thymol [Ligand Id: 2499] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL29411 (3-hydroxy-p-cymene, Apiguard, Eftab, FEMA NO. 3066, Gppe mthwsh tab, Listerine, NSC-11215, NSC-47821, NSC-49142, P-cymen-3-ol, Sotol, Tellodont, Tellora, Thyme camphor, Thymol, Thymolum, Valda) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Heat sensitive channel TRPV3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879847] [UniProtKB: Q4QYD9] | ||||||||
| ChEMBL | Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-aminoethoxydiphenyl borate-induced intracellular calcium concentration by Fluo-4AM dye-based spectrofluorometry | B | 4.54 | pEC50 | 29000 | nM | EC50 | J Nat Prod (2016) 79: 1762-1768 [PMID:27352042] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at TRPA1 (unknown origin) by calcium imaging assay | B | 4.06 | pEC50 | 86900 | nM | EC50 | Bioorg Med Chem Lett (2021) 31: 127639-127639 [PMID:33129991] |
| ChEMBL | Activation of TRPA1 channel | B | 4.2 | pEC50 | 62500 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.22 | pEC50 | 60255.96 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.22 | pEC50 | 60000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by calcium-3 dye based FLIPR analysis | B | 4.7 | pEC50 | 20000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| GtoPdb | FLIPR calcium influx assay | - | 4.7 | pEC50 | 20000 | nM | EC50 | Br J Pharmacol (2008) 153: 1739-49 [PMID:18334983] |
| ChEMBL | Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx | F | 5.22 | pEC50 | 6000 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| ChEMBL | Activation of human TRPA1 assessed as stimulation of intracellular Ca2+ levels | B | 5.22 | pEC50 | 6000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 3535-3539 [PMID:22503249] |
| TRPM8/Transient receptor potential cation channel subfamily M member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5011] [GtoPdb: 500] [UniProtKB: Q8R455] | ||||||||
| ChEMBL | Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels | B | 4.28 | pEC50 | 52200 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 3535-3539 [PMID:22503249] |
| TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] | ||||||||
| GtoPdb | Patch clamp electrophysiology | - | 3.3 | pEC50 | - | - | - | Nat Neurosci (2006) 9: 628-35 [PMID:16617338] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
