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Antibacterial Data In GtoPdb

Quick links: Resources | Inclusion Criteria | Data Content | Citing | Ligands | Targets

Introduction

Modern medicine has been transformed by the discovery and use of antibacterial drugs, allowing previously fatal infectious diseases to be treated, enabling vital medical procedures to be carried out, and to prevent infection. However, the future utility of these therapies is threatened by a reduction in the development of new antibacterial compounds coupled with the growing challenge of antimicrobial resistance, which has been recognized by the World Health Organization (WHO) as a major global health threat [1]. The rapid spread of bacterial strains resistant to available antibacterial medicines is of particular concern, including the 'ESKAPE' pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) that are responsible for many nosocomial infections [2-3].

IUPHAR/BPS Guide to Pharmacology (GtoPdb) collaborates with AntibioticDB (ADB; www.antibioticdb.com), an open-access database of antibacterial agents. The maintenance and further development of ADB has been supported by the Global Antibiotic Research and Development Partnership (GARDP; https://gardp.org/) since 2022. ADB was set up to serve as a reference and a source of starting points for future research and (re-)development of antibacterial therapeutics [4]. This collaboration has provided expert-driven oversight to increase the coverage of antibacterial compounds in GtoPdb.

Definition

An antibacterial can be defined as a drug, chemical or other substance that kills bacteria (bactericidal) or stops their growth (bacteriostatic). The term antibiotic refers to compounds with antimicrobial activity derived from bacteria or molds but is often used synonymously with antibacterial.

Inclusion Criteria

Antibacterials will be prioritised for inclusion in the Guide to PHARMACOLOGY if:

  • They are single molecules
  • The chemical structure/s are fully defined
  • There are validated minimum inhibitory concentration (MIC) values against relevant bacterial species
  • There is validated (preferably quantitative) evidence for a molecular target or targets through which the biological effects are mediated

Compounds of undisclosed formulation or undefined mixtures of compounds will not be included.

Data Content

Breakdown of antibacterial data in GtoPdb:
All Antibacterials: 668
Antibacterials (Approved Drugs): 269

Cite this page

The information on this page is curated by the GtoPdb curation team at the University of Edinburgh. If the information is useful to you, please cite it by referring to our citation page.

Download all Antibacterials as CSV
All Antibacterials.
A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Z  
Ligand name ID Synonyms
A Back to top
A2315A 10846
ACHN-975 PDB Ligand 13333
acorafloxacin 10753 avarofloxacin (former name), JNJ-Q2, JNJQ2
afabicin 10754 AFN-1720, Debio 1450, Debio1450
AHPN 3431 CD 437, CD437, Ro 47-2077
alafosfalin PDB Ligand 9503 alaphosphin
alalevonadifloxacin 10756 WCK 2349, WCK-2349, WCK2349
alchivemycin A 13437
alpibectir 12957 BVL-GSK098
Altromycin B 10964
amifloxacin 10758 compound 7 [PMID: 2834557], WIN 49, 375, WIN 49,375-3, WIN-49375, WIN49375
amikacin Approved drug PDB Ligand 10894 Amikin®, AMK, Arikayce liposomal®, BB-K8
amoxicillin Approved drug 10895 Amoxil®, BRL-2333, co-amoxiclav (amoxicillin + clavulanic acid), Moxatag®, NSC-277174, Trimox®
amphomycin 13516 glumamycin
ampicillin Approved drug PDB Ligand 10896 aminobenzylpenicillin, KS-R1, Penbritin®, Polycillin, Principen®
AN0128 10983 AN 0128, AN-0128, compound 2g [PMID: 16997550]
ancremonam 13161 BOS-228, LYS228
ANT3310 12795
apalcillin 10759 PC-904, PC904, WY-44,417, WY-44417
APC148 13418 ZN148
APL-2301 13957 ASN-1733, MET-102
apramycin PDB Ligand 10760 EBL-1003, EL-857, EL857, nebramycin factor 2, nebramycin II
arachidonic acid PDB Ligand 2391 C20:4
arbekacin Approved drug PDB Ligand 7345 arbekacin sulfate, habekacin, ME1100, NPC-14
aspoxicillin Approved drug 12293 Doyle®, TA-058
auranofin Approved drug Immunopharmacology Ligand 6306 MMV688978, Ridaura®, SK&F-39162, SK-39162
auriclosene 13417 NVC-422
avibactam Approved drug PDB Ligand 10761 AVI, Emblaveo® (aztreonam and avibactam), NXL 104, NXL-104, NXL104
avibactam tomilopil 12949 ARX-1796, AV-006, PF-07338233
AVP-21D9 13720 Thravixa®
AZ1 PDB Ligand 13348
azidamfenicol Approved drug 12397 azidamphenicol, azidoamfenicol, azidoamphenicol, Thilocof®
azidocillin 12291 BRL 2534, SPC 297 D
azithromycin Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6510
azlocillin Approved drug 12260 Azlin®, BAY-E-6905
aztreonam Approved drug 10763 Azactam®, Cayston®, Emblaveo® (aztreonam and avibactam), SQ 26776, SQ-26776, SQ26776
 
B Back to top
bacampicillin Approved drug 12292 Penglobe®, Spectrobid®
bacitracin A Approved drug 12812
BAL19403 10981 BAL 19403, BAL-19403
BAL30072 11004 BAL-30072
balofloxacin Approved drug 13105 Q-35, Q-Roxin®
BAS-118 10976 BAS118, compound 7n [PMID: 11728192]
BB2-50F PDB Ligand 13072
BC-3205 10998
BC-7013 11034 BC7013
bedaquiline Approved drug PDB Ligand 11171 BDQ, compound 1a [PMID: 17496888], R-207910, Sirturo®, TMC-207, TMC207
bederocin PDB Ligand 10764 REP-8839, REP8839
bekanamycin Approved drug PDB Ligand 12182 kanamycin B, nebramycin V
benapenem 12793
berberine PDB Ligand 11353 umbellatine
besifloxacin Approved drug 12877 Besivance®, BOL-303224-A, ISV-403, SS734
beta-defensin 4A 3648 beta-defensin 2, HBD2, skin-antimicrobial peptide 1 (SAP1)
bezlotoxumab Approved drug 13334 BLA 761046, MBL-CDB1, MDX-1388, Zinplava®
biapenem Approved drug 12022 L-627, LJC10,627, Omegacin®, RPX2003
BLI-489 free acid 10995 BLI489
bluensomycin 10765 bluensin, U-12898, U12898
boromycin Antimalarial Ligand 13447
borrelidin Antimalarial Ligand 11306 (-)-borrelidin
bosutinib Approved drug PDB Ligand Immunopharmacology Ligand 5710 Bosulif®, SK 606, SK-606, SKI 606
brilacidin Antimalarial Ligand 13807 MMV1634402, PMX30063
BRL-42715 10993 C6-(N1-Methyl-1,2,3-trazolylmethylene)penem, LS-186900 (sodium salt), LS-187554
BRL-44154 11036 analogue 4f [Brown et al., 1991], BRL44154
brodimoprim 12325 Ro 10-5970
BT-33 PDB Ligand 13822
BTZ-043 13034 BTZ-10526043, MMV676603
butikacin 10766 UK-18,892, UK-18892, UK18892
BWC0977 12809
 
C Back to top
cadazolid PDB Ligand 10767 ACT-179811, ACT179811
caffeic acid PDB Ligand 5155
calpurbatug 13036 TRL1068
caprazamycin B 13474
capreomycin IB Approved drug 13256 Capastat®
capuramycin PDB Ligand 13471 A-500359 B, antibiotic 446-S3-1
carbenicillin Approved drug 10768 BRL-2064, BRL2064, carboxybenzylpenicillin, CBPC, CP 15639-2, CP-156392, Pyopen®
carfecillin Approved drug 12288 BRL 3475, carbenicillin phenyl, Uticillin®
carindacillin Approved drug 12276 carbenicillin indanyl, CP-15,464-2, CP-15464-2, Geocillin®
carumonam Approved drug 12296 AMA-1080, Ro 17-2301
cationomycin 11002 BRN-6263205, BRN6263205, LS-52659, LS52659
CB-182804 11003 CB-182,804, CB182804
cefacetrile 12192 Celospor®, cephacetrile
cefaclor Approved drug 10897 Ceclor®, Lilly 99638, Raniclor®
cefadroxil Approved drug PDB Ligand 4831 Duricef®
cefaloglycin Approved drug 12193 cephaloglycin, Kafocin®
cefalonium 13609 cephalonium, Cepravin® (veterinary)
cefaloridine 12189 cephaloridine, ceporin
cefalotin Approved drug PDB Ligand 8798 cephalothin, cephalotin, Keflin®
cefamandole Approved drug PDB Ligand 12210 cephamandole
cefapirin Approved drug 12191 Cefadyl®, cephapirin
cefatrizine 12204 BL-S640
cefazaflur 10770 SK&F 59962
cefazedone 12203 EMD-30087, Refosporen®
cefazolin Approved drug PDB Ligand 10935 Ancef®, cephazolin, CEZ, Kefzol®, SK&F-41558
cefbuperazone 12253
cefcapene Approved drug 12053 Flomox® (cefcapene pivoxil), S-1006
cefclidin 10771 cefclidine, E-1040, E1040
cefdinir Approved drug 12023 FK 482, Omnicef®
cefditoren Approved drug 12030 ME 1206, Spectracef® (cefditoren pivoxil)
cefepime Approved drug 10772 BMY-28142, BMY28142, CFPM, Maxipime®, Renapime®
cefetamet 12416 Ro 15-8074
cefetecol 10775 GR-69153, GR-69153X, GR69153
cefiderocol Approved drug 10776 compound 3 [PMID: 29960205], Fetcroja®, Fetroja®, GSK-2696266, GSK2696266, RSC 649266, RSC-649266, RSC649266, S-649266
cefixime Approved drug PDB Ligand 10898 (E)-Cefixime, Cefspan®, CFIX, FK-027, FR-17027, Suprax®
cefluprenam 10777 E-1077, E1077
cefmatilen 10778 S-1090, S1090
cefmenoxime Approved drug 12024 A-50912, Abbott 50192, Bestron®, Cefmax®, SCE-1365
cefmetazole Approved drug PDB Ligand 12215 CS-1170, U-72791, Zefazone®
cefminox 12255 MT 141
cefodizime 12032 HR 221
cefonicid Approved drug 12217 Monocid®, SK&F 75073
cefoperazone Approved drug 12025 Cefobid®, T-1551
ceforanide Approved drug 12218 BL-S786, Precef®
cefoselis Approved drug 12034 FK-037, Wincef®
cefotaxime Approved drug PDB Ligand 10893 Claforan®, Ru-24756
cefotetan Approved drug 10936 Apatef®, Cefotan®, ICI-156834, ICI156834
cefotiam 12254 SCE 963
cefovecin 13654 Convenia® (veterinary)
cefoxitin Approved drug PDB Ligand 10937 Cenomycin®, CFX, Mefoxin®, MK-306, MK306
cefozopran Approved drug 12054 SCE-2787
cefpimizole 10779 CPIZ, U 63196E, U-63,196, U-63196E
cefpiramide Approved drug 12027 SM-1652, WY-44635
cefpirome Approved drug 12033 HR 810, Romecef®
cefpodoxime Approved drug 10780 RU-51746, Vantin®
cefprozil Approved drug 12219 BMY-28100, Cefzil®
cefquinome 13622 Cobactan® (veterinary), HR 111V
cefroxadine Approved drug 13619 CGP 9000, CGP-9000, Oraspor®
cefsulodin 10783 Cefonomil®, CGP-7174-E, CGP7174/E
ceftaroline fosamil Approved drug 10899 PPI-0903, TAK-599, Teflaro®, Zinforo®
ceftazidime Approved drug 10762 CAZ, Fortaz®, Fortum®, GR 20263, GR-20263, GR20263, LY-139381, LY139381, Pentacef®, Tazicef®
cefteram Approved drug 11051 cefterame, ceftetrame, CFTM, Ro 19-5247, T-2525
ceftezole 12259 ceftezol, FR10123
ceftibuten Approved drug 12029 7432-S, Cedax®, SCH 39720
ceftiofur 13653 Naxcel® (veterinary)
ceftiolene 10784 42980RP, cefatiolene, RP 42,980, RP 42980, RP-42980, RP42980
ceftizoxime Approved drug 10785 Cefizox®, compound 22 {PMID: 2342058], Epocelin®, FK-749, FK749, FR-13749, FR13749, SK&F 88373-Z
ceftizoxime alapivoxil 10786 AS-924, AS924, KY-020, KY020
ceftobiprole Approved drug 10787 BAL-9141, BAL9141, BAL9141-000, BAL9141000, Ro-63-9141, Ro-639141, Zeftera®, Zevtera®
ceftolozane Approved drug 10788 CXA-101, CXA101, FR-264205, FR264205, Zerbaxa® (ceftolozane + tazobactam)
ceftriaxone Approved drug 5326 Rocephin®
cefuroxime Approved drug PDB Ligand 10900 Ceftin®, CXM, Kefurox®, Zinacef®
cephalexin Approved drug 4832 cefalexin, Ceporex®, Keflex®
cephalosporin P1 12330 acremonic acid
cephradine Approved drug 4830 cefradine, Infexin®, Velocef®
cervimycin C 13603
cetefloxacin 10790 compound 43f [PMID: 7990118], E-4868, E4868
cethromycin PDB Ligand 10791 A-195773, Abbott-195773, ABT-773, ABT773, Restanza®
cetocycline 10792 A-40728, Abbott 40728, chelocardin, compound 1 [PMID: 379332]
CG-400549 PDB Ligand 10984 CG400549
CGP-31608 10963 CGP 31608, CGP31608
chalcomycin 11058
chinfloxacin 11017
chloramphenicol Approved drug PDB Ligand 10901 Brolene®, chloromycetin
chlorocardicin 11044
chlorotonil A Antimalarial Ligand 13589
chlortetracycline Approved drug PDB Ligand 13537 Aureomycin®
chrysin PDB Ligand 8789 NSC-407436
cilastatin Approved drug 5166 MK 0791, MK-791, MK791, Primaxin®
cinoxacin Approved drug 12401 Cinobac®, Lilly 64716
ciprofloxacin Approved drug PDB Ligand 10902 BAY-O-9867, BAY-O9867, Cetraxal®, Ciloxan®, Cipro®, CPFX, Proquin XR
CJ-15,801 Antimalarial Ligand 10610 CJ-15801
cladosporin PDB Ligand Antimalarial Ligand 10247 asperentin
clarithromycin Approved drug PDB Ligand 10903 6-O-methylerythromycin, A-56268, ABBOTT-56268, Biaxin®, Klaricid®, TE-031
clavulanic acid Approved drug PDB Ligand 11128 BRL-14151, BRL-14151K, BRL14151, clavulanate, MM 14151
clinafloxacin 10793 AM 1091, CI-960, PD-127321
clindamycin Approved drug PDB Ligand Antimalarial Ligand 10607
clofazimine Approved drug Immunopharmacology Ligand 9184 Lamprene®
clofoctol Approved drug 12926 Gramplus®, Octofene®
clometocillin 12294 clometacillin, clomethacillin
clomocycline Approved drug 13541 chlormethylenecycline, Megaclor®
clorobiocin PDB Ligand 12127 chlorobiocin, RP 18,631
clovibactin 13080 Novo29
cloxacillin Approved drug PDB Ligand 11126 BRL-1621, BRL1621, chloroxacillin, Methocillin S, Syntarpen®, Tegopen®
CMTX-101 13582
colistin Approved drug 10794 Colobreathe®, polymyxin E, Promixin®
compound 4b [PMID: 40259683] 13929
compound M1 PDB Ligand 13669 phenylisoxazole 4
compound 16 [PMID: 38385364] 13259
compound 5 [Stecula et al., 2020] 11155 MCULE-2879769428
contezolid Approved drug PDB Ligand 10795 MRX-1, MRX-I, Youxitai®
contezolid acefosamil (parent) 10796 MRX-4
Corallopyronin A 11029 CorA, LS-54950, LS54950
coumamycin PDB Ligand 10879 coumermycin A1, notomycin
CPZEN-45 13508
cresomycin PDB Ligand 13428
CRS3123 PDB Ligand 10991 CRS-3123, REP-3123, REP3123
cyclacillin Approved drug 4817 ciclacillin, Cyclapen®, Vastcillin®, Wy-4508
cyclohexylgriselimycin 13756 cyclohexyl-griselimycin
cyclothialidine 10988 Ro 09-1437
 
D Back to top
dactimicin 11001 Formimidoyl-fortimicin A, SF-2052, SF2052
dalbavancin Approved drug 10876 BI-397, BI397, Dalvance®, Xydalba®
dalfopristin Approved drug PDB Ligand 10797 RP-54476, RP54476, Synercid® (dalfopristin + quinupristin)
danirixin Immunopharmacology Ligand 8500 GSK-1325756B, GSK1325756, GSK1325756B
danofloxacin 13667 Advocid® (veterinary), Advocin® (veterinary), CP-76,136
dapsone Approved drug Antimalarial Ligand 10934 Aczone®, NSC-6091
daptomycin Approved drug 10904 Cubicin®, LY-146032, LY146032
DC-159a 10982
D-cycloserine Approved drug PDB Ligand 9489 Seromycin®
DEBIO 1452 10755 afabicin desphosphono, AFN-1252, AFN-12520000, DEBIO-1452, DEBIO1452
decaplanin 10968 M 861410, M86-1410, MM-47761
declovanillobiocin 12128 novclobiocin 313
delafloxacin Approved drug PDB Ligand 10799 Abbott 492, ABT-492, ABT492, Baxdela®, Quofenix®
delamanid Approved drug 12876 Deltyba®, OPC-67683
delpazolid 10999 LCB-01,0371, LCB-01-0371, LCB01-0371
demeclocycline Approved drug 10905 Declomycin®, Ledermycin®
diacerein Approved drug 10800 Artrodar®, Fisiodar®
diazoquinomycin H 13821
dibekacin Approved drug PDB Ligand 12134 3',4'-dideoxykanamycin B, debecacin
dicloxacillin Approved drug 12261 BRL-1702, Diclocil®, Dynapen®
difficidin 11062
difloxacin 10801 A 56619, A-56619, Dicural®
dihydrostreptomycin Approved drug PDB Ligand 12163
dihydroxybenzofuran 10992 2,3-Benzofurandiol
dirithromycin Approved drug PDB Ligand 12928 AS-E 136, Dynabac®, LY237216
DK-507k 11037
doripenem Approved drug PDB Ligand 12183 compound 1m [PMID: 8621362], Doribax®, S-4661
dovramilast 13581 AMG-634, CC-11050
doxycycline Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6464 BMY-28689, Monodox®, Vibramycin®
DS-8587 10955 DS8587
DS-2969b 10985 DS 11960558 (DS-2969b prodrug), DS-2969, example 2 [WO2017/056012A1]
Dup-105 10950 DuP 105, DuP105
DuP-721 10960 DuP 721
durlobactam Approved drug 12693 ETX-2514, EXT2514, Xacduro® (sulbactam and durlobactam)
DX-619 11039 compound 4 [PMID: 19736016], DX619
 
E Back to top
E-0702 11056
eAmSPC 2593 13565
ebselen 10583 DR 3305, PZ51, SPI-1005
ecenofloxacin 10802 CFC-222, CFC222
E-1010 free base 11050 E1010, ER-35786
Enduracidin 10989
enmetazobactam Approved drug 12188 AAI101, Exblifep® (cefepime + enmetazobactam), OCID-5090
enoxacin Approved drug 8882 AT-2266, CI-919, Penetrex®
enoxolone PDB Ligand 11264 18β-Glycyrrhetinic acid, glycyrrhetic acid, glycyrrhetinic acid
enrofloxacin 13668 BAY Vp 2674, Baytril® (veterinary)
enteromycin carboxamide 11063 BRN 2416858, BRN-2416858, BRN2416858, LS-14645
enviomycin Approved drug 13276 Tuberactin®, tuberactinomycin N
eperezolid 10803 comound 2 [PMID: 23584544], PNU-100592, PNU100592, U-100592, U100592
epetraborole 13079 AN3365, BRII-658, GSK2251052
epicillin 10804 Dexacillin®, SQ 11302, SQ-11302, SQ11302
epigallocatechin-3-gallate PDB Ligand 7002 EGCG, EGCG, epigallocatechin gallate
epiroprim 12327 Ro 11-8958, TCMDC-137295
eravacycline Approved drug PDB Ligand 10805 compound 17j [PMID: 2148514], TP-434, TP434, Xerava®
eremomycin 10959 A82846A
ertapenem Approved drug 10906 Invanz®, L-749345, MK-0826, MK-826
erucamide PDB Ligand 13954
erythromycin Approved drug PDB Ligand 1456 EM-A, E-Mycin®, Erythrocin®, erythromycin-A
ethambutol Approved drug PDB Ligand 12996 Myambutol®
etheromycin 10994 CP‐38 295
ethionamide Approved drug PDB Ligand 12954 1314 TH, Bayer 5312, Trecator®
ethyl bromopyruvate 10952
ETX0282 10781 ETX-0282
ETX0462 PDB Ligand 11753 ETX-0462, VMM
ETX1317 10782 ETX-1317
evernimicin 10806 SCH 27899, SCH-27899, SCH27899, Ziracin®
evybactin 12922 GLXC-26146
exeporfinium 13323 XF-73 (exeporfinium chloride)
 
F Back to top
F598 13554 SAR279356
fandofloxacin 10807 DW-116, DW116
faropenem PDB Ligand 10808 compound 1 [PMID: 9216830], faropenem medoxomil, fropenem
feldamycin 10979 BMY-28565, BMY28565, U-48266
Ferrimycin A1 10966
FG-2101 13854
ficellomycin 10965 U-47,929, U-47929, U47929
fidaxomicin Approved drug PDB Ligand 10909 Dificid®, Dificlir®, lipiarmycin, OPT-80, PAR-101, tiacumicin B
finafloxacin Approved drug 10809 AL-60371, AL60371, Xtoro®
fleroxacin Approved drug 12476 AM-833, Megalone®, Quinodis®, Ro 23-6240
flomoxef 12251 6315-S, Flumarin®
florfenicol 12923 SCH 25298
flucloxacillin Approved drug 10910 BRL-2039, BRL2039, floxacillin
fludalanine 10810 3-fluoro-D-alanine, MK-0642, MK0642
flumequine Approved drug 13650 R-802
fluorothiazinon 13810 CL-55, fluorothiazinone, Ftortiazinon
flurithromycin Approved drug 12927 (8S)-8-fluoroerythromycin A, P-0501A
FNDR-20081 13544
fobrepodacin 13062 pVXc-486, SPR720
fosfomycin Approved drug PDB Ligand 10813 Monurol®, phosphomycin, phosphonomycin, Veramina®
fosmidomycin PDB Ligand Antimalarial Ligand 9739 FR-31564
fudapirine 13002 sudapyridine, WX-081
funobactam 13114 XNW4107
furagin Approved drug 12367 furazidin, furazidine, NF416
furaltadone Approved drug 13898 Altafur®, furmethonol
furazolidone Approved drug 12343 Furoxone®
furazolium 10814 Novofur
fusidic acid Approved drug PDB Ligand 10815 CEM-102, CEM102, Fucidin®, fusidate, sodium fusidate, Taksta®
 
G Back to top
G0775 13608
gamithromycin 13688 ML-1709460, Zactran® (veterinary)
ganfeborole 12796 GSK3036656, GSK656
garenoxacin Approved drug 12402 BMS-284756, Ganefloxacin, Garenfloxacin, Geninax®, T-3811
gatifloxacin Approved drug 10816 AM-1155, AM1155, Gatiflo®, GTFX, Tequin®, Zymar®
geldanamycin PDB Ligand 9829
gemifloxacin Approved drug 12406 Factive®, LB20304, SB 265805
gentamicin Approved drug 2427 Garamycin®, gentamicin sulfate
gepotidacin Approved drug PDB Ligand 10817 Blujepa®, GSK-2140944, GSK2140944
gloximonam 10880 SQ 82,531
gremubamab 13374 MEDI3902
grepafloxacin Approved drug 10818 OPC 17116, OPC-17116, OPC17116, Raxar®
GSK2556286 13078 GSK286
GSK839 13955
GT-1 13251 LCB10-0200
 
H Back to top
hedamycin 10958 antibiotic B 26,158, B26158, NSC-70929
helvolic acid 12329 fumigacin
hesperetin PDB Ligand 10953 3',5,7-Trihydroxy-4'-methoxyflavanone, NP-13, NSC-57654
hetacillin Approved drug 12263
hexachlorophene Approved drug PDB Ligand 11069 Inh 1 [PMID: 32284327], Nabac®
HSGN-218 13054
3-hydroxycezomycin 13814 AC7230
ω-Hydroxyemodin 11005 Citreorosein, omega-Hydroxyemodin
hygromycin A 13623 homomycin, totomycin
hymeglusin 5886 antibiotic 1233A, F-244, L-659,699
 
I Back to top
ibafloxacin 10819 R-835, R835, S-25930, S25930
ibezapolstat 11030 ACX-362E, ACX362E
iboxamycin 11790 IBX, OPP-3
iclaprim 10820 AR-100, AR100, Mersarex®, RO-48-2622, RO-482622
imatinib Approved drug PDB Ligand Immunopharmacology Ligand 5687 CGP 57148, Gleevec®, Glivec®, STI571
imipenem Approved drug 10821 MK-0787, MK0787, Primaxin® (imipenem + cilastatin), Recarbrio® (imipenem + cilastatin + relebactam).
indanomycin 10949 X-14547A
indolmycin PDB Ligand Antimalarial Ligand 11021 PA 155 A, PA-155-A, PA-155A, TAK-083
ionomycin 13591 SQ-23377
Irresistin-16 10973 IRS-16, IRS16
iseganan 10822 IB-367, IB-367-03
isepamicin Approved drug 12136 HAPA-B, Sch 21420
isoniazid Approved drug PDB Ligand 12761 isonicotinic acid hydrazide, Nydrazid®, Rimifon®
isovanillobiocin 12129 novclobiocin 312
IT-62-B 11032
ivermectin Approved drug 2373 Heartgard®, ivermectin B1a, MK-933, Sklice®, Soolantra®
 
J Back to top
JEDI-852 PDB Ligand 13332
josamycin Approved drug 12924 kitasamycin A3, leucomycin A3, turimycin A5
JSF-3285 PDB Ligand 13585
 
K Back to top
kaempferol PDB Ligand 11052 Robigenin
kanamycin Approved drug PDB Ligand 12132 kanamycin A
Katanosin B 10970 Lysobactin
KB-5246 11046 KB5246, LS-99630
kibdelomycin A 11016
KSP-1007 13547
 
L Back to top
L-701677 11042 L-701,677
L-708365 10980 L 708,365, L 708365, L-708,365
lactivicin 11022 compound 1 [PMID: 17676039], LTV
lascufloxacin 10823 KRP-AM1977
latamoxef Approved drug 12031 6059-S, LY127935, moxalactam, Moxam®
LBM-415 11043 LBM415, NVP LBM-415, NVP-PDF-713, PDF-713, VIC-104959
L-cycloserine Approved drug 9488 levcycloserine, Seromycin®
ledaborbactam 13082 VNRX-5236
lefamulin Approved drug PDB Ligand 10824 BC-3781, BC3781, compound 7 [PMID: 24874438], Xenleta®
LEI-800 PDB Ligand 13475
leinamycin 11041 DC-107, DC107
lenapenem 10825 BO-2727, BO2727, L-739,428, L-739428
levofloxacin Approved drug PDB Ligand 10911 DR-3355, Levaquin®, Quinsair®
levonadifloxacin 10757 (S)-(-)-nadifloxacin, WCK 771, WCK-771, WCK771
levopropicillin 10826 BRL-284, BRL284, L-Propicillin, P-248, P248
lincomycin Approved drug PDB Ligand 10941 Bactramycin®, L-Mycin®, LCM, Lincocin®, Lincorex®, U 10,149A, U-10149
linezolid Approved drug PDB Ligand 10827 PNU-100766, PNU100766, U-100,766, U-100766, ZLD, Zyvox®
liposidomycin B 13520
LL-37 Immunopharmacology Ligand 5527 antibacterial protein LL-37, cathelicidin LL 37 (human)
lolamicin 13410
lomefloxacin Approved drug 12407 Maxaquin®, NY-198, SC-47111, Uniquin®
loracarbef Approved drug 12247 KT-3777, Lorabid®, LY163892
loureirin A 13446
LPC-233 PDB Ligand 13824
luminamicin 11053 coloradocin, LS-90907
lusutrombopag Approved drug 10032 Mulpleta®, S-888711, S888711
lymecycline Approved drug 10912 N-Lysinomethyltetracycline, tetracycline-L Methylene-Lysine, Tetralysal®
lysinomicin 10969
 
M Back to top
M14659 11047 GR 63116, GR-63116, M 14659, M-14659
macozinone 13055 PBTZ169
Macquarimicin A 10978
mafenide Approved drug PDB Ligand 12697 homosulfanilamide, Sulfamylon®
marbofloxacin 13670
maridomycin 10828 LS-87912, Maridomycin III
MC-02479 11033 MC 02479, MC02479, RWJ 54428, RWJ-54428
ME1071 13948
ME-1228 acid 11045 ME1228
mecillinam Approved drug 12813 amdinocillin, Coactin®, FL 1060, Selexidin®
meclocycline Approved drug 13540 GS-2989, Meclan®
meropenem Approved drug PDB Ligand 10829 ICI 194,660, Merrem®, SM-7338
mersacidin 11014 M87 1551, M87-1551
metacycline Approved drug 13618 GS-2876, methacycline, methylenecycline, Physiomycine®, Rondomycin®
metampicillin 12274 methampicillin, methylenampicillin, Micinovo®, Viderpen®
methenamine Approved drug 10913 Hiprex®, Mandelamine®, Urex®
methicillin Approved drug PDB Ligand 12264 meticillin
metronidazole Approved drug PDB Ligand 10914 BAY-5360, BAYER 5360, Flagyl®, Metrogel®, ROZEX®
mezlocillin Approved drug 12272 BAYPEN®, Mezlin®, Multocillin®
MGB-BP-3 10996 compound 50 [PMID: 17960927], MGB-BP3
micronomicin Approved drug 12162 gentamicin C2b, Sagamicin®, XK-62-2
midecamycin Approved drug 13158 espinomycin A, platenomycin B1, rubimycin, SF-837, turimycin P3
mideplanin 10830 CTA A1, MDL 62873, MDL-62873, MDL62873
minocycline Approved drug 10831 CL 59806, CL-59806, CL59806, Dynacin®, MINO, Minocin®, NSC-141993
MK-7762 13542 MK7762, TBD09
modithromycin 13000 EDP-420, EP-013420, S-013420
moiramide B PDB Ligand 13922
moxifloxacin Approved drug PDB Ligand 10915 Avelox®, BAY-12-8039, BAY-128039, BAY128039, MFX, MOXIVIG® (opthalmic solution)
mupirocin Approved drug PDB Ligand Antimalarial Ligand 10916 Bactroban®, BRL-4910A, BRL-4910F, Centany®, pseudomonic acid
muraminomicin F 13519
muraymycin D2 PDB Ligand 13501 muramycin D2
mureidomycin C 13517
murepavadin 10832 POL7080, RG-7929, RG7929, RO-7033877, RO7033877
MUT056399 PDB Ligand 11000 Fab-001, FAB001, MUT-056399
9MW1411 13956
MX-2401 13518
mycoplanecin A 13757
 
N Back to top
NAB739 13588
nacubactam 10833 OP-0595, OP0595, RG-6080, RG6080, RO-7079901, RO7079901
nadifloxacin Approved drug 12919 Nadixa®, OPC-7251
nafcillin Approved drug 10942 Ethoxynaphthamido Penicillin Sodium, Nallpen®, Unipen®
nafithromycin 10834 WCK 4873, WCK-4873, WCK4873
nalidixic acid Approved drug PDB Ligand 12773 NegGram®, Win 18,320
napsamycin C 11008
napsamycin D 11009
narasin 10835 C-7819B, Lilly 79891, Monteban®, Narasin A
nemonoxacin Approved drug 10836 Taigexyn®, TG-873870, TG873870
neomycin Approved drug PDB Ligand 709 Neo-Rx®, neomycin sulfate
neopyrrolomycin 10962
netilmicin Approved drug 12159 1-N-ethylsisomicin, Sch 20569
niclosamide Approved drug PDB Ligand 8494 VU0243604
nifuratel Approved drug 12348 Macmiror®, Magmilor®, methylmercadone
nifuroxazide Approved drug 12358 NSC-759261, RC-27109, SJ000287313
nifurprazine 10837 carofur, HB-115, HB115
nifurquinazol 12344 NF-1088
nifurtimox Approved drug 12364 BAY 2502, BAY A2502, Bayer 2502, Lampit®
nifurtoinol Approved drug 12346 hydroxymethylnitrofurantoin, Urfadyn PL®
nifurzide 12365 Ricridene®
NITD-349 PDB Ligand 13874
nitrofural Approved drug PDB Ligand 12366 Furacin®, Furacine®, nitrofurazone
nitrofurantoin Approved drug PDB Ligand 10917 Furadantin®, Macrobid®, Macrodantin®, Nitro Macro®, NSC-2107, NSC-44150
nocardicin A 12295
nodusmicin 11019 nodusmicin 1
nojirimycin 10951 5-amino-5-deoxy-D-glucopyranose, D-gluco-piperidinose
norfloxacin Approved drug 12408 AM-715, Chibroxin®, MK-0366, Noroxin®
NOSO-502 13157
novclobiocin 101 12131
novobiocin Approved drug PDB Ligand 12021 Albamycin®, cardelmycin, cathomycin, PA 93, streptonivicin
NPS 2143 PDB Ligand 716 NPS-2143, NPS2143
NSC-84963 10956 NSC 84963, NSC84963
NSC-93169 10957 NSC 93169, NSC93169
NTB-3119 13584 compound 6b [PMID: 30336450]
 
O Back to top
obiltoxaximab Approved drug 13342 Anthim®, ETI-204, Nyxthracis®
ofloxacin Approved drug 10918 DL-8280, Exocin® (eye drops), Floxin®, HOE-280, OFX, Tarivid®
olamufloxacin 10838 HSR-903, HSR903
oleandomycin Approved drug 13280 amimycin, landomycin, Matromycin®, P.A.105, Romicil®
oleanolic acid 3306 oleanic acid
oleuropein 11027
olivanic acid 12811
omadacycline Approved drug PDB Ligand 10839 amadacycline, compound 6 [PMID: 21302930], Nuzyra®, PTK-0796, PTK0796
omodenbamab 13379 514G3
OPS-2071 13197
orbifloxacin 13671 AT-4526, CP-104,354, Orbax® (veterinary)
oritavancin Approved drug 10877 Kimyrsa®, LY-333328, LY333328, Orbactiv®
OTB-658 13548 compound 19c [PMID: 32666789]
oxacillin Approved drug 10943 Bactocill®
oxantel Approved drug 10840 CP-14,445, CP-14445
oxaquin 10997 DNV-3837, DNV3837, MCB-3837, MCB3837
oximonam 12297 SQ 82,291
oxolinic acid Approved drug PDB Ligand 12999
oxytetracycline Approved drug PDB Ligand 10919 E703, NSC-9169, Terramycin®
ozenoxacin Approved drug 10841 Ozadub®, T-3912, T3912, Xepi®
 
P Back to top
pacidamycin 13473
pafuramidine 10842 DB-289, DB289
paldimycin 10843 Antibiotic 273 A, U-70,138, U-70138F
panipenem Approved drug 12184 Carbenin® (panipenem + betamipron), CS-533, RS-533
panobacumab 13377 Aerumab 11, Aerumab™, AR-101, KBPA101
para-aminosalicylic acid Approved drug PDB Ligand 13652 4-aminosalicylic acid, Granupas®, p-aminosalicylic acid, Paser®, Rezipas®
paromomycin Approved drug PDB Ligand 12160 aminosidine, catenulin, Humatin®, monomycin A
pazufloxacin Approved drug 12410 Pasil®, Pazucross®, T-3761
peceleganan 13758 PL-5, V681
pefloxacin Approved drug 12411 1589 RB, AM-725
penamecillin Approved drug 12808 Havapen®, WY-20788
penicillin G Approved drug PDB Ligand 4796 penicillin G sodium, penicillin-G potassium
pestalotinone B 13923
pheneticillin Approved drug 12275 alfacilin, Broxil®, feneticillin, phenethicillin
phenoxymethylpenicillin Approved drug PDB Ligand 10920 Oracillin®, PC Pen VK®, Pen-V®, penicillin V, Penicillin VK, PNV
phleomycin 10954 NSC 61586, NSC-61586
phthalylsulfathiazole 13907 sulfathalidine
pikromycin PDB Ligand 13472 albomycetin, amaromycin, picromycin
pipacycline 13612 mepicycline
pipemidic acid Approved drug 12774 Pipram®
piperacillin Approved drug PDB Ligand 10921 CL 227,193, CL-227193, PIPC, T-1220, Tazocin® (piperacillin + tazobactam)
pirazmonam 10844 compound 2 [PMID: 25658376], SQ 83,360, SQ-83360, SQ83360
pirbenicillin 10845 CP-33,994, CP-33,994-2
pirlimycin 13621 Pirsue® (veterinary), U-57,930E, U-57930E
piromidic acid Approved drug 12475 Bactramyl®, Panacid®, PD-93
pivampicillin 12920 MK-191, Pondocillin®
pivmecillinam Approved drug 10922 amdinocillin pivoxil, pivmecillinam hydrochloride, Pivya®, RO-10-9071, RO-109071, Selexid®
plazomicin Approved drug PDB Ligand 10847 ACHN-490, ACHN490, Zemdri®
pleuromulin 12935 drosophilin B, pleuromutilin
PLG0206 13313 WLBU2
plusbacin A3 11020
PNU-288034 10977 compound 2 [PMID: 16644216], PNU288034
polymyxin B Approved drug 10338 Aerosporin®
polypeptin 13820 circulin (former name)
posizolid 12762 AZD2563, AZD5847
poststatin 10967 L-Val-L-Val-3-amino-2-oxo-valeryl-D-Leu-L-Val
pradofloxacin 13687 Veraflox® (veterinary)
pralurbactam 13037
pravibismane 13590 BisEDT, MBN-101
premafloxacin 10848 compound 21 [PMID: 17303420], U-95376, U95376
pretomanid Approved drug 11172 PA-824, PA824
pristinamycin IA Approved drug 12934 mikamycin B, ostreogrycin B, Pyostacine®, streptogramin B, virginiamycin B
pristinamycin IIA Approved drug PDB Ligand 12933 mikamycin A, ostreogrycin A, Pyostacine®, streptogramin A, virginiamycin M1
prontosil 12743 prontosil red, prontosil rubrum, sulfamidochrysoidine
prulifloxacin Approved drug 12860 NM441
puromycin PDB Ligand 13311 achromycin
pyrazinamide Approved drug PDB Ligand 7287 aldinamide, Zinamide®
pyridomycin PDB Ligand 13449 erizomycin
 
Q Back to top
quabodepistat 13059 OPC-167832
quinupristin Approved drug 10798 RP 57669, RP-57669, RP57669, Synercid® (dalfopristin + quinupristin)
 
R Back to top
radezolid PDB Ligand 10849 Rx-01_667, RX-103, RX-1741, RX103, RX1741
ranbezolid 11007 RBx 7644
rancinamycin IA 11015 Rancomycin 1, U-22583, U22583
ranimycin 10850 Rancomycin 2, U-25,873, U-25873
raxibacumab Approved drug 13344 Abthrax, PAmAb
razupenem 10851 PZ-601, SM-216601, SMP-601
relebactam Approved drug 10852 MK-7655, MK-7655A, MK7655
reltecimod 13721 AB 103, AB103, p2TA
retapamulin Approved drug 11035 Altabax®, Altargo®, SB-275833, SB275833
ribostamycin PDB Ligand 12161 SF-733
ridinilazole PDB Ligand 10853 SMT-19969, SMT19969
rifabutin Approved drug 12015 BV100 (for infusion), LM 427, Mycobutin®, Rifabutine
rifampicin Approved drug PDB Ligand 2765 Rifadin®, rifampin
rifamycin Approved drug 4570 Aemcolo®, rifamycin SV
rifapentine Approved drug PDB Ligand 12014 DL 473, MDL 473, Priftin®
rifaquizinone 11028 CBR-2092, TNP-2092
rifasutenizol 12959 TNP-2198
rifaximin Approved drug PDB Ligand 12012 L/105, Rifamycin L 105, Xifaxan®
ritipenem 10854 FCE-22101, FCE22101
Ro-406890 11048 ceftrazonal, Ro 40-6890, Ro 406890, Ro406890
RO7075573 PDB Ligand 13375
rokitamycin Approved drug 12879 Ricamycin®, TMS-19-Q
rolitetracycline Approved drug 12760 pyrrolidinylmethyltetracycline, Reverin®, SQ 15,659, Syntetrin®, Velacycline®
rosaramicin 10855 Antibiotic 67-694, Antibiotic 67694, juvenimicin A3, rosamicin, SCH-14947, SCH14947
rosoxacin Approved drug 12474 acrosoxacin, Eracine®, Eradacil®, Eradacin®, WIN 35213, Winuron®
roxithromycin Approved drug PDB Ligand 1465 RU 28965
RP60556A 11006
RS-102895 PDB Ligand Immunopharmacology Ligand 779 abaucin, RS102895
rufloxacin Approved drug 12473 MF 934, Monos®
 
S Back to top
SAAP-148 13873 P148
sanfetrinem 10856 GV104326
sanfetrinem cilexetil 13812 GV118819
sansanmycin A 13521
sarafloxacin Approved drug 10857 A-56620, A56620
sarecycline Approved drug PDB Ligand 12921 P005672, Seysara®
Sch 29482 11031
SCH-79797 10971 SCH 79797, SCH79797
secnidazole Approved drug 12925 14,539 RP, Solosec®, SYM-1219
SEQ-9 PDB Ligand 13159 sequanamycin 9
sisomicin Approved drug PDB Ligand 10858 Antibiotic 66-40, Antibiotic 6640, rickamicin, Sch-13475, Sch13475, sisomycin, Sissomicin
sitafloxacin Approved drug 11040 compound 33 [PMID: 7932562], DU-6859, DU-6859a, DU6859a, Gracevit®, STX
SK&F 88070 11049 Skf 88070
solithromycin PDB Ligand 10859 CEM-101, CEM101, compound 3 [PMID: 30258539], OP-1068, OP1068, Solithera, T-4288, T4288
sorangicin A PDB Ligand 11038 (+)-Sorangicin A
sparfloxacin Approved drug 10860 AT-4140, AT4140, CI-978, CI978, SPFX, Zagam ®
spectinomycin Approved drug PDB Ligand 11127 actinospectacin, M-141, Trobicin®, U-18409, U-18409E, U18409
spenolimycin 10961 acmimycin
spiramycin Approved drug PDB Ligand 13312 foromacidin, Rovamycine®
SPR719 13545 SPR-719, VXc-486
SPR741 13250 NAB741
SQ-109 Antimalarial Ligand 7997 MMV687273, SQ 109, SQ109
SQ641 13503
squalamine 10861 7alpha-Hydroxy, 3beta-spermidine, MSI-1256F (squalamine lactate)
SRI-20864 10986 SRI20864
SRI-20920 10987 SRI 20920, SRI20920
streptomycin Approved drug PDB Ligand 10923 Gerox®, NSC-14083, Strepcen®
SU-3327 10703 compound 9 [PMID: 19271755], halicin, SU3327
sulbactam Approved drug PDB Ligand 10769 Betamaze, CP-45,899, CP-45899
sulbenicillin 12273 SBPC
sulfabenzamide Approved drug PDB Ligand 12632
sulfacetamide Approved drug 12633 Bleph-10®, Klaron®, sulphacetamide
sulfachlorpyridazine Approved drug 12634 BA-10370, sulfachloropyridazine, sulphachlorpyridazine
sulfadiazine Approved drug 12635
sulfadimethoxine Approved drug 12638 Albon® (veterinary), sulfadimethoxydiazine, sulphadimethoxine
sulfadimidine Approved drug 12642 sulfamethazine
sulfadoxine Approved drug Antimalarial Ligand 10173 sulphadoxine
sulfaguanidine Approved drug PDB Ligand 12639 sulfanilylguanidine, sulphaguanidine
sulfalene Antimalarial Ligand 10174 Kelfizine®, sulfamethopyrazine, sulfamethoxypyrazine, sulfametopyrazine
sulfamazone Approved drug 13711 Marespin®, sulphenazone
sulfamerazine Approved drug 12640 2-sulfanilamido-4-methylpyrimidine, sulfamethyldiazine, sulphamerazine
sulfamethizole Approved drug 12683 Rufol®, sulphamethizole, Thiosulfil®
sulfamethoxazole Approved drug PDB Ligand 10933 Gantanol®, RO 4-2130, RO-42130, SMX, STX-608
sulfamethoxypyridazine Approved drug 12686 Kynex®, sulphamethoxypyridazine
sulfametomidine 12701 methofadin, sulfamethomidine
sulfametoxydiazine Approved drug 12641 sulfameter, sulfamethoxydiazine, Sulla®
sulfametrole Approved drug 12702
sulfamonomethoxine Approved drug PDB Ligand 12688 Daimeton®
sulfamoxole Approved drug 12744 Nuprin®, sulfadimethyloxazole, Sulfuno®, sulphamoxole
sulfanilamide Approved drug PDB Ligand 12631 AVC®, sulphanilamide
sulfanitran 13897
sulfaperin 12742 Sulfaperine
sulfaphenazole 11352 Sulfabid®
sulfapyridine Approved drug PDB Ligand 12698 Dagenan®, M&B 693, sulphapyridine
sulfaquinoxaline 13878
sulfasalazine Approved drug PDB Ligand 4840 Azulfidine®, Salazopyridin®, Salazopyrin®, SAS-500
sulfathiazole Approved drug PDB Ligand 12699 M&B 760, Thiazamide®
sulfathiourea 12745 sulfathiocarbamide
sulfisoxazole Approved drug 12700 Gantrisin®, NU-445, sulfafurazole, sulphafurazole
sulopenem Approved drug 10862 CP-70,429, CP-70429, CP70429, Orlynvah® (sulopenem etzadroxil and probenecid)
sultamicillin Approved drug 12290 CP-49,952, Unasyn®
sutezolid PDB Ligand 12772 MMV688756, PF-02341272, PNU-100480, U-100480
suvratoxumab 13361 AR-320, MEDI4893
 
T Back to top
tacapenem 10863 R-95867, R95867
talampicillin Approved drug 12289 BRL 8988, Talpen®
taniborbactam PDB Ligand 10774 VNRX-5133, VNRX5133
taurolidine Approved drug 13030 Defencath® (taurolidine + heparin), taurolin
tazobactam PDB Ligand 10789 CXA-201, CXA201, YTR 830, YTR 830H, Zerbaxa® (ceftolozane + tazobactam)
TBA-354 13546
TBA-7371 13133 AZ-7371, compound 1 [PMID:24957839], TBA7371
TBAJ-587 PDB Ligand 13060 compound 8 [PMID: 30803745]
TBAJ-876 PDB Ligand 13132 compound 46 [PMID: 30803745]
TBI-166 12961 pyrifazimine
TBI-223 13029
tebipenem pivoxil Approved drug 10864 L-084, LJC 11,084, LJC-11,084, LJC-11084, Orapenem®, TBPM-PI
tedizolid Approved drug PDB Ligand 10865 DA-7157, previously torezolid, Sivextro®, TR-700, TR700
teicoplanin Approved drug 10924 Antibiotic 8327A, MDL-507, Targocid®, teichomycin, teicoplanin A2
teixobactin 10972 compound of formula II [WO2014089053A1], N-[N-Methyl-D-Phe-Ile-Ser-D-Gln-D-aIle-Ile-Ser-]cyclo[D-Thr*-Ala-[3-(2-iminoimidazolidine-4beta-yl)-Ala-]-Ile-]
telacebec PDB Ligand 12953 MMV687696, Q203
telavancin Approved drug 10925 TD-6424, TD6424, Vibativ®
telithromycin Approved drug 10878 HMR-3647, Ketek®, Levviax®, RU-66647, RU66647
temafloxacin Approved drug 10866 A-62254, A62254, Abbott 62254, Omniflox®
temocillin Approved drug 10926 BRL-17421, BRL17421, Negaban®
tetracycline Approved drug 10927 Achromycin®, Ala-Tet®, Brodspec®, NSC-108579, Panmycin®, Sumycin®, TCN
tetroxoprim 12328
tevenel 12398
thiamphenicol PDB Ligand 12400
Thiazomycin A 10990 compound 6 [PMID: 18804380]
thioridazine Approved drug 100 Mellaril®, thioridazin, TP-21
tiamulin PDB Ligand 13651 81.723 hfu, Denagard® (veterinary), thiamutilin
ticarcillin Approved drug 10928 BRL-2288, BRL2288, Ticar, Timentin® (ticarcillin + clavulanate)
tideglusib 6929 NP-12, NP031112
tigecycline Approved drug 10929 GAR-936, GAR936, Tygacil®, WAY-GAR-936
tigemonam 10867 SQ-30213, SQ-30836 (tigemonam dicholate), SQ30213, SQ30836 (tigemonam dicholate)
tildipirosin 13689 Zuprevo® (veterinary)
tilmicosin 13690 EL-870, Micotil® (veterinary)
timcodar 10868 VX-853, VX853
tinidazole Approved drug 12341 CP 12574, Fasigyn®, Tindamax®
tirandalydigin 11012
tobramycin Approved drug PDB Ligand 10930 Bethkis®, Kitabis®, Tobi Podhaler®, Tobradex® (tobramycin + dexamethasone), Vantobra®
tomopenem 10869 CS-023, CS023, R-115685, R115685, RO-4908463
tosatoxumab 13362 AR-301, KBSA301, Salvecin™
tosufloxacin Approved drug 12878 Ozex®, T-3262
TP-271 11013 TP271
TP-6076 PDB Ligand 13198
trimethoprim Approved drug PDB Ligand 10931 BW-56-72, BW-5672, NSC-106568, Primsol®, Proloprim®, Trimpex®
troleandomycin Approved drug 10209 oleandocetin, Tao®, triacetyloleandomycin
trospectomycin 10870 U-63,366F, U-63366F, U63366F
trovafloxacin Approved drug 13476 CP-99,219, Trovan®, Turvel®
tulathromycin 13691 Draxxin® (veterinary), tulathromycin A
tunicamycin PDB Ligand 13510 tunicamycin A, tunicamycin B2, tunicamycin V
TXA6101 PDB Ligand 13012
TXA709 13160
tylosin PDB Ligand 13707 tylosin A
tylvalosin 13706 acetylisovaleryltylosin, Aivlosin® (veterinary)
 
U Back to top
upleganan 12797 compound 44 [PMID: 31525992], EVER206, SPR206
 
V Back to top
vaborbactam Approved drug PDB Ligand 10871 compound 9f [PMID: 25782055], RPX-7009, RPX7009, Vabomere (vaborbactam + meropenem)
valnemulin 13813 Econor® (veterinary)
vancomycin Approved drug 10932 Vancocin®, Vancor®
vanillobiocin 12130 novclobiocin 311
verapamil Approved drug 2406 Ansyr®, CP-165331 / CP-16533-1, Securon®
verdamicin 11010 6'-C-Methylsisomicin
vermisporin 11011
vertilmicin 11018
viomycin Approved drug 13252 celiomycin, florimycin, tuberactinomycin B
viquidacin 10872 AVE-4221, AVE4221, compound 1 [PMID: 23968485], NXL-101, NXL101
virginiamycin S1 13755 staphylomycin S, virgimycin
voxvoganan 13759 AMC-109, LTX 109, LTX-109, Lytixar®
 
W Back to top
walrycin B 11256
wollamide B 13452
 
X Back to top
xeruborbactam PDB Ligand 13131 QPX7728
xeruborbactam isoboxil 13241 QPX-7831, QPX7831
 
Z Back to top
zabofloxacin 10873 DW-224a
zidebactam 10874 WCK-5107, WCK5107
zifanocycline 12794 KBP-7072
zoliflodacin PDB Ligand 10875 AZD-0914, AZD0914, EXT-0914, EXT0914
zosurabalpin PDB Ligand 12950 Abx MCP, RG6006, RO7223280
 
Antibacterial targets curated in GtoPdb.
Target Target ID Comments

Resources

AntibioticDB, an open-access database of antibacterial agents

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GARDP’s REVIVE supports the antimicrobial research and development community through open-access webinars, conferences, articles and other materials.

References

  1. Bertagnolio S, Dobreva Z, Centner CM, Olaru ID, Donà D, Burzo S, Huttner BD, Chaillon A, Gebreselassie N, Wi T, Hasso-Agopsowicz M et al.. WHO global research priorities for antimicrobial resistance in human health. Lancet Microbe. 2024 Nov;5(11):100902. doi: 10.1016/S2666-5247(24)00134-4. Epub 2024 Aug 13. [PMID: 39146948]
  2. Rice LB. (2008) Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J Infect Dis, 197 (8): 1079-81. [PMID: 18419525]
  3. Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y et al.. (2018) Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis, 18 (3): 318-327. [PMID: 29276051]
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Further Reading

  • Cook MA, Wright GD. (2022) The past, present, and future of antibiotics. Sci Transl Med, 14 (657): eabo7793. [PMID: 35947678]
  • Piddock LJV, Alimi Y, Anderson J, de Felice D, Moore CE, Røttingen JA, Skinner H, Beyer P. Advancing global antibiotic research, development and access. Nat Med. 2024 Sep;30(9):2432-2443. [PMID: 39227444]