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Target not currently curated in GtoImmuPdb
Target id: 1957
Nomenclature: calcium/calmodulin dependent protein kinase kinase 2
Abbreviated Name: CAMKK2
Family: Meta subfamily
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 588 | 12q24.31 | CAMKK2 | calcium/calmodulin dependent protein kinase kinase 2 | |
Mouse | - | 588 | 5 F | Camkk2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | |
Rat | - | 587 | 12q16 | Camkk2 | calcium/calmodulin-dependent protein kinase kinase 2 |
Database Links | |
Alphafold | Q96RR4 (Hs), Q8C078 (Mm), O88831 (Rn) |
BRENDA | 2.7.11.17 |
ChEMBL Target | CHEMBL5284 (Hs), CHEMBL4295888 (Mm), CHEMBL1795115 (Rn) |
Ensembl Gene | ENSG00000110931 (Hs), ENSMUSG00000029471 (Mm), ENSRNOG00000001309 (Rn) |
Entrez Gene | 10645 (Hs), 207565 (Mm), 83506 (Rn) |
Human Protein Atlas | ENSG00000110931 (Hs) |
KEGG Enzyme | 2.7.11.17 |
KEGG Gene | hsa:10645 (Hs), mmu:207565 (Mm), rno:83506 (Rn) |
OMIM | 615002 (Hs) |
Pharos | Q96RR4 (Hs) |
RefSeq Nucleotide | NM_001270485 (Hs), NM_001199676 (Mm), NM_031338 (Rn) |
RefSeq Protein | NP_006540 (Hs), NP_001186605 (Mm), NP_112628 (Rn) |
UniProtKB | Q96RR4 (Hs), Q8C078 (Mm), O88831 (Rn) |
Wikipedia | CAMKK2 (Hs) |
Selected 3D Structures | |||||||||||||
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Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,5 |
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: CAMKK2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1 |
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Target used in screen: nd/CAMKK2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T et al.. (2011) Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem, 286 (25): 22570-9. [PMID:21504895]
4. Tokumitsu H, Inuzuka H, Ishikawa Y, Ikeda M, Saji I, Kobayashi R. (2002) STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem, 277 (18): 15813-8. [PMID:11867640]
5. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
Meta subfamily: calcium/calmodulin dependent protein kinase kinase 2. Last modified on 30/03/2016. Accessed on 03/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1957.