Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Associated Proteins
- Functional Characteristics
- Ion Selectivity and Conductance
- Voltage Dependence
- Gating Inhibitors
- Channel Blockers
- Tissue Distribution
- Functional Assays
- Physiological Functions
- Physiological Consequences of Altering Gene Expression
- Phenotypes, Alleles and Disease Models
- Clinically-Relevant Mutations and Pathophysiology
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 24 | 0 | 2339 | 9q34.3 | CACNA1B | calcium voltage-gated channel subunit alpha1 B | |
| Mouse | 24 | 0 | 2327 | 2 16.58 cM | Cacna1b | calcium channel, voltage-dependent, N type, alpha 1B subunit | |
| Rat | 24 | 0 | 2336 | 3p13 | Cacna1b | calcium voltage-gated channel subunit alpha1 B | |
| Previous and Unofficial Names |
| CACNL1A5 | CACNN | brain calcium channel III | Cchn1a | α1B | calcium channel |
| Database Links |
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| Alphafold | Q00975 (Hs), O55017 (Mm), Q02294 (Rn) |
| ChEMBL Target | CHEMBL4478 (Hs), CHEMBL3637936 (Mm), CHEMBL5107 (Rn) |
| DrugBank Target | Q00975 (Hs) |
| Ensembl Gene | ENSG00000148408 (Hs), ENSMUSG00000004113 (Mm), ENSRNOG00000004560 (Rn) |
| Entrez Gene | 774 (Hs), 12287 (Mm), 257648 (Rn) |
| Human Protein Atlas | ENSG00000148408 (Hs) |
| KEGG Gene | hsa:774 (Hs), mmu:12287 (Mm), rno:257648 (Rn) |
| OMIM | 601012 (Hs) |
| Pharos | Q00975 (Hs) |
| RefSeq Nucleotide | NM_000718 (Hs), NM_001042528 (Mm), NM_147141 (Rn) |
| RefSeq Protein | NP_000709 (Hs), NP_001035993 (Mm), NP_671482 (Rn) |
| UniProtKB | Q00975 (Hs), O55017 (Mm), Q02294 (Rn) |
| Wikipedia | CACNA1B (Hs) |
| Associated Proteins |
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| Associated Protein Comments | ||||||||||||||||||||||
| Cav2.2 channels are associated with and regulated by G protein β/γ subunits (reviewed in [9]). | ||||||||||||||||||||||
| Functional Characteristics |
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| N-type calcium current: High voltage-activated, moderate voltage-dependent inactivation | |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Voltage Dependence Comments | ||||||||||||||||||||||
| Activation kinetics and current-voltage relations are affected by Cav2.2 alternative splicing [31,45,58]. Activation and inactivation time courses depend upon the nature of the coexpressed β subunit (slower with β2) [45]. Notable Cav2.2 splice variants that affect channel biophysical properties, modulation and interaction with synaptic proteins are found in refs [17,25,31,45,58]. | ||||||||||||||||||||||
Download all structure-activity data for this target as a CSV file 
| Gating inhibitors
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific gating inhibitor tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gating Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ω-grammotoxin SIA causes at +100mV shift in the voltage dependence of Cav2.2 containing channels [37]. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific channel blocker tables | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blocker Comments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The efficacy of ω-conotoxin MVIIC is highly dependent on [Ba2+]. ω-conotoxin GVIA is routinely used at concentrations of 500nM to 1μM to completely and irreversibly block native and cloned N-type currents. Cilnidipine is a dihydropyridine derivative that blocks both N-type and L-type calcium channels and has been used clinically to treat patients with renal and cardiovascular disease [61,71]. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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References
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