ofloxacin [Ligand Id: 10918] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4 (DL-8280, Exocin, Floxin, Floxin otic, HOE 280, HOE-280, J01MA01, NSC-727071, NSC-758178, Ocuflox, Ofloxacin, Tarivid, Tarivid 400, Tarivid i.v., Visiren) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] | ||||||||
| GtoPdb | DNA-supercoiling assay | - | 5.46 | pIC50 | 3500 | nM | IC50 | Antimicrob Agents Chemother (2001) 45: 1994-2000 [PMID:11408214] |
| ChEMBL | Inhibition of Escherichia coli DNA gyrase GyrA/GyrB | B | 5.82 | pIC50 | 1500 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2909-2914 [PMID:18426901] |
| DNA gyrase subunit A/DNA gyrase subunit B in Escherichia coli [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] | ||||||||
| GtoPdb | DNA-supercoiling assay | - | 5.46 | pIC50 | 3500 | nM | IC50 | Antimicrob Agents Chemother (2001) 45: 1994-2000 [PMID:11408214] |
| DNA gyrase subunit A/DNA gyrase subunit B in Mycobacterium tuberculosis (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430898] [UniProtKB: P9WG45, P9WG47] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB | B | 4.55 | pIC50 | 28000 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2909-2914 [PMID:18426901] |
| GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14] | ||||||||
| ChEMBL | Inhibition of [3H]muscimol binding to GABA A receptor with compound alone at 10 e-4 M | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1993) 36: 1356-1363 [PMID:8388467] |
| ChEMBL | Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (1993) 36: 1356-1363 [PMID:8388467] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| TAS2R9 in Human [GtoPdb: 665] [UniProtKB: Q9NYW1] | ||||||||
| GtoPdb | - | - | 3.7 | pEC50 | 200000 | nM | EC50 | PLoS One (2008) 3: e3974 [PMID:19092995] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
