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moxifloxacin   Click here for help

GtoPdb Ligand ID: 10915

Synonyms: Avelox® | BAY-12-8039 | BAY-128039 | BAY128039 | MFX | MOXIVIG® (opthalmic solution)
Approved drug PDB Ligand
moxifloxacin is an approved drug (FDA (1999), UK (2009))
Compound class: Synthetic organic
Comment: Moxifloxacin is a fourth generation fluoroquinolone antibacterial. Compared to earlier generation fluoroquinolones it has expanded activity against Gram-positive bacteria and some atypical pathogens.

moxifloxacin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 83.8
Molecular weight 401.18
XLogP 4.53
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES COc1c(N2C[C@@H]3[C@H](C2)CCCN3)c(F)cc2c1n(cc(c2=O)C(=O)O)C1CC1
Isomeric SMILES COc1c(N2C[C@@H]3[C@H](C2)CCCN3)c(F)cc2c1n(cc(c2=O)C(=O)O)C1CC1
InChI InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1
InChI Key FABPRXSRWADJSP-MEDUHNTESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. UK MHRA (2009)  |  US FDA (1999)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
7659 moxifloxacin
Synonyms Click here for help
Avelox® | BAY-12-8039 | BAY-128039 | BAY128039 | MFX | MOXIVIG® (opthalmic solution)
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Moxifloxacin
Other databases
BindingDB Ligand 50366824
CAS Registry No. 151096-09-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL32
DrugBank Ligand DB00218
DrugCentral Ligand 1854
GtoPdb PubChem SID 405560356
PubChem CID 152946
RCSB PDB Ligand MFX
Search Google for chemical match using the InChIKey FABPRXSRWADJSP-MEDUHNTESA-N
Search Google for chemicals with the same backbone FABPRXSRWADJSP
Search PubMed clinical trials moxifloxacin
Search PubMed titles moxifloxacin
Search PubMed titles/abstracts moxifloxacin
UniChem Compound Search for chemical match using the InChIKey FABPRXSRWADJSP-MEDUHNTESA-N
UniChem Connectivity Search for chemical match using the InChIKey FABPRXSRWADJSP-MEDUHNTESA-N

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MedChemExpress
Moxifloxacin (links to external site)
Cat. No. HY-66011A