daunorubicin [Ligand Id: 7063] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL178 (Daunomycin, Daunorubicin, Daunorubicina, Daunorubicin component of vyxeos, Daunorubicine, Daunoxome, Epirubicin hydrochloride impurity, daunorubicin-, FI 6339, FI-6339, NSC-83142, RP 13057, RP-13057, Valrubicin impurity, daunorubicin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MMP2/72 kDa type IV collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibitory concentration against Clostridium histolyticum Collagenase | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (1992) 35: 2768-2771 [PMID:1322986] |
| ABCC2/ATP-binding cassette sub-family C member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) in MRP2-expressing MDCK cells | F | 4.31 | pKi | 49400 | nM | Ki | Pharm Res (2002) 19: 773-779 [PMID:12134946] |
| ABCB1/ATP-dependent translocase ABCB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells | F | 5.6 | pKi | 2500 | nM | Ki | Pharm Res (2001) 18: 171-176 [PMID:11405287] |
| DNA topoisomerase II alpha/DNA topoisomerase 2-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388] | ||||||||
| ChEMBL | Inhibition of Topo IIalpha (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2023) 95: 117486-117486 [PMID:37847948] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 7.33 | pIC50 | 47 | nM | IC50 | Eur J Med Chem (2021) 209: 112844-112844 [PMID:33143937] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of HDAC6 (unknown origin) | B | 7.7 | pIC50 | 20 | nM | IC50 | Eur J Med Chem (2021) 209: 112844-112844 [PMID:33143937] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| ChEMBL | Inhibition of HDAC8 (unknown origin) | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2021) 209: 112844-112844 [PMID:33143937] |
| ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of DNP-SG uptake in membrane vesicles from GLC4/ADR cells | F | 6.02 | pKi | 950 | nM | Ki | Biochim Biophys Acta (1997) 1326: 12-22 [PMID:9188796] |
| ChEMBL | TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cells | F | 7.15 | pKi | 70 | nM | Ki | Biochem Biophys Res Commun (1998) 247: 859-863 [PMID:9647783] |
| ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells | F | 5.1 | pIC50 | 8000 | nM | IC50 | J Biol Chem (1996) 271: 9683-9689 [PMID:8621644] |
| Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
| ChEMBL | HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells | F | 5.52 | pIC50 | 2990 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | HARVARD: Inhibition of blood stage Plasmodium falciparum 3D7 infection | F | 6.47 | pIC50 | 340 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
| ChEMBL | HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection | F | 6.81 | pIC50 | 155 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
| transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
| ChEMBL | Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2021) 44: 116292-116292 [PMID:34225167] |
| peptidase D/Xaa-Pro dipeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955] | ||||||||
| ChEMBL | Inhibition of prolidase (unknown origin) | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2024) 110: 117833-117833 [PMID:38996544] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
