cefotaxime [Ligand Id: 10893] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1730 (Cefotaxima, Cefotaxime, Cefotaxim hikma)
Created with Highcharts 10.3.3ValuesChart context menuADC-11pKd Acinetobacter baumanniipKi Acinetobacter baumanniipIC50 Acinetobacter baumanniipEC50 Acinetobacter baumannii0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuBeta-lactamase ADC-33pKd Acinetobacter baumanniipKi Acinetobacter baumanniipIC50 Acinetobacter baumanniipEC50 Acinetobacter baumannii01234567Highcharts.com
  • Organic anion transporter 4/Solute carrier family 22 member 11 in Human [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
Created with Highcharts 10.3.3ValuesChart context menuSolute carrier family 22 member 11pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
Created with Highcharts 10.3.3ValuesChart context menuSolute carrier family 22 member 6pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
Created with Highcharts 10.3.3ValuesChart context menuSolute carrier family 22 member 8pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADC-11 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667701] [UniProtKB: D6NSM8]
ChEMBL Activity of Acinetobacter baumannii ADC-11 beta-lactamase B 5.6 pKi 2500 nM Ki Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808]
Beta-lactamase ADC-33 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667700] [UniProtKB: B2ZTR6]
ChEMBL Activity of Acinetobacter baumannii ADC-33 beta-lactamase B 6.3 pKi 500 nM Ki Antimicrob Agents Chemother (2010) 54: 3484-3488 [PMID:20547808]
Organic anion transporter 4/Solute carrier family 22 member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells F 5.21 pKi 6150 nM Ki Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells F 5.5 pKi 3130 nM Ki Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells F 6.54 pKi 290 nM Ki Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]