GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

xeruborbactam isoboxil   Click here for help

GtoPdb Ligand ID: 13241

Synonyms: QPX-7831 | QPX7831
Compound class: Synthetic organic
Comment: QPX7831 is an orally bioavailable prodrug of xeruborbactam [1].
The chemical structure of QPX7831 is identical to that for the INN xeruborbactam isoboxil (proposed list 132, Feb. 2025).
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 82.06
Molecular weight 322.09
XLogP 1.46
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CC(C)C(=O)OCOC(=O)C1=C2C(=CC=C1F)[C@@]3([H])C[C@@]3([H])B(O)O2
Isomeric SMILES [H][C@]12C[C@@]1([H])B(O)OC3=C2C=CC(=C3C(=O)OCOC(C(C)C)=O)F
InChI InChI=1S/C15H16BFO6/c1-7(2)14(18)21-6-22-15(19)12-11(17)4-3-8-9-5-10(9)16(20)23-13(8)12/h3-4,7,9-10,20H,5-6H2,1-2H3/t9-,10-/m1/s1
InChI Key FCXHIXHOQJYLTG-NXEZZACHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Is prodrug? Yes
Active form xeruborbactam
IUPAC Name Click here for help
[(2S,4R)-9-fluoro-5-hydroxy-6-oxa-5-boratricyclo[5.4.0.02,4]undeca-1(7),8,10-triene-8-carbonyloxy]methyl 2-methylpropanoate
International Nonproprietary Names Click here for help
INN number INN
13428 xeruborbactam isoboxil
Synonyms Click here for help
QPX-7831 | QPX7831
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo QPX7831 (Prodrug of QPX7728)
Other databases
CAS Registry No. 2708983-65-5 (source: WHO INN record)
GtoPdb PubChem SID 491300023
PubChem CID 156858930
Search Google for chemical match using the InChIKey FCXHIXHOQJYLTG-NXEZZACHSA-N
Search Google for chemicals with the same backbone FCXHIXHOQJYLTG
Search PubMed clinical trials xeruborbactam isoboxil
Search PubMed titles xeruborbactam isoboxil
Search PubMed titles/abstracts xeruborbactam isoboxil
UniChem Compound Search for chemical match using the InChIKey FCXHIXHOQJYLTG-NXEZZACHSA-N
UniChem Connectivity Search for chemical match using the InChIKey FCXHIXHOQJYLTG-NXEZZACHSA-N