clindamycin [Ligand Id: 10607] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1753 (7(s)-chloro-7-deoxylincomycin, Antirobe, Chlorodeoxylincomycin, Chlorolincomycin, Cleocin, Cleocin T, Clindamycin, Sobelin, U-21,251, U-21251) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry | F | 4 | pIC50 | >100000 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry | F | 4 | pIC50 | >100000 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 48 hrs | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 96 hrs | F | 6.35 | pIC50 | 450 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay | F | 7.94 | pIC50 | 11.6 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 540-542 [PMID:19841147] |
| ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free | F | 8.06 | pIC50 | 8.81 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free | F | 8.51 | pIC50 | 3.12 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 96 hrs | F | 8.51 | pIC50 | 3.1 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs | F | 8.89 | pIC50 | 1.3 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
