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rosoxacin   Click here for help

GtoPdb Ligand ID: 12474

Synonyms: acrosoxacin | Eracine® | Eradacil® | Eradacin® | WIN 35213 | Winuron®
Approved drug
rosoxacin is an approved drug
Compound class: Synthetic organic
Comment: Rosoxacin is a quinolone antibacterial compound with activity against Gram-negative bacteria.

rosoxacin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 69.97
Molecular weight 294.31
XLogP 1.44
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCN1C=C(C(=O)C2=CC=C(C=C21)C3=CC=NC=C3)C(=O)O
Isomeric SMILES CCN1C=C(C(=O)C2=C1C=C(C=C2)C3=CC=NC=C3)C(=O)O
InChI InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
InChI Key XBPZXDSZHPDXQU-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes.
Withdrawn drug? Yes
IUPAC Name Click here for help
1-ethyl-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
3903 rosoxacin
Synonyms Click here for help
acrosoxacin | Eracine® | Eradacil® | Eradacin® | WIN 35213 | Winuron®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo 2044
Other databases
CAS Registry No. 40034-42-2 (source: Scifinder)
ChEBI CHEBI:131715
ChEMBL Ligand CHEMBL291157
DrugBank Ligand DB00817
DrugCentral Ligand 83
GtoPdb PubChem SID 479821264
PubChem CID 287180
Search Google for chemical match using the InChIKey XBPZXDSZHPDXQU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XBPZXDSZHPDXQU
Search PubMed clinical trials rosoxacin
Search PubMed titles rosoxacin
Search PubMed titles/abstracts rosoxacin
UniChem Compound Search for chemical match using the InChIKey XBPZXDSZHPDXQU-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey XBPZXDSZHPDXQU-UHFFFAOYSA-N

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
Rosoxacin (links to external site)
Cat. No. HY-A0208