seliciclib [Ligand Id: 6035] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL14762 (AL-39256, Cyc-202, CYC-202, NSC-701554, Roscovitin, Roscovitine, R-roscovitine, Seliciclib) |
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 26S protease regulatory subunit 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831205] [UniProtKB: P43686] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530] | ||||||||
| ChEMBL | Binding constant for full-length PDPK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Actin-related protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6090] [UniProtKB: P61160] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Actin-related protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105857] [UniProtKB: P61158] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ACVR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ACVR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037] | ||||||||
| ChEMBL | Binding constant for ACVR2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ACVR2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Acyl-CoA dehydrogenase family member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105816] [UniProtKB: Q6JQN1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Acyl-CoA dehydrogenase family member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105707] [UniProtKB: Q709F0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| AP2 associated kinase 1/Adaptor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Adenine phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105819] [UniProtKB: P07741] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Adenylate kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4938] [UniProtKB: P54819] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| ChEMBL | Binding constant for ALK kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a ALK | B | 5.64 | pKd | 2300 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AMPK-alpha1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646] | ||||||||
| ChEMBL | Binding constant for AMPK-alpha2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/AMP-activated protein kinase, gamma-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase AMP-activated non-catalytic subunit gamma 2/AMP-activated protein kinase, gamma-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2] | ||||||||
| ChEMBL | Binding constant for ANKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ATP-dependent RNA helicase DDX1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010634] [UniProtKB: Q92499] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DDX3X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5553] [UniProtKB: O00571] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DDX42 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105782] [UniProtKB: Q86XP3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BIKE kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BMPR1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BMPR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Brain glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3856] [UniProtKB: P11216] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3] | ||||||||
| ChEMBL | Binding constant for BRSK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3] | ||||||||
| ChEMBL | Binding constant for full-length BRSK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012] | ||||||||
| ChEMBL | Binding constant for full-length CAMK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] | ||||||||
| ChEMBL | Binding constant for CAMK1D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5] | ||||||||
| ChEMBL | Binding constant for CAMK1G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] | ||||||||
| ChEMBL | Binding constant for CAMK2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554] | ||||||||
| ChEMBL | Binding constant for CAMK2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMK2D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMK2G kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9] | ||||||||
| ChEMBL | Binding constant for CAMKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMKK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKAC-alpha kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a PRKACA | B | 4.3 | pIC50 | >50000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length PKAC-beta | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase, cAMP-dependent, catalytic, gamma subunit/cAMP-dependent protein kinase, gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2743] [GtoPdb: 1478] [UniProtKB: P22612] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase, cAMP-dependent, regulatory, type II, alpha subunit/cAMP-dependent protein kinase type II-alpha regulatory subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2221] [GtoPdb: 1474] [UniProtKB: P13861] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Inhibition of recombinant full length human GST-tagged CK1apha expressed in baculovirus using peptide as substrate after 3 hrs by kinase-glo luminescent assay | B | 4.31 | pIC50 | 49000 | nM | IC50 | J Med Chem (2019) 62: 1989-1998 [PMID:30707835] |
| ChEMBL | Inhibition of CK1 after 30 mins by liquid scintillation counter | B | 5.4 | pIC50 | 4000 | nM | IC50 | Eur J Med Chem (2012) 56: 210-216 [PMID:22982525] |
| casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1D | B | 6.59 | pKd | 260 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CSNK1D | B | 6.59 | pKd | 260 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of recombinant N-terminal human GST-tagged CK1delta (1 to 294 residues) expressed in Escherichia coli using RKKKAEpSVASLTSQCSYSS peptide as substrate after 3 hrs by kinase-glo luminescent assay relative to control | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2019) 62: 1989-1998 [PMID:30707835] |
| casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.91 | pKd | 12409 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a CSNK1E | B | 4.91 | pKd | 12409 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Binding constant for full-length CSNK1E | B | 6.49 | pKd | 320 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CSNK1E | B | 6.49 | pKd | 320 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Average Binding Constant for CSNK1E; NA=Not Active at 10 uM | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CSNK1E | B | 6.8 | pKd | 160 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CSNK1G1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Average Binding Constant for CSNK1G1; NA=Not Active at 10 uM | B | 5.48 | pKd | 3300 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CSNK1G1 | B | 5.48 | pKd | 3300 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1G2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Average Binding Constant for CSNK1G2; NA=Not Active at 10 uM | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CSNK1G2 | B | 5.85 | pKd | 1400 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Binding constant for full-length CSNK2A1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK2A2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752] | ||||||||
| ChEMBL | Binding constant for full-length CSNK1A1L | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1G3 | B | 5.54 | pKd | 2900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CSNK1G3 | B | 5.54 | pKd | 2900 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| cyclin dependent kinase 2/CDK2/Cyclin A2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941] | ||||||||
| GtoPdb | CDK2/cyclin A complex used in assay | - | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins in presence of [gamma32P]ATP by beta counting method | B | 5.46 | pIC50 | 3490 | nM | IC50 | J Med Chem (2017) 60: 4949-4962 [PMID:28557430] |
| ChEMBL | Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay | B | 6.71 | pIC50 | 193 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2136-2140 [PMID:31272794] |
| ChEMBL | Inhibition of recombinant human N-terminal GST-tagged CDK2/CyclinA2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate incubated for 10 mins by luminescence based assay | B | 6.96 | pIC50 | 110 | nM | IC50 | Eur J Med Chem (2020) 198: 112322-112322 [PMID:32361064] |
| ChEMBL | Inhibition of recombinant human CDK2/cyclin A after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 7.14 | pIC50 | 72 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| ChEMBL | Inhibition of CDK2/Cyclin A2 (unknown origin) after 10 mins by ADP-Glo reagent based assay | B | 7.36 | pIC50 | 43.2 | nM | IC50 | Eur J Med Chem (2021) 218: 113389-113389 [PMID:33784602] |
| ChEMBL | Inhibition of CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis | B | 9.15 | pIC50 | 0.7 | nM | IC50 | J Med Chem (2022) 65: 6390-6418 [PMID:35485642] |
| cyclin dependent kinase 6/CDK6/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111455] [GtoPdb: 1978] [UniProtKB: P24385, Q00534] | ||||||||
| ChEMBL | Inhibition of CDK6/cyclinD1 assessed as amount of ATP released by luciferase activity based PKLight assay | B | 4.63 | pIC50 | 23500 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| cyclin dependent kinase 6/CDK6/cyclin D3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111448] [GtoPdb: 1978] [UniProtKB: P30281, Q00534] | ||||||||
| ChEMBL | Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamma32P]ATP by beta counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2017) 60: 4949-4962 [PMID:28557430] |
| cyclin dependent kinase 7/CDK7/Cyclin H/MNAT1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038473] [GtoPdb: 1979] [UniProtKB: P50613, P51946, P51948] | ||||||||
| ChEMBL | Inhibition of recombinant full length C-terminal human His-tagged CDK7/cyclin H/N-terminal MAT1 expressed in baculovirus expression system using Cdk7/9 peptide as substrate after 3 hrs by kinase-glo luminescent assay relative to control | B | 5.66 | pIC50 | 2200 | nM | IC50 | J Med Chem (2019) 62: 1989-1998 [PMID:30707835] |
| cyclin dependent kinase 8/CDK8/Cyclin C in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038474] [GtoPdb: 1980] [UniProtKB: P24863, P49336] | ||||||||
| ChEMBL | Inhibition of CDK8/Cyclin C (unknown origin) | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (2022) 65: 6390-6418 [PMID:35485642] |
| cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
| GtoPdb | CDK9/cyclin T complex used in assay | - | 6.1 | pKi | 790 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Inhibition of CDK9/Cyclin T (1 to 330 amino acid residues) (unknown origin) by differential scanning fluorimetry assay | B | 6.1 | pKi | 790 | nM | Ki | J Med Chem (2013) 56: 660-670 [PMID:23252711] |
| ChEMBL | Inhibition of CDK9/CyclinT1 (unknown origin) using (YSPTSPS)2KK as substrate | B | 5.57 | pIC50 | 2694 | nM | IC50 | Eur J Med Chem (2013) 61: 61-72 [PMID:22770608] |
| ChEMBL | Inhibition of human full-length N-terminal GST/His6-tagged CDK9 (1 to 372 residues)/His6-tagged Cyclin-T1 (1 to 726 residues) expressed in sf9 cells using (YSPTSPS)2KK peptide as substrate in presence of [gamma33P]ATP | B | 5.74 | pIC50 | 1800 | nM | IC50 | Eur J Med Chem (2020) 189: 112019-112019 [PMID:31972394] |
| ChEMBL | Inhibition of human recombinant CDK9/cyclin T1 | B | 5.75 | pIC50 | 1770 | nM | IC50 | J Med Chem (2011) 54: 2980-2993 [PMID:21417417] |
| ChEMBL | Inhibition of CDK9/cyclinT assessed as amount of ATP released by luciferase activity based PKLight assay | B | 6.02 | pIC50 | 950 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| ChEMBL | Inhibition of CDK9/CyclinT1 (unknown origin) | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2013) 56: 640-659 [PMID:23301767] |
| ChEMBL | Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus-infected insect cells | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2009) 52: 655-663 [PMID:19128055] |
| ChEMBL | Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus-infected insect cells | B | 6.64 | pIC50 | 230 | nM | IC50 | Eur J Med Chem (2012) 56: 210-216 [PMID:22982525] |
| ChEMBL | Inhibition of recombinant human CDK9/cyclin T expressed in insect cells using CDK7/9-tide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| ChEMBL | Inhibition of CDK9/Cyclin T1 (unknown origin) | B | 9.22 | pIC50 | >0.6 | nM | IC50 | J Med Chem (2022) 65: 6390-6418 [PMID:35485642] |
| Cell cycle and apoptosis regulator protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483141] [UniProtKB: Q8N163] | ||||||||
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a CCAR2 | B | 5.49 | pKd | 3261 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
| ChEMBL | Binding constant for CDK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336] | ||||||||
| ChEMBL | Binding constant for CDK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKG1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237] | ||||||||
| ChEMBL | Binding constant for PRKG2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ADCK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Choline-phosphate cytidylyltransferase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105855] [UniProtKB: P49585] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Chromodomain-helicase-DNA-binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105742] [UniProtKB: Q14839] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length JNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length JNK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for JNK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Inhibition of human recombinant CDK1 | B | 5.62 | pIC50 | 2421 | nM | IC50 | J Med Chem (2013) 56: 6234-6247 [PMID:23829517] |
| ChEMBL | Inhibition of CDK1 (unknown origin) | B | 5.82 | pIC50 | 1500 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| ChEMBL | Inhibition of CDC2 (unknown origin) | B | 6.19 | pIC50 | 650 | nM | IC50 | Eur J Med Chem (2023) 249: 115101-115101 [PMID:36724635] |
| ChEMBL | Inhibition of CDK1 (unknown origin) | B | 6.35 | pIC50 | 450 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
| ChEMBL | Inhibitory concentration against Cyclin dependent kinase 1. | B | 6.35 | pIC50 | 450 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2993-2996 [PMID:12941319] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 1 (CDK1) | B | 6.35 | pIC50 | 450 | nM | IC50 | J Med Chem (2000) 43: 4098-4108 [PMID:11063606] |
| ChEMBL | Inhibition of CDK1 | B | 6.35 | pIC50 | 450 | nM | IC50 | AAPS J (2006) 8: E204-E221 [PMID:16584130] |
| ChEMBL | Inhibition of CDK1 (unknown origin) | B | 6.48 | pIC50 | 330 | nM | IC50 | Eur J Med Chem (2019) 172: 143-153 [PMID:30978559] |
| ChEMBL | Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis. | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (1997) 40: 408-412 [PMID:9046330] |
| ChEMBL | Inhibition of Cdc2 | B | 6.7 | pIC50 | 200 | nM | IC50 | J Nat Prod (2001) 64: 525-526 [PMID:11325241] |
| ChEMBL | Inhibition of CDK1 (unknown origin) | B | 7.09 | pIC50 | 81.7 | nM | IC50 | RSC Med Chem (2022) 13: 1150-1196 [PMID:36325400] |
| cyclin dependent kinase 10/Cyclin-dependent kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795191] [GtoPdb: 1962] [UniProtKB: Q15131] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a CDK1 | B | 5.57 | pIC50 | 2690 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of Cyclin B-cyclin-dependent kinase 1 | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2000) 43: 1282-1292 [PMID:10753466] |
| ChEMBL | Inhibition of recombinant Cyclin-dependent kinase 1-cyclin B | B | 6.35 | pIC50 | 450 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 3283-3286 [PMID:12392733] |
| ChEMBL | Inhibition of cyclin-dependent kinase 1-cyclin B | B | 6.35 | pIC50 | 450 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1703-1704 [PMID:15026054] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of CDK1/cyclin B | B | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem (2011) 19: 6949-6965 [PMID:21982796] |
| ChEMBL | Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins in presence of [gamma32P]ATP by beta counting method | B | 5.1 | pIC50 | 7890 | nM | IC50 | J Med Chem (2017) 60: 4949-4962 [PMID:28557430] |
| ChEMBL | Inhibition of CDK1/Cyclin B (unknown origin) | B | 5.54 | pIC50 | 2900 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3093-3097 [PMID:27189674] |
| ChEMBL | Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP | B | 5.57 | pIC50 | 2690 | nM | IC50 | J Med Chem (2014) 57: 578-599 [PMID:24417566] |
| ChEMBL | Inhibition of CDK1/cyclin B1 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition by mobility shift assay | B | 5.57 | pIC50 | 2690 | nM | IC50 | Eur J Med Chem (2021) 215: 113281-113281 [PMID:33611192] |
| ChEMBL | Inhibition of recombinant CDK1/cyclin B (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATP | B | 5.62 | pIC50 | 2400 | nM | IC50 | Eur J Med Chem (2013) 62: 443-452 [PMID:23399722] |
| ChEMBL | Inhibition of CDK1/cyclinB1 assessed as amount of ATP released by luciferase activity based PKLight assay | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 1-cyclin B1 from starfish. | B | 6.35 | pIC50 | 450 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 793-798 [PMID:9871543] |
| ChEMBL | Inhibition of CDK1/cyclinB | B | 6.35 | pIC50 | 450 | nM | IC50 | Eur J Med Chem (2008) 43: 1469-1477 [PMID:17981370] |
| ChEMBL | Inhibition of CDK2/cyclin B (unknown origin) after 30 mins by scintillation counting | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 125-131 [PMID:23218601] |
| ChEMBL | Inhibition of CDK1/cyclinB (unknown origin) | B | 7.09 | pIC50 | 81.7 | nM | IC50 | Bioorg Med Chem (2020) 28: 115633-115633 [PMID:32773088] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK2 | B | 5.47 | pKd | 3400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CDK2 | B | 5.47 | pKd | 3400 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Average Binding Constant for CDK2; NA=Not Active at 10 uM | B | 5.54 | pKd | 2900 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CDK2 | B | 5.54 | pKd | 2900 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| GtoPdb | CDK2/cyclin A complex used in assay | - | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using IMR90 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4 | pIC50 | >100000 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using CHAGO-K1 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.52 | pIC50 | 30200 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using NCI-H69 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.59 | pIC50 | 26000 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using WI38 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.62 | pIC50 | 24000 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using HS27 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.65 | pIC50 | 22200 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using DU145 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.73 | pIC50 | 18800 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using HT1376 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.74 | pIC50 | 18400 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using HCT15 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.74 | pIC50 | 18300 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MDA-MB-435S cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.76 | pIC50 | 17500 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using A549 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.8 | pIC50 | 15900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MiaPaCa2, mean cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.82 | pIC50 | 15200 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using HT29 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.84 | pIC50 | 14600 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using AN3CA cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.85 | pIC50 | 14100 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MiaPaCa2, median cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.86 | pIC50 | 13900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MiaPaCa2, pancreatic cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.86 | pIC50 | 13900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using A498 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.88 | pIC50 | 13200 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using NCI-H460 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.88 | pIC50 | 13100 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MES-SA cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.92 | pIC50 | 11900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using ACHN cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.92 | pIC50 | 11900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using HepG2 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.95 | pIC50 | 11300 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MCF7 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.96 | pIC50 | 10900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using HCT116 cells, 72 h incubation)) EUB0000650a CDK2 | F | 4.97 | pIC50 | 10700 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cell cytotoxicity in LOVO cells, 72 h)) EUB0000650a CDK2 | F | 5.03 | pIC50 | 9300 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity Phenotypic Cellular interaction: (MTT assay (cytotoxicity using MES-SA/Dx5 cells, 72 h incubation)) EUB0000650a CDK2 | F | 5.1 | pIC50 | 7900 | nM | IC50 | Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of CDK2/Cyclin A | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2008) 43: 2316-2322 [PMID:18313174] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2017) 142: 424-458 [PMID:28911822] |
| ChEMBL | Inhibition of CDK2 | B | 6.15 | pIC50 | 700 | nM | IC50 | AAPS J (2006) 8: E204-E221 [PMID:16584130] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2020) 203: 112571-112571 [PMID:32707525] |
| ChEMBL | Inhibition of CDK2 (unknown origin) in baculovirus infected Sf9 insect cell extract using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2022) 65: 6356-6389 [PMID:35235745] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2023) 249: 115101-115101 [PMID:36724635] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 2 (CDK2/cyclin A) | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 461-464 [PMID:10743948] |
| ChEMBL | Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP | B | 6.3 | pIC50 | 500 | nM | IC50 | Eur J Med Chem (2013) 68: 1-9 [PMID:23933045] |
| ChEMBL | Inhibition of human CDK2 using TMB as substrate preincubated for 210 mins followed by substrate addition and measured after 15 to 25 mins by spectrophotometric analysis | B | 6.37 | pIC50 | 430 | nM | IC50 | Eur J Med Chem (2020) 203: 112571-112571 [PMID:32707525] |
| ChEMBL | Inhibition of CDK2 (unknown origin) after 3 hrs by kinase-glo luminescent assay relative to control | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2019) 62: 1989-1998 [PMID:30707835] |
| ChEMBL | Inhibition of CDK2/Cyclin A by radiometric assay | B | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (2008) 51: 4986-4999 [PMID:18656911] |
| ChEMBL | Inhibition of human recombinant CDK2/cyclin A expressed in baculovirus-infected insect cells | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2009) 52: 655-663 [PMID:19128055] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2019) 172: 143-153 [PMID:30978559] |
| ChEMBL | Binding affinity to CDK2 | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2008) 51: 5035-5042 [PMID:18680271] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2023) 66: 7140-7161 [PMID:37234044] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2020) 63: 13228-13257 [PMID:32866383] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 7.05 | pIC50 | 90 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| ChEMBL | Inhibition of CDK2 (unknown origin) | B | 9.15 | pIC50 | 0.7 | nM | IC50 | J Med Chem (2022) 65: 935-954 [PMID:33970631] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
| GtoPdb | CDK2/cyclin A complex used in assay | - | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Inhibition of CDK2/Cyclin A (174 to 432 amino acid residues) (unknown origin) by differential scanning fluorimetry assay | B | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2013) 56: 660-670 [PMID:23252711] |
| ChEMBL | Inhibition of recombinant Cdk2/cyclinA | B | 5.34 | pIC50 | 4600 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6613-6617 [PMID:19854650] |
| ChEMBL | Inhibition of recombinant CDK2/cyclin A | B | 5.34 | pIC50 | 4600 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6608-6612 [PMID:19846305] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a CDK2 | B | 6.15 | pIC50 | 710 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of Cyclin A-cyclin-dependent kinase 2 | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of CDK2/Cyclin A | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem (2011) 19: 359-373 [PMID:21144757] |
| ChEMBL | Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP | B | 6.15 | pIC50 | 700 | nM | IC50 | Med Chem Res (2010) 19: 817-835 |
| ChEMBL | Inhibition of recombinant human CDK2/cyclin A after 30 mins by scintillation counting | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 125-131 [PMID:23218601] |
| ChEMBL | Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay | B | 6.3 | pIC50 | 500 | nM | IC50 | Eur J Med Chem (2011) 46: 5825-5832 [PMID:22000924] |
| ChEMBL | Inhibition of human recombinant CDK2/cyclin A expressed in baculovirus-infected insect cells | B | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2012) 56: 210-216 [PMID:22982525] |
| ChEMBL | Inhibition of CDK2-cyclinA in the presence of 20uM ATP | B | 6.85 | pIC50 | 140 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| ChEMBL | Inhibition of CDK2/Cyclin A (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2013) 56: 640-659 [PMID:23301767] |
| ChEMBL | Inhibition of human Cdk2/cyclin A activity | B | 6.82 | pEC50 | 151 | nM | EC50 | ACS Med Chem Lett (2012) 3: 985-990 [PMID:24936234] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
| GtoPdb | CDK2/cyclin A complex used in assay | - | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Inhibition of Cyclin E-cyclin-dependent kinase 2 | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of cyclic dependent kinase 2 (CDK2)/cyclin E | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2001) 44: 524-530 [PMID:11170642] |
| ChEMBL | Inhibition of recombinant CDK2/cyclin E | B | 6.28 | pIC50 | 520 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6608-6612 [PMID:19846305] |
| ChEMBL | Inhibition of Cdk2/cyclinE | B | 6.28 | pIC50 | 520 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6613-6617 [PMID:19854650] |
| ChEMBL | Inhibition of CDK2/cyclin E | B | 7 | pIC50 | 100 | nM | IC50 | Cancer Res (2005) 65: 5399-5407 [PMID:15958589] |
| ChEMBL | Affinity Biochemical interaction: (Radiometric kinase assay (CDK2/cyclin E)) EUB0000650a CDK2 | B | 7 | pIC50 | 100 | nM | IC50 | Affinity Biochemical Literature for EUbOPEN Chemogenomic Library |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
| GtoPdb | CDK2/cyclin A complex used in assay | - | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) | B | 6.15 | pIC50 | 707.95 | nM | IC50 | Eur J Med Chem (2016) 108: 701-719 [PMID:26741853] |
| ChEMBL | Inhibition of GST-fused CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP | B | 6.15 | pIC50 | 700 | nM | IC50 | Med Chem Res (2010) 19: 817-835 |
| ChEMBL | Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins in presence of [gamma32P]ATP by beta counting method | B | 6.21 | pIC50 | 620 | nM | IC50 | J Med Chem (2017) 60: 4949-4962 [PMID:28557430] |
| ChEMBL | Inhibition of human recombinant CDK2/cyclin E | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2011) 54: 2980-2993 [PMID:21417417] |
| ChEMBL | Competitive reversible inhibition of CDK2/cyclin E (unknown origin) | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126637-126637 [PMID:31477350] |
| ChEMBL | Inhibition of CDK2/cyclin E | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem (2011) 19: 6949-6965 [PMID:21982796] |
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2016) 108: 701-719 [PMID:26741853] |
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate | B | 6.74 | pIC50 | 180 | nM | IC50 | Eur J Med Chem (2013) 61: 61-72 [PMID:22770608] |
| ChEMBL | Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2013) 56: 6234-6247 [PMID:23829517] |
| ChEMBL | Inhibition of recombinant CDK2/cyclin E (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATP | B | 6.77 | pIC50 | 170 | nM | IC50 | Eur J Med Chem (2013) 62: 443-452 [PMID:23399722] |
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP | B | 6.8 | pIC50 | 158 | nM | IC50 | Eur J Med Chem (2016) 110: 291-301 [PMID:26851505] |
| ChEMBL | Inhibition of CDK2/cyclinE assessed as amount of ATP released by luciferase activity based PKLight assay | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| ChEMBL | Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells in presence of [gamma33P]ATP | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2020) 63: 7458-7474 [PMID:32150405] |
| ChEMBL | Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells using histone H1 as substrate in presence of [gamma33P]ATP | B | 7 | pIC50 | 100 | nM | IC50 | Eur J Med Chem (2020) 189: 112019-112019 [PMID:31972394] |
| ChEMBL | Inhibition of human CDK2/cyclin E (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition by mobility shift assay | B | 7 | pIC50 | 100 | nM | IC50 | Eur J Med Chem (2021) 215: 113281-113281 [PMID:33611192] |
| ChEMBL | Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2014) 57: 578-599 [PMID:24417566] |
| ChEMBL | Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP | B | 7 | pIC50 | 100 | nM | IC50 | Eur J Med Chem (2014) 78: 217-224 [PMID:24681986] |
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) using histone H1 as substrate by [gamma-33P]ATP assay | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603] |
| ChEMBL | Inhibition of CDK2/Cyclin E (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3093-3097 [PMID:27189674] |
| ChEMBL | Inhibition of His-tagged CDK2/cyclin E1 (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of ATP and [gamma33-P]ATP by radioisotope filter binding assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2022) 65: 8881-8896 [PMID:35749742] |
| cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 4 (CDK4/cyclin Dl) | B | 4 | pIC50 | 100000 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 461-464 [PMID:10743948] |
| ChEMBL | Inhibition of CDK4 | B | 4 | pIC50 | >100000 | nM | IC50 | AAPS J (2006) 8: E204-E221 [PMID:16584130] |
| ChEMBL | Inhibition of CDK4 (unknown origin) | B | 4.79 | pIC50 | 16400 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| ChEMBL | Inhibition of CDK4 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2019) 172: 143-153 [PMID:30978559] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| ChEMBL | Inhibition of Cyclin D1-cyclin-dependent kinase 4 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of CDK4/cyclin D1 | B | 4.57 | pIC50 | 27000 | nM | IC50 | Bioorg Med Chem (2011) 19: 6949-6965 [PMID:21982796] |
| ChEMBL | Inhibition of His-6-tagged recombinant human CDK4/cyclinD1 using GST-retinoblastoma (773 to 928) as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP | B | 4.85 | pIC50 | 14210 | nM | IC50 | J Med Chem (2014) 57: 578-599 [PMID:24417566] |
| ChEMBL | Inhibition of human CDK4/cyclin D (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition by mobility shift assay | B | 4.85 | pIC50 | 14210 | nM | IC50 | Eur J Med Chem (2021) 215: 113281-113281 [PMID:33611192] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a CDK4 | B | 4.85 | pIC50 | 14210 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of CDK4/cyclinD1 assessed as amount of ATP released by luciferase activity based PKLight assay | B | 4.87 | pIC50 | 13500 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Average Binding Constant for CDK5; NA=Not Active at 10 uM | B | 5.7 | pKd | 2000 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CDK5 | B | 5.7 | pKd | 2000 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Binding constant for full-length CDK5 | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CDK5 | B | 5.72 | pKd | 1900 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATP | B | 5.97 | pIC50 | 1069 | nM | IC50 | Eur J Med Chem (2016) 110: 291-301 [PMID:26851505] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 6.57 | pIC50 | 270 | nM | IC50 | Eur J Med Chem (2019) 172: 143-153 [PMID:30978559] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2019) 164: 615-639 [PMID:30639897] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2023) 249: 115101-115101 [PMID:36724635] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a CDK5 | B | 6.8 | pIC50 | 160 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of CDK5 | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2011) 19: 359-373 [PMID:21144757] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2017) 142: 424-458 [PMID:28911822] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2020) 203: 112571-112571 [PMID:32707525] |
| ChEMBL | Inhibition of CDK5 | B | 6.8 | pIC50 | 160 | nM | IC50 | AAPS J (2006) 8: E204-E221 [PMID:16584130] |
| ChEMBL | Inhibition of CDK5 (unknown origin) | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2022) 65: 935-954 [PMID:33970631] |
| Cyclin-dependent kinase 5 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5169144] [UniProtKB: Q02399] | ||||||||
| ChEMBL | Inhibition of bovine brain CDK5 using histone H1 as substrate incubated for 15 mins in presence of [gamma-32P]ATP by radiometric scintillation assay | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2022) 65: 6356-6389 [PMID:35235745] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibition of CDK5/P35 (unknown origin) using histone H1 as substrate | B | 5.97 | pIC50 | 1080 | nM | IC50 | Eur J Med Chem (2013) 61: 61-72 [PMID:22770608] |
| ChEMBL | Inhibition of human recombinant CDK5/p35 | B | 6.03 | pIC50 | 940 | nM | IC50 | J Med Chem (2011) 54: 2980-2993 [PMID:21417417] |
| ChEMBL | Inhibition of CDK5/p25 (unknown origin) after 30 mins by SDS-PAGE analysis | B | 6.03 | pIC50 | 930 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5150-5154 [PMID:23927974] |
| ChEMBL | Inhibition of Cyclin-dependent kinase 5-p35nck5a | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 1129-1132 [PMID:11909733] |
| ChEMBL | Inhibition of human recombinant CDK5/p25 expressed in Escherichia coli | B | 6.55 | pIC50 | 280 | nM | IC50 | Eur J Med Chem (2012) 56: 210-216 [PMID:22982525] |
| ChEMBL | Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into biotinylated PKTPKKAKKL substrate after 60 mins by scintillation counting | B | 6.55 | pIC50 | 280 | nM | IC50 | Eur J Med Chem (2011) 46: 2066-2074 [PMID:21420204] |
| ChEMBL | Inhibition of human recombinant CDK5/p25 using [gamma-33P]ATP after 30 mins incubation by scintillation counting analysis | B | 6.55 | pIC50 | 280 | nM | IC50 | Eur J Med Chem (2014) 83: 617-629 [PMID:24998602] |
| ChEMBL | Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay | B | 6.57 | pIC50 | 270 | nM | IC50 | ACS Med Chem Lett (2019) 10: 786-791 [PMID:31098000] |
| ChEMBL | Inhibition of human recombinant CDK5/p25 expressed in Escherichia coli | B | 6.57 | pIC50 | 270 | nM | IC50 | J Med Chem (2009) 52: 655-663 [PMID:19128055] |
| ChEMBL | Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counter | B | 6.57 | pIC50 | 270 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2098-2101 [PMID:21353545] |
| ChEMBL | Inhibition of cyclin-dependent kinase 5/p25; range 0.1-0.2 | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2005) 48: 671-679 [PMID:15689152] |
| ChEMBL | Inhibition of recombinant human CDK5/p25 after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| ChEMBL | Inhibition of recombinant human CDK5/p25 after 30 mins by scintillation counting | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 125-131 [PMID:23218601] |
| ChEMBL | Inhibition of human recombinant CDK5/P25 using myelin basic protein substrate | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2012) 57: 225-233 [PMID:23063566] |
| ChEMBL | Inhibition of CDK5/p25 | B | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2008) 43: 1469-1477 [PMID:17981370] |
| ChEMBL | Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2011) 19: 359-373 [PMID:21144757] |
| ChEMBL | Inhibition of human Cyclin-dependent kinase 5-p35nck5a | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1703-1704 [PMID:15026054] |
| cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Inhibition of CDK6 (unknown origin) | B | 4.61 | pIC50 | 24500 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.43 | pKd | 3705 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a CDK7 | B | 5.43 | pKd | 3705 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Binding constant for full-length CDK7 | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CDK7 | B | 5.74 | pKd | 1800 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of CDK7 (unknown origin) | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2019) 172: 143-153 [PMID:30978559] |
| ChEMBL | Inhibition of CDK7 (unknown origin) | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2020) 63: 7458-7474 [PMID:32150405] |
| ChEMBL | Inhibition of CDK7 (unknown origin) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2020) 63: 13228-13257 [PMID:32866383] |
| ChEMBL | Inhibition of CDK7 (unknown origin) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2023) 66: 7140-7161 [PMID:37234044] |
| ChEMBL | Inhibition of CDK7 (unknown origin) | B | 6.32 | pIC50 | 480 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613, P51946] | ||||||||
| ChEMBL | Inhibition of human recombinant CDK7/cyclin H expressed in baculovirus-infected insect cells | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2009) 52: 655-663 [PMID:19128055] |
| ChEMBL | Inhibition of CDK7/CyclinH/MAT1 (unknown origin) using (YSPTSPS)2KK as substrate | B | 6.1 | pIC50 | 793 | nM | IC50 | Eur J Med Chem (2013) 61: 61-72 [PMID:22770608] |
| ChEMBL | Inhibition of CDK7/cyclinH/MAT1 assessed as amount of ATP released by luciferase activity based PKLight assay | B | 6.27 | pIC50 | 540 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| ChEMBL | Competitive irreversible inhibition of CDK7/cyclinH (unknown origin) | B | 6.28 | pIC50 | 520 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126637-126637 [PMID:31477350] |
| ChEMBL | Inhibition of CDK7/cyclin H | B | 6.28 | pIC50 | 520 | nM | IC50 | Bioorg Med Chem (2011) 19: 6949-6965 [PMID:21982796] |
| ChEMBL | Inhibition of CDK7/cyclin H (unknown origin) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2013) 56: 640-659 [PMID:23301767] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a CDK7 | B | 6.31 | pIC50 | 490 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP | B | 6.31 | pIC50 | 490 | nM | IC50 | J Med Chem (2014) 57: 578-599 [PMID:24417566] |
| ChEMBL | Inhibition of human CDK7/cyclin H (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition by mobility shift assay | B | 6.31 | pIC50 | 490 | nM | IC50 | Eur J Med Chem (2021) 215: 113281-113281 [PMID:33611192] |
| ChEMBL | Inhibition of human recombinant CDK7/cyclin H/MAT1 | B | 6.32 | pIC50 | 480 | nM | IC50 | J Med Chem (2011) 54: 2980-2993 [PMID:21417417] |
| ChEMBL | Inhibition of CDK7/cyclin H | B | 6.44 | pIC50 | 360 | nM | IC50 | Cancer Res (2005) 65: 5399-5407 [PMID:15958589] |
| ChEMBL | Inhibition of CDK7/Cyclin H (unknown origin) | B | 9.34 | pIC50 | 0.46 | nM | IC50 | J Med Chem (2022) 65: 6390-6418 [PMID:35485642] |
| cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| ChEMBL | Binding constant for full-length CDK9 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.31 | pKd | 4860 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a CDK9 | B | 5.31 | pKd | 4860 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| GtoPdb | CDK9/cyclin T complex used in assay | - | 6.1 | pKi | 790 | nM | Ki | J Med Chem (2013) 56: 660-70 [PMID:23252711] |
| ChEMBL | Inhibition of CDK9 (unknown origin) | B | 5.98 | pIC50 | 1050 | nM | IC50 | Eur J Med Chem (2019) 183: 111641-111641 [PMID:31514062] |
| ChEMBL | Inhibition of CDK9 (unknown origin) | B | 6.64 | pIC50 | 230 | nM | IC50 | Eur J Med Chem (2019) 172: 143-153 [PMID:30978559] |
| ChEMBL | Inhibition of CDK9 (unknown origin) | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2020) 63: 13228-13257 [PMID:32866383] |
| ChEMBL | Inhibition of CDK9 (unknown origin) | B | 6.64 | pIC50 | 230 | nM | IC50 | J Med Chem (2023) 66: 7140-7161 [PMID:37234044] |
| cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 5/Cyclin-T1/Cyclin-dependent-like kinase 5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885549] [GtoPdb: 1977] [UniProtKB: O60563, Q00535] | ||||||||
| ChEMBL | Inhibition of CDK5/cyclinT assessed as amount of ATP released by luciferase activity based PKLight assay | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2010) 53: 8508-8522 [PMID:21080703] |
| Cysteine--tRNA ligase, cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105937] [UniProtKB: P49589] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Cytochrome c1, heme protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105975] [UniProtKB: P08574] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| dCTP pyrophosphatase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769292] [UniProtKB: Q9H773] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355] | ||||||||
| ChEMBL | Binding constant for DAPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4] | ||||||||
| ChEMBL | Binding constant for full-length DAPK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
| ChEMBL | Binding constant for full-length DLK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for DAPK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Delta(24)-sterol reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331059] [UniProtKB: Q15392] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Deoxycytidine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2447] [UniProtKB: P27707] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for DDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| DnaJ homolog subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189122] [UniProtKB: P31689] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA replication licensing factor MCM4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105745] [UniProtKB: P33991] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA topoisomerase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MEK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MEK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MEK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MEK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Average Binding Constant for CLK1; NA=Not Active at 10 uM | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CLK1 | B | 5.68 | pKd | 2100 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Binding constant for full-length CLK1 | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CLK1 | B | 5.92 | pKd | 1200 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518] | ||||||||
| ChEMBL | Inhibition of mouse recombinant CLK1 expressed in Escherichia coli after 30 mins by liquid scintillation counter | B | 5.37 | pIC50 | 4300 | nM | IC50 | Eur J Med Chem (2012) 56: 210-216 [PMID:22982525] |
| ChEMBL | Inhibition of recombinant GST-tagged mouse CLK1 expressed in Escherichia coli using RS peptide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CLK2 kinase domain | B | 6.15 | pKd | 700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a CLK2 | B | 6.15 | pKd | 700 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Average Binding Constant for CLK2; NA=Not Active at 10 uM | B | 6.33 | pKd | 470 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CLK2 | B | 6.33 | pKd | 470 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491] | ||||||||
| ChEMBL | Inhibition of recombinant GST-tagged mouse CLK2 expressed in Escherichia coli using RS peptide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 6.15 | pIC50 | 710 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
| ChEMBL | Binding constant for full-length CLK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492] | ||||||||
| ChEMBL | Inhibition of recombinant GST-tagged mouse CLK3 expressed in Escherichia coli using RS peptide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
| ChEMBL | Binding constant for CLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Average Binding Constant for CLK4; NA=Not Active at 10 uM | B | 5.35 | pKd | 4500 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CLK4 | B | 5.35 | pKd | 4500 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493] | ||||||||
| ChEMBL | Inhibition of recombinant GST-tagged mouse CLK4 expressed in Escherichia coli using RS peptide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 6.21 | pIC50 | 620 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Average Binding Constant for TTK; NA=Not Active at 10 uM | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a TTK | B | 5.68 | pKd | 2100 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Binding constant for TTK kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition binding assay) EUB0000650a TTK | B | 5.8 | pKd | 1600 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TESK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470] | ||||||||
| ChEMBL | Inhibition of rat recombinant GST-tagged DYRK1A expressed in Escherichia coli using myelin basic protein substrate | B | 4.96 | pIC50 | 11000 | nM | IC50 | Eur J Med Chem (2012) 57: 225-233 [PMID:23063566] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.39 | pKd | 40291 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a DYRK1A | B | 4.39 | pKd | 40291 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of human recombinant DYRK1A | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Nat Prod (2008) 71: 689-692 [PMID:18271552] |
| ChEMBL | Inhibition of Dyrk1 autophosphorylation | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2324-2328 [PMID:19282176] |
| ChEMBL | Inhibition of human GST-fused DYRK1A expressed in Escherichia coli using KISGRLSPIMTEQ as substrate | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2013) 56: 9569-9585 [PMID:24188002] |
| ChEMBL | Inhibition of DYRK1A (unknown origin) by cell-based assay | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2018) 61: 9791-9810 [PMID:29985601] |
| ChEMBL | Inhibition of human recombinant DYRK1A expressed in Escherichia coli after 30 mins by liquid scintillation counter | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2012) 56: 210-216 [PMID:22982525] |
| ChEMBL | Inhibition of recombinant GST-tagged human DYRK1A expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4750] [GtoPdb: 2009] [UniProtKB: Q61214] | ||||||||
| ChEMBL | Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3772-3776 [PMID:16698266] |
| dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
| ChEMBL | Binding constant for full-length DYRK1B | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000650a DYRK1B | B | 5.96 | pKd | 1100 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of recombinant GST-tagged human DYRK1B expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
| ChEMBL | Inhibition of recombinant GST-tagged human DYRK2 expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 5.77 | pIC50 | 1700 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] | ||||||||
| ChEMBL | Inhibition of recombinant GST-tagged human DYRK3 expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [gamma-33P] by scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2018) 158: 1-6 [PMID:30199702] |
| Dynamin-like 120 kDa protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105705] [UniProtKB: O60313] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Electron transfer flavoprotein subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105744] [UniProtKB: P38117] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Elongation factor Tu, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105970] [UniProtKB: P49411] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
| ChEMBL | Binding constant for EPHA3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33] | ||||||||
| ChEMBL | Binding constant for EPHA6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] | ||||||||
| ChEMBL | Binding constant for EPHA8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
| ChEMBL | Binding constant for EPHB1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EGFR(E746-A750del) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(G719C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(G719S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L747-E749del, A750P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L747-T751del,Sins) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L858R) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L861Q) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(S752-I759del) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L747-S752del, P753S) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for DDR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8] | ||||||||
| ChEMBL | Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Exosome RNA helicase MTR4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105889] [UniProtKB: P42285] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ferrochelatase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879831] [UniProtKB: P22830] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FGFR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
| ChEMBL | Binding constant for FGFR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Binding constant for FGFR3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FGFR3(G697C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
| ChEMBL | Binding constant for FGFR4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PTK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| General transcription and DNA repair factor IIH helicase subunit XPD in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105743] [UniProtKB: P18074] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.92 | pKd | 12022 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a ERCC2 | B | 4.92 | pKd | 12020 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| Glycine--tRNA ligase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105815] [UniProtKB: P41250] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length GSK3A | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length GSK3B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| GTP-binding nuclear protein Ran in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741190] [UniProtKB: P62826] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Haem oxygenase 2/Heme oxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MET kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length IKK-epsilon | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for IGF1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for INSR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616] | ||||||||
| ChEMBL | Binding constant for INSRR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
| ChEMBL | Binding constant for PRKR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for IRAK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Isoleucine--tRNA ligase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105821] [UniProtKB: Q9NSE4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376] | ||||||||
| ChEMBL | Binding constant for LTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length LIMK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length LIMK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Liver glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2568] [UniProtKB: P06737] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Long-chain-fatty-acid--CoA ligase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105818] [UniProtKB: Q9ULC5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| ChEMBL | Binding constant for CSF1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAPKAPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAPKAPK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length ERK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1) | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of ERK1 | B | 4.47 | pIC50 | 34000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length ERK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Inhibition of N-terminal GST-tagged recombinant full-length human MAPK1 expressed in Escherichia coli using MBP1 as substrate after 3 hrs by kinase-glo luminescent assay relative to control | B | 4.12 | pIC50 | 75000 | nM | IC50 | J Med Chem (2019) 62: 1989-1998 [PMID:30707835] |
| ChEMBL | Inhibition of ERK2 | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem (2011) 19: 6949-6965 [PMID:21982796] |
| ChEMBL | Inhibition of Mitogen-activated protein kinase 1 (MAPK-ERK2) | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of ERK2 | B | 4.85 | pIC50 | 14000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a MAPK1 | B | 5.93 | pIC50 | 1170 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
| ChEMBL | Binding constant for full-length MKNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length p38-alpha | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a MAPK14 | B | 4.7 | pIC50 | >20000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length p38-beta | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
| ChEMBL | Binding constant for full-length p38-gamma | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
| ChEMBL | Binding constant for MKNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MARK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MARK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MELK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Midasin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105779] [UniProtKB: Q9NU22] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ERK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152] | ||||||||
| ChEMBL | Binding constant for ERK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659] | ||||||||
| ChEMBL | Binding constant for ERK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ERK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] | ||||||||
| ChEMBL | Binding constant for MLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP3K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP3K5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
| ChEMBL | Binding constant for MLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| BUB1 mitotic checkpoint serine/threonine kinase/Mitotic checkpoint serine/threonine-protein kinase BUB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1772932] [GtoPdb: 1949] [UniProtKB: O43683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ZAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Multifunctional protein ADE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5922] [UniProtKB: P22234] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] | ||||||||
| ChEMBL | Binding constant for MUSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Myosin-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105746] [UniProtKB: P35580] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Myosin-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105888] [UniProtKB: Q7Z406] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| myosin IIIA/Myosin IIIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4] | ||||||||
| ChEMBL | Binding constant for MYO3A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| myosin IIIB/Myosin-IIIB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4] | ||||||||
| ChEMBL | Binding constant for MYO3B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| myosin light chain kinase 3/Myosin light chain kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3] | ||||||||
| ChEMBL | Binding constant for MYLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6] | ||||||||
| ChEMBL | Binding constant for SgK085 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799] | ||||||||
| ChEMBL | Binding constant for MLCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MYLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013] | ||||||||
| ChEMBL | Binding constant for DMPK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TRKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Binding constant for TRKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length TNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| ChEMBL | Binding constant for TRKC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285] | ||||||||
| ChEMBL | Binding constant for ARK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SNARK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Nucleolar GTP-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105780] [UniProtKB: Q9BZE4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Obg-like ATPase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105704] [UniProtKB: Q9NTK5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Peroxisomal acyl-coenzyme A oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105748] [UniProtKB: Q15067] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Peroxisomal acyl-coenzyme A oxidase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105817] [UniProtKB: O15254] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Phenylalanine--tRNA ligase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105969] [UniProtKB: Q9NSD9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Phosphatidylethanolamine-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105856] [UniProtKB: P30086] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755] | ||||||||
| ChEMBL | Binding constant for full-length PIP5K1A | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 alpha/Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795194] [GtoPdb: 2858] [UniProtKB: P48426] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356] | ||||||||
| ChEMBL | Binding constant for full-length PIP5K2B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Phosphofructokinase platelet type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2972] [UniProtKB: Q01813] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816] | ||||||||
| ChEMBL | Binding constant for full-length PHKG1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PHKG2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Binding constant for PIK3CA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PIK3CA(E545K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127] | ||||||||
| ChEMBL | Binding constant for CDC2L1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88] | ||||||||
| ChEMBL | Binding constant for CDC2L2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Inhibitory activity against Plasmodium falciparum D6 | F | 4.48 | pIC50 | 33000 | nM | IC50 | J Med Chem (2003) 46: 3877-3882 [PMID:12930149] |
| ChEMBL | Inhibitory activity against Plasmodium falciparum W2 | F | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2003) 46: 3877-3882 [PMID:12930149] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.55 | pIC50 | 28000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | Antiplasmodial activity against blood stage plasmodium falciparum assessed as inhibition of parasite growth | F | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (2022) 65: 13172-13197 [PMID:36166733] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
| ChEMBL | Binding constant for PDGFRA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PDGFRB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Probable ATP-dependent RNA helicase DDX6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105783] [UniProtKB: P26196] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Radiometric kinase assay) EUB0000650a PRKCA | B | 4 | pIC50 | >100000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKCD kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| ChEMBL | Binding constant for PRKCE kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
| ChEMBL | Binding constant for PRKCH kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| ChEMBL | Binding constant for PRKD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKD3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKCQ kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase N1/Protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKN1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKN2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length PTK2B | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| ChEMBL | Binding constant for MERTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| ChEMBL | Binding constant for ROS1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Putative heat shock protein HSP 90-beta 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105858] [UniProtKB: Q58FF8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Rab-like protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105853] [UniProtKB: Q5HYI8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ras-related protein Rab-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105971] [UniProtKB: P61026] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| RAB27A, member RAS oncogene family/Ras-related protein Rab-27A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105702] [GtoPdb: 2916] [UniProtKB: P51159] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| ChEMBL | Binding constant for RIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
| ChEMBL | Binding constant for ERBB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349] | ||||||||
| ChEMBL | Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RPS6KA2(Kin.Dom.2 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Average Binding Constant for RPS6KA2 (Kin.Dom. 1); NA=Not Active at 10 uM | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a RPS6KA2 | B | 5.49 | pKd | 3200 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.1 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| RNA cytidine acetyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105935] [UniProtKB: Q9H0A0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| S-adenosylmethionine synthase isoform type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313835] [UniProtKB: P31153] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Septin-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105891] [UniProtKB: Q9UHD8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LOK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length LKB1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for STK16 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5] | ||||||||
| ChEMBL | Binding constant for DRAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768] | ||||||||
| ChEMBL | Binding constant for full-length DRAK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MST3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506] | ||||||||
| ChEMBL | Binding constant for YSK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57] | ||||||||
| ChEMBL | Binding constant for full-length YANK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6] | ||||||||
| ChEMBL | Binding constant for YANK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3] | ||||||||
| ChEMBL | Binding constant for full-length STK33 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7] | ||||||||
| ChEMBL | Binding constant for STK36 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1] | ||||||||
| ChEMBL | Binding constant for NDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AKT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AKT2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AKT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AURKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AURKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9] | ||||||||
| ChEMBL | Binding constant for full-length AURKC | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BRAF kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for BRAF(V600E) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CHEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MARK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKD2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075] | ||||||||
| ChEMBL | Binding constant for DCAMKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568] | ||||||||
| ChEMBL | Binding constant for DCAMKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098] | ||||||||
| ChEMBL | Binding constant for DCAMKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for GAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| integrin linked kinase/Serine/threonine-protein kinase ILK-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LATS1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7] | ||||||||
| ChEMBL | Binding constant for LATS2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2] | ||||||||
| ChEMBL | Binding constant for MARK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MRCKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MRCKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for DMPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MST1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MST2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MST4 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase N3/Serine/threonine-protein kinase N3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3627581] [GtoPdb: 1522] [UniProtKB: Q6P5Z2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8] | ||||||||
| ChEMBL | Binding constant for NEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
| ChEMBL | Binding constant for NEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length NEK7 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length NLK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
| ChEMBL | Binding constant for PAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PAK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914] | ||||||||
| ChEMBL | Binding constant for full-length PAK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
| ChEMBL | Binding constant for PAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.3 | pKd | 5024 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Selectivity interaction (Competition-binding assay (Kinases and other enzymes) ) EUB0000650a PAK4 | B | 5.3 | pKd | 5024 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Inhibition of PAK4 in the presence of 5uM ATP | B | 5.16 | pIC50 | 6900 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5] | ||||||||
| ChEMBL | Binding constant for PAK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286] | ||||||||
| ChEMBL | Binding constant for PAK7/PAK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PCTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Average Binding Constant for PCTK1; NA=Not Active at 10 uM | B | 6 | pKd | 990 | nM | Kd | Nat Biotechnol (2005) 23: 329-336 [PMID:15711537] |
| ChEMBL | Selectivity interaction (Kinase panel (competition-binding assay, literature)) EUB0000650a CDK16 | B | 6 | pKd | 990 | nM | Kd | Selectivity Literature for EUbOPEN Chemogenomic Library |
| cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length PCTK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002] | ||||||||
| ChEMBL | Binding constant for full-length PCTK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921] | ||||||||
| ChEMBL | Binding constant for full-length PFTK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PIM1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PIM2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
| ChEMBL | Binding constant for PIM3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
| ChEMBL | Binding constant for PLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PLK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817] | ||||||||
| ChEMBL | Binding constant for full-length PRKX | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| ChEMBL | Binding constant for RAF1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
| ChEMBL | Binding constant for ACVRL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2] | ||||||||
| ChEMBL | Binding constant for full-length RIOK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730] | ||||||||
| ChEMBL | Binding constant for full-length RIOK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RIPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059] | ||||||||
| ChEMBL | Binding constant for SNF1LK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length SNF1LK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4] | ||||||||
| ChEMBL | Binding constant for full-length SRPK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362] | ||||||||
| ChEMBL | Binding constant for full-length SRPK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18] | ||||||||
| ChEMBL | Binding constant for full-length TNNI3K | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8] | ||||||||
| ChEMBL | Binding constant for TLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8] | ||||||||
| ChEMBL | Binding constant for TLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for WEE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Signal recognition particle receptor subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105934] [UniProtKB: P08240] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Binding constant for KIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(D816V) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(V559D,T670I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(V559D,V654A) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(V559D) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to human KIT incubated for 1 hr by kinase binding assay | B | 5 | pKd | >10000 | nM | Kd | Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632] |
| ChEMBL | Binding affinity to human KIT D816V mutant incubated for 1 hr by kinase binding assay | B | 5 | pKd | >10000 | nM | Kd | Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632] |
| Structural maintenance of chromosomes protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105747] [UniProtKB: Q14683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Structural maintenance of chromosomes protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105890] [UniProtKB: O95347] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Synapsin-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3817719] [UniProtKB: P17599] | ||||||||
| ChEMBL | Inhibition of bovine brain synapsin-1 incubated for 1 hr by ATP-[gamma35S] binding assay | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2016) 59: 4121-4151 [PMID:27046190] |
| testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7] | ||||||||
| ChEMBL | Binding constant for full-length TSSK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TGFBR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TGFBR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Thyroid hormone receptor-associated protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105820] [UniProtKB: Q9Y2W1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TP53 regulating kinase/TP53-regulating kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TNIK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tubulin alpha 1a/Tubulin alpha-1 chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370] | ||||||||
| ChEMBL | Binding constant for ERBB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKMYT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TNK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ABL1(E255K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(H396P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(M351T) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(T315I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(Y253F) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(Q252H) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2014) 78: 217-224 [PMID:24681986] |
| ChEMBL | Inhibition of Abl (unknown origin) using GGEAIYAAPFKK peptide as substrate by [gamma-33P]ATP assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603] |
| ChEMBL | Inhibition of Abl (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3093-3097 [PMID:27189674] |
| ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ABL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
| ChEMBL | Binding constant for BLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813] | ||||||||
| ChEMBL | Binding constant for full-length BMX | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PTK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length BTK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| FER tyrosine kinase/Tyrosine-protein kinase FER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FER kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FES kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FGR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FYN kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for HCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
| ChEMBL | Binding constant for ITK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for JAK1(Kin.Dom.1/JH2 - pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LYN kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FLT3(ITD) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3(N841I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3(D835H) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3(D835Y) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RET kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RET(M918T) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590] | ||||||||
| ChEMBL | Binding constant for TIE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418] | ||||||||
| ChEMBL | Binding constant for TYRO3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| ChEMBL | Binding constant for AXL kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SRC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6] | ||||||||
| ChEMBL | Binding constant for SRMS kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SYK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TEC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
| ChEMBL | Binding constant for TIE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] | ||||||||
| ChEMBL | Binding constant for TXK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for YES kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Binding constant for ZAP70 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Tyrosyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3179] [UniProtKB: P54577] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| U5 small nuclear ribonucleoprotein 200 kDa helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105972] [UniProtKB: O75643] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| UMP-CMP kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5681] [UniProtKB: P30085] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| aarF domain containing kinase 1/Uncharacterized aarF domain-containing protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53] | ||||||||
| ChEMBL | Binding constant for full-length ADCK4 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Uncharacterized protein FLJ45252 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105933] [UniProtKB: Q6ZSR9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | Binding constant for FLT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Binding constant for VEGFR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
| ChEMBL | Binding constant for FLT4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105892] [UniProtKB: P49748] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 4.63 | pIC50 | 23400 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
| ChEMBL | Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp method | F | 4.56 | pEC50 | 27580 | nM | EC50 | ACS Med Chem Lett (2012) 3: 985-990 [PMID:24936234] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
