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ChEMBL ligand: CHEMBL184618 (Actilin, Antibiotic 10676, ANTIBIOTIQUE EF 185, Dekamycin iii, Enterfram, Fradiomycin b, Framidal, Framycetin, Framycin, Framygen, Francetin, Neomycin b) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Anthrax lethal factor in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4372] [UniProtKB: P15917] | ||||||||
ChEMBL | Inhibition of anthrax lethal factor metalloprotease | B | 6.3 | pKi | 500 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 5183-5189 [PMID:16870442] |
Human immunodeficiency virus type 1 REV in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3852] [UniProtKB: Q77YF8] | ||||||||
ChEMBL | Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy | F | 6.74 | pKd | 180 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1127-1131 [PMID:11354359] |
Menin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1615381] [UniProtKB: O00255] | ||||||||
ChEMBL | Binding affinity to menin (unknown origin) by isothermal titration calorimetry analysis | B | 4.81 | pKd | 15600 | nM | Kd | Bioorg Med Chem Lett (2014) 24: 2090-2093 [PMID:24709560] |
Phosphatidylcholine-retinol O-acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2202] [UniProtKB: O95237] | ||||||||
ChEMBL | Compound tested in vitro for inhibition of translation using highly active Escherichia coli S30 and a plasmid containing a gene expressing truncated lecithin retinol acyltransferase | B | 4.83 | pIC50 | 14900 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 901-903 [PMID:12617917] |
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
ChEMBL | Inhibition of TRPV1-mediated membrane currents in human DRG neurons | B | 6.4 | pIC50 | 400 | nM | IC50 | Medchemcomm (2011) 2: 181-184 |
CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442] | ||||||||
GtoPdb | - | - | 4 | pKd | - | - | - | Proc Natl Acad Sci USA (1995) 92: 131-5 [PMID:7816802] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]