Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho YL, Iyengar SK, Kosik NM, Vujkovic M et al.. Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. (2021)  Nat Med, 27 (4): 668-676. [PMID:33837377]

  • The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice.
    Dekeryte R, Franklin Z, Hull C, Croce L, Kamli-Salino S, Helk O, Hoffmann PA, Yang Z, Riedel G, Delibegovic M et al.. The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice. (2021)  Biochim Biophys Acta Mol Basis Dis, 1867 (7): 166149 [Epub ahead of print]. [PMID:33892080]

  • Novel drug targets in 2020.
    Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2020. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:33824485]

  • The Promise and Peril of Chemical Probe Negative Controls.
    Lee J, Schapira M. The Promise and Peril of Chemical Probe Negative Controls. (2021)  ACS Chem Biol, [Epub ahead of print]. [PMID:33745272]

  • Road to effective data curation for translational research.
    Gu W, Hasan S, Rocca-Serra P, Satagopam VP. Road to effective data curation for translational research. (2021)  Drug Discov Today, 26 (3): 626-630. [PMID:33338655]

  • The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape.
    Fraser N, Brierley L, Dey G, Polka JK, Pálfy M, Nanni F, Coates JA. The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape. (2021)  PLoS Biol, 19 (4): e3000959 [Epub ahead of print]. [PMID:33798194]

  • A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
    Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI et al.. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. (2021)  ACS Chem Biol, 16 (4): 642-650. [PMID:33787221]

  • COVID vaccines and blood clots: five key questions
    Ledford H. COVID vaccines and blood clots: five key questions. (2021)  Nature, 592 (7855): 495-496. [PMID:33864049]
    Ledford H. How could a COVID vaccine cause blood clots? Scientists race to investigate. (2021)  Nature, 592 (7854): 334-335. [PMID:33846607]

  • Biden pursues giant boost for science spending.
    Tollefson J, Maxmen A, Remmel A, Subbaraman N, Witze A. Biden pursues giant boost for science spending. (2021)  Nature, 592 (7855): 498-499. [PMID:33846608]

  • Structural insights into the lipid and ligand regulation of serotonin receptors.
    Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV et al.. Structural insights into the lipid and ligand regulation of serotonin receptors. (2021)  Nature, [Epub ahead of print]. [PMID:33762731]

  • March 2021


  • The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.
    Smith BAH, Bertozzi CR. The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans. (2021)  Nat Rev Drug Discov, 20 (3): 217-243. [PMID:33462432]

  • Signals of hope: gauging the impact of a rapid national vaccination campaign.
    Shilo S, Rossman H, Segal E. Signals of hope: gauging the impact of a rapid national vaccination campaign. (2021)  Nat Rev Immunol, [Epub ahead of print]. [PMID:33712744]

  • AI and Drug Discovery: Attacking the Right Problems
    Bender A, Cortes-Ciriano I. Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 2: a discussion of chemical and biological data. (2021)  Drug Discov Today, [Epub ahead of print]. [PMID:33508423]
    Bender A, Cortés-Ciriano I. Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet. (2021)  Drug Discov Today, 26 (2): 511-524. [PMID:33346134]
    Lowe D. AI and Drug Discovery: Attacking the Right Problems.  In the Pipeline, https://blogs.sciencemag.org/pipeline/archives/2021/03/19/ai-and-drug-discovery-attacking-the-right-problems

  • Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
    Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP et al.. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. (2021)  Cell, 184 (4): 931-942.e18. [PMID:33571431]

  • Trends in COVID-19 therapeutic clinical trials.
    Bugin K, Woodcock J. Trends in COVID-19 therapeutic clinical trials. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:33633370]

  • Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
    Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, Zhou R, Chan KH, Zhao H, Zhu Let al.. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. (2021)  Cell, Preprint. DOI: 10.1016/j.cell.2021.02.053

  • February 2021


  • Constitutive G protein coupling profiles of understudied orphan GPCRs.
    Lu S, Jang W, Inoue A, Lambert NA. Constitutive G protein coupling profiles of understudied orphan GPCRs. (2021)  PLoS One, 16 (4): e0247743. [PMID:33886554]

  • Structure and inhibition mechanism of the human citrate transporter NaCT.
    Sauer DB, Song J, Wang B, Hilton JK, Karpowich NK, Mindell JA, Rice WJ, Wang DN. Structure and inhibition mechanism of the human citrate transporter NaCT. (2021)  Nature, [Epub ahead of print]. [PMID:33597751]

  • Structures of the human dopamine D3 receptor-Gi complexes.
    Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y et al.. Structures of the human dopamine D3 receptor-Gi complexes. (2021)  Mol Cell, [Epub ahead of print]. [PMID:33548201]

  • Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
    Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y et al.. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites. (2021)  Sci Rep, 11 (1): 2121. [PMID:33483532]

  • Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
    Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R et al.. Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. (2021)  Br J Pharmacol, 178 (3): 626-635. [PMID:33125711]

  • Identification of the Core Chemical Structure in SureChEMBL Patents.
    Falaguera MJ, Mestres J. Identification of the Core Chemical Structure in SureChEMBL Patents. (2021)  J Chem Inf Model, 61 (5): 2241-2247. [PMID:33929850]

  • SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor.
    Zahradník J, Marciano S, Shemesh M, Zoler E, Chiaravalli J, Meyer B, Rudich Y, Dym O, Elad N, Schreiber G. SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor. (2021)  bioRxiv, Preprint. DOI: 10.1101/2021.01.06.425392

  • January 2021


  • CoV3D: a database of high resolution coronavirus protein structures.
    Gowthaman R, Guest JD, Yin R, Adolf-Bryfogle J, Schief WR, Pierce BG. CoV3D: a database of high resolution coronavirus protein structures. (2021)  Nucleic Acids Res, 49 (D1): D282-D287. [PMID:32890396]

  • Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.
    Greaney AJ, Loes AN, Crawford KHD, Starr TN, Malone KD, Chu HY, Bloom JD. Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies. (2021)  Cell Host Microbe, 29 (3): 463-476.e6. [PMID:33592168]

  • The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres.
    Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan M, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M et al.. The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres. (2021)  MedRxiv, Preprint. DOI: 10.1101/2021.01.13.21249725

  • The role of orphan receptor GPR139 in neuropsychiatric behavior.
    Dao M, Stoveken HM, Cao Y, Martemyanov KA. The role of orphan receptor GPR139 in neuropsychiatric behavior. (2021)  Neuropsychopharmacology, [Epub ahead of print]. [PMID:33479510]

  • Hot Topics: Gene Symbol usage and the need to do better

    Comments by Chris Southan, Fellow of the University of Edinburgh, Owner of TW2Informatics, Chair of NC-IUPHAR Subcommitees for Proteases and Drug Targets and Chemistry (DRUTACS).

    The GtoPdb team need no convincing about the importance of ameliorating equivocality in gene and gene product names, both as they are used (often incorrectly) in the pharmacology and drug discovery literature. Crucially, this also applies to their inclusion in curated database records such as GtoPdb.. Read the full article on our blog

  • Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases.
    Tabassum R, Ripatti S. Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases. (2021)  Cell Mol Life Sci, [Epub ahead of print]. [PMID:33449144]

  • The influence of evolutionary history on human health and disease.
    Benton ML, Abraham A, LaBella AL, Abbot P, Rokas A, Capra JA. The influence of evolutionary history on human health and disease. (2021)  Nat Rev Genet, [Epub ahead of print]. [PMID:33408383]

  • Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK.
    du Plessis L, McCrone JT, Zarebski AE, Hill V, Ruis C, Gutierrez B, Raghwani J, Ashworth J, Colquhoun R, Connor TR et al.. Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK. (2021)  Science, 371 (6530): 708-712. [PMID:33419936]

  • Evolution of the endothelin pathway drove neural crest cell diversification.
    Square TA, Jandzik D, Massey JL, Romášek M, Stein HP, Hansen AW, Purkayastha A, Cattell MV, Medeiros DM. Evolution of the endothelin pathway drove neural crest cell diversification. (2020)  Nature, 585 (7826): 563-568. [PMID:32939088]

  • December 2020


  • Genetic mechanisms of critical illness in COVID-19.
    Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD et al.. Genetic mechanisms of critical illness in COVID-19. (2021)  Nature, 591 (7848): 92-98. [PMID:33307546]

  • KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies.
    Ávalos Prado P, Häfner S, Comoglio Y, Wdziekonski B, Duranton C, Attali B, Barhanin J, Sandoz G. KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies. (2021)  Cell, 184 (2): 534-544.e11. [PMID:33373586]

  • 'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures
    Callaway E. 'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures. (2020)  Nature, 588 (7837): 203-204. [PMID:33257889]
    Outeiral C. CASP14: what Google DeepMind’s AlphaFold 2 really achieved, and what it means for protein folding, biology and bioinformatics.  Oxford Protein Informatics Group, https://www.blopig.com/blog/2020/12/casp14-what-google-deepminds-alphafold-2-really-achieved-and-what-it-means-for-protein-folding-biology-and-bioinformatics/

  • Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics.
    Walsh MA, Grimes JM, Stuart DI. Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics. (2021)  Biochem Biophys Res Commun, 538: 40-46. [PMID:33248689]

  • November 2020


  • Pathway information extracted from 25 years of pathway figures.
    Hanspers K, Riutta A, Summer-Kutmon M, Pico AR. Pathway information extracted from 25 years of pathway figures. (2020)  Genome Biol, 21 (1): 273. [PMID:33168034]

  • Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data.
    Hu J, Li C, Wang S, Li T, Zhang H. Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data. (2020)  medRxiv, Preprint. DOI: 10.1101/2020.11.05.20226761

  • Combinatorial expression of GPCR isoforms affects signalling and drug responses.
    Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J et al.. Combinatorial expression of GPCR isoforms affects signalling and drug responses. (2020)  Nature, 587 (7835): 650-656. [PMID:33149304]

  • Biogen’s Alzheimer’s drug candidate takes a beating from FDA advisers.
    Servick K. Biogen’s Alzheimer’s drug candidate takes a beating from FDA advisers. 
    Accessed on 11/11/2020. Modified on 11/11/2020. https://www.sciencemag.org/news/2020/11/biogen-s-alzheimer-s-drug-candidate-takes-beating-fda-advisers

  • Interferon deficiency can lead to severe COVID
    Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V et al.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. (2020)  Science, 370 (6515). [PMID:32972996]
    Meffre E, Iwasaki A. Interferon deficiency can lead to severe COVID. (2020)  Nature, 587 (7834): 374-376. [PMID:33139913]
    Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C et al.. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. (2020)  Science, 370 (6515). [PMID:32972995]

  • A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research
    Zahoránszky-Kőhalmi G, Siramshetty VB, Kumar P, Gurumurthy M, Grillo B, Mathew B, Metaxatos D, Backus M, Mierzwa T, Simon R et al.. A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research. (2020)  bioRxiv, Preprint. [PMID:33173863]
    National Center for Advancing Translational Sciences (NCATS). Neo4COVID-19.  https://neo4covid19.ncats.io

  • COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning.
    The COVID Moonshot Consortium. COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning. (2020)  bioRxiv, Preprint. DOI: 10.1101/2020.10.29.339317

  • The ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug.
    Cohen J, Kupferschmidt K. The ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug. 
    Accessed on 02/11/2020. Modified on 02/11/2020. https://www.sciencemag.org/news/2020/10/very-very-bad-look-remdesivir-first-fda-approved-covid-19-drug

  • COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms.
    Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, Singh V, Aghamir SS, Acencio ML, Glaab E et al.. COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms. (2020)  bioRxiv, Preprint. DOI: 10.1101/2020.10.26.356014

  • October 2020


  • The COVID-19 Pandemic and the $16 Trillion Virus.
    Cutler DM, Summers LH. The COVID-19 Pandemic and the $16 Trillion Virus. (2020)  JAMA, 324 (15): 1495-1496. [PMID:33044484]

  • PROTAC-DB: an online database of PROTACs.
    Weng G, Shen C, Cao D, Gao J, Dong X, He Q, Yang B, Li D, Wu J, Hou T. PROTAC-DB: an online database of PROTACs. (2021)  Nucleic Acids Res, 49 (D1): D1381-D1387. [PMID:33010159]

  • The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.
    Zeberg H, Pääbo S. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. (2020)  Nature, 587 (7835): 610-612. [PMID:32998156]

  • A Thalamic Orphan Receptor Drives Variability in Short-Term Memory.
    Hsiao K, Noble C, Pitman W, Yadav N, Kumar S, Keele GR, Terceros A, Kanke M, Conniff T, Cheleuitte-Nieves C et al.. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. (2020)  Cell, 183 (2): 522-536.e19. [PMID:32997977]

  • Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients.
    Siggaard T, Reguant R, Jørgensen IF, Haue AD, Lademann M, Aguayo-Orozco A, Hjaltelin JX, Jensen AB, Banasik K, Brunak S. Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients. (2020)  Nat Commun, 11 (1): 4952. [PMID:33009368]

  • September 2020


  • Emerging Pandemic Diseases: How We Got to COVID-19.
    Morens DM, Fauci AS. Emerging Pandemic Diseases: How We Got to COVID-19. (2020)  Cell, 182 (5): 1077-1092. [PMID:32846157]

  • Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.
    Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE et al.. Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor. (2020)  Cell, 182 (6): 1574-1588.e19. [PMID:32946782]

  • Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening.
    Zhu W, Xu M, Chen CZ, Guo H, Shen M, Hu X, Shinn P, Klumpp-Thomas C, Michael SG, Zheng W. Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening. (2020)  bioRxiv,. [PMID:32803196]

  • Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19.
    Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H et al.. Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19. (2020)  bioRxiv,. [PMID:32935104]

  • Hot Topics: Soluble ligands as drug targets.

    Comments by Misty Attwood and Helgi Schiöth, University of Uppsala, Uppsala, Sweden. Helgi Schiöth is Chair for NC-IUPHAR Subcommitees for Melanocortin receptors and Prolactin-releasing peptide receptor.

    Historically, the main classes of drug targets have been receptors, enzymes, ion channels and transporters which are primarily targeted by small molecules. However, advances in molecular biology, genomics, and pharmacology have facilitated the development of different therapeutic modalities which in turn have broadened the types of drug targets.. Read the full article on our blog

  • August 2020


  • Computational design of transmembrane pores.
    Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H et al.. Computational design of transmembrane pores. (2020)  Nature, 585 (7823): 129-134. [PMID:32848250]

  • Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms.
    Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ. Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms. (2020)  Elife, 9. [PMID:32804077]

  • The Human Genome Project changed everything.
    Gibbs RA. The Human Genome Project changed everything. (2020)  Nat Rev Genet, 21 (10): 575-576. [PMID:32770171]

  • Guidelines for human gene nomenclature.
    Bruford EA, Braschi B, Denny P, Jones TEM, Seal RL, Tweedie S. Guidelines for human gene nomenclature. (2020)  Nat Genet, 52 (8): 754-758. [PMID:32747822]

  • The chemokine X-factor: Structure-function analysis of the CXC motif at CXCR4 and ACKR3.
    Wedemeyer MJ, Mahn SA, Getschman AE, Crawford KS, Peterson FC, Marchese A, McCorvy JD, Volkman BF. The chemokine X-factor: Structure-function analysis of the CXC motif at CXCR4 and ACKR3. (2020)  J Biol Chem, 295 (40): 13927-13939. [PMID:32788219]

  • The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020.
    Liu Y, Liang C, Xin L, Ren X, Tian L, Ju X, Li H, Wang Y, Zhao Q, Liu H et al.. The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020. (2020)  Eur J Med Chem, 206: 112711. [PMID:32810751]

  • Watcher in the wastewater.
    Schmidt C. Watcher in the wastewater. (2020)  Nat Biotechnol, 38 (8): 917-920. [PMID:32724212]

  • Expanded ENCODE delivers invaluable genomic encyclopedia.
    Hon CC, Carninci P. Expanded ENCODE delivers invaluable genomic encyclopedia. (2020)  Nature, 583 (7818): 685-686. [PMID:32728235]

  • A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets.
    Breuza L, Arighi CN, Argoud-Puy G, Casals-Casas C, Estreicher A, Famiglietti ML, Georghiou G, Gos A, Gruaz-Gumowski N, Hinz U et al.. A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets. (2020)  J Alzheimers Dis, 77 (1): 257-273. [PMID:32716361]

  • How does SARS-CoV-2 cause COVID-19?.
    Matheson NJ, Lehner PJ. How does SARS-CoV-2 cause COVID-19?. (2020)  Science, 369 (6503): 510-511. [PMID:32732413]