cloxacillin [Ligand Id: 11126] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL891 (Cloxacillin, Cloxapen, Orbenin, Tegopen)
  • Beta-lactamase ACC-4 in Escherichia coli [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9]
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  • Beta-lactamase TEM in Escherichia coli [ChEMBL: CHEMBL2065] [UniProtKB: P62593]
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  • Class C beta-lactamase CMY-36 in Klebsiella pneumoniae [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase ACC-4 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5305] [UniProtKB: A4ZYU9]
ChEMBL Inhibition of Escherichia coli beta-lactamase ACC4 B 7.59 pIC50 26 nM IC50 Antimicrob Agents Chemother (2007) 51: 3763-3767 [PMID:17664321]
Beta-lactamase TEM in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2065] [UniProtKB: P62593]
ChEMBL Inhibition constant (Ki) for TEM-1 beta-lactamase B 4.89 pKi 13000 nM Ki J Med Chem (1988) 31: 370-374 [PMID:3257523]
Class C beta-lactamase CMY-36 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641338] [UniProtKB: Q48435]
ChEMBL Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin B 8.4 pIC50 4 nM IC50 Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021]
Efflux transporter in Salmonella newport (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641337] [UniProtKB: Q3S5C3]
ChEMBL Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin B 8.4 pIC50 4 nM IC50 Antimicrob Agents Chemother (2009) 53: 1256-1259 [PMID:19104021]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]