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eravacycline   Click here for help

GtoPdb Ligand ID: 10805

Synonyms: compound 17j [PMID: 2148514] | TP-434 | TP434 | Xerava®
Approved drug PDB Ligand
eravacycline is an approved drug (EMA & FDA (2018))
Compound class: Synthetic organic
Comment: Eravacycline is a parenteral tetracycline antibacterial.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 11
Hydrogen bond donors 6
Rotatable bonds 6
Topological polar surface area 193.73
Molecular weight 558.21
XLogP 0.79
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C(Nc1cc(F)c2c(c1O)C(=C1[C@@H](C2)C[C@@H]2[C@@](C1=O)(O)C(=C(C(=O)[C@H]2N(C)C)C(=O)N)O)O)CN1CCCC1
Isomeric SMILES O=C(Nc1cc(F)c2c(c1O)C(=C1[C@@H](C2)C[C@@H]2[C@@](C1=O)(O)C(=C(C(=O)[C@H]2N(C)C)C(=O)N)O)O)CN1CCCC1
InChI InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34-35,38,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1
InChI Key AKLMFDDQCHURPW-ISIOAQNYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (2018)  |  US FDA (2018)
IUPAC Name Click here for help
(4S,4aS,5aR,12aR)-4-(dimethylamino)-7-fluoro-1,10,11,12a-tetrahydroxy-3,12-dioxo-9-[(2-pyrrolidin-1-ylacetyl)amino]-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
International Nonproprietary Names Click here for help
INN number INN
9702 eravacycline
Synonyms Click here for help
compound 17j [PMID: 2148514] | TP-434 | TP434 | Xerava®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Eravacycline (Xerava)
Other databases
CAS Registry No. 1207283-85-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL1951095
GtoPdb PubChem SID 405560246
PubChem CID 54726192
RCSB PDB Ligand YQM
Search Google for chemical match using the InChIKey AKLMFDDQCHURPW-ISIOAQNYSA-N
Search Google for chemicals with the same backbone AKLMFDDQCHURPW
Search PubMed clinical trials eravacycline
Search PubMed titles eravacycline
Search PubMed titles/abstracts eravacycline
UniChem Compound Search for chemical match using the InChIKey AKLMFDDQCHURPW-ISIOAQNYSA-N
UniChem Connectivity Search for chemical match using the InChIKey AKLMFDDQCHURPW-ISIOAQNYSA-N