sulfasalazine [Ligand Id: 4840] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL421 (Azulfidine, Azulfidine en-tabs, Benzosulfa, Colizine, NSC-203730, NSC-667219, Salazopyrin, Salazopyrin e.c., Salazopyrin-en, Salazosulfapyridine, Salicylazosulfapyridine, S.a.s.-500, SAS-500, Sulfasalazina, Sulfasalazine, Sulfasalazinum, Sulfasalazopyridine, Sulphasalazine, Ucine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldo-keto reductase family 1 member B1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) | B | 4.77 | pIC50 | 17042 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Androgen receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) | B | 4.53 | pKi | 29301 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) | B | 4.36 | pIC50 | 43951 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ABCB1/ATP-dependent translocase ABCB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | Activation of ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substrate measured after 1 hr by colorimetric assay | B | 6.04 | pEC50 | 916 | nM | EC50 | Eur J Med Chem (2020) 191: 112133-112133 [PMID:32105979] |
| Bifunctional purine biosynthesis protein ATIC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2518] [UniProtKB: P31939] | ||||||||
| ChEMBL | Inhibition of AICAR transformylase (unknown origin) | B | 4.66 | pKi | 22000 | nM | Ki | J Med Chem (2020) 63: 8314-8324 [PMID:32658475] |
| ABCG2/Broad substrate specificity ATP-binding cassette transporter ABCG2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] | ||||||||
| ChEMBL | Inhibition of ABCG2 (unknown origin) expressed in human HEK cells membrane vesicle assessed as inhibition of BCRP- mediated transport of [3H]-E3S using [3H]-oestrone 3-sulfate as radiolabeled substrate by liquid scintillation counter analysis | B | 6.34 | pIC50 | 460 | nM | IC50 | Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322] |
| carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot | B | 5.16 | pKi | 6870 | nM | Ki | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry | B | 5.52 | pIC50 | 3040 | nM | IC50 | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot | B | 5.06 | pKi | 8720 | nM | Ki | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry | B | 5.35 | pIC50 | 4490 | nM | IC50 | Bioorg Med Chem (2008) 16: 9101-9105 [PMID:18819808] |
| Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
| ChEMBL | DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) | B | 4.54 | pIC50 | 28812 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Cystine/glutamate transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075149] [GtoPdb: 902] [UniProtKB: Q9UPY5] | ||||||||
| ChEMBL | Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6184-6187 [PMID:21889337] |
| ChEMBL | Inhibition of XCT (unknown origin) | B | 4.98 | pIC50 | 10400 | nM | IC50 | EP-4008330-A1. Combined inhibition of amino acid transporters for inhibiting human plasmacytoid dendritic cell activity during autoimmunity (2022) |
| ChEMBL | Inhibition of XCT (unknown origin) | B | 4.98 | pIC50 | 10400 | nM | IC50 | WO-2022122668-A1. Combined inhibition of amino acid transporters for inhibiting human plasmacytoid dendritic cell activity during autoimmunity (2022) |
| ChEMBL | Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptake | B | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2019) 163: 215-242 [PMID:30522056] |
| Flavin reductase (NADPH) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5019] [UniProtKB: P30043] | ||||||||
| ChEMBL | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | B | 6.36 | pKd | 440 | nM | Kd | J Med Chem (2022) 65: 2548-2557 [PMID:34957824] |
| ChEMBL | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | B | 6.36 | pKd | 436.52 | nM | Kd | J Med Chem (2022) 65: 2548-2557 [PMID:34957824] |
| Sodium/bile acid and sulphated solute cotransporter 1/Hepatic sodium/bile acid cotransporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
| ChEMBL | Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed by [14C] taurocholate addition and further incubation for 10 mins by scintillation counting method | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126623-126623 [PMID:31439379] |
| ChEMBL | Inhibition of human NTCP mediated TCA uptake in U2OS expresseing HA-tagged NTCP cells preincubated for 10 mins followed by substrate addition and measured after 2 mins using [3H]-taurocholate as substrate by liquid scintillation counter analysis | B | 5.02 | pIC50 | 9600 | nM | IC50 | J Med Chem (2022) 65: 12546-12561 [PMID:36111355] |
| ChEMBL | Inhibition of preS1-peptide binding to human HA-tagged NTCP in U2OS expresseing NTCP in incubated for 24 hrs using Myrcludex B as substrate by competitive binding assay | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2022) 65: 12546-12561 [PMID:36111355] |
| MMP1/Interstitial collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) | B | 4.63 | pIC50 | 23549 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) | B | 5.2 | pIC50 | 6332 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| nuclear factor kappa B subunit 1/nuclear factor kappa B subunit 2/RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B complex in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094258] [GtoPdb: 3281, 3282, 3280] [UniProtKB: P19838, Q00653, Q04206] | ||||||||
| ChEMBL | Inhibition of NF-kappaB (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | Eur J Med Chem (2024) 270: 116333-116333 [PMID:38569434] |
| Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
| ChEMBL | Binding affinity to MERS-CoV papain-like protease by SPR analysis | B | 5.12 | pKd | 7600 | nM | Kd | Bioorg Med Chem (2019) 27: 1981-1989 [PMID:30940566] |
| CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
| ChEMBL | DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) | B | 4.71 | pIC50 | 19639 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Proton-coupled folate transporter in Human [GtoPdb: 1213] [UniProtKB: Q96NT5] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 60000 | nM | IC50 | Cell (2006) 127: 917-28 [PMID:17129779] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
