cladosporin [Ligand Id: 10247] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL448685 (Cladosporin) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.1 | pIC50 | 80.1 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.06 | pIC50 | 87.9 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium yoelii [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 7.41 | pIC50 | 39.1 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase/Lysine--tRNA ligase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3301561] [GtoPdb: 3059] [UniProtKB: Q8IDJ8] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum KRS expressed in Escherichia coli BL21 using tRNA(Lys) as substrate after 45 mins in presence of L-lysine by AMP-GLO assay | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2018) 61: 5664-5678 [PMID:29779382] |
| GtoPdb | Parasite growth inhibition assay | - | 7.34 | pIC50 | 45.4 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum D6 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.14 | pIC50 | 72.1 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046] | ||||||||
| ChEMBL | Inhibition of human recombinant cytoplasmic lysyl-tRNA synthetase | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum D10 | F | 7.05 | pEC50 | 90 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| ChEMBL | Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum 3D7 | F | 7.35 | pEC50 | 45 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green-1 staining based assay | F | 7.4 | pEC50 | 40 | nM | EC50 | J Med Chem (2018) 61: 5664-5678 [PMID:29779382] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
