Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	552	1p32.2	PRKAA2	protein kinase AMP-activated catalytic subunit alpha 2
Mouse	-	552	4 C6	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit
Rat	-	552	5q34	Prkaa2	protein kinase AMP-activated catalytic subunit alpha 2

Previous and Unofficial Names

AMPK alpha-2 chain | ACACA kinase | acetyl-CoA carboxylase kinase | AMP kinase α2 subunit | HMGCR kinase | hydroxymethylglutaryl-CoA reductase kinase | AMPKa2 | AMP-activated protein kinase, alpha 2 catalytic subunit | protein kinase

Database Links
Alphafold	P54646 (Hs), Q8BRK8 (Mm), Q09137 (Rn)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL2116 (Hs), CHEMBL1255154 (Mm), CHEMBL4637 (Rn)
Ensembl Gene	ENSG00000162409 (Hs), ENSMUSG00000028518 (Mm), ENSRNOG00000007706 (Rn)
Entrez Gene	5563 (Hs), 108079 (Mm), 78975 (Rn)
Human Protein Atlas	ENSG00000162409 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:5563 (Hs), mmu:108079 (Mm), rno:78975 (Rn)
OMIM	600497 (Hs)
Pharos	P54646 (Hs)
RefSeq Nucleotide	NM_006252 (Hs), NM_178143 (Mm), NM_023991 (Rn)
RefSeq Protein	NP_006243 (Hs), NP_835279 (Mm), NP_076481 (Rn)
UniProtKB	P54646 (Hs), Q8BRK8 (Mm), Q09137 (Rn)
Wikipedia	PRKAA2 (Hs)

Selected 3D Structures
	Description:  Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain) PDB Id:  2H6D Resolution:  1.85Å Species:  Human References:  3

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,4
Key to terms and symbols		Click column headers to sort
Target used in screen: AMPK-alpha2
Ligand Sp. Type Action Value Parameter JNJ-28312141 Hs Inhibitor Inhibition 8.4 pKd staurosporine Hs Inhibitor Inhibition 7.9 pKd NVP-TAE684 Hs Inhibitor Inhibition 7.3 pKd lestaurtinib Hs Inhibitor Inhibition 7.3 pKd sunitinib Hs Inhibitor Inhibition 7.1 pKd SU-14813 Hs Inhibitor Inhibition 6.5 pKd tozasertib Hs Inhibitor Inhibition 6.5 pKd KW-2449 Hs Inhibitor Inhibition 6.4 pKd midostaurin Hs Inhibitor Inhibition 6.3 pKd tamatinib Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 2...
Key to terms and symbols		Click column headers to sort
Target used in screen: AMPKα2/nd
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM K-252a Hs Inhibitor Inhibition -5.0 1.0 Tpl2 kinase inhibitor Hs Inhibitor Inhibition -5.0 -1.0 Cdk1/2 inhibitor III Hs Inhibitor Inhibition -3.0 0.0 staurosporine Hs Inhibitor Inhibition -2.5 1.0 GSK-3 inhibitor IX Hs Inhibitor Inhibition 1.0 10.0 midostaurin Hs Inhibitor Inhibition 1.0 4.0 indirubin-3'-monoxime Hs Inhibitor Inhibition 1.0 3.0 indirubin derivative E804 Hs Inhibitor Inhibition 3.0 4.0 PKR inhibitor Hs Inhibitor Inhibition 3.0 3.0 SU11652 Hs Inhibitor Inhibition 4.0 4.0
Displaying the top 10 most potent ligands  View all ligands in screen »