DEBIO 1452 [Ligand Id: 10755] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1652621 (Afabicin desphosphono, Afn-1252, AFN-1252, API 1252, API-1252, DEBIO-1452, DEBIO1452) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3994] [UniProtKB: Q6GI75] | ||||||||
| ChEMBL | Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate | B | 5.02 | pIC50 | 9600 | nM | IC50 | Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635] |
| ChEMBL | Inhibition of N-terminal his 6 tagged Staphylococcus aureus Fabi (1 to 771 residues) expressed in Escherichia coli BL21 incubated for 30 mins in presence of NADPH by fluorescence based microplate reader analysis | B | 7.37 | pIC50 | 42.3 | nM | IC50 | J Med Chem (2024) 67: 10096-10134 [PMID:38845361] |
| ChEMBL | Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometry | B | 7.54 | pIC50 | 29 | nM | IC50 | Eur J Med Chem (2014) 84: 382-394 [PMID:25036796] |
| ChEMBL | Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 mins | B | 7.85 | pIC50 | 14 | nM | IC50 | Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
